Transcriptional activator 3D structures

3D Structures of transcriptional activator3D Structures of transcriptional activator

Updated on 03-February-2021 - For a general description of the protein see Transcriptional activator

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• Gcn4 transcriptional activator see Gcn4
• Gcn5 transcriptional activator
  • 1e6i – yTA brododomain + histone H4 peptide - yeast
    
  • 1ygh – yTA histone acetyltransferase domain
    
• C-Myb transcriptional activator; domains - DBD repeat 1 38-89; DBD repeat 2 90-141; DBD repeat 3 142-193; transcriptional activation (TAD) 291-315
  • 1mse, 1msf – mTA DBD repeat 1,2 + DNA - mouse - NMR
    
  • 1mbe, 1mbf – mTA DBD repeat 1 + DNA - NMR
    
  • 1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
    
  • 1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
    
  • 1h88 – mTA DBD repeat 1,2,3 + DNA + CCAAT/enhancer binding protein β
    
  • 1h89 – mTA DBD repeat 1,2,3 + DNA + CAAT/enhancer binding protein β
    
  • 1guu – mTA DBD repeat 1
    
  • 1gv2 – mTA DBD repeat 2,3
    
  • 1gv5 – mTA DBD repeat 2
    
  • 1gvd – mTA DBD repeat 2 (mutant)
    
  • 1idy, 1idz – mTA DBD repeat 3 (mutant) - NMR
    
  • 1sb0, 2agh – mTA TAD + CREB-binding protein - NMR
    
  • 2agh – mTA TAD + CREB-binding protein + HRX - NMR
    
  • 6dmx, 6dnq – mTA TAD + CREB-binding protein + BZIP factor
    
• Psp operon transcriptional activator
  • 2bjw – EcTA AAA domain – Escherichia coli
    
  • 2bjv, 2c9c, 4qnm – EcTA AAA domain (mutant)
    
  • 2c96 – EcTA AAA domain + ATP
    
  • 4qnr – EcTA AAA domain (mutant) + ATP
    
  • 4qos – EcTA AAA domain (mutant) + ADP
    
  • 2c98 – EcTA AAA domain + ADP
    
  • 2c99 – EcTA AAA domain + AMPPNP
    
  • 2vii – EcTA AAA domain + AMP + Mg
    
  • 5nss – EcTA AAA domain + RNAP subunits αββ'ω + DNA - Cryo EM
    
• TenA transcriptional activator
  • 1tyh, 1yaf – BsTA – Bacillus subtilis
    
  • 2qzc – TA – Sulfolobus solfataricus
    
  • 3no6 – TA – Staphylococcus epidermidis
    
  • 1yak – BsTA + pyrimidine derivative
    
  • 2qcx – BsTA (mutant) + pyrimidine derivative
    
  • 1udd – TA – Pyrococcus horikishii
    
• LasR transcriptional activator or transcriptional regulator LasR
  • 6mww – PaTA – Pseudomonas aeruginosa
    
  • 2uv0 – PaTA LBD residues 1-173
    
  • 3ix3, 6mvn, 6mvm – PaTA LBD + oxo-dodecanoyl-homoserine lactone
    
  • 3ix4, 3ix8, 3jpu, 6d6a, 6d6b, 6d6c, 6d6d, 6d6l, 6d6m, 6d6n, 6d6o, 6d6p – PaTA LBD + benzoate derivative
    
  • 6mwl – PaTA + oxothiolan derivative
    
  • 6mwh – PaTA + acetamide derivative
    
  • 4ng2 – PaTA LBD + protein
    
  • 6mwz – PaTA (mutant) + peptide
    
• CadC transcriptional activator; domains - DBD 1-107; periplasmic 188-512
  • 3ly7, 3lya – EcTA periplasmic domain
    
  • 3ly8, 3ly9 – EcTA periplasmic domain (mutant)
    
  • 5ju7 – EcTA DBD domain
    
• CynR transcriptional activator
  • 2hxr – EcTA LBD
    
  • 3hfu – EcTA LBD + N3
    
• Mal-Rpel transcriptional activator
  • 2v51, 2v52 – mTA residues 16-41 + actin
    
  • 2yje, 2yjf – mTA Rpel domain + actin
    
• Brg1 transcriptional activator
  • 5ea1 – hTA bromodomain - human
    
  • 3uvd – hTA bromodomain + pyrrolidone derivative
    
  • 5dkd – hTA bromodomain + pyridine derivative
    
• VP30 transcriptional activator
  • 2i8b – TA C terminal – Zaire ebolavirus
    
  • 3v7o – TA C terminal – Reston ebolavirus
    
• TraR transcriptional activator
  • 1v4r – AtTA N-terminal - Streptomyces - NMR
    
  • 1l3l – AtTA + pheromone + DNA – Agrobacterium tumefaciens
    
  • 1h0m – AtTA + auto-inducer + DNA
    
  • 5w1s – EcTA + RNAP subunits αββ'ω + PROD + DNA
    
• Flagelar transcriptional activator
  • 1g8e – EcTA FlhD
    
  • 2avu – EcTA FlhC+FlhD
    
  • 5hxg – StTA FlhD + STM1697
    
• TipA transcriptional activator
  • 1ny9 – SlTA antibiotic binding domain – Streptomyces lividans - NMR
    
  • 2mbz, 2mc0 - SlTA antibiotic binding domain + thiopeptide - NMR
    
  • 2vz4 – SlTA DBD + DNA
    
• MtaN transcriptional activator
  • 1r8d, 1jbg – BsTA N-terminal
    
  • 4p54 – TA (mutant) - Helicobacter pylori
    
• RfaH transcriptional activator
  • 2oug – EcTA
    
  • 2lcl – EcTA C terminal - NMR
    
  • 5ond – EcTA (mutant) + DNA
    
• SoxR transcriptional activator
  • 2zhh – EcTA
    
  • 2zhg – EcTA + DNA
    
• AmpR transcriptional activator
  • 3kos – CfTA effector binding domain – Citrobacter freundii
    
  • 3kot – CfTA effector binding domain (mutant)
    
  • 4wkm – CfTA effector binding domain + peptide
    
  • 5mmh – PaTA effector binding domain
    
• GlxR transcriptional activator
  • 4byy – CgTA – Corynebacterium glutamicum
    
  • 3r6s, 4cyd – CgTA + cAMP
    
• OxyR transcriptional activator
  • 3t22, 3ho7, 3uki – TA regulatory domain – Porphyromonas gingivalis
    
  • 3jvt – TA – Neiserria meningitidis
    
  • 4x6g – PaTA (mutant)
    
  • 4y0m – PaTA regulatory domain
    
  • 4xws – PaTA regulatory domain (mutant)
    
  • 5x0v – VvTA-2 regulatory domain - Vibrio vulnificus
    
  • 5x0q, 5b70, 5b7d, 5b7h – VvTA-2 regulatory domain (mutant)
    
• PlcR transcriptional activator
  • 4fsc – BtTA - Bacillus thuringiensis
    
  • 2qfc – BtTA + PAPR peptide
    
  • 3u3w – BtTA + DNA + PAPR peptide
    
• VirB transcriptional activator
  • 3vwb, 3w2a, 3w3c – TA core domain + DNA – Shigella flexneri
    
• MafA transcriptional activator
  • 4eot – hTA DBD
    
• CysB transcriptional activator
  • 4gwo, 4gxa, 4lon, 4lp2 – StTA C terminal – Salmonella typhimurium
    
  • 4lq2, 4lq5, 4m4g – StTA C terminal + acetylserine
    
  • 1al3 – TA cofactor binding domain – Klebsiella aerogenes
    
  • 5z50 – PaTA regulatory domain
    
  • 5z4y, 5z4z – PaTA NTD domain
    
• HlyU transcriptional activator
  • 4k2e, 4ooi – VcTA - Vibrio cholerae
    
  • 3jth – VvTA - Vibrio vulnificus
    
  • 5znx – VvTA + inhibitor
    
• ToxR TA
  • 6uue, 6utc – VvTA
    
• LysR TA
  • 5x0o – VvTA
    
  • 5x0n – VvTA (mutant)
    
  • 3t1b, 3szp – VcTA
    
  • 6yz3 – PaTA
    
  • 5z7h – SaTA
    
  • 4pzj – TA – Eggerthella lenta
    
  • 3hhf – NmTA – Neisseria meningitidis
    
  • 3fzj – TA – Comamonas testosteroni
    
• Aft2 transcriptional activator
  • 4lmg – yTA + DNA
    
• Cmpr transcriptional activator
  • 5z49 – TA effector-binding domain + ribulose bisphosphate – Synechococcus elongatus
    
• Mga transcriptional activator
  • 5way – SpTA – Streptococcus pneumoniae
    
• RhaR transcriptional activator
  • 5u9e, 5u93 – TA regulatory domain – Bacteria latreille
    
• Spt7 transcriptional activator
  • 6t9k, 6t9i – yTA in SAGA – Cryo EM
    
• Quorum-sensing TA
  • 5l07 – YeTA – Yersinia enterocolitica
    
  • 5l09 – YeTA + THF derivative
    
• MexT TA
  • 6l33 – PaTA regulatory domain
    
• ComR TA
  • 5juf – TA – Streptococcus thermophilus
    
• GabR TA
  • 5t4k, 5t4j, 5t4l – BsTA EBO domain + pyridine derivative
    
• FasR TA
  • 6o6p – MtTA + DNA – Mycobacterium tuberculosis
    
  • 6o6o – MtTA + myristic acid
    
• PrpR TA
  • 6d2s, 6cyj, 6cz6, 6cyy – MtTA
    
• LrpC TA
  • 2cfx – BsTA
    
• ModE TA
  • 1o7l, 1h9s – EcTA + Mo
    
  • 1b9m, 1b9n , 1h9r– EcTA + Ni
    
• RutR TA
  • 4x1e – EcTA
    
  • 4xk4, 4jyk – EcTA + uracil derivative
    
• TetR family TA
  • 1z77, 2id6, 2iek, 1zkg, 4i76, 3ih2, 3ih3, 3ih4 – TmTA – Thermotoga maritima
    
  • 4i6z – TmTA + DNA
    
  • 1zk8, 2fq4, 4me9 – BcTA – Bacillus cereus
    
  • 3cwr – TA – Rhodspirillum rubrum
    
  • 1z0x – EfTA – Enterococcus faecalis
    
  • 3vuq – TtTA – Thermus thermophilus
    
  • 3c2b – AfTA – Agrobacterium fabrum
    
  • 2o7t – CgTA
    
  • 2g7s – AtTA
    
  • 5d19 – MtTA
    
  • 3gzi – TA – Shewanella loihica
    
  • 3dcf – TA – Thermobifida fusca
    
  • 2qib, 2zcx, 7ky1 – TA – Streptomyces coelicolor
    
  • 2hyt – TA – Pectobacterium atrosepticum
    
  • 3cdl – PsTA – Pseudomonas syringae
    
  • 3kkc – TA – Streptococcus agalactiae
    
  • 3mvp – TA – Streptococcus mutans
    
  • 3nnr – TA – Marinobacter aquaeolei
    
  • 3on4 – TA – Legionella pneumophila
    
  • 2eh3 – TA – Aquifex aeolicus
    
  • 3f1b – RjTA – Rhodococcus jostii
    
  • 3eup – TA – Cytophaga hutchinsonii
    
  • 3egq – TA – Archaeoglobus fulgidus
    
  • 4hku – TA – Listeria monocytogenes
    
  • 3nrg, 3qbm – TA – Chlotoflexus aurantiacus
    
  • 6g87 – BdTA – Bradyrhizobium diazoefficiens
    
  • 6g8h – BdTA + naringenin
    
  • 6g8g – BdTA + genistein
    
  • 6nsr – PaTA (mutant) + DNA
    
  • 4jkz – MsTA – Mycobacterium smegmatis
    
  • 6el2 – SacTA – Sulfolobus acidocaldarius
    
  • 6en8 – SacTA + DNA
    
• GntR family TA
  • 3l5z – BcTA
    
  • 3ddv – EfTA
    
  • 3sxy – TmTA
    
  • 3c7j – PsTA
    
  • 2p19 – CgTA
    
  • 3tqn – TA – Coxiella burnetii
    
• MarR family TA
  • 3boq, 3cjn, 3e6m – RpTA - Ruegeria pomeryi
    
  • 3s2w – TA – Methanosarcina mazei
    
  • 2fbk – DrTA – Deinococcus radiodurans
    
  • 5dd8 – DrTA (mutant)
    
  • 2fa5 – TA – Xanthomonas campestris
    
  • 5aiq – NmTA
    
  • 5aip – NmTA + hydroxyphenylacetate
    
  • 5e1w – DmTA – Dihalococcoides mccartyi
    
  • 5e1z, 5e1x, 5e20 – DmTA + phenol derivative
    
  • 6c28 – TA + coumaroyl-CoA – Rhodopseudomonas palustris
    
  • 3fm5 – RjTA
    
  • 1z91 – BsTA
    
• MerR family TA
  • 3hh0 – BcTA
    
  • 3gpv – BtTA
    
• AsnC family TA
  • 3i4p – AfTA
    
• AraC family TA
  • 3gra – PpTA – Pseudomonas putida
    
  • 3cu5 – TA – Lacnoclostridium phytofermentans
    
  • 5chh – PaTA
    
• LacI family TA
  • 3kjx, 3e3m – RpTA
    
  • 3jy6 – TA - Lactobacillus brevis
    
  • 6chk – LcTA - Lactobacillus casei
    
  • 4rk5, 4rk4 – LcTA + sugar
    
  • 4rk0, 4rk1 – EfTA + ribose
    
  • 3h5t – CgTA
    
  • 3kke – MsTA
    
  • 4rkq, 4rkr – TA - Arthrobacter
    
• PadR family TA
  • 5zhv, 5zi8, 5zhc – MtTA
    
  • 5zqh – SpTA
    
  • 5x12 – BsTA
    
  • 5y8t – BsTA + coumaric acid
    
• TrmB TA
  • 2f5t – TA – Thermococcus litoralis
    
• IclR TA
  • 1mkm – TmTA
    
• BgaR TA
  • 6nwo – CpTA – Clostridium perfringens
    
  • 6nx3, 6nwj, 6nwm, 6nwh – CpTA + pyranose derivative
    
• SlyA TA
  • 1lj9 – EfTA
    
  • 3qpt – StTA
    
  • 3q5f – StTA + DNA
    
  • 4aih – YpTA – Yersinia pseudotuberculosis
    
  • 4aij, 4aik – YpTA + DNA
    
• BenM TA
  • 3k1n – AbTA – Acinetobacter baylyi
    
  • 3k1p – AbTA (mutant)
    
  • 2f6g, 2f6p, 2f97 – AbTA effector-binding domain 81-304
    
  • 3m1e – AbTA DBD 1-87
    
  • 4ihs, 4iht – AbTA effector-binding domain + DNA
    
  • 2f78, 2f7a, 2f7c – AbTA effector-binding domain + effector
    
  • 2h9b – EfTA (mutant)
    
• CatM TA
  • 2f7b, 2h98 – AbTA effector-binding domain
    
• CouR TA
  • 5cyv – RjTA + coumaroyl-CoA – Rhodococcus jostii
    
• MgrA TA
  • 2bv6 – SaTA – Staphylococcus aureus
    
• SarX TA
  • 5hs5, 5ywj, 6k8e – SaTA
    
• QacR TA
  • 2gby – SaTA
    
  • 3br6 – SaTA (mutant) + rhodamine
    
  • 3bqz – SaTA + malachite green
    
  • 3br1, 3br2 – SaTA (mutant) + dequalinium
    
  • 2g0e – TA + drug – Staphylococcus haemolyticus
    
• AcrR TA
  • 2qop – EcTA
    
• CueR TA
  • 1q07, 1q06, 1q05 – EcTA
    
• PurR TA
  • 3d8u – VpTA – Vibrio parahaemolyticus
    
• LuxR TA
  • 6wae – VvTA
    
  • 6wai, 6wah, 6wag, 6waf – VvTA (mutant)
    
• LuxT TA
  • 3ljl – VpTA
    
• ClgR TA
  • 5woq – MsTA
    
• LmrR TA
  • 3f8b, 6i8n – LlTA – Lactococcus lactis
    
  • 3f8c, 3f8f – LlTA + drug
    
  • 6vwe, 6do0 – LlTA + Rh complex
    
  • 6r1l – LlTA + Cu + phenanthroline
    
• MvfR TA
  • 6z17 – PaTA
    
  • 6z5k – PaTA + inhibitor
    
• HdfR TA
  • 6wn5 – TA – Klebsiella pneumoniae
    
• McbR TA
  • 4p9f – EcTA
    
• MetR TA
  • 5fo5 – EcTA DBD
    
• McbR TA
  • 3nxh – BsTA
    
• CgmR TA
  • 2zoy – CgTA
    
  • 2zoz – CgTA + ethidium
    
• AraR TA
  • 5bs6 – TA – Bacterioides thetaiotaomicron
    
• CarH TA
  • 5c8d – TtTA + adnosylcobalamin
    
• ZitR TA
  • 5yhy, 5yi0, 5yi1 – LlTA (mutant)
    
• LsrR TA
  • 4l4y – EcTA
    
  • 4l4z, 4l50, 4l51, 4l5i, 4l5j – EcTA + ligand
    
• HTH-type TA
  • 2uxu – PpTA TtgR + naringenin
    
  • 2uxh – PpTA TtgR + quercetin
    
  • 2uxi – PpTA TtgR + phloretin
    
  • 6ugl, 6kju – VcTA + pyrazine derivative
    
  • 3hrm, 3hse – SaTA SarZ
    
  • 6r1p – MtTA EthR
    
  • 1ysq – EcTA YiaJ
    
  • 2gfn – RjTA Rha1
    
  • 1i1g – TA LrpA – Pyrococcus furiosus
    
  • 7cla – TA SkgA – Caulobacter vibrioides