5ywj

Global regulatory element SarXGlobal regulatory element SarX

Structural highlights

5ywj is a 1 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.102Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SARX_STAA8 Involved in the regulation of virulence genes. Acts as a repressor of the agr locus and consequently targets genes regulated by the agr system such as sspA, hla and hlb. Binds directly to the agr promoter region.^[1]

References

↑ Manna AC, Cheung AL. Expression of SarX, a negative regulator of agr and exoprotein synthesis, is activated by MgrA in Staphylococcus aureus. J Bacteriol. 2006 Jun;188(12):4288-99. doi: 10.1128/JB.00297-06. PMID:16740935 doi:http://dx.doi.org/10.1128/JB.00297-06

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OCA

[1] Manna AC, Cheung AL. Expression of SarX, a negative regulator of agr and exoprotein synthesis, is activated by MgrA in Staphylococcus aureus. J Bacteriol. 2006 Jun;188(12):4288-99. doi: 10.1128/JB.00297-06. PMID:16740935 doi:http://dx.doi.org/10.1128/JB.00297-06

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