3tup

Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open stateCrystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state

Structural highlights

3tup is a 2 chain structure with sequence from Homo sapiens and Thermus thermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.05Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYFM_HUMAN Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.^[1]

References

↑ Klipcan L, Moor N, Kessler N, Safro MG. Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11045-8. Epub 2009 Jun 22. PMID:19549855

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OCA

[1] Klipcan L, Moor N, Kessler N, Safro MG. Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11045-8. Epub 2009 Jun 22. PMID:19549855

[1]

3tup

Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open stateCrystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state

Structural highlights

Function

See Also

References

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3tup

Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open stateCrystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state

Structural highlights

Function

See Also

References

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