Beta-lactamase 3D structures

3D Structures of Beta-lactamase3D Structures of Beta-lactamase

Updated on 16-February-2023

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• β-lactamase class A
  • 3dtm, 1bza, 1ck3, 1esu, 1jwp, 1lhy, 1li0, 1m40, 1zg6, 2v1z, 2v20, 3cmz, 3jyi, 4ibr, 4ibx, 4mez, 4rx2, 4rx3, 6b2n, 5kpu, 5iq8, 5i63, 5i52, 5hw5, 5hw1, 5hvi, 6ayk, 6apa - EcBlac A Tem-1 (mutant) - Escherichia coli
    
  • 1btl, 1iys, 1xpb, 1zg4, 4gku, 4rva, 5npo, 7u6q - EcBlac A Tem-1
    
  • 4r4s, 4r4r, 4qy6, 4qy5 - EcBlac A Tem-1/PSE-4
    
  • 1lhy - EcBlac A Tem-30 (mutant)
    
  • 1li0 - EcBlac A Tem-32 (mutant)
    
  • 1li9 - EcBlac A Tem-34 (mutant)
    
  • 1yt4 - EcBlac A Tem-76 (mutant)
    
  • 3toi - EcBlac A Tem-116 (mutant)
    
  • 7qor – EcBlac Tem-171
    
  • 5chu, 5cgs – EcBlac FOX-4
    
  • 5cgw – EcBlac FOX-4 (mutant)
    
  • 4zj2, 4zj1 – EcBlac Tem (mutant)
    
  • 4id4 – EcBlac/PaBlac Tem
    
  • 1o7e, 1n4o, 5ne2 – StmBlac A – Stenotrophonas maltophilia
    
  • 1htz – KpBlac A Tem-52 – Klebsiella pneumoniae
    
  • 1shv, 4fh4, 4fcf, 4jpm - KpBlac A Shv-1
    
  • 1tdl, 2a3u, 3oph, 3opl, 3v50, 3v5m, 4fd8 - KpBlac A Shv-1 (mutant)
    
  • 1n9b – KpBlac A Shv-2
    
  • 6nfd - KpBlac A Shv-11 (mutant)
    
  • 5haq, 5hap - KpBlac A (mutant)
    
  • 2qpn – KpBlac A Ges-1
    
  • 3ni9 - PaBlac A Ges-2
    
  • 1hzo – Blac A – Proteus vulgaris
    
  • 1kge, 1kgf, 1kgg, 1ome – SaBlac A (mutant) - Staphylococcus aureus
    
  • 3blm – SaBlac A
    
  • 1mbl, 3ly3, 3soi, 4n92, 5ghx, 5zfl – BlBlac A (mutant) – Bacillus licheniformis
    
  • 2blm, 3sh7, 4blm – BlBlac A
    
  • 2cc1 – Blac A – Mycobacterium fortuitum
    
  • 3bfd, 3bfe – CsBlac A Sed-1 (mutant) - Citrobacter sedlakii
    
  • 3s4x, 5har, 5hai - EncBlac A (mutant) – Enterobacter cloacae
    
  • 3zdj, 4b88 – Blac – precambrian
    
  • 4c6y, 4c75, 5fqm, 6tww, 6txd, 6ty6, 6yrs – Blac – synthetic
    
  • 5tfq – Blac – Bacterioides cellulosilyticus
    
  • 5glc, 5gla, 5gl9 - BtBlac A - Burkholderia thailandensis
    
  • 6afm, 6afo - BtBlac A (mutant)
    
  • 4yfm – Blac – Mycobacterium abscessus
    
  • 6ni1 – BsBlac A – Bacillus subtilis
    
  • 6niq – Blac A – Rhodopseudomonas palustris
    
  • 6nj1 – Blac A – Clostridium kluyveri
    
  • 6b6a, 6b6b, 6b69, 6b68, 6b5x, 6n14 – MtBlac – Mycobacterium tuberculosis
    
  • 6v6n - Blac A (mutant) – Agrobacterium tumefaciens
    
  • 6w34 – BcBlac A (mutant) - Bacillus cereus
    
  • 6wip – Blac A – Micromonospora aurantiaca
    
  • 6l3s – MmBlac Imp-27 – Morganella morganii
    
• β-lactamase class A binary complex
  • 1axb, 5ksc - EcBlac A (mutant) + transition state analog
    
  • 5ujo - EcBlac A (mutant) + organometallics
    
  • 5fa7 - EcBlac A + inhibitor
    
  • 1nxy, 1ny0, 1nym, 1nyy - EcBlac A (mutant) + boronic acid inhibitor
    
  • 8de0 - EcBlac A Tem-1 + drug
    
  • 8de1, 8de2 - EcBlac A Tem-1 (mutant) + drug
    
  • 1pzo, 1pzp - EcBlac A Tem-1 (mutant) + inhibitor
    
  • 1erm, 1ero, 1erq – EcBlac A Tem-1 + boronic acid inhibitor
    
  • 1jwv, 1jwz - EcBlac A Tem-1 (mutant) + boronic acid inhibitor
    
  • 1ong, 1q2p, 1vm1, 2h5s, 2zd8, 3d4f, 3mke, 3mkf, 3mxr, 3mxs, 4fh2, 4gd6, 4gd8, 4gdb, 4mbf, 4r3b, 5ee8, 4zam - KpBlac A Shv-1 + inhibitor
    
  • 1rcj, 1tdg, 2a49, 2h0t, 2h0y, 2h10, 4mbh, 4mbk - KpBlac A Shv-1 (mutant) + inhibitor
    
  • 5t66, 5zyb - KpBlac A + boronic acid inhibitor
    
  • 1w7f, 3b3x, 2y91, 4a5r - BlBlac A + inhibitor
    
  • 3m2j, 4n9k, 4n9l - BlBlac A (mutant) + inhibitor
    
  • 4m3k, 4n1h, 5lwf - BlBlac A + antibody
    
  • 2q9m, 2q9n - EncBlac A + inhibitor
    
  • 3bfc, 3bff, 3bfg – CsBlac A Sed-1 (mutant) + inhibitor
    
  • 3nia - PaBlac A Ges-2 + inhibitor - Pseudomonas aeruginosa
    
  • 6q35 - PaBlac A Ges-5 + boronic acid inhibitor
    
  • 3p98 – MmBlac Tem-72 + citrate
    
  • 5tg7, 5tg6, 5tg5, 5tg4 - AbBlac A + boronic acid inhibitor
    
  • 5gld, 5glb - BtBlac A + boronic acid inhibitor
    
  • 6afn, 6afp - BtBlac A (mutant) + boronic acid inhibitor
    
  • 5ne1 - StmBlac A + boronic acid inhibitor
    
  • 6qw7, 6qw8, 7bj8 - StmBlac A + inhibitor
    
  • 6w2z - BsBlac A + inhibitor
    
  • 6w33 – BcBlac A (mutant) + inhibitor
    
• β-lactamase class A binary complex with antibiotics
  • 7qlp, 7qnk – EcBlac Tem-171 + antibiotic
    
  • 1tem, 1bt5, 1fqg, 1iyo, 1iyp, 1iyq, 1jvj, 3q07, 3q1f - EcBlac A (mutant) + antibiotic
    
  • 5kmw - EcBlac A (mutant) + penicillin derivative
    
  • 5chm, 5chj, 5za2 – EcBlac FOX-4 + antibiotic
    
  • 5cgx – EcBlac FOX-4 (mutant) + antibiotic
    
  • 4zj3 – EcBlac Tem (mutant) + antibiotic
    
  • 3opp, 3opr- KpBlac A Shv-1 (mutant) + antibiotic
    
  • 2wk0, 2x71– BlBlac A + antibiotic
    
  • 3ly4, 3m2k, 3sh8, 3sh9, 5ghz, 5ghy, 5zg6, 5zft – BlBlac A (mutant) + antibiotic
    
  • 5l2f - AbBlac A + antibiotic
    
  • 5ne3 - StmBlac A + antibiotic
    
  • 6dmh - SfBlac A (mutant) + antibiotic - Serratia fonticola
    
  • 6b6f, 6b6e, 6b6d, 6b6c, 6b5y – MtBlac + antibiotic
    
• Extended-spectrum β-lactamase class A
  • 3ni9 - PaESBL A Ges-2
    
  • 4gnu, 4h8r - PaESBL A Ges-5
    
  • 5f83, 5f82 - PaESBL A Ges-5 (mutant)
    
  • 3v3s – PaESBL Ges-18
    
  • 1e25 – PaESBL Per-1 (mutant)
    
  • 5eoe, 5eoo – PaESBL Bel-1
    
  • 4wz5 – PaESBL Oxa-10
    
  • 5mmy, 5mnu – PaESBL Oxa-10 (mutant)
    
  • 4yin – PaESBL Oxa-145
    
  • 4d2o, 6dgu - CfESBL PER-2 – Citrobacter freundii
    
  • 5kzh - AbESBL A - Acinetobacter baumannii
    
  • 3v3r - AbESBL A Ges-11
    
  • 3tsg – AbESBL Ges-14
    
  • 4oqi, 4op8, 4op5 - EcESBL Tem-1 (mutant)
    
  • 4opy - EcESBL Tem-63 (mutant)
    
  • 4opr, 4opq - EcESBL Tem-94 (mutant)
    
  • 1ylj, 2p74 – EcESBL Ctx-M-9
    
  • 3hre, 5kmt, 5kmu, 5kkf - EcESBL Ctx-M-9 (mutant)
    
  • 4ua6, 6d7h – EcESBL Ctx-M-14
    
  • 1ylt, 5vth, 5twd, 6cyn, 6cyk, 6d7i, 6v5e, 6v6g, 6v6p, 7k2x - EcBlac A Ctx-M-14 (mutant)
    
  • 4hbt, 7u57 – EcESBL Ctx-M-15
    
  • 1ylw - EcESBL Ctx-M-16
    
  • 1ylp - EcESBL Ctx-M-27 (mutant)
    
  • 5zb7 – EcESBL Ctx-M-64
    
  • 6j25 - EcESBL Ctx-M-64 (mutant)
    
  • 4c3q, 5a93, 5a92, 5a90 - EcESBL Ctx-M-97 (mutant)
    
  • 6c78, 6c79, 6c7a - EcESBLToho-1
    
  • 1we4, 2xr0, 2zq7, 2zq8, 2zq9, 2zqa, 2zqc, 2zqd, 4bd0, 4bd1, 4c3k, 6u58 - EcESBLToho-1 (mutant)
    
  • 2xqz, 2wyx - EcESBL Toho-1 (mutant) – Neutron
    
  • 6nvt – EcESBL Tla-1
    
  • 6pq9 – EcESBL Tla-1 (mutant)
    
  • 3zny - KpBlac A Ctx-M-12A (mutant)
    
  • 4pm8 - KpBlac A Ctx-M-14
    
  • 4pm6, 4pma - KpBlac A Ctx-M-14 (mutant)
    
  • 7bh3, 7bh4, 7bh5, 7bh6, 7bh7 - KpBlac A Ctx-M-15
    
  • 7qqc, 7r3q, 7r3r - KpBlac A Ctx-M-15 (mutant)
    
  • 2qpn – KpESBL A Ges-1
    
  • 6ts9 - PaESBL A Ges-5
    
  • 5gs8 – SmESBL Tla-3
    
  • 6bn3 – SeESBL Ctx-M-151 – Salmonela enterica
    
• Extended-spectrum β-lactamase class A binary complex
  • 4gog - PaESBL A GES-1 + acyl intermediate
    
  • 3nia - PaESBL A GES-2 + inhibitor
    
  • 3g2y, 3g2z, 3g30, 3g31, 3g32, 3g34, 3g35, 4dds, 4ddy, 4de0, 4de1, 4de2, 4de3, 1yly, 1ym1, 1yms - EcBlac A Ctx-M-9 + inhibitor
    
  • 4len - EcESBL Ctx-M-9 (mutant) + inhibitor
    
  • 4uaa, 4ua7, 6md8, 6mia, 6mz1, 6mz2, 6ooe, 6oof, 6ooj, 6ook, 7s0v – EcESBL Ctx-M-14 + inhibitor
    
  • 6bt6, 6v7h, 6v7t, 6v83, 6v8v – EcESBL Ctx-M-14 (mutant) + inhibitor
    
  • 4ua9, 1ylz – EcESBL Ctx-M-14 + boronic acid inhibitor
    
  • 5vle, 5top, 5toy, 6vnu - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor
    
  • 6unb – EcESBL Ctx-M-14 + antibiotic
    
  • 7k2w, 7k2y – EcESBL Ctx-M-14 (mutant) + antibiotic
    
  • 4xxr, 5u53, 5tw6, 5twe - EcESBL Ctx-M-14 (mutant) + antibiotic
    
  • 4hbu, 6sp6, 7u49 – EcESBL Ctx-M-15 + inhibitor
    
  • 4xuz, 7ti0 - KpBlac A Ctx-M-15 + boronic acid inhibitor
    
  • 7u4b – EcESBL Ctx-M-15 + antibiotic
    
  • 6bu3 – EcESBL Ctx-M-27 + inhibitor
    
  • 4x69 – EcESBL Ctx-M-44 + inhibitor
    
  • 6ity, 6j2o – EcESBL Ctx-M-64 + inhibitor
    
  • 6j2b, 6j2k – EcESBL Ctx-M-64 (mutant) + inhibitor
    
  • 5g18 - EcESBL Ctx-M-97 + substrate
    
  • 4oqh - EcESBL Tem-63 (mutant) + boronic acid inhibitor
    
  • 4oq0, 4opz - EcESBL Tem-94 (mutant) + boronic acid inhibitor
    
  • 4c3q, 4opz - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron
    
  • 6nvu, 6pq8 – EcESBL Tla-1 + inhibitor
    
  • 5x5g – SmESBL Tla-3 + inhibitor
    
  • 6bpf – SeESBL Ctx-M-151 + inhibitor
    
  • 6d3g – CfESBL Per-2 + inhibitor
    
  • 7bds – KpESBL Ctx-M-15 + drug
    
  • 7bdr, 7qq5 – KpESBL Ctx-M-15 (mutant) + drug
    
• Extended-spectrum β-lactamase class A binary complex with antibiotics
  • 4qu3 - PaESBL A Ges-2 + antibiotic
    
  • 5eph, 5eua – PaESBL Bel-1 + antibiotic
    
  • 1ymx - EcESBL Ctx-M-9 + antibiotic
    
  • 3hlw, 3huo, 3hvf - EcESBL Ctx-M-9 (mutant) + antibiotic
    
  • 4xxr, 5u53, 5tw6, 5twe, 6cyu, 6cyq. 6bt6 - EcESBL Ctx-M-14 (mutant) + antibiotic
    
  • 4pm9, 7q11 - KpBlac A Ctx-M-14 + antibiotic
    
  • 4pm5, 4pm7 - KpBlac A Ctx-M-14 (mutant) + antibiotic
    
  • 4s2i - KpBlac A Ctx-M-15 + antibiotic
    
  • 5gwa, 7o0o – SmESBL Tla-3 + antibiotic
    
• β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
  • 3c7u, 3c7v, 1jtg, 2b5r – EcBlac A (mutant) + Protein Blip
    
  • 1jtd, 3gmw - EcBlac A + Protein Blip
    
  • 1s0w, 1xxm - EcBlac A + Protein Blip (mutant)
    
  • 2g2u - KpBlac A Shv-1 + Protein Blip
    
  • 2g2w, 3n4i - KpBlac A Shv-1 (mutant) + Protein Blip
    
  • 3c4o, 3c4p - KpBlac A Shv-1 + Protein Blip (mutant)
    
  • 3e2k, 3e2l - KpBlac A Kpc-2 (mutant) + Protein Blip
    
  • 3qhv, 3qhy - Blac A + Protein Blip – Bacillus anthracis
• β-lactamase class B (Zn containing) or metallo-β-lactamase or NDM
  • 3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15, 1bc2, 1bvt, 1mqo, 2bc2, 3bc2, 1bmc, 4c09, 4nq4, 5fqa, 6dja – BcBlac B
    
  • 2m5c - BcBlac B – NMR
    
  • 3knr, 3kns, 1dxk, 2bfk, 2bfl, 2bfz, 2bg2, 2bg6, 2bg7, 2bg8, 2bga, 2nxa, 2nyp, 2nze, 2nzf, 2uyx - BcBlac B (mutant)
    
  • 1a7t, 1znb, 2bmi – BfBlac B – Bacterioides fragilis
    
  • 2znb - BfBlac B (Cd)
    
  • 3znb – BfBlac B (Zn, Hg)
    
  • 4znb - BfBlac B (mutant)
    
  • 1k07 – FgBlac B - Fluoribacter gormanii
    
  • 1l9y - FgBlac B (mutant)
    
  • 5n5g - PaBlac B Vim-1
    
  • 1ko2, 1ko3, 4bz3, 4nq2, 5yd7, 7cjl – PaBlac B Vim-2 - Pseudomonas aeruginosa
    
  • 2whg, 2wrs - PaBlac B Vim-4
    
  • 4d1t - PaBlac B Vim-7
    
  • 4d1u, 4d1v, 4d1w - PaBlac B Vim-7 (mutant)
    
  • 4awy, 4awz, 4p62 - PaBlac B Aim-1
    
  • 2ynt, 2ynu, 2ynv, 2ynw - PaBlac B Gim-1
    
  • 5act, 5acs, 5acr, 5acq, 5acp - PaBlac B Gim-1 (mutant)
    
  • 4ax0, 4ax1 - PaBlac B Aim-1 (mutant)
    
  • 2y87, 2y8a, 2y8b - PaBlac B Vim-7
    
  • 2x02, 7b3r, 7b3s, 7b3u - PaBlac Oxa-10
    
  • 2x01 - PaBlac Oxa-10 (mutant)
    
  • 4uam, 2fhx, 4bp0, 5nde - PaBlac Imp-1
    
  • 4f6h, 4f6z, 5ls3 – PaBlac Imp-1 (mutant)
    
  • 6r79, 6yi4 - PaBlac Imp-13
    
  • 5b3r - PaBlac Imp-18
    
  • 5ev6, 5y5b, 7dtm - SmBlac Imp-1 – Serratia marcescens
    
  • 1wuo, 1wup, 7dtn - SmBlac Imp-1 (mutant)
    
  • 3vpe - SmBlac Smb-1
    
  • 5fdh - SmBlac Oxa-405
    
  • 2dkf, 2zo4, 2zwr – TtBlac B – Thermus thermophilus
    
  • 2zzi – TtBlac B (Fe)
    
  • 2fm6, 2fu6, 2fu7, 2h6a – StmMlac B
    
  • 2qin, 2qjs - StmBlac B (mutant)
    
  • 2gmn, 3lvz – BjBlac B – Bradyrhizobium japonicum
    
  • 2p4z – Blac B – Thermoanaerobacter tengcongensis
    
  • 3l6n – Blac B – Chryseobacter indolegenes
    
  • 3r2u – SaBlac B
    
  • 3rkj, 3sbl, 3sfp, 3spu, 3zr9, 3pg4, 6c6i, 3srx, 4h0d, 6c6i, 5xp6, 5n0i, 5k4m, 5jqj, 5xp9, 5zgi, 5nbk, [[[6cac]], 6ex7, 6lhe, 6twt - KpBlac B Ndm-1 + metal ion
    
  • 5zgf, 7ct2 - KpBlac B Ndm-1 (mutant) + metal ion
    
  • 6mh0 - KpBlac B Ndm-3 + Zn
    
  • 3rkk, 4gyq, 4gyu - KpBlac B Ndm-1 (mutant)
    
  • 5wig, 6mgz - KpBlac B Ndm-4 + Zn
    
  • 6mgy - KpBlac B Ndm-5 + Zn
    
  • 6mgx - KpBlac B Ndm-6 + Zn
    
  • 6r78 - KpBlac Imp-13
    
  • 5n5g - PaBlac B Vim-1
    
  • 3s0z, 6c89, 5zr8 - EcBlac B Ndm-1
    
  • 4tz9 - EcBlac B Ndm-3
    
  • 4tyf - EcBlac B Ndm-4
    
  • 4tzf - EcBlac B Ndm-8
    
  • 5wih - EcBlac B Ndm-12
    
  • 6bm9 – EcBlac B Vim-2
    
  • 7xhx - EcBlac Imp-6
    
  • 6skp, 6skq, 6skr - EcBlac Oxa-10
    
  • 6ovz - EcBlac
    
  • 2yz3 – Blac Vim-2 – Pseudomonas putida
    
  • 3sd9 – SfBlac B - Serratia fonticola
    
  • 4ubq - AbBlac Imp-2
    
  • 5mmd - AbBlac Tmb-1
    
  • 5a87 - KpBlac B Vim-5
    
  • 4uwo, 4uwp, 4uwr, 4uws - KpBlac B Vim-26
    
  • 4wd6 – PsBlac Dim-1 – Pseudomonas stutzeri
    
  • 5iqk, 7byq, 7bz1, 7bz3, 7bz4, 7bzi – Blac – uncultured
    
  • 5ctn, 5ctm – Blac – Bacillus pumilus
    
  • 4ysb – Blac + Fe – Myxococcus xanthus
    
  • 6cqs – Blac + Zn – Sediminispirochaeta smaragdinae
    
  • 6dn4 – CsBlac – Cronobacter sakazakii
    
  • 6dq2, 6dqh, 6dr8, 6nc5 – CsBlac (mutant)
    
  • 6mfi – Blac Mim-2 – Simiduia agarivorans
    
  • 6t5l – Blac B1 Myo-1 – Myroides odoratimimus
    
  • 6v54, 6v5m, 6v70, 6v71 – HbBlac (mutant) – Hirschia baltica
    
  • 6v72, 6v73 – ElBlac – Erythrobacter litoralis
    
  • 6jv4 - VaBlac Vmb-1 – Vibrio alginolyticus
    
• β-lactamase class B binary complex with antibiotic
  • 5n5i - PaBlac B Vim-1 + antibiotic
    
  • 4s2o, 5mox, 5moz - PaBlac Oxa-10 + antibiotic
    
  • 6r73, 6rzr, 6rzs, 6s0h - PaBlac Imp-13 + antibiotic
    
  • 5b1u, 5b15, 5aya, 5axo - SmBlac Smb-1 + antibiotic
    
  • 4zej - PsBlac Dim-1 + antibiotic
    
  • 2aio, 7a63 – StmBlac B + antibiotic
    
  • 5zge, 4ey2, 4eyb, 4eyf, 4efl, 4hl1, 4hl2, 4eyl, 4hky, 4ram, 4raw, 4rbs, 4rl0, 4rl2, 5of2, 5o2e, ]], 5o2f, 6jkb – KpBlac B Ndm-1+ antibiotic
    
  • 4rm5 – KpBlac B Ndm-1 (mutant) + antibiotic
    
  • 5ypi, 5ypk, 5ypl, 5ypm, 5ypn – EcBlac B Ndm-1 + antibiotic
    
  • 6ol8 – EcBlac B Ndm-12 + antibiotic
    
  • 6lf4 - VaBlac Vmb-1 + antibiotic
    
• β-lactamase class B binary complex
  • 1a8t, 1hlk, 1kr3 - BfBlac B + inhibitor
    
  • 1jt1 – FgBlac + captopril
    
  • 1jje, 1jjt, 3lce, 3wxc, 4c1f, 4c1g, 5ndb - PaBlac B Imp-1+ inhibitor
    
  • 5n5h, 7afy, 7ayj - PaBlac B Vim-1 + inhibitor
    
  • 4c1d, 4c1e, 4pvo, 4pvt, 4ua4, 5lm6, 5le1, 5lch, 5lcf, 5lca, 5fqc, 5acx, 5acw, 5acv, 5acu, 5y6d, 5nhz, 5ni0, 5n4s, 5n4t, 5mxq, 5mxr, 5k48, 6hf5, 6ew3, 5y6e, 5o7n, 6dd0, 6dd1, 6j8r, 6kxo, 6kzn, 6sp7, 6v1p, 6zyn, 6zyo, 6zyp, 7afx, 7chv, 7du1. 7dub, 7due, 7duy, 7duz, 7dv1, 7dyy, 7dz0, 7dz1 - PaBlac B Vim-2 + inhibitor
    
  • 6ibs, 6ibv, 6jn6, 6o5t, 6rpn - PaBlac B Vim-2 + boronic acid inhibitor
    
  • 7a60 - PaBlac B Vim-2 + antibiotic
    
  • 5n55, 5n58 - PaBlac B Vim-5 + inhibitor
    
  • 5mm9 - PaBlac B Vim-17 + inhibitor
    
  • 5fq9, 6rtn - PaBlac Oxa-10 + inhibitor
    
  • 1m2x – Blac B + captopril – Elizabethkingia meningoseptica
    
  • 1vgn, 3vqz, 5hh4, 5ewa, 5ev8, 5axr, 6jed, 6jka, 6lbl - SmBlac Imp-1+ inhibitor
    
  • 6k4t, 6k4x - SmBlac Smb-1+ inhibitor
    
  • 2doo - SmBlac Imp-1+ fluorescent agent
    
  • 2fu8, 2fu9, 2gfj, 2gfk, 2hb9, 2qdt, 5dpx, 5evk, 5evd, 5evb, 5hh6, 5hh5, 7afz - StmBlac B L1 , 6xbe, 6xbf, 6zyq+ inhibitor
    
  • 3iof, 1x8i, 3iog– AhBlac B (mutant) + inhibitor
    
  • 1x8g, 2gkl, 2qds – AhBlac B + inhibitor
    
  • 5wcm – BjBlac B + inhibitor
    
  • 2m5d, 4c1c, 4c1h, 4nq5, 4nq6, 5w8w, 4tyt, 5jmx, 6f2n, 6ewe, 6eum - BcBlac B + inhibitor
    
  • 5ew0 - SfBlac B + inhibitor
    
  • 3q6v – SfBlac B + glycerol
    
  • 4exy, 4exs, 4eyl, 4hky, 4ram, 4raw, 4rbs, 4rl0, 4rl2, 4u4l, 5a5z, 5n0h, 5zjc, 5zj8, 5zj7, 5zj2, 5zj1, 5zio, 5zh1, 5zgz, 5zgy, 5zgx, 5zgw, 5zgv, 5zgu, 5zgt, 5zgr, 5zgq, 5zgp, 6d1a, 6d1b, 6d1c, 6d1d, 6d1e, 6d1f, 6d1g, 6d1h, 6d1i, 6d1j, 6d1k, 6efj, 6mdu, 6ny7, [[6rmf], 6v1m, 6xbe, 6xbf, 6zyq – KpBlac B Ndm-1+ inhibitor
    
  • 6o3r – KpBlac B Ndm-1 (mutant) + inhibitor
    
  • 6q2y, 6q30 – KpBlac B Ndm-1 + boronic acid inhibitor
    
  • 5nai – KpBlac B Vim-5 + inhibitor
    
  • 6kxi, 6kzl – EcBlac B Ndm-1+ inhibitor
    
  • 5hh6, 5hh5 - StmBlac B + inhibitor
    
  • 5fqb - BcBlac B + inhibitor
    
  • 5evk, 5evd, 5evb - StmBlac B + inhibitor
    
  • 6v61 – HbBlac (mutant) + inhibitor
    
• β-lactamase class C
  • 5f1g, 5ggw, 6g9t, 6xg1 – EcBlac C
    
  • 3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)
    
  • 1zkj, 5f1f, 5k1d, 5gsc – EaBlac C – Enterobacter aerogenes
    
  • 2qz6 – Blac C – Pseudomonas fluorescens
    
  • 7mqn – Blac C – Rhodobacter sphaeroides
    
  • 3w8k, 6k8x, 6m5p – KpBlac C
    
  • 6m5h, 6m5q – KpBlac C (mutant)
    
  • 4u0t – AbBlac C Adc-7
    
  • 4qd4 – AbBlac C Adc-68
    
  • 6fm6 - AeBlac C Tru-1 – Aeromonas enteropelogenes
    
• β-lactamase class C binary complex
  • 3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb, 6xfs - EcBlac C + inhibitor
    
  • 3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid inhibitor
    
  • 3ixb, 3ixg - EcBlac C (mutant) + boronic acid inhibitor
    
  • 6whf - EcBlac C + antibiotic
    
  • 3ixh - EcBlac C (mutant) + antibiotic
    
  • 1onh, 1q2q, 1y54 - EncBlac C + inhibitor
    
  • 1s6r - EncBlac C+ boronic acid inhibitor
    
  • 1rgz, 5xhr - EncBlac C + antibiotic
    
  • [1rgy]] - CfBlac C + antibiotic
    
  • 1zc2, 2zc7, 6k9t, 6ka5 – KpBlac C + inhibitor
    
  • 4wbg - KpBlac C + antibiotic
    
  • 6kby - KpBlac C + AMP
    
  • 2wzx, 2wzz, 6i30 – PaBlac C + inhibitor
    
  • 4ooy - PaBlac C + antibiotic
    
  • 4u0x, 5wac, 5wad, 5wae, 5waf, 5wag, 5w12, 5w13, 5w14, 6tzf, 6tzg, 6tzi, 6tzj, 6wif - AbBlac C Adc-7 + boronic acid inhibitor
    
  • 6pwm - AbBlac C + antibiotic
    
  • 6fm7 - AeBlac C Tru-1 + inhibitor
    
  • 5k1f - EaBlac C + inhibitor
    
• β-lactamase class D
  • 2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof, 1ddk, 1e3u, 1e4d, 1h8z – PaBlac D
    
  • 2hp5, 2hp6, 2hp9, 2hpb, 2wgw, 2wki - PaBlac D (mutant)
    
  • 1k56, 2k02 - PaBlac Pse-2
    
  • 1g68, 1k4f – PaBlac Pse-4
    
  • 1g6a – PaBlac Pse-4 (mutant)
    
  • 1ko2 – PaBlac Vim-2
    
  • 7l5v, 7n1m - PaBlac D Oxa-935
    
  • 1k38 – Blac D – Salmonella typhimurium
    
  • 1m6k – EcBlac D
    
  • 3if6, 4s2p - KpBlac D Oxa-46
    
  • 3hbr, 6hoo, 7ass, 7lxg – KpBlac D Oxa-48
    
  • 6i5d, 6rj7 - KpBlac D Oxa-48 (mutant)
    
  • 6huh - KpBlac D Oxa-427
    
  • 6hb8 - KpBlac D Oxa-517
    
  • 6n6w, 6n6t - AbBlac D Oxa-23 (mutant)
    
  • 4zdx - AbBlac D Oxa-51
    
  • 4y0o - AbBlac D Oxa-58
    
  • 6t1h - AbBlac D Oxa-66
    
  • 6nz8 - AbBlac D Oxa-231
    
  • 4s2l, 5odz - EncBlac D Oxa-163
    
  • 5e2f, 6w5e – BsBlac D
    
  • 4ied – Blac – Fusobacterium nucleatum
    
  • 6nlw – Blac D – Shewanella oneidensis
    
  • 6nhs – Blac D – Nostoc
    
  • 6nhu – Blac D – Agrobacterium fabrum
    
  • 6ni0 – BtBlac D
    
  • 6n1n – Blac D – Sebaldella termitidis
    
  • 6ue2 – Blac D – Peptoclostridium difficile
    
  • 6wy4, 7rl8 – CdBlac D – Clostridium difficile
    
  • 7rlr – CdBlac D (mutant)
    
  • 6w5g – BaBlac D – Bacillus atrophaeus
    
  • 6w5o – BaBlac D (mutant)
    
  • 7k3m – CpBlac D
    
• β-lactamase class D binary complex
  • 1k6s - PaBlac D + phenylboronic acid
    
  • 1dd6, 1h5x, 1h8y, 2wgv - PaBlac D + inhibitor
    
  • 3isg – EcBlac D + inhibitor
    
  • 4s2m - EncBlac D Oxa-163+ inhibitor
    
  • 7khy, 7khz - EncBlac D Oxa-163 (mutant) + drug
    
  • 3pae, 3pag, 4f94 - AbBlac D (mutant) + inhibitor
    
  • 3znt, 4y0u, 4y0t - AbBlac D + inhibitor
    
  • 6mpq, 6b22 - AbBlac D Oxa-24 + inhibitor
    
  • 5vfd - AbBlac D Oxa-24 (mutant) + inhibitor
    
  • 5fat, 5fas, 5faq, 5fap, 5fao, 5dva, 5dtt, 5dts, 5dtk, 5qa4, 5qa5, 5qa6, 5qa7, 5qa8, 5qa9, 5qaa, 5qab, 5qac, 5qad, 5qae, 5qaf, 5qag, 5qah, 5qai, 5qaj, 5qak, 5qal, 5qam, 5qan, 5qao, 5qap, 5qaq, 5qar, 5qas, 5qat, 5qau, 5qav, 5qaw, 5qax, 5qay, 5qaz, 5qb0, 5qb1, 5qb2, 5qb3, 5qb4, 6uvk, 6v1o, 7ass, 7aux, 7aw5, 7jhq, 7k5v, 7l8o, 7r6z - KpBlac D Oxa-48 + inhibitor
    
• β-lactamase class D binary complex with antibiotics
  • 1k6r, 1k54, 7l5t - PaBlac D + antibiotic
    
  • 2wgi, 2wkh - PaBlac D (mutant) + antibiotic
    
  • 6n6x, 6n6y, 6n6v, 6n6u - AbBlac D Oxa-23 (mutant) + antibiotic
    
  • 7rpg, 7rpe, 7rpf - AbBlac D Oxa-24 + antibiotic
    
  • 7rp8, 7rp9, 7rpa, 7rpb, 7rpc, 7rpd - AbBlac D Oxa-24 (mutant) + antibiotic
    
  • 4x56 - AbBlac D Oxa-160 + antibiotic
    
  • 4x53 - AbBlac D Oxa-160 (mutant) + antibiotic
    
  • 4x55 - AbBlac D Oxa-225 (mutant) + antibiotic
    
  • 4mll - KpBlac D Oxa-1 + antibiotic
    
  • 4s2j, 4s2k, 4s2n, 4wmc, 6pqi, 6psg, 6pt1, 6pt5, 6ptu, 7kh9, 7khq - KpBlac D Oxa-48 + antibiotic
    
  • 6pxx, 7kh9 - KpBlac D Oxa-48 (mutant) + antibiotic
    
  • 7khy - KpBlac D Oxa-163 + antibiotic
    
  • 6xj3 - KpBlac D + antibiotic
    
• AmpC β-lactamase
  • 1ke4, 2bls, 2zj9, 3bls, 5gzw, 6t3d, 7cin – EcBlac
    
  • 1l0d, 1l0e, 1l0f, 1l0g, 4kg6, 5joc - EcBlac (mutant)
  • 6lc7 - EncBlac
    
  • 4gzb, 4wz4, 4wyy – PaBlac
    
  • 4net – AbBlac
    
  • 5e2h – Blac – Mycobacterium smegmatis
    
  • 5e2g – Blac – Burkholderia cenocepacia
    
• AmpC -lactamase binary complex
  • 1fcn – EcBlac (mutant) + substrate
    
  • 1iel, 1fcm, 1iem, 1kvm, 1ll5, 1ll9, 1llb, 4kz3, 4kz4, 4okp, 4olg, 4jxg, 6t35, 6t5y, 6tbw - EcBlac + antibiotic
    
  • 1fco, 1i5q, 1kvl, 4ken, 4kg2, 4kg5, 4kg6, 4kz3, 4kz4, 4kg9, 4kz5, 4kz6, 4kz7, 4kz8, 4kza, 4kzb - EcBlac (mutant) + antibiotic
    
  • 1fsw, 1fsy, 1kds, 1kdw, 1ke0, 1ke3, 1mxo, 1my8, 4e3i, 4e3j, 4e3k, 4e3l, 4e3m, 4e3n, 4e3o, 2i72, 4lv0, 4lv1, 4lv2, 4lv3, 4oqg, 6yeo, 6ypd, 6t7l, 6tpm - EcBlac + boronic acid inhibitor
    
  • 1pi4, 1pi5, 2ffy - EcBlac (mutant) + boronic acid inhibitor
    
  • 1l2s, 1xgi, 1xgj, 2hdq, 2hdr, 2hds, 2hdu, 2p9v, 2pu2, 2pu4, 2r9w, 2r9x, 2rcx, 4jxs, 4jxv, 4jxw, 4old, 6dpz, 6dpy, 6dpx, 6dpt - EcBlac + inhibitor
    
  • 4jxg – EcBlac + oxacillin
    
  • 1o07, 4kz9 - EcBlac (mutant) + inhibitor
    
  • 6lc8, 6lc9 - EncBlac + inhibitor
    
  • 4xux - EncBlac + boronic acid inhibitor
    
  • 4hef, 4nk3, 4x68 - PaBlac + inhibitor
    
  • 3s1y, 3s22 - PaBlac (mutant) + inhibitor
    
  • 6s1s - PaBlac + boronic acid inhibitor
    
• Carbapenemase
  • 3f9o - AhBlac B – Aeromonas hydrophila
    
  • 3fai, 1x8h, 3sw3, 3t9m - AhBlac B (mutant)
    
  • 6p96 - KpBlac Oxa-48
    
  • 7o5t, 7o9n, 7peh - KpBlac D
    
  • 7pgo - KpBlac D (mutant)
    
  • 3rxw, 3rxx, 2ov5, 5ul8 – KpBlac Kpc-2
  • 6xd5, 7ljk, 7lk8, 7tb7, 7tbx - KpBlac Kpc-2 (mutant)
    
  • 6qwd - KpBlac Kpc-3
    
  • 6qwe - KpBlac Kpc-4
    
  • 6z21, 6z22 - KpBlac Kpc-4 (mutant)
    
  • 4eqi – SfBlac Sfc-1
  • 4jf5, 4jf6 - AbBlac Oxa-23
    
  • 4oh0, 4z9q - AbBlac Oxa-58
    
  • 5boh - AbBlac Oxa-58 (mutant)
    
  • 5iy2 - AbBlac Oxa-143
    
  • 1bue – EncBlac
    
  • 4tze, 4tzb - EcBlac Ndm-5
    
  • 6ogo - EcBlac Ndm-9
    
  • 3dw0, 3c5a - EcBlac Kpc-2
    
• Carbapenemase binary complexes
  • 6p97, 6p98, 6p99, 6p9c, 6pk0 - KpBlac Oxa-48 + antibiotic
    
  • 67dml - KpBlac Oxa-48 + inhibitor
    
  • 3rxw, 3rxx, 2ov5, 5ul8 – KpBlac Kpc
    
  • 5eec, 6td1 - KpBlac Kpc-2 + boronic acid inhibitor
    
  • 4zbe, 6b1y, 6b1x, 6b1w, 6b1j, 6b1h, 6b1f, 6d15, 6d16, 6d17, 6d18, 6d19, 6j8q, 6jn3, 6jn4, 6jn5, 6m7i, 6mey, 6mll, 6mnp, 6qw9, 6td0, 6v1j, 7vqn, 7ti2 - KpBlac Kpc-2 + inhibitor
    
  • 5uj3, 5uj4, 6v7i, 7a61, 7pep, 7tc1 - KpBlac Kpc-2 + antibiotic
    
  • 6xd7, 6z23, 6z25, 7llb, 7llh, 7lnl, 7lr9, 7pse, 7psf - KpBlac Kpc-2 (mutant) + antibiotic
    
  • 6qwa - KpBlac Kpc-3 + inhibitor
    
  • 6qwb, 6qwc - KpBlac Kpc-4 + inhibitor
    
  • 6tt8, 6ttc - KpBlac NDM-1 + inhibitor
    
  • 6lip, 6liz, 6lj0, 6lj1, 6lj2, 6lj4, 6lj5, 6lj6, 6lj7, 6lj8 - KpBlac NDM-1 + drug
    
  • 4euz, 4ev4 – SfBlac Sfc-1 (mutant) + antibiotic
    
  • 4jf4 - AbBlac Oxa-23 + antibiotic
    
  • 5ll7 - EcBlac Kpc-2 + boronic acid inhibitor
    
  • 6mkq, 6mk6 - Blac + inhibitor – Vibrio cholerae
    
  • 5mgi - KoBlac Kpc-2 + boronic acid inhibitor - Klebsiella oxytoca
    
• Other β-lactamase
  • 1bsg – Blac – Streptomyces albus
    
  • 6wgr - SaBlac
    
  • 1alq, 1blp, 1dja, 1djb, 1djc, 1ghi – SaBlac (mutant)
    
  • 1gce, 1xx2 - EncBlac
    
  • 6op6, 6op7 - EncBlac Vim-20
    
  • 4fr7, 4fsb - EncBlac Vim-31 (mutant)
    
  • 5hfo - EcBlac Oxa-232
    
  • 1dy6 – SmBlac Sme-1
    
  • 1fr1, 1fr6 – CfBlac
    
  • 1i2s, 4blm – BlBlac
    
  • 2gdn, 3zhh, 5oyo, 5nj2, 7k8l – MtBlac – Mycobacterium tuberculosis
    
  • 4whi – MtBlac C terminal
    
  • 4jlf, 6h28, 6h27, 7a5u, 7a5w - MtBlac (mutant)
    
  • 2jc7, 3g4p – AbBlac
    
  • 3byd – KoBlac
    
  • 3i7j – Blac – Mycobacterium bovis
    
  • 3lez – Blac – Oceanobacter iheyensis
    
  • 3p09 – Blac – Francisella tularensis
    
  • 4ewf – Blac – Sphaerobacter thermophilus
    
  • 3w4o, 3w4p, 4efz – Blac – Burkholderia pseudomallei
    
  • 3w4q – Blac – Burkholderia multivorans
    
  • 5ihv – Blac – Burkholderia ambifaria
    
  • 5hx9, 5hw3 – Blac – Burkholderia vietnamiensis
    
  • 5vpq – Blac – Burkholderia phymatum
    
  • 5evl – Blac – Chromobacterterium violaceum
    
  • 5e43 – Blac – Streptoporangium roseum
    
  • 5e2e – Blac – Yersinia enterocolitica
    
  • 4k0w – AbBlac Oxa-23 (mutant)
    
  • 4k0x – AbBlac Oxa-23
    
  • 6goa – AbBlac Oxa-48 (mutant)
    
  • 5oft – KpBlac Oxa-48 (mutant)
    
  • 5oe0 – KpBlac Oxa-181
    
  • 5oe2 – KpBlac Oxa-245
    
  • 6gth – KpBlac
    
  • 7oda – Blac Oxa-436 – Enterobacter asburiae
    
  • 3wrt – ChBlac – Chromohalobacter
    
  • 3wrz, 3ws0, 3ws1, 3ws2, 3ws3, 3ws4, 3ws5 – ChBlac (mutant)
    
  • 6njk – Blac – Sulfitobacter
    
  • 6n9k, 6x9y – EcBlac
    
  • 6n36 – Blac – Chitinophaga pinensis
    
  • 6mu9 – Blac – Bacillus megaterium
    
  • 6ch0, 6cgy – AaBlac – Alicyclobacillus acidoterrestris
    
  • 6edm, 7lno, 7lnr, 7me9 – CdBlac
    
  • 6izc – VpBlac – Vibrio parahaemolyticus
    
  • 6izd – VpBlac (mutant)
    
  • 6wgp – Blac – Xanthomonas campestris
    
  • 6wgq – Blac – Shigella flexneri
    
  • 6whl – Blac – Legionella pneumophila
    
  • 6wjm – Blac – Desulfarculus baarsii
    
• Other β-lactamase binary complex
  • 1ghm, 1ghp, 1pio - SaBlac (mutant) + antibiotic
    
  • 1blc, 1blh – SaBlac + inhibitor
    
  • 1bls – EncBlac + phosphonate derivative
    
  • 1bul - EncBlac + penicillin derivative
    
  • 1ga0 - EncBlac + inhibitor
    
  • 1i2w – BlBlac + cifoxitin
    
  • 3cg5, 4q8i, 4qb8, 7k8e, 7k8f, 7k8h, 7k8k – MtBlac + antibiotic
    
  • 3n8s, 3ny4, 3n6i, 3n7w, 3n8l, 3n8r, 3nbl, 3nc8, 3nck, 3nde, 3ndg - MtBlac (mutant) + antibiotic
    
  • 3dwz, 3iqa, 3m6b, 3m6h, 4df6, 6h2k, 6h2i, 6h2h, 6h2g, 6h2c – MtBlac + inhibitor
    
  • 4x6t, 4qhc – MtBlac (mutant) + inhibitor
    
  • 3vff, 3vfh, 4ebl, 4ebn, 4ebp – MtBlac (mutant) + intermediate
    
  • 6h2a – MtBlac (mutant) + protein
    
  • 3fv7, 3fyz, 3fzc, 3mbz – AbBlac + inhibitor
    
  • 4wm9 – AbBlac Oxa-24 + antibiotic
    
  • 6q5b, 6q5f – KpBlac Oxa-48 (mutant) + inhibitor
    
  • 6uqs, 6uqt, 6uqu, 6ur3 – PaBlac (mutant) + boronic acid inhibitor
    
  • 6cgz – AaBlac + lactone derivative
    
  • 7kep, 7keq, 7ker, 7lnq, 7mea, 7meb, 7mec, 7med, 7mee, 7mef, 7meg, 7meh – CdBlac + drug
    
  • 6pqc – CdBlac (mutant) + antibiotic
    
  • 7doo – BmBlac + antibiotic
    
  • 7ddm – BmBlac + peptide
    
• Serine beta-lactamase (ClbP)
  • 7mde, 7mdf – EcClbP (mutant)
    
  • 7ul6 – EcClbP – Cryo EM
    
  • 3o3v – EcClbP peptidase domain 38-372
    
  • 4e6w, 4e6x, 7mdc – EcClbP + boronic acid inhibitor