Aminoacyl tRNA synthetase 3D structures

3D Structures of Aminoacyl tRNA Synthetase3D Structures of Aminoacyl tRNA Synthetase

Updated on 24-September-2024

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• Class I aaRS
• Arg-RS
  • 4zaj - hArgRS – human
    
  • 4q2y – hArgRS (mutant)
    
  • 1bs2 – yArgRS - yeast
    
  • 3gdz – KpArgRS residues 1-106 – Klebsiella pneumoniae
    
  • 1iq0 – TtArgRS - Thermus thermophilus
    
• Arg-RS + small substrates or analogs
  • 4q2t – hArgRS (mutant) + Arg
    
  • 4q2x – hArgRS (mutant) + canavanine
    
  • 6ao8 - NgArgRS + Arg – Neisseria gonorrhoeae
    
  • 5yym, 4oby - EcArgRS + Arg – Escherichia coli
    
• Arg-RS + tRNA
  • 1f7v - yArgRS + Arg-tRNA
    
  • 2zuf - PhArgRS + tRNA-Arg - Pyrococcus horikoshii
    
  • 5yyn, 5b63 - EcArgRS + Arg-tRNA
    
• Arg-RS ternary complex
  • 4z3z - hArgRS + GlnRS + AIMP1
    
  • 1f7u – yArgRS + Arg-tRNA + Arg
    
  • 2zue – PhArgRS + tRNA-Arg + ATP analog
    
• Cys-RS
  • 1li5 - EcCysRS
    
  • 1li7 - EcCysRS + Cys
    
  • 1u0b – EcCysRS + Cys-tRNA
    
  • 3tqo – CysRS – Coxiella burnetii
    
  • 3sp1 - BbCysRS – Borrelia burgdorferi
    
  • 3c8z – MsCysRS + Cys-SA - Mycobacterium smegmatis
    
  • 6ujd - ElCysRS (mutant) – Elizabethkingia
    
• Gln-RS
  • 4ye6 – hGlnRS
    
  • 4ye8, 4ye9 – hGlnRS (mutant)
    
  • 4h3s – yGlnRS
    
  • 3tl4 – yGlnRS tRNA-binding domain
    
  • 1nyl – EcGlnRS
    
  • 5zdo – TtGlnRS
    
  • 5zdk, 5zdl – TtGlnRS + ATP
    
  • 2gls, 1lgr – StGlnRS – Salmonella typhimurium
    
  • 5bnz – PaGlnRS – Pseudomonas aeruginosa
    
  • 4p2b – TgGlnRS catalytic domain – Toxoplasma gondii
    
  • 2lgs – StGlnRS + Glu<br /
  • 1qrs, 1qrt, 1qru - EcGlnRS (mutant) + Gln-tRNA
    
  • 1gtr, 1gts, 1gsg - EcGlnRS + Gln-tRNA
    
• Gln-RS ternary complex
  • 1euq, 1euy – EcGlnRS + Gln-tRNA + Gln-SA
    
  • 1exd - EcGlnRS + Gln-tRNA (mutant) + AMP
    
  • 4jxx, 4jxz, 4jyz - EcGlnRS + Gln-tRNA + ATP
    
  • 1qtq - EcGlnRS + Gln-tRNA + Gln analog
    
• Glu-RS
  • 2hra – yGluRS N-terminal
    
  • 1gln – TtGluRS
    
  • 2o5r - TmGluRS
    
  • 3aii – GluRS – Methanothermobacter thermautotrophicus
    
  • 2ja2, 3pny – MtGluRS – Mycobacterium tuberculosis
    
  • 3pnv - MtGluRS (mutant)
    
  • 4a91 – EcGluRS
    
  • 2hz7 – DrGluRS – Deinococcus radiodurans
    
  • 6b1p - HpGluRS – Helicobacter pylori
    
  • 6b1z - EaGluRS – Elizabethkingia anophelis
    
  • 5tgt – PaGluRS
    
  • 5h4v – GluRS – Xanthomonas oryzae
    
  • 7k86 – SmGluRS – Stenotrophomonas maltophilia
    

• Glu-RS + small substrates or analogs
  • 3afh - TmGluRS + Glu-AMP analog
    
  • 2rd2, 2re8 – EcGluRS (mutant) + Glu-SA
    
  • 2cuz – TtGluRS + Glu
    
  • 1j09 - TtGluRS + Glu + ATP
    
  • 1n75 - TtGluRS + ATP
    
  • 2cfo - GluRS residues 2-485 + Glu – Synechococcus elongatus
    
  • 6brl - GluRS + Glu - Elizabethkingia meningoseptica
    
  • 4grl - BbGluRS + Glu
    
  • 4g6z - BtGluRS + Glu – Burkholderia thailandensis
    
• Glu-RS + tRNA
  • 1zjw – EcGluRS + Glu-tRNA
    
  • 1g59 – TtGluRS + Glu-tRNA
    
• Glu-RS ternary complex
  • 5bmu – hGluRS GST-like domain + EPRS-AIMP3
    
  • 2hrk, 2hsm - yGluRS N-terminal + GU4 nucleic-binding protein 1
    
  • 3akz, 3al0 – TmGluRS + tRNA + Glu-AMP analog – Thermotoga maritima
    
  • 1o0b, 1o0c - EcGluRS + Glu-tRNA + Glu + AMP
    
  • 2cv0, 1n77 - TtGluRS + Glu + Glu-tRNA
    
  • 1n78 - TtGluRS + Glu-ol + Glu-tRNA
    
  • 2cv1 - TtGluRS + Glu-ol + ATP + Glu-tRNA
    
  • 2cv2 - TtGluRS + Glu-SA + Glu-tRNA
    
• Ile-RS
  • 1ile - TtIleRS
    
  • 1wny, 1udz – TtIleRS editing domain 201-381
    
• Ile-RS + small substrates or analogs
  • 1ue0 - TtIleRS editing domain + Val
    
  • 1wnz - TtIleS editing domain + Val-adenylate
    
  • 1wk8 - TtIleRS editing domain + Val-SA
    
  • 1jzq – TtIleS + Ile-adenylate analog
    
  • 1jzs – TtIleS + antibiotic
    
• Ile-RS ternary complex
  • 1ffy, 1qu2, 1qu3 - SaIleRS + Ile-tRNA + antibiotic - Staphylococcus aureus
    
  • 6ldk - CaIleRS + AMP + Ile – Candida albicans
    
• Leu-RS; Domains – editing 260-530;
  • 2wfd – hLeuRS editing domain 260-509
    
  • 3o0a, 3pz0 – AaLeuRS editing domain – Aquifex aeolicus
    
  • 3pz5 – AaLeuRS editing domain (mutant)
    
  • 2wfe - CaLeuRS editing domain – Candida albicans
    
  • 5agh - CaLeuRS editing domain (mutant)
    
  • 2ajg - EcLeuRS editing domain 228-413
    
  • 1wkb – PhLeuRS residues 1-810
    
  • 5fon - CmLeuRS editing domain – Cryptosporidium muris
    
  • 5foc - PfLeuRS editing domain
    
  • 5fod - PfLeuRS editing domain (mutant)
    
  • 5fof - LeuRS editing domain – Plasmodium knowlesi
    
  • 4k48 - SpLeuRS editing domain (mutant) – Streptococcus pneumoniae
    
  • 3pz6 - LeuRS editing domain (mutant) – Giardia intestinalis
    
  • 7nu4 - NgLeuRS
    
  • 7nty, 7nu1, 7nua - NgLeuRS (mutant)
    
  • 7n11 - MaLeuRS editing domain – Mycobacteroides abscessus
    
• Leu-RS + small substrates or analogs
  • 6kqy - hLeuRS + Leu
    
  • 7d5c - yLeuRS + inhibitor
    
  • 7nu5 - NgLeuRS + Leu
    
  • 6ykk, 6ykl, 6ykn, 6yko, 6ykq, 6yks, 6ykt, 6yku, 6ykv, 6kyw, 6ykx, 7a0p, 7ap2 - NgLeuRS (mutant) + inhibitor
    
  • 6q89, 6q8a, 6q8b, 6q8c, 7ntz, 7nu2, 7nub - NgLeuRS (mutant) + intermediate analog
    
  • 7nu6, 7nu7 - NgLeuRS + ATP
    
  • 7nu9 - NgLeuRS + ATP + leucinol
    
  • 7nu3, 7nuc - NgLeuRS (mutant) + ATP + leucinol
    
  • 7nu8 - NgLeuRS + Leu-AMP
    
  • 2wfg - CaLeuRS editing domain + benzoxaborole-AMP
    
  • 1h3n - TtLeuRS + Leu-SA
    
  • 1obc, 1obh – TtLeuRS + substrate analog
    
  • 2ajh, 2aji - EcLeuRS editing domain + aa
    
  • 4aq7 - EcLeuRS editing domain + Leu-adenylate analog
    
  • 4cqn - EcLeuRS editing domain + Ile-adenylate analog
    
  • 5fog - CmLeuRS editing domain + norvaline
    
  • 5fol - CmLeuRS editing domain + Ile
    
  • 5fom - CmLeuRS editing domain + inhibitor
    
  • 5agj - CaLeuRS editing domain + AMP derivative
    
  • 5agi - CaLeuRS editing domain (mutant) + AMP derivative
    
  • 5agr, 5ags, 5agt - MtLeuRS editing domain + inhibitor
    
  • 7bzj - SpLeuRS + inhibitor
    
  • 4k47 - SpLeuRS editing domain (mutant) + benzoxaborole-AMP
    
  • 3ziu - LeuRS editing domain + Leu-SA – Mycoplasma mobile
    
  • 7n12 - MaLeuRS editing domain + epetraborole-AMP
    
• Leu-RS + tRNA
  • 1wz2 – PhLeuRS + Leu-tRNA
    
  • 5ah5 - LeuRS + Leu-tRNA – Agrobacterium radiobacter
    
• Leu-RS ternary complex
  • 6kie, 6kr7 - hLeuRS + Leu-SA + Leu
    
  • 6lpf, 6lr6 - hLeuRS + Leu-SA + adenosine derivative
    
  • 6kid - hLeuRS + ATP + Leu
    
  • 4arc - EcLeuRS + Leu-tRNA + Leu
    
  • 5omw - EcLeuRS + Leu-tRNA + Leu-adenylate analog
    
  • 4ari, 4as1, 3zjt, 3zju, 3zjv - EcLeuRS + Leu-tRNA + benzoxaborole
    
  • 3zgz - EcLeuRS + Leu-tRNA + inhibitor
    
  • 5onh - EcLeuRS + Leu-tRNA + Leu-adenylate analog + norvaline
    
  • 5on2 - EcLeuRS (mutant) + Leu-tRNA + Leu-adenylate analog + norvaline
    
  • 5on3 - EcLeuRS (mutant) + Leu-tRNA + Leu-adenylate analog + Leu
    
  • 2v0g - TtLeuRS + Leu-tRNA + benzoxaborole-AMP
    
  • 2bte, 2byt - TtLeuRS + Leu-tRNA + Leu
    
  • 2v0c – TtLeuRS + Leu-SA + benzoxaborole-AMP
    
• Lys-RS
  • 3bju – hLysRS residues 70-579
    
  • 6ilh, 7ea9 - hLysRS (mutant)
    
  • 7f6w – yLysRS
    
  • 1irx – PhLysRS
    
  • 1bbw – EcLysRS
    
  • 5yzx - EcLysRS (mutant)
    
  • 1krs, 1krt – EcLysRS anticodon-binding domain – NMR
    
  • 3dsq – DhLysRS – Desulfitobacterium hafniense
    
  • 4up8 - EhLysRS – Entamoeba histolytica
    
  • 4h02 - PfLysRS – Plasmodium falciparum
    
• Lys-RS binary complexes
  • 6chd - hLysRS + Lys-adenylate derivative
    
  • 4up7 - EhLysRS + Lys-adenylate
    
  • 4up9 - EhLysRS + ATP
    
  • 4upa - EhLysRS (mutant) + AMPPNP
    
  • 3e9h, 3e9i]] – BsLysRS + Lys-SA - Bacillus stearothermophilus
    
  • 3a74 - BsLysRS + diadenosine tetraphosphate
    
  • 5zh2, 5zh3, 5zh4, 5zh5, 4pg3, 6hcv - PfLysRS + inhibitor
    
  • 4ycv - PfLysRS + cladosporin
    
  • 5vl1 - MuLysRS + Lys – Mycobacterium ulcerans
    
  • 5hgq - LysRS + cladosporin – eye worm
    
  • 1bbu, 1e1o, 1lyl – EcLysRS + Lys
    
  • 1e1t - EcLysRS + Lys-adenylate
    
  • 6c86 - CpLysRS + Lys-adenylate derivative - Cryptosporidium parvum
    
  • 5eln - CpLysRS + Lys
    
  • 4ex5 - BtLysRS + Lys
    
  • 6wbd - SmLysRS + Lys
    
• Lys-RS ternary complexes
  • 6ild, 4dpg - hLysRS + P38 + AIMP2
    
  • 4ycu - hLysRS + P38 + cladosporin
    
  • 4ycw - hLysRS (mutant) + P38 + cladosporin
    
  • 1e22 - EcLysRS + Lys + AMPPCP
    
  • 1e24 - EcLysRS + Lys + ATP
    
  • 6nrz - CtLysRS + Lys + adenosine – Chlamydia trachomatis
    
  • 6ns0, 6o3f - CtLysRS + Lys + cladosporin
    
  • 6bni - CpLysRS + Lys + adenine
    
  • 5elo - CpLysRS + Lys + cladosporin
    
  • 6aqg - MuLysRS + Lys + cladosporin
    
  • 6agt, 6ka6, 6kab, 6kbf, 6kcn, 6kct - PfLysRS + Lys + cladosporin derivative
    
  • 7bt5 - PfLysRS + Lys + drug
    
  • 6hcu, 6hcw - PfLysRS + Lys + inhibitor
    
  • 6aqh - LysRS + Lys + cladosporin – Mycobacterium thermoresistibile
    
• Met-RS
  • 5gl7 – hMetRS residues 221-834
    
  • 2djv – hMetRS WHEP-TRS domain 835-900 – NMR
    
  • 1med, 1mea – EcMetRS Zinc-binding domain - NMR
    
  • 1qqt, 3h9c - EcMetRS residues 2-552
    
  • 3h97, 6spp – EcMetRS residues 2-548 (mutant)
    
  • 1a8h – TtMetRS
    
  • 2d54, 2d5b – TtMetRS (mutant)
    
  • 1woy – TtMetRS residues 1-500 (mutant)
    
  • 1pyb – AaMetRS subunit
    
  • 1rqg – PabMetRS – Pyrococcus abyssi
    
  • 1mkh – PabMetRS C-terminal
    
  • 5xgq – MtMetRS
    
  • 5h34 – NeMetRS C-terminal – Nanoarchaeum equitans
    
  • 2x1l - MsMetRS residues 2-515
    
  • 7wpj – SaMetRS
    
• Met-RS + small substrates or analogs
  • 5goy – hMetRS residues 221-834 + Met
    
  • 3kfl – LmMetRS residues 206-747+ Met-adenylate - Leishmania major
    
  • 2x1m - MsMetRS residues 2-515 + Met
    
  • 1p7p, 1pfu, 1pfv, 1pfw - EcMetRS residues 2-548 + Met
    
  • 1pfy - EcMetRS residues 1-551 + Met-SA
    
  • 1f4l, 6spo - EcMetRS residues 1-551 + Met
    
  • 6spq - EcMetRS (mutant) + Met
    
  • 6spn - EcMetRS + beta-Met
    
  • 6spr - EcMetRS (mutant) + beta-Met
    
  • 1pg0 - EcMetRS residues 1-551 + Met-adenylate
    
  • 1pg2 - EcMetRS residues 1-551 + Met + adenine
    
  • 3h99 - EcMetRS residues 2-548 (mutant) + Met
    
  • 3h9b - EcMetRS residues 2-548 (mutant) + azidonorleucine
    
  • 4dlp - BmMetRS + SMet – Brucella melitensis
    
  • 4py2 – BmMetRS + inhibitor
    
  • 6ax8, 5xet – MtMetRS + Met-adenylate
    
  • 3vu8 – TtMetRS + Met-adenylate analog
    
  • 5urb - AbMetRS + Met – Acinetobacter baumannii
    
  • 5k0s, 5k0t – MetRS + inhibitor – Brucella suis
    
  • 4zt2, 4zt3, 4zt4, 4zt5, 4zt6, 4zt7, 4mvw, 4mvx, 4mvy, 4mw0, 4mw1, 4mw2, 4mw4, 4mw5, 4mw6, 4mw7, 4mw9, 4mwb, 4mwc, 4mwd, 4mwe - TbMetRS residues 237-773 (mutant) + inhibitor – Trypanosoma brucei
    
  • 6cml, 6mes - TbMetRS residues 237-773 (mutant) + Met + inhibitor
    
  • 4qrd, 4qre - SaMetRS + antibacterial
    
  • 7wpi, 7wpn - SaMetRS + inhibitor
    
  • 7wpk - SaMetRS + Met
    
  • 7wpl - SaMetRS + ATP
    
  • 7wpm, 7wpt, 7wpx, 7wq0 - SaMetRS + inhibitor + ATP
    
  • 7ulz - PaMetRS + Met
    
• Met-RS + tRNA
  • 2csx – AaMetRS + Met-tRNA
    
  • 2ct8 - AaMetRS + Met-tRNA + Met-SA
    
  • 2dxi – TtMetRS + tRNA + ATP + Glu-ol
    
• Met-RS + protein
  • 4bl7, 4bvx, 4bvy - hMetRS N-terminal + elongation factor P18
    
  • 2hsn - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
    
• Trp-RS
  • 1o5t, 1ulh – hTrpRS catalytic fragment
    
  • 5uji – hTrpRS catalytic fragment (mutant)
    
  • 3kt0, 2ip1 – yTrpRS
    
  • 1d2r - BsTrpRS
    
  • 3prh – TrpRS (mutant) – Bacillus subtilis
    
  • 3n9i – TrpRS – Yersinia pestis
    
  • 3m5w – CjTrpRS – Campylobacter jejuni
    
  • 3a04 – ApTrpRS – Aeropyrum pernix
    
  • 3hzr – EhTrpRS
    
  • 3i05 – TbTrpRS residues 3-389
    
  • 3hv0 – CpTrpRS residues 206-593
    
  • 3foc – GlTrpRS – Giardia lamblia
    
  • 2el7 – TtTrpRS
    
  • 2yy5 – TrpRS – Mycoplasma pneumoniae
    
  • 2g36 – TmTrpRS
    
  • 6mtk - EaTrpRS
    
  • 5tev - NgTrpRS
    
  • 4j76 - PfTrpRS
    
  • 7el8 - MtTrpRS
    
• Trp-RS + small substrates or analogs
  • 5ujj – hTrpRS + Trp-AMP
    
  • 2quh – hTrpRS + Trp
    
  • 2qui - hTrpRS + Trp-amide + ATP
    
  • 2quj - hTrpRS + Trp-adenylate
    
  • 2quk – hTrpRS + ATP
    
  • 3kt3 – yTrpRS + Trp-adenylate
    
  • 3kt6, 3kt8 – yTrpRS + Trp
    
  • 3a05 – ApTrpRS + Trp
    
  • 3jxe – PhTrpRS + Trp-adenylate
    
  • 2ov4 – BsTrpRS + adenosine tetraphosphate
    
  • 1i6k, 1i6l, 1i6m – BsTrpRS + Trp-adenylate
    
  • 1maw, 1m83 - BsTrpRS + ATP
    
  • 1mb2 - BsTrpRS + Trp
    
  • 7cms - BsTrpRS + antibiotic
    
  • 1yid, 2a4m – DrTrpRS + ATP
    
  • 1yi8, 1yia– DrTrpRS + Trp
    
  • 1bks – StTrpRS + pyridoxal phosphate
    
  • 6ncr - CtTrpRS + Trp
    
  • 5tew - NgTrpRS + Trp
    
  • 4j75 - PfTrpRS + Trp-AMP
    
  • 7elt - MtTrpRS + Trp-AMP
    
  • 6dfu - TrpRS + Trp – Haemophilus influenzae
    
• Trp-RS ternary complex
  • 5ekd – hTrpRS + ATP + antibiotic
    
  • 5dk4, 7cki – BsTrpRS + ATP + antibiotic
    
  • 7eer – BsTrpRS + ATP + inhibitor
    
  • 3fhj, 3ghd, 3fi0 – BsTrpRS + Trp + AMP + Pi
    
  • 1mau – BsTrpRS + Trp + ATP
    
  • 5v0i - EcTrpRS + Trp + AMP
    
  • 7ens – MtTrpRS + ATP + antibiotic
    
  • 7ent, 7ev2, 7ev3 – MtTrpRS + ATP + inhibitor
    
• Trp-RS + tRNA
  • 2ake, 2dr2 - hTrpRS + Trp-tRNA
    
  • 2azx – hTrpRS (mutant) + tRNA
    
• Tyr-RS
  • 1n3l - hTyrRS
    
  • 5thh, 5thl - hTyrRS (mutant)
    
  • 1ntg - hTyrRS C-terminal
    
  • 1r6t, 1r6u – yTyrRS (mutant)
    
  • 1tya, 1tyb, 1tyc, 1tyd, 2ts1 – BsTyrRS
    
  • 1jh3 – BsTyrRS C-terminal – NMR
    
  • 3qe4, 3d6u, 3d6v, 2pxh, 2hgz, 1u7d, 5n5v, 5nsf, 7c5c, 7ckh – MjTyrRS – Methanocaldococcus jannaschii
    
  • 1u7x, 4hjr, 4hk4, 5u36, 5l7p - MjTyrRS (mutant)
    
  • 2jan – MtTyrRS
    
  • 1y42, 4ojm - NcTyrRS – Neurospora crassa
    
  • 2cya – ApTyrRS
    
  • 6n0w - EaTyrRS
    
  • 6byq - HpTyrRS
    
  • 6bqz, 6bqy - AbTyrRS
    
  • 5ihx - AnTyrRS – Aspergillus nidulans
    
  • 2ktl - AnTyrRS C-terminal - NMR
    
  • 5ijx - TyrRS – Coccidiodides posadasii
    
  • 7fg6 - NeTyrRS
    
• Tyr-RS + small substrates or analogs
  • 1q11 – hTyrRS residues 1-364 + Tyr-ol
    
  • 2pid – hTyrRS residues 28-375 + Tyr-SA
    
  • 4q93 - hTyrRS + resveratrol
    
  • 4qbt - hTyrRS + Tyr
    
  • 3zxi - hTyrRS + Tyr-adenylate analog
    
  • 7rou – hTyrRS + Tyr derivative
    
  • 3ts1 – BsTyrRS + Tyr-adenylate intermediate
    
  • 4ts1 – BsTyrRS + Tyr
    
  • 3p0h, 3p0i, 3p0j – LmTyrRS + inhibitor
    
  • 3n2y – MjTyrRS + tetrazolyl phenylalanine
    
  • 2zp1 – MjTyrRS (mutant) + Tyr
    
  • 1zh0 - MjTyrRS (mutant) + naphthyl-Ala
    
  • 1zh6, 2ag6, 4pbr, 7ckg - MjTyrRS (mutant) + Phe derivative
    
  • 4hjx - MjTyrRS (mutant) + di-fluoro-Tyr
    
  • 4nx2 - MjTyrRS (mutant) + di-chloro-Tyr
    
  • 4hpw - MjTyrRS (mutant) + methyl-Tyr
    
  • 5n5u - MjTyrRS + borono-Phe + AMP
    
  • 2yxn – EcTyrRS residues 1-322 + azido-Tyr
    
  • 1vbm – EcTyrRS + Tyr-SA
    
  • 1vbn – EcTyrRS (mutant) + Tyr-SA
    
  • 1x8x – EcTyrRS + Tyr
    
  • 1wq3, 1wq4 - EcTyrRS (mutant) + Tyr
    
  • 6wn2, 6wrn, 6wrt - EcTyrRS (mutant) + Tyr derivative
    
  • 4oud - EcTyrRS + bi-Phe
    
  • 6i5y - EcTyrRS + Tyr-SA
    
  • 6hb5 - EcTyrRS + Tyr-SC
    
  • 6hb6, 6hb7 - EcTyrRS + Tyr-SU
    
  • 7ap3 - EcTyrRS + inhibitor
    
  • 2j5b – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus
    
  • 2cyb – AfTyrRS + Tyr - Archaeoglobus fulgidus
    
  • 2cyc – PhTyrRS + Tyr
    
  • 1h3f- TtTyrRS + Tyr-ol
    
  • 1jii, 1jij, 1jil, 1jik – SaTyrRS + inhibitor
    
  • 6otj – NgTyrRS + Tyr
    
  • 7ror – PfTyrRS + Tyr-AMP
    
  • 7ros – PfTyrRS + Tyr derivative
    
  • 7rot – PfTyrRS (mutant) + Tyr derivative
    
• Tyr-RS + tRNA
  • 2dlc – yTyrRS + tRNA + Tyr-SA
    
  • 1j1u – MjTyrRS + Tyr-tRNA
    
  • 1h3e - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP
    
  • 2rkj – NcTyrRS + RNA
    
  • 7sc6, 7scq – TyrRS + RNA – Phaseolus vulgaris
    
• 3-nitroTyr-RS
  • 4nd6, 4nd7 - MjNTyrRS (mutant)
    
  • 4nda - MjNTyrRS (mutant) + nitro-Tyr
    
• Val-RS
  • 4xkz - hLysRS C-terminal
    
  • 1iyw - TtValRS
    
  • 1wk9, 1wka – TtValRS CP1 domain
    
  • 1ivs – TtValRS + Val-SA + Val-tRNA
    
  • 1gax - TtValRS + Val-adenylate analog + Val-tRNA
    
• Class II aaRS
• Ala-RS
  • 5t76, 4xem - hAlaRS catalytic domain
    
  • 4xeo - hAlaRS catalytic domain (mutant)
    
  • 5t5s, 5t76 - hAlaRS residues 757-965
    
  • 6nlq, 6nly, 6now - hAlaRS C-terminal
    
  • 3g98 – AaAlaRS residues 758-867
    
  • 1riq - AaAlaRS catalytic fragment
    
  • 2zze, 2zzf, 1wnu, 1wxo, 1v4p, 1v7o – PhAlaRS
    
  • 2zvf – AfAlaRS C-terminal
    
• Ala-RS + small substrates or analogs
  • 5v59 - hAlaRS + AZ-SA
    
  • 3hxu, 3hxv, 3hxw – EcAlaRS catalytic fragment + aa-adenylate
    
  • 3hxz, 3hy0, 3hy1 - EcAlaRS catalytic fragment (mutant) + aa-adenylate
    
  • 3hxx - EcAlaRS catalytic fragment + AMPPCP
    
  • 3hxy - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP
    
  • 3htz - AaAlaRS residues 2-454 + Ser
    
  • 1yfr – AaAlaRS + ATP
    
  • 1yfs – AaAlaRS + Ala
    
  • 1yft, 1ygb - AaAlaRS catalytic fragment + aa
    
  • 2zzg - PhAlaRS + Ala-SA
    
  • 2ztg– AfAlaRS + Ala-SA
    
• Ala-RS + tRNA
  • 3wqy, 3wqz – AfAlaRS + Ala-tRNA + Ala-SA
    
• Asp-RS
  • 4j15, 4ah6 - hAspRS
    
  • 1eov - yAspRS
    
  • 3nen, 1b8a – TkAspRS - Thermococcus kodakarensis
    
  • 3i7f – EhAspRS
    
  • 1wyd – AspRS – Sulfolobus tokodaii
    
  • 1n9w, 1l0w, 1g51 – TtAspRS
    
  • 1eqr – EcAspRS
    
  • 5gro – HpAspRS N terminal
    
  • 4rmf – MsAspRS
    
  • 6wom – ElAspRS
    
• Asp-RS + small substrates or analogs
  • 3nel – TkAspRS + Asp
    
  • 3nem - TkAspRS + Asp-adenylate
    
  • 5w25 – MtAspRS + Asp
    
  • 4o2d – MsAspRS + Asp
    
• Asp-RS + tRNA
  • 1asy, 1asz – yAspRS + Asp-tRNA
    
  • 3kfu, 1efw – TtAspRS + tRNA
    
• Asp-RS complex
  • 5y6l - hAspRS + MetRS + Glu/ProRS + P18 + P38
    
  • 6iy6 - hAspRS + AIMP2 + Glu/ProRS residues 1-157
    
  • 1il2, 1c0a – EcAspRS + Asp-tRNA + Asp-adenylate
    
  • 7ap4 – TtAspRS + inhibitor
    
  • 6hhv, 6hhw – TtAspRS + Asp-SU
    
  • 6hhx – TtAspRS + Asp-SC
    
  • 6sjc – TtAspRS + Asp-SA
    
  • 4wj4 – PaAspRS + Asn-tRNA + Asp
    
  • 4wj3 – PaAspRS + Asn-tRNA + amidotransferase
    
• Asn-RS
  • 5xix - hAsnRS
    
  • 4zya - hAsnRS N terminal
    
  • 1x56 - PhAsnRS
    
  • 2kqr – BmAsnRS N-terminal – NMR – Brugia malayi
    
  • 6pqh – ElAsnRS
    
• Asn-RS + small substrates or analogs
  • 2xti – BmAsnRS catalytic fragment + Asn-adenine analog
    
  • 2xgt - BmAsnRS catalytic fragment + Asn-SA
    
  • 1x54 – PhAsnRS + Asn-adenylate
    
  • 1x55 - PhAsnRS + Asn-SA
    
  • 11as – EcAsnRS + Asn
    
  • 12as - EcAsnRS + Asn + AMP
    
  • 3rl6 - PaAsnRS + Asn + AMP
    
• Gly-RS
  • 2q5h – hGlyRS residues 55-739
    
  • 2q5i, 4kqe - hGlyRS residues 55-739 (mutant)
    
  • 2pme – hGlyRS
    
  • 2pmf – hGlyRS (mutant)
    
  • 1j5w – TmGlyRS chain
    
  • 1ati – TtGlyRS
    
  • 3rf1 - CjGlyRS a subunit
    
• Gly-RS + small substrates or analogs
  • 2zt5, 2zxf – hGlyRS residues 55-739 + bis-adenosine tetraphosphate
    
  • 2zt6 - hGlyRS residues 55-739 + AMPCPP
    
  • 2zt7 - hGlyRS residues 55-739 + Gly + ATP
    
  • 2zt8 - hGlyRS residues 55-739 + Gly-AMP analog
    
  • 1b76 – TtGlyRS + ATP
    
  • 1ggm – TtGlyRS + Gly-adenylate
    
  • 5f5w - AaGlyRS + Gly-adenylate
    
  • 3ufg - CjGlyRS + ATP
    
  • 7eiv - EcGlyRS + ANP + Gly
    
• Gly-RS + tRNA
  • 5e6m, 4qei, 4kr2 - hGlyRS + Gly-tRNA
    
  • 4kr3 - hGlyRS (mutant) + Gly-tRNA
    
• His-RS
  • 4x5o, 4g84, 4g85, 6o76 - hHisRS
    
  • 5w6m - hHisRS (mutant)
    
  • 1x59, 2lw7 – hHisRS WHEP-TRS domain - NMR
    
  • 1htt - EcHisRS
    
  • 3net – HisRS – Nostoc
    
  • 1h4v – TtHisRS
    
  • 1qe0 – SaHisRS
    
  • 3hri – TbHisRS
    
  • 1wu7 – HisRS – Thermoplasma acidophilum
    
• His-RS + small substrates or analogs
  • 4phc - hHisRS + His
    
  • 3lc0 – TcHisRS residues 45-478 + His – Trypanosoma cruzi
    
  • 4yp0, 4ypf, 4yrc, 4yrr, 4yrs - TcHisRS + quinoline derivative
    
  • 4yre, 4yrj, 4yrk, 4yrp - TcHisRS + phenyl derivative
    
  • 4yrg, 4yrm, 4yrn, 4yro - TcHisRS + pyridine derivative
    
  • 4yrl - TcHisRS + aniline derivative
    
  • 4yrq - TcHisRS + chromenone derivative
    
  • 4yrt - TcHisRS + naphthalene derivative
    
  • 4rdx – TtHisRS + tRNA
    
  • 1adj – TtHisRS + His
    
  • 3hrk - TbHisRS + His-adenylate
    
  • 2el9 - EcHisRS + His-SA
    
  • 1kmm, 1ady - EcHisRS + His-adenylate
    
  • 1kmn - EcHisRS + His-ol + ATP
    
  • 5e3i - AbHisRS + His + ATP
    
  • 4e51 - BtHisRS + His
    
• Phe-RS
  • 3l4g, 3cmq – hPheRS
    
  • 5mgw, 5mgh, 5mgu, 5mgv – hPheRS (mutant)
    
  • 1pys – TtPheRS
    
  • 2cxi – PhPheRS β chain N-terminal
    
  • 3ica – PheRS β chain – Porphyromonas gingivalis
    
  • 4p71 – PaPheRS α+β chain
    
  • 3ig2 – PheRS β chain – Bacterioides fragilis
    
  • 7daw – MtPheRS + α+β chains
    
  • 6p24 – EcPheRS + α+β chains
    
  • 7n8y - SePheRS + chains – Salmonella enterica
    

• Phe-RS + small substrates or analogs
  • 3hfv – hPheRS + Tyr
    
  • 3teg – hPheRS + L-DOPA
    
  • 3pco – EcPheRS + phenylalanine+ AMP
    
  • 6oz5, 6p26 – EcPheRS α+β chains + inhibitor
    
  • 3hfz, 2amc – TtPheRS α+β chains + Tyr
    
  • 2akw, 1b70 - TtPheRS α+β chains + Phe
    
  • 4tva - TtPheRS α+β chains + Phe + puromycin
    
  • 3teh - TtPheRS α+β chains + L-DOPA
    
  • 1jjc, 1b7y - TtPheRS α+β chains + Phe-adenylate
    
  • 2aly - TtPheRS α+β chains + Phe-SA
    
  • 2rhq, 2rhs – PheRS α+β+ chains (mutant) + inhibitor – Staphylococcus haemolyticus
    
  • 4p72, 4p73, 4p74, 4p75 – PaPheRS α+β chains + inhibitor
    
  • 7db7, 7db8 – MtPheRS α+β chains + inhibitor
    
  • 6p8t – AbPheRS α+β chains + inhibitor
    
  • 7dpi – PfPheRS + α+β chains + inhibitor
    
• Phe-RS + tRNA
  • 3tup – hPheRS + Phe-tRNA
    
  • 1eiy - TtPheRS α+β chains + Phe-tRNA
    
  • 2iy5 - TtPheRS α+β chains + Phe-ol + Phe-tRNA
    
  • 7k98, 7k9m, 7ka0 - MtPheRS + chains + Phe-tRNA + Phe-AMS
    
  • 7kab - MtPheRS + chains + Phe-tRNA + Phe
    
• Pro-RS
  • 4k86 – hProRS residues 1000-1512
    
  • 1hc7 – TtProRS
    
  • 2i4l – RpProRS – Rhodopseudomonas palustris
    
  • 1nj2 - MtProRS – Methanothermobacter thermautotrophicus
    
  • 1nj8 – MjProRS
    
  • 5xif, 6aa0 – TgProRS residues 334-830
    
  • 5ucm – PaProRS
    
  • 4twa, 4ncx – PfProRS residues 249-746
    
• Pro-RS + small substrates or analogs
  • 3ial – GlProRS residues 34-542 + Pro-adenylate
    
  • 2i4m, 2i4n – RpProRS + aa-SA
    
  • 2i4o – RpProRS + ATP
    
  • 2j3l – EfProRS + Pro-SA – Enterococcus faecalis
    
  • 1nj1, 1nj5, 1nj6 – MtProRS + aa-SA
    
  • 1h4t - TtProRS + Pro
    
  • 5ifu – PfProRS residues 249-746 + glyburide
    
  • 4wi1, 6t7k, 7qc1 – PfProRS residues 249-746 + inhibitor
    
• Pro-RS ternary complex
  • 4k87 – hProRS residues 1000-1512 + proline + adenosine
    
  • 4k88 – hProRS residues 1000-1512 + halofunginone
    
  • 1h4q - TtProRS + Pro-tRNA + Pro-ol
    
  • 1h4s - TtProRS + Pro-tRNA + Pro-SA
    
  • 2j3m – EfProRS + Pro-ol + ATP
    
  • 5f9z – CpProRS residues 186-688 + halofuginone + AMPPNP
    
  • 5f9y – CpProRS residues 186-688 + proline + AMP
    
  • 5xio – CpProRS residues 225-719 + halofuginone + ANP
    
  • 5znj – SaProRS + halofuginone + ANP
    
  • 5znk – SaProRS + inhibitor + ANP
    
  • 6nab - NfProRS + Pro + AMP – Naegleria fowleri
    
  • 6uyh – NfProRS + halofuginone + ANP
    
  • 5xiq – TgProRS residues 334-830 + halofuginone + ANP
    
  • 7evu, 7f9u, 7f9v – TgProRS residues 215-711 + halofuginone + inhibitor
    
  • 7f9r – TgProRS residues 215-711 + febrifugine + inhibitor + Pro
    
  • 7evv, 7fal – TgProRS residues 215-711 + inhibitor + Pro
    
  • 5xik, 6a88 – TgProRS residues 334-830 + febrifugine derivative + ANP
    
  • 5xig, 5xih, 5xij – TgProRS residues 334-830 + inhibitor + ANP
    
  • 5xii – TgProRS residues 334-830 (mutant) + inhibitor + ANP
    
  • 4ydq, 4q15, 4olf – PfProRS residues 254-746 + halofuginone + AMPPNP
    
  • 7qb7, 7qc2 – PfProRS residues 249-746 + inhibitor + Pro
    
• Bifunctional RS (bifunctional glutamate/proline tRNA ligase)
  • 4hvc – hGlu/ProRS residues 1003-1513 + halofunginone + ATP analog
    
  • 5v58 – hGlu/ProRS residues 1003-1513 + AZ-SA
    
  • 5vad – hGlu/ProRS residues 1003-1513 + inhibitor
    
  • 7osy – hGlu/ProRS residues 1003-1513 + Pro
    
  • 7bbu, 7f98, 7f99, 7f9a, 7f9b, 7f9c, 7f9d, 7osz, 7ot0, 7ot1, 7ot2, 7ot3 – hGlu/ProRS residues 1003-1513 + inhibitor + Pro
    
  • 7x09, 7x1o – hGlu/ProRS residues 1003-1513 + inhibitor + halofuginone
    
  • 7y1w, 7y28, 7y3s – hGlu/ProRS residues 1003-1513 + inhibitor + ATP
    
  • 5a1n, 5a34, 5a5h – hGlu/ProRS GST-like domain 1-175 + EPRS-AIMP2
    
  • 1fyj – hGlu/ProRS 677-733 – NMR
    
• Pyrrolysyl-RS; domains – RNA-binding 1-101; catalytic 188-454
  • 2e3c - MmPylRS catalytic domain - Methanosarcina mazei
    
  • 3vqw, 3vqx, 4cs2 - MmPylRS catalytic domain (mutant)
    
  • 3dsq – DhPylRS
    
  • 6ezd, 6jp2 – PylRS – Methanomethylophilus alvus
    
  • 7r6o - PylRS 1-273 – Methanogenic archaeon"
    
• Pyrrolysyl-RS binary complex
  • 3qtc – MmPylRS catalytic domain (mutant) + AMP-ATP analog
    
  • 2q7e - MmPylRS catalytic domain + ATP analog
    
  • 3vqv - MmPylRS catalytic domain + AMPPNP
    
  • 4bw9, 4cs4, 5k1p, 5k1x - MmPylRS catalytic domain (mutant) + AMPPNP
    
  • 4bwa - MmPylRS catalytic domain (mutant) + adenylated norbornene
    
  • 4ch3, 4ch4, 4ch5, 4ch6 - MmPylRS catalytic domain + adenylated lysine derivative
    
  • 4cs3 - MmPylRS catalytic domain (mutant) + adenylated lysine derivative
    
  • 5ud5 - MmPylRS RNA-binding domain + Pyl-RNA
    
  • 5v6x - MmPylRS RNA-binding domain (mutant) + Pyl-RNA
    
  • 2zni, 2znj – DhLysRS + tRNA
    
• Pyrrolysyl-RS ternary complex
  • 2zce - MmPylRS catalytic domain + pyrrolysine + ATP analog
    
  • 2q7g - MmPylRS catalytic domain + pyrrolysine analog + ATP
    
  • 2zim, 2q7h - MmPylRS catalytic domain + adenylated pyrrolysine + pyrophosphate
    
  • 2zio - MmPylRS catalytic domain + AlocLys-AMP + ATP analog
    
  • 3vqy - MmPylRS catalytic domain + butoxycarbonyl lysine + AMPPNP
    
  • 4q6g - MmPylRS catalytic domain + acetyl lysine + ADPNP
    
  • 4tqd - MmPylRS catalytic domain + iodo-Phe + ATP
    
  • 4tqf, 4zib - MmPylRS catalytic domain + bromothienylo-Ala + ATP
    
  • 6ly3, 6ly6, 6lyb - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP
    
  • 6ly7, 6lya - MmPylRS catalytic domain (mutant) + Trp derivative + ANP
    
  • 7rsm - MmPylRS catalytic domain (mutant) + Phe derivative + ANP
    
  • 2zin - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog
    
  • 6aac, 6aad, 6aao, 6aap, 6aaz, 6ab0, 6ab1, 6ab2, 6ab8, 6abk, 6abl, 6abm, 6aan, 6anq - MmPylRS catalytic domain + azanyl derivative + ATP
    
• Ser-RS
  • 3vbb - hSerRS
    
  • 6gir - SerRS – Arabidopsis thaliana
    
  • 3lsq – TbSerRS
    
  • 1sry - TtSerRS
    
  • 3lss – TbSerRS + ATP
    
  • 3err – TtSerRS/dynein heavy chain
    
  • 2zr3 – PhSerRS
    
  • 2dq3 – AaSerRS
    
  • 2du7 – MjSerRS
    
  • 2odr – MemSerRS – Methanococcus maripaludis
    
  • 2cim – MbSerRS – Methanosarcina barkeri
    
  • 3qne, 3qo5, 3qo7, 3qo8 - CaSerRS
    
• Ser-RS + small substrates or analogs
  • 4l87 - hSerRS + Ser-SA
    
  • 1wle – bSerRS + Ser-adenylate - bovine
    
  • 2zr2 – PhSerRS + ATP
    
  • 2dq0 – PhSerRS + Ser-SA
    
  • 2cj9 – MbSerRS + Ser-SA
    
  • 2cjb – MbSerRS + Ser
    
  • 2cja – MbSerRS + ATP
    
  • 1ses, 1set – TtSerRS + Ser-adenylate analog
    
  • 6r1m, 6r1n – SaSerRS + Ser-SA
    
  • 6hdz, 6he1, 6hhy, 6hi0 – PaSerRS + Ser-SU
    
  • 6he3, 6hhz – PaSerRS + Ser-SC
    
  • 6r1o – EcSerRS + Ser-SA
    
  • 6h9x – KpSerRS + Ser-SA
    
  • 7ap1 – KpSerRS + inhibitor
    
  • 6ote – CpSerRS + Ser-SA
    
  • 6x94 – MmSerRS + Ser-SA
    
• Ser-RS + tRNA
  • 4rqf - hSerRS + SeCys-tRNA
    
  • 4rqe - hSerRS (mutant) + SeCys-tRNA
    
  • 3w3s - SerRS (mutant) + SeCys-tRNA + Ser-SA – Methanopyrus kandleri
    
  • 1ser – TtSerRS + Ser-tRNA
    
• PhosphoSer-RS
  • 2du4 - AfPSerRS + Cys-tRNA
    
  • 2du3, 5x6c – AfPSerRS + Cys-tRNA + phosphoserine
    
  • 2du5, 2du6 - AfPSerRS (mutant) + Cys-tRNA + phosphoserine
    
  • 2odr - MemPSerRS
    
• Thr-RS
  • 1wwt – hThrRS TGS domain – NMR
    
  • 3ugq, 3ugt - yThrRS
    
  • 1y2q - PabThrRS editing domain 1-143
    
  • 1tje - EcThrRS editing domain 1-224
    
  • 7l3o RBD 330-763 - CpThrRS
    
• Thr-RS + small substrates or analogs
  • 4p3n - hThrRS editing domain 322-723 + borrelidin
    
  • 4hws - hThrRS editing domain + inhibitor
    
  • 3uh0 - yThrRS editing domain + Thr-SA
    
  • 4eo4 - yThrRS editing domain + Ser-SA
    
  • 3pd2, 3pd3, 3pd4, 3pd5 – PabThrRS editing domain + aa-aminoadenosine
    
  • 2hkz – PabThrRS editing domain + Ser
    
  • 2hl0, 2hl1 - PabThrRS editing domain + Ser-adenylate
    
  • 2hl2 - PabThrRS editing domain + Ser-SA
    
  • 1tke - EcThrRS editing domain + Ser
    
  • 1tkg - EcThrRS editing domain + Ser-SA
    
  • 1tky - EcThrRS editing domain + Ser-adenylate
    
  • 4p3o, 4p3p - EcThrRS editing domain + borrelidin
    
  • 4hwo, 4hwp, 4hwr, 4hws - EcThrRS editing domain + inhibitor
    
  • 1fyf, 1evl - EcThrRS catalytic and anticodon-binding domains + aa-SA
    
  • 1evk - EcThrRS catalytic and anticodon-binding domains + Thr
    
  • 1nyq – SaThrRS + Thr-SA
    
  • 1nyr – SaThrRS + ATP
    
  • 4s02, 4s03, 4s0i, 4s0j, 4s0k, 4s0l - PabThrRS (mutant) + bi-Phe
    
  • 4rrq - PabThrRS editing domain + Ser
    
  • 4rrr - PabThrRS editing domain + Thr
    
  • 4rrf - MjThrRS editing domain + Ser
    
  • 4rrg - MjThrRS editing domain + Thr
    
  • 6l2q, 7cbg, 7cbi, 7cbh, 7wm7, 7wmf, 7wmi - SeThrRS 222-622 + inhibitor
    
• Thr-RS + tRNA
  • 4yye - yThrRS + Thr-tRNA + Thr-SA
    
  • 1qf6 – EcThrRS + Thr-tRNA
  • 1kog – EcThrRS catalytic and anticodon-binding domains + mRNA