Transcriptional activator

Function Transcriptional activators or Transcriptional regulators (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD). PrfA is an activator of virulence genes in Listeria monocytogenes. See also Listeriolysin positive regulatory factor A. Structural highlights TA contains 3 domains: DBD, trans-activating domain (TAD) which binds coregulator proteins and an optional ligand-binding domain (LBD) which senses external signals. (PDB entry 1h89). . . Water molecules are shown as red spheres. 3D Structures of transcriptional activator Transcriptional activator 3D structures

spinqualitylabelsall models Structure of transcriptional activator C-Myb DNA-binding domain (deeppink) complex with DNA, CAAT/enhancer binding protein β (cyan and green) and K+ ion (purple) (PDB entry 1h89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image