Gcn4

Function Gcn4 or General control protein Gcn4 is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also Intrinsically Disordered Protein. Structural highlights Gcn4 and other family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical. See Coiled coil. 3D Structures of Gcn4 Gcn4 3D Structures

spinqualitylabelsall models Structure of Gcn4 leucine zipper domain complex with DNA (PDB entry 2dgc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image