Heat Shock Protein structures: Difference between revisions

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**[[2wj7]], [[3l1g]] – hHspB5 crystallin domain – human<br />
**[[2wj7]], [[3l1g]] – hHspB5 crystallin domain – human<br />
**[[4jus]] - hHsp20 6 residues 57-160<br />
**[[6f2r]] - hHsp β2 +  hHsp 3<br />
**[[4jut]] - hHsp20 6 residues 57-160 (mutant)<br />
**[[4jus]] - hHsp20 β6 residues 57-160<br />
**[[5lum]] - hHsp20 6 ACD domain<br />
**[[4jut]] - hHsp20 β6 residues 57-160 (mutant)<br />
**[[5ltw]], [[5lu1]], [[5lu2]] - hHsp20 6 residues 1-149 + 14-3-3 sigma<br />
**[[5lum]] - hHsp20 β6 ACD domain<br />
**[[5ltw]], [[5lu1]], [[5lu2]] - hHsp20 β6 residues 1-149 + 14-3-3 sigma<br />
**[[6dv5]] - hHsp27 β1 <br />
**[[6dv5]] - hHsp27 β1 <br />
**[[6gjh]] - hHsp27 β1 crystallin domain +peptide<br />
**[[3q9p]], [[3q9q]] – hHsp28 β1<br/>
**[[3q9p]], [[3q9q]] – hHsp28 β1<br/>
**[[2n3j]], [[4mjh]] - hHsp28 1 crystallin domain<br />
**[[2n3j]], [[4mjh]] - hHsp28 β1 crystallin domain<br />
**[[2wj5]] – rHsp20 crystallin domain – rat<br />
**[[2wj5]] – rHsp20 crystallin domain – rat<br />
**[[1gme]] – wHsp 17kD – wheat<br />
**[[1gme]] – wHsp 17kD – wheat<br />
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**[[5ds1]] - pHsp 17.7 - pea<br />
**[[5ds1]] - pHsp 17.7 - pea<br />
**[[5ds2]] - pHsp 18.1<br />
**[[5ds2]] - pHsp 18.1<br />
**[[5nms]] - Hsp 25.3 – ''Arabidopsis thaliana'' - Cryo EM<br />
**[[7bzw]] - AtHsp 21 – ''Arabidopsis thaliana'' - Cryo EM<br />
**[[7bzy]] - AtHsp 21 + DXPS - Cryo EM<br />
**[[5nms]] - AtHsp 25.3 - Cryo EM<br />
**[[2h50]], [[2h53]] – yHsp26 – yeast<br />
**[[2h50]], [[2h53]] – yHsp26 – yeast<br />
**[[2l9q]], [[2ljl]], [[4axp]] – yHsp12 - NMR<br />
**[[2l9q]], [[2ljl]], [[4axp]] – yHsp12 - NMR<br />
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**[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br />
**[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br />
**[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br />
**[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br />
**[[4i2n]] – VcHsp31<br />
**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
**[[1dm9]] – EcHsp15<br />
**[[8ap4]] – EcHsp15 in 50S ribosome – Cryo-EM<br />
**[[1ons]] – EcHsp31<br />
**[[1ons]] – EcHsp31<br />
**[[3gla]], [[3gt6]], [[3guf]]  – Hsp – ''Xanthomonas axonopodis''<br />
**[[3gla]], [[3gt6]], [[3guf]]  – Hsp – ''Xanthomonas axonopodis''<br />
**[[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
**[[3aac]], [3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
**[[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
**[[3aab]], [[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
**[[5j7n]] – Hsp – ''Xylella fastidiosa''<br />
**[[5j7n]] – Hsp – ''Xylella fastidiosa''<br />
**[[6l6m]] – Hsp18.5 – ''Entamoeba histolytica''<br />
**[[4fei]] – Hsp17.7 – ''Deinococcus radiodurans''<br />
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br />
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
**[[5zs6]], [[5zs3]] – MmaHsp + peptide<br />
**[[5zs6]], [[5zs3]] – MmaHsp + peptide<br />
**[[7ck4]] – Hsp – ''Synechococcus'' phage<br />
**[[6ewn]] – HspA – ''Thermosynechococcus vulcanus''<br />


*Hsp33
*Hsp33


**[[3kkl]] – yHsp33 <br />
**[[1hw7]], [[3m7m]] – EcHsp33 NTD <br />
**[[1hw7]], [[3m7m]] – EcHsp33 NTD <br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
Line 45: Line 57:
**[[1vzy]] – Hsp33 – ''Bacillus subtilis''
**[[1vzy]] – Hsp33 – ''Bacillus subtilis''


*HslV, HslU, HslJ
*HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU


**[[1e94]], [[1yyf]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[5ji3]] – EcHslV+HslU <br />
**[[1e94]], [[1yyf]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[5ji3]] – EcHslV+HslU <br />
**[[5txv]] – EcHslU<br />
**[[5txv]] – EcHslU<br />
**[[5ji2]] – EcHslV + EcHslU (mutant)<br />
**[[6pxl]], [[6pxk]] – EcHslU + ADP<br />
**[[5ji2]], [[6pxi]] – EcHslV + EcHslU (mutant)<br />
**[[1ned]] – EcHslV<br />
**[[1ned]] – EcHslV<br />
**[[4g4e]] – EcHslV (mutant)<br />
**[[4g4e]] – EcHslV (mutant)<br />
**[[2kts]] – EcHslJ - NMR<br />
**[[2kts]] – EcHslJ - NMR<br />
**[[1g41]] – HiHslU – ''Haemophilus influenza''<br />
**[[1g41]] – HiHslU – ''Haemophilus influenza''<br />
**[[1im2]] – HiHslU NBD
**[[1im2]] – HiHslU NBD<br />
**[[1kyi]] – HiHslV + HiHslU + ATP + inhibitor<br />
**[[6kww]] – SaHslU – ''Staphylococcus aureus''<br />
**[[7mhb]] – HslU + ADP – ''Brucella abortus''<br />


*Hsp40 or DnaJ homolog subfamily C member 12
*Hsp40 or DnaJ homolog subfamily C member 12


**[[2qld]] – hHsp40<br />
**[[2qld]] – hHsp40 residues 158-340<br />
**[[1hdj]], [[2ctq]] – hHsp40 J domain - NMR<br />
**[[1hdj]], [[2ctq]], [[2lgw]], [[2m6y]], [[6iws]] – hHsp40 J domain 1-76 - NMR<br />
**[[6byr]] – hHsp40 J domain 1-70 + CAMP-dependent protein kinase<br />
**[[6z5n]] – hHsp40 1-110 – NMR<br />
**[[6cgh]] – hHsp40 346-432 – NMR<br />
**[[6u3r]], [[6u3s]] – hHsp40 1-127+CT – NMR<br />
**[[7jsq]] – hHsp40 CT – NMR<br />
**[[7ndx]] – hHsp40 CT + NudC peptide<br />
**[[7ciz]], [[7cj0]] – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4<br />
**[[6jmg]] – DnaJ + GTP - frog<br />
**[[6ekb]] – AtDnaJ 57-136 (mutant)<br />
**[[6ekc]] – AtDnaJ 57-136 (mutant) + RbcL<br />
**[[1c3g]] – yHsp40 CT<br />  
**[[1c3g]] – yHsp40 CT<br />  
**[[5vso]] – yHsp40 J domain – NMR<br />
**[[5vso]] – yHsp40 J domain – NMR<br />
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**[[1exk]] – EcHsp40 Cys-rich domain - NMR<br />
**[[1exk]] – EcHsp40 Cys-rich domain - NMR<br />
**[[4j7z]] – TtHsp40 residues 2-114 (mutant - ''Thermus thermophilus''<br />
**[[4j7z]] – TtHsp40 residues 2-114 (mutant - ''Thermus thermophilus''<br />
**[[6prp]] – TtDnaJ/DnaK - NMR<br />
**[[6psi]] – TtDnaJ + alkaline phosphatase - NMR<br />
**[[6jzb]] – SpDnaJ – ''Streptococcus pneumoniae'' - NMR<br />
**[[6rzy]] – PfHsp40 residues 81-148  – ''Plasmodium falciparum''<br />


*Hsp47
*Hsp47


**[[3zha]] – dHsp47 + collagen peptide - dog<br />
**[[4au4]] – dHsp47 - dog<br />
**[[3zha]] – dHsp47 + collagen peptide<br />


* Hsp60 mitochondrial
* Hsp60 mitochondrial
**[[4pj1]] – hHsp60 + hHsp10<br />
**[[7azp]], [[7l7l]], [[7l7s]] – hHsp60 – Cryo EM<br />
**[[7azp]], [[7l7l]], [[7l7s]], [[8g7j]] – hHsp60 – Cryo EM<br />
**[[8u39]] – hHsp60 (mutant) - Cryo EM
**[[8g7k]] – hHsp60 (mutant) + ADP – Cryo EM
**[[8g7m]], [[8g7o]] – hHsp60 (mutant) + ATP – Cryo EM
**[[4pj1]], [[6ht7]] – hHsp60 + hHsp10 + ADP<br />
**[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />


* Hsp60 - the large subunit of the chaperonin molecule GroEL  
* Hsp60 - the large subunit of the chaperonin molecule GroEL ; See [[Chaperonin]]


**[[3los]] – MmHsp60 - GroEL – ''Methanococcus maripaludis'' – closed state<br />
* Hsp65
**[[3iyf]]  - MmHsp60 - GroEL – open state<br />
 
**[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br />
**[[3rtk]] – MtHsp65 – ''Mycobacterium tuberculosis''<br />
**[[2nwc]], [[1oel]], [[1grl]], [[1la1]] - EcHsp60 – GroEL<br />
**[[2eu1]] - EcHsp60 (mutant) – GroEL<br />
**[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br />
**[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br />
**[[1gr5]] - EcHsp60 – GroEL – cryo EM<br />
**[[1gru]] - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM<br />
**[[1dkd]] - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide<br />
**[[1dk7]], [[1jon]] - EcHsp60 – GroEL apical domain <br />
**[[1kid]] - EcHsp60 (mutant) – GroEL apical domain<br />
**[[1srv]] - TtHsp60 – GroEL apical domain<br />
**[[4v4o]] - TtHsp60 – GroEL+GroES <br />
**[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br />


* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.  
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.  
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**[[4io8]], [[5aqw]], [[5aqx]], [[5aqy]], [[5aqz]], [[5ar0]], [[5mkr]], [[5mks]] - hHsp70 NBD + inhibitor<br />
**[[4io8]], [[5aqw]], [[5aqx]], [[5aqy]], [[5aqz]], [[5ar0]], [[5mkr]], [[5mks]] - hHsp70 NBD + inhibitor<br />
**[[6b1i]] - hHsp70 NBD + ADP<br />
**[[6b1i]] - hHsp70 NBD + ADP<br />
**[[6b1n]] - hHsp70 NBD (mutant) + ADP<br />
**[[6b1n]], [[6zyi]] - hHsp70 NBD (mutant) + ADP<br />
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
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**[[4po2]] - hHsp70 CT + peptide<br />
**[[4po2]] - hHsp70 CT + peptide<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
**[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[2p32]] - CeHsp70 CT<br />
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
**[[4j8f]], [[4wv5]], [[5xi9]], [[5gjj]] - hHsp70 SBD<br />
**[[4j8f]], [[4wv5]], [[5xi9]], [[5gjj]] - hHsp70 SBD<br />
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**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
**[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[2p32]] - CeHsp70 CT<br />
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
**[[3lca]] – yHsp70 Ssa1 CT+yTOM71<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
**[[3l6q]] - CpHsp70 NBD – ''Cryptosporidium parvum''<br />
**[[3l6q]] - CpHsp70 NBD – ''Cryptosporidium parvum''<br />
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />
**[[7ooe]], [[7oog]], [[7p31]] – PfHsp70 NTD+AMP derivative + inhibitor <br />
**[[7nqr]], [[7nqs]], [[7nqu]], [[7nqz]] - PfHsp70 NBD + inhibitor<br />
**[[6zhi]] - PfHsp70 CT + peptide<br />


*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
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**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster <br />
**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster <br />


*DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607  
*DnaK or chaperone protein DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607  


**[[4b9q]] - EcDnaK NBD + SBD + ATP<br />
**[[4b9q]] - EcDnaK NBD + SBD + ATP<br />
**[[7ko2]], [[7krt]], [[7kru]], [[7krv]] - EcDnaK (mutant) + ATP<br />
**[[5oow]] - EcDnaK + AMPPCP<br />
**[[5oow]] - EcDnaK + AMPPCP<br />
**[[5nro]] – EcDnaK (mutant) + DnaJ<br />
**[[5nro]] – EcDnaK (mutant) + DnaJ<br />
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**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
**[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]] – EcDnaK SBD + peptide<br />
**[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br />
**[[7krw]], [[7kzi]], [[7kzu]] – EcDnaK/peptide<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
**[[4r5g]] - EcDnaK CT + inhibitor<br />
**[[4r5g]] - EcDnaK CT + inhibitor<br />
**[[4rtf]] DnaK + ATP – ''Mycobacterium tuberculosis''<br />
**[[4rtf]] - MtDnaK + ATP – ''Mycobacterium tuberculosis''<br />
**[[6w6e]] - MtDnaK NBD + ClpB + ADP<br />
**[[7l6n]] - MtDnaK NBD + ClpB + ADP – Cryo EM<br />
**[[5obx]] - MgDnaK NBD – ''Mycoplasma genitalium''<br />
**[[5obx]] - MgDnaK NBD – ''Mycoplasma genitalium''<br />
**[[5obv]], [[5obu]] - MgDnaK NBD (mutant) <br />
**[[5obv]], [[5obu]] - MgDnaK NBD (mutant) <br />
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**[[5obw]] - MgDnaK NBD + ATP <br />
**[[5obw]] - MgDnaK NBD + ATP <br />


*Hsp75
*Hsp75 or TRAP-1
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5hph]] – hHsp75 residues 60-554<br />
**[[5hph]], [[7ulk]] – hHsp75 residues 60-554<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]] – hHsp75 + inhibitor<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]] – hHsp75 + inhibitor<br />
**[[6xg6]] – hHsp75 residues 60-704 + ADP – Cryo EM<br />
**[[7kck]], [[7klu]], [[7klv]] – hHsp75 residues 60-704 + AMPPNP – Cryo EM<br />
**[[7kcl]], [[7kcm]] – hHsp75 residues 60-704 + SDHB + AMPPNP – Cryo EM<br />


*Hsp83
*Hsp83
Line 161: Line 199:
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''


* Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker;  middle (MD); C-terminus (CT)  
* Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker 237-283;  middle (MD) 284-543; C-terminus (CT)  


*''Hsp90-α NTD''
*''Hsp90-α NTD''


**[[3t0h]], [[5j2v]], [[6gpw]] - hHsp90 NTD – human<br />
**[[3t0h]], [[5j2v]], [[6gpw]], [[7s8y]], [[7s8z]][[5xr]],  - hHsp90 NTD – human<br />
**[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br />
**[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br />
**[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br />
**[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br />
Line 177: Line 215:
**[[6gqr]], [[3t0z]], [[3t2s]], [[3t10]], [[3t1k]], [[6gq6]], [[6gpy]], [[6gpt]], [[6gpr]], [[1byq]] - hHsp90-α NTD + nucleotide<br />
**[[6gqr]], [[3t0z]], [[3t2s]], [[3t10]], [[3t1k]], [[6gq6]], [[6gpy]], [[6gpt]], [[6gpr]], [[1byq]] - hHsp90-α NTD + nucleotide<br />
**[[6gr5]], [[6gr3]], [[6gr1]], [[6gqu]], [[6gqs]], [[6gpp]], [[6gpo]], [[6gph]], [[6gpf]], [[6gp8]] - hHsp90-α NTD (mutant) + nucleotide<br />
**[[6gr5]], [[6gr3]], [[6gr1]], [[6gqu]], [[6gqs]], [[6gpp]], [[6gpo]], [[6gph]], [[6gpf]], [[6gp8]] - hHsp90-α NTD (mutant) + nucleotide<br />
**[[6gjh]] - hHsp90 NTD+ peptide<br />
**[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
**[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]] - hHsp90 NTD+indole derivative<br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]], [[7lsz]], [[7lt0]] - hHsp90 NTD+indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
Line 185: Line 222:
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3bm9]], [[3bmy]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br />
**[[3bm9]], [[3bmy]], [[5xrd]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]] - hHsp90-α NTD - hHsp90-a NTD+triazol derivative<br />
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]], [[8agi]], [[8agl]] - hHsp90-α NTD +triazol derivative<br />
**[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]] - hHsp90 NTD+pyrimidine derivative<br />
**[[8agj]] - hHsp90-a NTD (mutant) +triazol derivative<br />
**[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]], [[7dmc]], [[7s98]], [[7s99]], [[7s9f]], [[7s9g]], [[7s9h]], [[7s9i]] - hHsp90 NTD+pyrimidine derivative<br />
**[[7a90]], [[7s95]] - hHsp90 NTD+ adenine <br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br />
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br />
Line 195: Line 234:
**[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
**[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
**[[4hy6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[5odx]], [[5oci]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]] - hHsp90 NTD + indazole derivative<br />
**[[4hy6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[5odx]], [[5oci]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]], [[6lti]], [[6ltk]] - hHsp90 NTD + indazole derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
Line 201: Line 240:
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]] - hHsp90 NTD + inhibitor<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]], [[6lr9]], [[6lt8]], [[6tn4]], [[6tn5]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]] - hHsp90 NTD + inhibitor<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]], [[6lsz]] - hHsp90 NTD+ drug <br />
**[[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[1u0z]], [[1qy8]], [[1ysz]], [[1u2o]], [[6d28]], [[6d1x]], [[1qye]], [[3o2f]] - dHsp90B1 NTD+ligand<br />
**[[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[1u0z]], [[1qy8]], [[1ysz]], [[1u2o]], [[6d28]], [[6d1x]], [[1qye]], [[3o2f]], [[6d1x]], [[6d28]]  - dHsp90B1 NTD+ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
**[[1yt0]], [[1tc6]], [[1tba]], [[1tc0]] - dHsp90B1 NTD+ nucleotide<br />
**[[1yt0]], [[1tc6]], [[1tba]], [[1tc0]] - dHsp90B1 NTD+ nucleotide<br />
**[[5wmt]], [[6aol]], [[6aom]], [[6asq]], [[6baw]], [[6c91]], [[6cyi]] - dHsp90B1 NTD+ inhibitor<br />
**[[6asp]] - dHsp90B1 NTD + drug <br />
**[[7d1v]], [[7d22]], [[7d24]], [[7d25]], [[7d26]] - mHsp90-a NTD + inhibitor - mouse<br />
**[[2jki]] - baHsp90 NTD+SGT1 domain protein – barley<br />
**[[2jki]] - baHsp90 NTD+SGT1 domain protein – barley<br />
**[[2xcm]] – baHsp90 NTD+CGT1+RAR1 <br />
**[[2xcm]] – baHsp90 NTD+CGT1+RAR1 <br />
Line 212: Line 254:
**[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
**[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
**[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
**[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
**[[3ied]] - PfHsp90 NTD+AMPPN – ''Plasmodium falciparum''<br />
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[6cji]] – CaHsp90 NTD – ''Candida albicans''<br />
**[[6cjl]], [[6cjp]] – CaHsp90 NTD + radicicol<br />
**[[6cjj]] – CaHsp90 NTD + ADP<br />
**[[6cjr]], [[6cjs]] – CaHsp90 NTD + inhibitor<br />
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br />
*''Hsp90-a NTD+linker residues 1-293''
**[[7ur3]] - hHsp90 + inhibitor <br />


*''Hsp90-α MD''
*''Hsp90-α MD''


**[[6ksq]] - hHsp90 MD <br />
**[[2gq0]] - EcHsp90 MD<br />
**[[2gq0]] - EcHsp90 MD<br />


Line 230: Line 282:
*''Hsp90-α MD + CT'' residues 293-732
*''Hsp90-α MD + CT'' residues 293-732


**[[3q6m]], [[3q6n]] - hHsp90 MD + CT<br />
**[[3q6m]], [[3q6n]], [[7rxz]], [[7ry0]], [[7ry1]] - hHsp90 MD + CT<br />
**[[2o1t]] – dHsp90B1 MD+CT<br />
**[[2o1t]] – dHsp90B1 MD+CT<br />


*''Hsp90-α full length''
*''Hsp90-α full length 1-732''


**[[2qf6]] - hHsp90 + antigen<br />
**[[2qf6]] - hHsp90 + antigen<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[7l7j]] - hHsp90 + P23 + ANP – Cryo EM <br />
**[[7krj]] - hHsp90 + GR + P23 + ATP – Cryo EM <br />
**[[8h77]] - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM <br />
**[[7l7i]] - hHsp90 + FKBP51 + P23 + ANP – Cryo EM <br />
**[[7kw7]] - hHsp90 + Hsp70 + GR + STI1 + ADP – Cryo EM <br />
**[[2o1u]] – dHsp90B1+AMPPNP<br />
**[[2o1u]] – dHsp90B1+AMPPNP<br />
**[[2o1v]] - dHsp90B1+ADP<br />
**[[2o1v]] - dHsp90B1+ADP<br />
Line 244: Line 301:
*Hsp90-β
*Hsp90-β


**[[8eob]] - hHsp90 – Cryo EM <br />
**[[6n8w]] - hHsp90 NTD <br />
**[[6n8w]] - hHsp90 NTD <br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[1uym]], [[6n8y]] - hHsp90 NTD+ purine inhibitor<br />
**[[1uym]], [[6n8y]], [[7ulj]] - hHsp90 NTD+ purine inhibitor<br />
**[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br />
**[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br />
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3pry]] – hHsp90 MD<br />
**[[3pry]] – hHsp90 MD<br />
**[[7zub]] - hHsp90 + AIP + AH receptor + ADP -  Cryo EM <br />
**[[8e0a]] - hHsp90 + AIPL1 + ANP – Cryo EM <br />
**[[7z37]], [[7z38]] - hHsp90 + Cdc37 + RAF-1 – Cryo EM <br />
**[[8gae]] - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM <br />
**[[7zr0]] - hHsp90 + Cdc37 + BRAF – Cryo EM <br />
**[[7zr5]], [[7zr6]] - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM <br />
**[[7y04]] - mHsp90 + AH receptor + P23 + ADP -  mouse - Cryo EM <br />


* Hsp82 is the yeast equivalent of Hsp90 in mammals  
* Hsp82 is the yeast equivalent of Hsp90 in mammals  
Line 272: Line 337:
**[[3fp2]] – yHsp82 CT+TOM71
**[[3fp2]] – yHsp82 CT+TOM71


* Hsp100 are named ClpA or ClpB  
* Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP


**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
Line 278: Line 343:
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
**[[1mg9]], [[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]] – EcClpA + YLJA<br />
**[[1mg9]], [[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]] – EcClpA + YLJA<br />
**[[6w1z]], [[6w20]], [[6w21]], [[6w22]], [[6w23]], [[6w24]] – EcClpA + RepA + GFP + ADP + ATP – Cryo EM<br />
**[[6uqe]], [[6uqo]] – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM<br />
**[[4ciu]] - EcClpB (mutant)<br />
**[[4ciu]] - EcClpB (mutant)<br />
**[[4d2u]], [[4d2x]], [[4d2q]] - EcClpB – Cryo EM<br />
**[[4d2u]], [[4d2x]], [[4d2q]] - EcClpB – Cryo EM<br />
**[[5og1]], [[5ofo]] - EcClpB + ATPgS – Cryo EM<br />
**[[5og1]], [[5ofo]] - EcClpB + ATPgS – Cryo EM<br />
**[[6qs8]], [[6qs7]], [[6qs6]], [[6og3]] - EcClpB + casein – Cryo EM<br />
**[[6qs8]], [[6qs7]], [[6qs6]], [[6og3]] - EcClpB (mutant) + casein – Cryo EM<br />
**[[6og2]] - EcClpB (mutant) + ADP – Cryo EM<br />
**[[6og1]] - EcClpB (mutant) + ADP + ATPgS – Cryo EM<br />
**[[6qs4]] - EcClpB + casein + ADP + ATPgS – Cryo EM<br />
**[[6rn4]] - EcClpB (mutant) + casein + ATPgS – Cryo EM<br />
**[[6oax]], [[6oay]] - EcClpB (mutant) + casein + ADP + ATPgS – Cryo EM<br />
**[[1khy]] – EcClpB NTD <br />
**[[1khy]] – EcClpB NTD <br />
**[[1jbk]] – EcClpB nucleotide binding domain 1<br />
**[[1jbk]] – EcClpB nucleotide binding domain 1<br />
**[[1yg6]] – EcClpP<br />
**[[1yg8]], [[3hln]] – EcClpP (mutant)<br />
**[[2fzs]], [[7mk5]] – EcClpP + inhibitor<br />
**[[6nb1]] – EcClpP + activator<br />
**[[3mt6]] – EcClpP + Adep1<br />
**[[6wr2]], [[6wsg]] – EcClpP + ClpX – Cryo EM<br />
**[[6wrf]] – EcClpP + ClpX + GFP – Cryo EM<br />
**[[8et3]] – EcClpP + ClpX + GFP + SSPB – Cryo EM<br />
**[[4iod]], [[4irf]] - PfClpB <br />
**[[4iod]], [[4irf]] - PfClpB <br />
**[[1qvr]] - TtClpB <br />
**[[1qvr]] - TtClpB <br />
Line 297: Line 377:
**[[3zri]] - VcClpB NTD – ''Vibrio cholerae''<br />
**[[3zri]] - VcClpB NTD – ''Vibrio cholerae''<br />
**[[3zrj]] - VcClpB NTD + peptide<br />
**[[3zrj]] - VcClpB NTD + peptide<br />
**[[6ed3]] - MtClpB – Cryo EM<br />
**[[6w6e]] - MtClpB + ADP + ATPgS – Cryo EM<br />
**[[6dju]], [[6djv]] - MtClpB + casein + ATPgS – Cryo EM<br />
**[[6em8]], [[6em9]] - SaClpC – Cryo EM<br />
**[[6emw]] - SaClpC + MecA – Cryo EM<br />
**[[6pba]], [[6pbq]] - MtClpC NTD <br />
**[[6pbs]] - MtClpC NTD + ecumicin<br />
**[[6cn8]] - MtClpC NTD + rufomycin<br />
**[[6lsy]] - SpClpL – Cryo EM<br />
**[[6lt4]] - SpClpL + ATPgS – Cryo EM<br />
**[[7m1l]], [[7m1m]] – ClpP2 – ''Pseudomonas aeruginosa''<br />
**[[6cfd]] – ClpP + antibiotic – ''Enterococcus faecium''<br />
**[[7tfm]] – ClpP N-domain – ''Leishmania mexicana''<br />


*Hsp101
*Hsp101
Line 310: Line 403:
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
**[[5vjh]] – yHsp104 + casein + ATP-γ-S<br />
**[[5vjh]] – yHsp104 + casein + ATP-γ-S<br />
**[[5u2l]] – Hsp104 NTD – ''Candida albicans''<br />
**[[5u2l]] – CaHsp104 NTD – ''Candida albicans''<br />
**[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br />
**[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br />
**[[6azy]] – CtHsp104 (mutant)<br />
**[[6azy]] – CtHsp104 (mutant)<br />
**[[5zui]] – Hsp104 – ''Chaetomium thermophilum''<br />
**[[5zui]] – ChtHsp104 – ''Chaetomium thermophilum''<br />
**[[7cg3]] – ChtHsp104 - Cryo EM<br />
**[[5d4w]] – ChtHsp104 (mutant)<br />


* Hsp110 in mammals is named Sse1, Sse2 in yeast  
* Hsp110 in mammals is named Sse1, Sse2 in yeast  
Line 324: Line 419:
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
**[[3lca]] – ySsa1 lid +yTOM71<br />
**[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br />
**[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br />
*HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637
**[[3ldn]] – hHspA5 NBD<br />
**[[5e85]] – hHspA5 SBD domain <br />
**[[5ex5]], [[5exw]], [[5ey4]] – hHspA5 + ATP analog<br />
**[[3ldl]], [[5e84]], [[5f1x]], [[6asy]] – hHspA5 + ATP<br />
**[[3iuc]], [[5evz]], [[5f0x]] – hHspA5 + ADP derivative<br />
**[[5f2r]] – hHspA5 + ACP<br />
**[[3ldo]] – hHspA5 + ANP<br />
**[[3ldp]] – hHspA5 + inhibitor<br />
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] – hHspA5 + adenosine derivative<br />
**[[6zmd]] – hHspA5 + FICD + ANP <br />
**[[6eob]], [[6eoc]], [[7a4u]] – haHspA5 28-549 - hamster<br />
**[[6hab]] – haHspA5 (mutant)<br />
**[[5e86]] – haHspA5 SBD <br />
**[[6zyh]], [[7a4v]] – haHspA5 + ADP <br />
**[[5o4p]] – haHspA5 + AMP<br />
**[[6eof]] – haHspA5 + AMP + ADP<br />
**[[6eoe]] – haHspA5 + ADP<br />
**[[7b7z]], [[7b80]] – haHspA5 + FICD + AMP <br />
**[[6h9u]], [[6ha7]] – haHspA5 NBD + MANF<br />


*HspQ
*HspQ


**[[5ycq]] – EcHspQ<br />
**[[5ycq]] – EcHspQ<br />
*Hsp DegP or Periplasmic serine endoprotease DegP; Domains PDZ1 38-385; PDZ2 400-474
**[[3mh4]] – EcDegP <br />
**[[1ky9]] – EcDegP (mutant) <br />
**[[8f0a]], [[8f0u]], [[8f1t]], [[8f1u]], [[8f21]] – EcDegP + telomeric repeat-binding factor peptide – Cryo EM<br />
**[[2zle]], [[4a8d]] – EcDegP + OmpC – Cryo EM<br />
**[[3cs0]], [[3mh5]], [[3mh6]], [[3mh7]], [[3ou0]], [[6jjk]], [[6jjl]], [[6jjo]] – EcDegP + peptide <br />
**[[3otp]] – EcDegP + lysozyme <br />


*'''Heat shock cognate protein (Hsc)'''
*'''Heat shock cognate protein (Hsc)'''
*''Hsc20''
**[[3bvo]] - hHsc20<br />


*''Hsc70''
*''Hsc70''
Line 339: Line 468:
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br />
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br />
**[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br />
**[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br />
**[[4h5t]] - hHsc70 NBD + ADP<br />
**[[4h5t]], [[6zyj]] - hHsc70 NBD + ADP<br />
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]]  - hHsc70 NBD+BAG domain regulator protein<br />
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]]  - hHsc70 NBD+BAG domain regulator protein<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
Line 353: Line 482:
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br />
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br />
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein – mouse<br />
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein <br />
 
*''Hsc82''
 
**[[6xlc]] - yHsc82 + ANP<br />
**[[6xlh]] - yHsc82 MD+co-chaperone AHA1 + ADP + ATPgS<br />
**[[6xld]], [[6xle]], [[6xlf]] - yHsc82 MD+co-chaperone AHA1 + ANP <br />
**[[6xlb]] - yHsc82 MD+co-chaperone AHA1 + ANP – Cryo EM<br />
**[[6xlg]] - yHsc82 MD+co-chaperone AHA1 + ATPgS<br />


*''Hsc90''
*''Hsc90''

Latest revision as of 12:49, 26 January 2025

3D Structures of Heat Shock Proteins3D Structures of Heat Shock Proteins

Updated on 26-January-2025

  • Hsp60 - the large subunit of the chaperonin molecule GroEL ; See Chaperonin
  • Hsp65
    • 3rtk – MtHsp65 – Mycobacterium tuberculosis
  • Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
  • Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
    • 6cz1, 6dfm, 6dfo, 6do2, 6dws - hBIP ATPase domain + adenosine derivative 26-407
    • 6hab - haBIP (mutant) - hamster
    • 6h9u, 6ha7 - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster
  • DnaK or chaperone protein DnaK (Hsp70 from E. coli) Domains: NBD 1-383; SBD 389-607
  • Hsp75 or TRAP-1

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman
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