7qb7

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT345 and L-ProlineCrystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT345 and L-Proline

Structural highlights

7qb7 is a 1 chain structure with sequence from Plasmodium falciparum 3D7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYP_PLAF7 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala).^[1]

References

↑ Ahel I, Korencic D, Ibba M, Soll D. Trans-editing of mischarged tRNAs. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15422-7. Epub 2003 Dec 8. PMID:14663147 doi:http://dx.doi.org/10.1073/pnas.2136934100

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OCA

[1] Ahel I, Korencic D, Ibba M, Soll D. Trans-editing of mischarged tRNAs. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15422-7. Epub 2003 Dec 8. PMID:14663147 doi:http://dx.doi.org/10.1073/pnas.2136934100

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