1jbg

Crystal Structure of MtaN, the Bacillus subtilis Multidrug Transporter Activator, N-terminusCrystal Structure of MtaN, the Bacillus subtilis Multidrug Transporter Activator, N-terminus

Structural highlights

1jbg is a 1 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.75Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTA_BACSU Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Baranova NN, Danchin A, Neyfakh AA. Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters. Mol Microbiol. 1999 Mar;31(5):1549-59. PMID:10200972
↑ Miethke M, Schmidt S, Marahiel MA. The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. J Bacteriol. 2008 Aug;190(15):5143-52. Epub 2008 May 23. PMID:18502870 doi:http://dx.doi.org/JB.00464-08

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OCA

[1] Baranova NN, Danchin A, Neyfakh AA. Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters. Mol Microbiol. 1999 Mar;31(5):1549-59. PMID:10200972

[2] Miethke M, Schmidt S, Marahiel MA. The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. J Bacteriol. 2008 Aug;190(15):5143-52. Epub 2008 May 23. PMID:18502870 doi:http://dx.doi.org/JB.00464-08

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