Helicase 3D structures: Difference between revisions

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Line 32: Line 32:
**[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
**[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
**[[6ppj]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
**[[6ppj]], [[7lhl]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
**[[6yi2]] – EcHel 645-720 - NMR<br />


*ATP-dependent helicase ATRX
*ATP-dependent helicase ATRX
Line 100: Line 101:
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
**[[5o6e]] – yPIF residues 237-780 + DNA + ADP<br />
**[[5o6e]] – yPIF residues 237-780 + DNA + ADP<br />
**[[6s3e]], [[7ada]] – ToPIF residues 64-507 – ''Thermus oshimai''<br />
**[[6xzt]] – ToPIF (mutant)<br />
**[[6s3p]], [[7bil]] – ToPIF + DNA<br />
**[[6s3h]], [[6s3i]], [[6s3m]], [[6s3n]], [[6s3o]] – ToPIF + DNA + ADP<br />
**[[6l3g]] – PIF + DNA + ADP - ''Bacterioides''<br />
**[[7otj]] – PIF + DNA + ADP – ''Candida albicans''<br />


*ATP-dependent DNA helicase TA0057
*ATP-dependent DNA helicase TA0057
Line 125: Line 132:
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[1vec]] – hP54 N terminal<BR />
**[[1vec]] – hP54 N terminal<BR />
**[[3fho]] – DBP5 – fission yeast<BR />
**[[3fho]] – Dbp5 – fission yeast<BR />
**[[2kbe]] – yDBP5 N terminal – NMR<BR />
**[[2kbe]] – yDbp5 N terminal – NMR<BR />
**[[2kbf]] - yDBP5 C terminal – NMR<BR />
**[[2kbf]] - yDbp5 C terminal – NMR<BR />
**[[3gfp]] - yDBP5 C-terminal<BR />
**[[3gfp]] - yDbp5 C-terminal<BR />
**[[2hjv]] – BsDBPA domain 2 – ''Bacillus subtilis''<BR />
**[[2hjv]] – BsDbpA domain 2 – ''Bacillus subtilis''<BR />
**[[2g0c]] - BsDBPA RNA-binding domain<br />
**[[2g0c]] - BsDbpA RNA-binding domain<br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophilus''<br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophilus''<br />
**[[3i31]] - TtHera residues 431-517<br />
**[[3i31]] - TtHera residues 431-517<br />
Line 136: Line 143:
**[[3nej]] - TtHera N terminal (mutant)<br />
**[[3nej]] - TtHera N terminal (mutant)<br />
**[[5ivl]] – GsDB CSHA - ''Geobacillus stearothermophilus''<br />
**[[5ivl]] – GsDB CSHA - ''Geobacillus stearothermophilus''<br />
**[[5b88]] - EcDBP RRM-like domain - NMR<br />
**[[5b88]] - EcDbp RRM-like domain - NMR<br />
**[[5gju]] - EcDBP residues 6-210<br />
**[[5gju]] - EcDbp residues 6-210<br />
**[[5gi4]] - EcDBP residues 218-445<br />
**[[5gi4]] - EcDbp residues 218-445<br />
**[[7bbb]] - EcDbpA residues 218-445 - NMR<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />


Line 191: Line 199:
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
**[[6q6r]] – hDHX36 G-quadruplex domain + DNA <br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
Line 198: Line 207:
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[6heg]], [[6eud]] – EcHRPB<br />
**[[6up4]] – mDHX36 + ADP <br />
**[[7dcq]] – yPrp2 – Cryo EM<br />
**[[7dcr]] – yPrp2 + Spp2 – Cryo EM<br />
**[[7dd3]] – yPrp2 + Spp2 + RNA – Cryo EM<br />
**[[7dcp]] – yPrp2 + Spp2 + ADP – Cryo EM<br />
**[[6zwx]] – EcHrpA<br />
**[[7akp]] – EcHrpA (mutant)<br />
**[[6zww]] – EcHrpA + RNA<br />
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />


*ATP-dependent RNA helicase
*ATP-dependent RNA helicase
Line 265: Line 282:
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
*ATP-dependent RNA helicase Rep
**[[7lar]], [[7las]] – Rep + DNA + ADP – Porcine circovirus – Cryo EM<br />


*ATP-dependent RNA helicase Repa
*ATP-dependent RNA helicase Repa
Line 325: Line 346:


**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
**[[7oa5]] - RuvA – ''Mycobacterium leprae''<BR />
**[[7oa5]] - MlRuvA – ''Mycobacterium leprae''<BR />
**[[7oa5]] - MlRuvA + DNA<br />
**[[1cuk]], [[1hjp]] – EcRuvA<br />
**[[1cuk]], [[1hjp]] – EcRuvA<br />
**[[1d8l]] – EcRuvA N terminal<BR />
**[[1d8l]] – EcRuvA N terminal<BR />
Line 393: Line 415:
**[[1b79]] - EcDnaB N terminal<BR />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />  
**[[1jwe]] - EcDnaB N terminal - NMR<BR />  
**[[6kza]] - EcDnaB C terminal + DnaC<br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
**[[6t66]] – DnaB + GDP – Vibrio cholerae<br />


*DnaC helicase
*DnaC helicase
Line 403: Line 428:
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
**[[3ecc]] – AaDnaC + ADP<br />
**[[3ecc]] – AaDnaC + ADP<br />
**[[6qel]] – EcDnaC + replicative DNA Hel <br />
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA<br />
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA - Cryo EM<br />


*Helicase BLM
*Helicase BLM
Line 416: Line 441:
**[[4w7s]] – yCa8<br />
**[[4w7s]] – yCa8<br />


*Helicase NSP
*Helicase NSP see [[Nonstructural protein]]
 
**[[6jim]] – NSP2 + RNA – Chicungunya virus<br />
**[[2hwk]] – NSP2 – Venzuelan equine encephalitis virus<br />
**[[6jyt]], [[6zsl]] – NSP13 – Human SARS-COV virus<br />


*Helicase SEN1
*Helicase SEN1


**[[5mzn]], [[6i59]] – ySEN1<br />
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />


*Helicase DING
*Helicase DING
Line 454: Line 476:
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />


*Pre-mRNA-splicing Helicase
*Pre-mRNA-splicing Helicase or Brr2


**[[6s8o]] – hBrr2 394-2136 (mutant)<br />
**[[6s8q]], [[6s9i]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8<br />
**[[7bdi]], [[7bdj]], [[7bdk]], [[7bdl]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
**[[6qws]] – CtBrr2 <br />
**[[6qv4]] – CtBrr2 + ATPgS<br />


*crispr-associated helicase Cas3
*crispr-associated helicase Cas3

Revision as of 10:50, 25 August 2021

3D structures of helicase3D structures of helicase

Updated on 25-August-2021

    • 5fhh, 6hpt – hPIF residues 200-641
    • 6hpu, 6hpq, 6hph – hPIF residues 206-620 + nucleotide
    • 5o6b, 5o6d – yPIF residues 237-780 + DNA + ATP
    • 5o6e – yPIF residues 237-780 + DNA + ADP
    • 6s3e, 7ada – ToPIF residues 64-507 – Thermus oshimai
    • 6xzt – ToPIF (mutant)
    • 6s3p, 7bil – ToPIF + DNA
    • 6s3h, 6s3i, 6s3m, 6s3n, 6s3o – ToPIF + DNA + ADP
    • 6l3g – PIF + DNA + ADP - Bacterioides
    • 7otj – PIF + DNA + ADP – Candida albicans
  • ATP-dependent DNA helicase TA0057
    • 5h8w – TaTA0 + DNA – Thermoplasma acidophilum
  • ATP-dependent DNA helicase LHR
    • 5v9x – MsLHR + DNA – Mycobacterium smegmatis
  • Dead box ATP-dependent RNA helicase
    • 4xw3 – hDDX1 SPRY domain
    • 2i4i – hDDX3X residues 167-581
    • 4px9 - hDDX3X residues 135-407
    • 4pxa - hDDX3X residues 135-407 (mutant)
    • 5e7i - hDDX3X residues 133-584
    • 2jgn – hDDX3X helicase domain residues 408-579
    • 3ly5 – hDDX18 dead domain
    • 6l5l, 6l5o – hDDX21 residues 120-495 (mutant)
    • 6l5m – hDDX21 + AMP
    • 6l5n – hDDX21 + RNA
    • 2rb4 – hDDX25 helicase domain
    • 2p6n – hDDX41 helicase domain (mutant)
    • 2e29, 2m3d - hDDX50 GUCT domain - NMR
    • 1vec – hP54 N terminal
    • 3fho – Dbp5 – fission yeast
    • 2kbe – yDbp5 N terminal – NMR
    • 2kbf - yDbp5 C terminal – NMR
    • 3gfp - yDbp5 C-terminal
    • 2hjv – BsDbpA domain 2 – Bacillus subtilis
    • 2g0c - BsDbpA RNA-binding domain
    • 3eaq, 3ear, 3eas – TtHera residues 215-426 - Thermus thermophilus
    • 3i31 - TtHera residues 431-517
    • 3i32 - TtHera residues 218-517
    • 3nej - TtHera N terminal (mutant)
    • 5ivl – GsDB CSHA - Geobacillus stearothermophilus
    • 5b88 - EcDbp RRM-like domain - NMR
    • 5gju - EcDbp residues 6-210
    • 5gi4 - EcDbp residues 218-445
    • 7bbb - EcDbpA residues 218-445 - NMR
    • 6aib – SaDB CSHA N-terminal – Staphylococcus aureus
  • Dead box ATP-dependent RNA helicase complexes
    • 3fmo, 3fhc – hDBP5 + Nup214
    • 3fht – hDBP5 + AMPPNP + RNA
    • 6cz5 - hDDX3X residues 132-607 + AMP
    • 6o5f - hDDX3X + RNA
    • 6b4k – hDDX19B residues 54-479 + ANP
    • 6b4j, 6b4i – hDDX19B residues 54-479 + GLE1 + Nup42 + ANP
    • 3fmp – hDDX19B + Nup214
    • 3g0h – hDDX19B residues 54-275 + ATP analog + RNA
    • 3ews - hDDX19B residues 54-275 + ADP
    • 5e7m, 5e7j – hDDX3X catalytic domain + nucleotide
    • 3dkp – hDDX52 domain I + ADP
    • 2wax, 2way – hDDX6 C terminal + EDC3-FDF peptide
    • 2j0s, 2j0q, 2hyi – hDDX48 + protein mago nashi homolog + RNA-binding protein 8A + protein CASC3 + RNA
    • 2j0u - hDDX48 + protein CASC3
    • 2db3 – DmVASA residues 200-623 + RNA – Drosophila melanogaster
    • 5nt7 – DmVASA RecA-like domain + maternal effect protein
    • 3rrm – yDBP5 residues 91-482 (mutant) + GLE1 + NUP159 + ADP + IP6
    • 3rrn - yDBP5 residues 91-482 (mutant) + GLE1 + IP6
    • 5elx - yDBP5 residues 91-482 + RNA
    • 3pew, 3pey - yDBP5 residues 91-482 (mutant) + ADP + BeF3 + RNA
    • 3peu, 3pev - yDBP5 C-terminal (mutant) + GLE1 + IP6
    • 3i5x, 3i5y – yMSS116 + AMPPNP + RNA
    • 3sqw, 3sqx - yMSS116 + AMPPNP + RNA
    • 3i61, 4tyw, 4tyy, 4tz0, 4tz6 - yMSS116 + nucleotide + BeF3 + RNA
    • 3i62 - yMSS116 + ADP + AlF4 + RNA
    • 4tyn - yMSS116 + ADP + DNA
    • 2xau, 3kx2, 5jpt – yPrp43 + nucleotide
    • 5i8q - yPrp43 + ADPNP + RNA
    • 5ltk, 5ltj, 5d0u - CtPrp43 + ADP – Chaetomium thermophilum
    • 5lta - CtPrp43 + ADP + RNA
    • 3jrv – DDX3X + protein K7 – Vaccinia virus
    • 3nbf - TtHera N terminal (mutant) + 8-oxo-ADP
    • 3moj - BsDBPA RNA-binding domain + RNA
    • 6aic – SaDB CSHA N-terminal + AMP
  • DEAH box RNA helicase
    • 2eqs – hDHX8 S1 domain residues 260-355
    • 3i4u – hDHX8 residues 950-1183
    • 6hys – hDHX8 helicase domain residues 548-1220 + ATP
    • 6hyt – hDHX8 helicase domain + ADP
    • 6hyu – hDHX8 helicase domain + RNA
    • 3llm – hDHX9
    • 5xdr – hDHX15 residues 110-795 (mutant)
    • 6sh6, 6sh7 – hDHX15 + Nfkb-repressing factor + ADP
    • 2n16 – hDHX36 G-quadruplex domain - NMR
    • 2rqa – hDHX58 C terminal – NMR
    • 3vyx, 3vyy – hDHX9 RNA-binding domain + RNA
    • 6q6r – hDHX36 G-quadruplex domain + DNA
    • 2n21 – hDHX36 G-quadruplex domain + DNA - NMR
    • 5e3h - hDHX58 residues 232-925 + RNA
    • 3eqt- hDHX58 residues 541-678 + RNA
    • 5vha – bDHX36 residues 150-1010 - bovine
    • 5vhc, 5vhd – bDHX36 residues 150-1010 + ADP
    • 5vhe – bDHX36 residues 56-1010 + DNA
    • 2rs6, 2rs7 – mDHX9 RNA-binding domain – NMR
    • 6up4 – mDHX36 + ADP
    • 7dcq – yPrp2 – Cryo EM
    • 7dcr – yPrp2 + Spp2 – Cryo EM
    • 7dd3 – yPrp2 + Spp2 + RNA – Cryo EM
    • 7dcp – yPrp2 + Spp2 + ADP – Cryo EM
    • 6zwx – EcHrpA
    • 7akp – EcHrpA (mutant)
    • 6zww – EcHrpA + RNA
    • 6heg, 6eud – EcHrpB + ADP
  • ATP-dependent RNA helicase
    • 2g9n - hEIF4A dead domain
    • 5zbz - hEIF4A dead domain + sanguinarine
    • 5zc9 - hEIF4A dead domain + ATP + RNA
    • 6ieg - hDOB1 residues 70-1042
    • 6ro1 - hDOB1 residues 70-1042 + NVL
    • 6ieh - hDOB1 residues 70-1042 + NRDE2
    • 6c90 - hDOB1 residues 70-600 + ZCCHC8
    • 6d6r, 6d6q - hDOB1 in exosome + RNA – Cryo EM
    • 2xzl – yNAM7 CH and helicase domains + RNA
    • 2xgj – yDOB1 residues 81-1073 + RNA
    • 4u4c - yDOB1 residues 81-1073 + poly(A) RNA polymerase protein 2
    • 4qu4 - yDOB1
    • 5ooq - yDOB1 residues 81-1073 + NOP53
    • 5suq – ySUB2 + TEX1 + THO2
    • 5sup – ySUB2 + YRA1 + RNA
    • 2vso, 2vsx – yEIF4A + initiation factor 4F middle domain
    • 2g9n - hEIF4A dead domain
  • Viral ATP-dependent RNA helicase NS3
    • 3o8b, 3o8d, 1cu1, 8ohm, 1hei, 4a92, 3rvb – HvHel NS3 residues 1186-1658 – Hepatitis C virus
    • 1onb, 1jr6 - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR
    • 2jlq, 2bhr, 2bmf, 2whx, 2wzq – DvHel NS3 residues 1646-2092 – Dengue virus
    • 5xc7 – DvHel NS3 residues 1646-2092 (mutant)
    • 2z83 – Hel NS3 residues 167-624 – Japanese encephalitis virus
    • 2v8o, 2wv9 - Hel NS3 helicase domain – Murray valley encephalitis virus
    • 2qeq - Hel NS3 residues 1691-2124 – Kunjin virus
    • 5txg, 5jmt, 5vi7, 5jps, 6mh3 - ZvHel NS3 helicase domain – Zika virus
    • 5k8u, 5k8l, 5k8i, 5jwh, 5jrz - ZvHel NS3 residues 164-621
    • 5x8y - ZvHel NS1 residues 168-352
    • 2v6i – KvHel helicase domain – Kokobera virus
    • 2v6j - KvHel helicase domain (mutant)
    • 5wso, 5gvu - Hel NS3 residues 1939-2414 – bovine viral diarrhea virus
  • Viral ATP-dependent RNA helicase NS3 complexes
    • 3o8c, 3o8r, 3kqh, 3kqk, 3kql, 3kqn, 3kqu, 1a1v - HvHel NS3 + RNA
    • 2f9v - HvHel NS3 protease domain + polyprotein
    • 2a4g, 1rtl, 1w3c, 1dxp - HvHel NS3 protease domain + NS4A peptide
    • 2a4q, 2a4r, 2f9u, 2fm2, 1dy8, 1dy9 - HvHel NS3 protease domain + NS4A peptide + inhibitor
    • 2jlr - DvHel NS3 residues 1646-2092 + AMPPNP
    • 2jls - DvHel NS3 residues 1646-2092 + ADP
    • 2jlu, 2jlw, 5xc6 - DvHel NS3 residues 1646-2092 + RNA
    • 2jlv - DvHel NS3 residues 1646-2092 + AMPPNP + RNA
    • 2jlx, 2jly, 2jlz - DvHel NS3 residues 1646-2092 + ADP + RNA
    • 2vbc - DvHel NS3 residues 1475-2092 + NS2A peptide
    • 5k8t - ZvHel NS3 residues 164-621 + GTP
    • 5gjc - ZvHel NS3 residues 1676-2119 + ATP
    • 5gjb - ZvHel NS3 residues 1676-2119 + RNA
    • 5y4z - ZvHel NS3 residues 1676-2119 + AMPPNP
  • ATP-dependent RNA helicase SUV3
    • 3rc3 – hSUV3 residues 47-722
    • 3og8 – hDDX58 C terminal + RNA
    • 3rc8 - hSUV3 residues 47-722 + RNA
    • 6f4a – ySUV3 + exoribonuclease II + RNA
  • ATP-dependent RNA helicase A
    • 3llm – hHel A
    • 3vyx, 3vyy - hHel A RNA-binding domain + RNA
    • 1whq, 2rs6, 2rs7 – Hel A RNA-binding domain – mouse - NMR
  • ATP-dependent RNA helicase Rep
    • 7lar, 7las – Rep + DNA + ADP – Porcine circovirus – Cryo EM
  • ATP-dependent RNA helicase Repa
  • ATP-dependent RNA helicase HEF
    • 1x2i – HEF DNA-binding domain – Pyrococcus furiosus
  • ATP-dependent RNA helicase Srmb
    • 2yjt - EcSrmb residues 219-388 + RRAA
  • ATP-dependent RNA helicase Dhh1
    • 4bru – yDhh1 (mutant) + EDC3
    • 4brw – yDhh1 (mutant) + PAT1
  • Werner syndrome ATP-dependent DNA helicase
    • 2e1e, 2e1f, 2dgz – hWRN HRDC domain 1142-1242
    • 2fbt - hWRN exonuclease domain 38-236
    • 2fbv, 2fbx, 2fby, 2fc0 - hWRN exonuclease domain + metal ion
    • 3aaf – hWRN C terminal 949-1079 + DNA
    • 6yhr - hWRN 517-1094
    • 2e6l, 2e6m - mWRN exonuclease domain
  • ATP-dependent DNA helicase Q
    • 2v1x - hQ1 residues 49-616
    • 2wwy, 4u7d – hQ1 residues 49-616 + DNA
    • 5lst – hQ4 residues 427-1116
    • 2kmu – hQ4 N terminal - NMR
    • 5lb8 – hQ5
    • 5lb5, 5lb3 – hQ5 + ADP
    • 5lba – hQ5 + urea derivative
  • ATP-dependent DNA helicase RecG
    • 1gm5 – TmRecG + DNA
  • ATP-dependent DNA helicase RecQ (Bloom Syndrome helicase)
    • 4cgz, 4o3m - hRecQ catalytic domain + DNA
    • 4cdg - hRecQ catalytic domain + nanobody
    • 1d8b - yRecQ HRDC domain - NMR
    • 3iuo – RecQ residues 604-725 – Porphyromonas gingivalis
    • 2rhf – DrRecQ HRDC domain 3 – Deinococcus radiodurans
    • 2ma1 - DrRecQ HRDC domain – NMR
    • 4q48 - DrRecQ catalytic domain
    • 4q47 - DrRecQ catalytic domain + ADP
    • 1wud - EcRecQ HRDC domain
    • 1oyw - EcRecQ catalytic domain
    • 1oyy - EcRecQ catalytic domain + ATP
  • ATP-dependent DNA helicase RuvA, RuvB
  • ATP-dependent DNA helicase RuvB-like
    • 2c9o – hRuvBL1 + ADP
    • 6h7x – hRuvBL2
    • 3uk6 – hRuvBL2 + ADP
    • 2cqa – hRuvBL2 C-terminal - NMR
    • 2xsz – hRuvBL1 + hRuvBL2 + ATP
    • 6qi8, 6qi9 – hRuvBL1 + hRuvBL2 + ADP
    • 5oaf – hRuvBL1 + hRuvBL2 + ADP - Cryo EM
    • 6fo1 – hRuvBL1 + hRuvBL2 + RPAP3 + ADP - Cryo EM
    • 6igm – hRuvBL1 + hRuvBL2 + actin-related protein + helicase SRCAP + protein - Cryo EM
    • 6hts – hRuvBL1 + hRuvBL2 + INO80 + ARP5 + histones + DNA - Cryo EM
    • 5oun – yRuvBL2 DII domain - yeast - NMR
    • 6gej, 6gen – yRuvBL1 + yRuvBL2 + vacuolar protein sorting-associated proteins + ARP6 + SWR complex protein 6 + histones + helicase SWR1 + ADP + ATP + DNA - Cryo EM
    • 4wvy – CtRuvBL1 + CtRuvBL2 + ATP
    • 4ww4 – CtRuvBL1 + CtRuvBL2 + ADP
    • 6fhs – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES5 + ARP5 + ADP + ATP - Cryo EM
    • 6fml – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES6 + actin-related protein + histones + ADP + ATP + DNA - Cryo EM
    • 5f4h, 5yww – RuvBL (mutant) - Sulfolobus islandicus
  • ATP-dependent DNA helicase UVSW
    • 2oca, 1rif- T4UVSW (mutant) – Enterobacteria phage T4
    • 2jpn - T4UVSW
  • ATP-dependent DNA helicase DDA
    • 3upu – T4DDA + DNA
  • ATP-dependent DNA helicase PriA
  • ATP-dependent DNA helicase PcrA
    • 1qhg – GsPcrA (mutant) + ADPNP
    • 1qhh - GsPcrA + ADPNP
    • 2pjr, 3pjr - GsPcrA + DNA
    • 1pjr - GsPcrA
    • 5dma – GsPcrA C-terminal tudor domain
  • DnaB helicase or replicative DNA helicase
    • 3gxv – HpDnaB – Helicobacter pylori
    • 4a1f – HpDnaB C terminal
    • 2r6d – BsDnaB – Bacillus stearothermophilus
    • 2r6e, 2r6d - GsDnaB
    • 2r5u – MtDnaB N terminal
    • 3bgw – BpDnaB-like – Bacillus phage SPP1
    • 3bh0 - BpDnaB-like G40P ATPase domain
    • 2q6t – DnaB – Thermus aquaticus
    • 1mi8, 6frh – SyDnaB – Synechocystis
    • 6frg, 6fre – SyDnaB (mutant)
    • 6bbm – EcDnaB + replication protein P – Cryo EM
    • 1b79 - EcDnaB N terminal
    • 1jwe - EcDnaB N terminal - NMR
    • 6kza - EcDnaB C terminal + DnaC
    • 2r6c, 2r6a – BsDnaB + DnaG helicase-binding domain
    • 6bs8, 6own – MsDnaB 238-376
    • 6rix, 6riy – DnaB (mutant) – Mycobacterium chimaera
    • 6own, 6bs8 – MsDnaB 238-376
    • 6t66 – DnaB + GDP – Vibrio cholerae
  • DnaC helicase
    • 2vyf– GkDnaC – Geobacillus kaustophilus
    • 2vye – GkDnaC + DNA
    • 3ec2 – AaDnaC – Aquifex aeolicus
    • 3ecc – AaDnaC + ADP
    • 6qel – EcDnaC + replicative DNA Hel - Cryo EM
    • 6qem – EcDnaC + replicative DNA Hel + DNA - Cryo EM
  • Helicase BLM
    • 5lup – hBLM DHBN domain
    • 5lut – BLM DHBN domain - chicken
    • 5lus – BLM DHBN domain - pelican
  • Helicase CA8 or Prp28
  • Helicase NSP see Nonstructural protein
  • Helicase SEN1
  • Helicase DING
  • Helicase SNF2
    • 1z5z – SsSNF2 C terminal – Sulfolobus solfataricus
    • 1z63 - SsSNF2 ATPase core + DNA
    • 1z6a - SsSNF2 ATPase core
  • Helicase SKI2
    • 4a4k – ySKI2 insertion domain
    • 4a4z – ySKI2 + AMPPNP
    • 2va8 – SsSKI2
  • Helicase SWR1
    • 5i9e – ySWR1 + actin + actin-related protein
  • Helicase XPD
    • 3crv, 3crw, 5h8c – XPD – Sulfolobus acidocaldarius
    • 4a15 - TaXPD + DNA
    • 2vsf - TaXPD
    • 2vl7 - XPD - Sulfolobus tokodaii
    • 5ivw - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
  • Pre-mRNA-splicing Helicase or Brr2
    • 6s8o – hBrr2 394-2136 (mutant)
    • 6s8q, 6s9i – hBrr2 394-2136 + pre-mRNA-splicing factor 8
    • 7bdi, 7bdj, 7bdk, 7bdl – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide
    • 3hib, 3im1, 3im2 – yBrr2 2nd SEC63 domain
    • 4bgd, 5m5p, 5m52, 5dca – yBrr2 + pre-mRNA-splicing factor 8
    • 6qws – CtBrr2
    • 6qv4 – CtBrr2 + ATPgS
  • crispr-associated helicase Cas3
    • 4q2c – TteCas3 – Thermobaculum terrenum
    • 4q2d – TteCas3 + DTP
    • 4qqw, 4qqx – TfCas3 – Thermobifida fusca
    • 4qqy – TfCas3 + ADP + HD nuclease
    • 4qqz – TfCas3 + AMPPNP
    • 6c66 – TfCas3 + Cse1 + Cse3 + Cse4 + Cas5e – Cryo EM
    • 5gqh – PaCas3 + anti-crispr protein 3
    • 5b7i – PaCas3 + ACRF3

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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