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Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)
Structural highlights
FunctionDNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] See Also |
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