6b4j

Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(AMPPNP) complexCrystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(AMPPNP) complex

Structural highlights

6b4j is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.4Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GLE1_HUMAN Lethal arthrogryposis - anterior horn cell disease;Lethal congenital contracture syndrome type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

GLE1_HUMAN Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).^[1] ^[2] ^[3]

References

↑ Kendirgi F, Barry DM, Griffis ER, Powers MA, Wente SR. An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J Cell Biol. 2003 Mar 31;160(7):1029-40. doi: 10.1083/jcb.200211081. PMID:12668658 doi:http://dx.doi.org/10.1083/jcb.200211081
↑ Kendirgi F, Rexer DJ, Alcazar-Roman AR, Onishko HM, Wente SR. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Mol Biol Cell. 2005 Sep;16(9):4304-15. Epub 2005 Jul 6. PMID:16000379 doi:http://dx.doi.org/E04-11-0998
↑ Watkins JL, Murphy R, Emtage JL, Wente SR. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84. PMID:9618489

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OCA

[1] Kendirgi F, Barry DM, Griffis ER, Powers MA, Wente SR. An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J Cell Biol. 2003 Mar 31;160(7):1029-40. doi: 10.1083/jcb.200211081. PMID:12668658 doi:http://dx.doi.org/10.1083/jcb.200211081

[2] Kendirgi F, Rexer DJ, Alcazar-Roman AR, Onishko HM, Wente SR. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Mol Biol Cell. 2005 Sep;16(9):4304-15. Epub 2005 Jul 6. PMID:16000379 doi:http://dx.doi.org/E04-11-0998

[3] Watkins JL, Murphy R, Emtage JL, Wente SR. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84. PMID:9618489

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