GTP-binding protein 3D structures

3D Structures of GTP-binding protein3D Structures of GTP-binding protein

Updated on 18-August-2021

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• Small GTP-binding protein
  • 2eki – hGBP TGS domain – NMR - human
    
  • 3r7w, 4arz – yGtr1 + Gtr2 – yeast
    
  • 3kxk, 3kxl – SsHflx (mutant) - Sulfolobus solfataricus
    
  • 2qtf – SsHflx
    
  • 2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM
    
  • 5a9v, 4zci – EcBipA – Escherichia coli
    
  • 4zck – EcBipA C-terminal
    
  • 1sul – BsYsxC - Bacillus subtilis
    
  • 2dwq – TtYchF
    
  • 1udx – TtObg
    
  • 1wxq – GBP – Pyrococcus horikoshii
    
  • 1yr6 - PaGBP – Pyrococcus abyssi
    
  • 1ni3 – YchF – Schizosaccharomyces pombe
    
  • 5oxf, 5owv – GBP – Campylobacter jejuni
    
• GTP-binding protein complex with nucleotide
  • 2nzj – hRem1 + GDP
    
  • 3cbq – hRem2 + GDP
    
  • 3q85 – hRem2 G domain + GTP analog
    
  • 4aii - rRem2 G domain + GDP - rat
    
  • 2ohf – hOla1 + AMP-PCP
    
  • 1e0a – hGBP (mutant) + GIP
    
  • 2b8w, 2d4h – hGBP N terminal + GMP
    
  • 2b92 - hGBP N terminal + GDP
    
  • 2bc9 - hGBP N terminal + GPPNHP
    
  • 2gao - hSar1A + GDP
    
  • 6eg8 – hGBP subunits α-1,β-1,γ-2 + GDP
    
  • 6au6 – hGBP subunit α-1 + GDP
    
  • 2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
    
  • 2fmx - ChSar1B + GDP
    
  • 1yzn – yPt1 + GPPNHP
    
  • 1ky2 – yPt7 + GPPNHP
    
  • 1ky3 – yPt7 + GDP
    
  • 4phg – yPt7 (mutant) + GTP
    
  • 4phh – yPt7 (mutant) + GNP
    
  • 4phf – yPt7 (mutant) + GDP
    
  • 3rwm, 3rwo – yPt32 + GPPNHP
    
  • 1ek0 – yPt51 + GPPNHP
    
  • 2hjg, 4dcs, 4dct, 4dcu, 4dcv, 4kyu, 5mbs – BsEngA + GDP
    
  • 5m7h – BsEngA + GMPPNP
    
  • 5x4b – BsEngA N-terminal + GDP
    
  • 1svi – BsYsxC + GDP
    
  • 1svw – BsYsxC + GMPPNP
    
  • 1lnz – BsObg + GTP
    
  • 5m04 – BsObg + GDP
    
  • 2dby – TtYchF + GDP
    
  • 1wf3 – Tt1341 + GNP
    
  • 5a9y, 4zcm – EcBipA + G-4-phosphate
    
  • 5a9x, 5a9w, 4zcl – EcBipA + GDP
    
  • 5dn8 – EngA + GDP – Coxiella burnetti
    
  • 1yr7, 1yr8 – PaGBP + GTP
    
  • 1yr9, 1yra, 1yrb, 2oxr – PaGBP + GDP
    
  • 3kxi, 2qth – SsHflx + GDP
    
  • 6xrs – GBP EngA + GDP – Neisseria gonorrhoeae
    
• GTP-binding protein complex with protein
  • 6m8s – bGBP subunits β-1,γ-2 + KCTD12
    
  • 6cmo, 6qno – hGBP subunits α-1,β-1,γ-t1 + antibody + rhodopsin – Cryo EM
    
  • 6oij, 6oik – hGBP subunits α-1,β-1,γ-2 + antibody + AChR – Cryo EM
    
  • 6ot0 – hGBP subunits α-1,β-1,γ-2 + antibody + smoothend homolog – Cryo EM
    
  • 6d9h – hGBP subunits α-1,β-1,γ-2 + AChR/adenosine receptor – Cryo EM
    
  • 6g79 – hGBP subunits α-1,β-1,γ-2 + hydroxytryptamine receptor – Cryo EM
    
  • 6li3 – hGBP subunits α-1,β-1,γ-2 + nanobody + G protein coupled receptor – Cryo EM
    
  • 6e3y – hGBP subunits α-1,β-1,γ-2 + nanobody + calcitonin receptor + receptor activity-modifying protein – Cryo EM
    
  • 6pb0, 6pb1 – hGBP subunits α-1,β-1,γ-2 + nanobody + corticotropin-releasing factor receptor + urocortin – Cryo EM
    
  • 7joz – hGBP subunits α-1,β-1,γ-2 + nanobody + dopamine receptor + agonist – Cryo EM
    
  • 6wi9, 6wzg – hGBP subunits α-1,β-1,γ-2 + nanobody + secretin receptor + secretin – Cryo EM
    
  • 6lmk, 6lml, 6wpw – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon receptor + glucagon – Cryo EM
    
  • 6b3j – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon-like peptide receptor + exendin – Cryo EM
    
  • 6osa – hGBP subunits α-1,β-1,γ-2 + JMV449 + neurotensin receptor – Cryo EM
    
  • 6os9 – hGBP subunits α-1,β-1,γ-2 + JMV449 + scFv + neurotensin receptor – Cryo EM
    
  • 7dfl – hGBP subunits α-1,β-1,γ-2 + scFv + histamine receptor + histamine – Cryo EM
    
  • 6kpf, 6kpg – hGBP subunits α-1,β-1,γ-2 + scFv + cannabinoid receptor – Cryo EM
    
  • 6lfm, 6lfo – hGBP subunits α-1,β-1,γ-2 + scFv + interleukin-8 + C-X-C chemokine receptor – Cryo EM
    
  • 6dde, 6ddf – bGBP subunits α-1,β-1,γ-2 + scFv + opioid receptor + DAMGO – Cryo EM
    
  • 6b20 – bGBP subunits β-1,γ-t1 (mutant) + nanobody – bovine
    
  • 6r3q, 6r4o, 6r4p – bGBP subunit α-1 + adenylae cyclase – Cryo EM
    
  • 7jjo – bGBP subunits α-1,β-1,γ-2 + nanobody + b1 adrenergic receptor – Cryo EM
    
  • 6mhe – rGBP subunit α-1 + peptide + GDP
    
  • 6mhf – rGBP subunit α-1 + girdin + GDP
    
  • 6tyl, 6ukt – rGBP subunit α-1 + nanobody + RIC8A
    
  • 6n9g – mGBP subunit β-5 + RGS7 - mouse
    
  • 3cue – yPt1 + transport protein subunits
    
  • 2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
    
  • 3cpj – yPt31 + Rab GDP-dissociation inhibitor
    
  • 1m2o – ySar1 + protein transport protein sec23
    
  • 6gni - ySar1 + protein transport protein sec23 + Sec24 + GNP
    
  • 6gwp – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP
    
  • 3syn – BsFlhf + ATP-binding protein
    
• GTP-binding protein 3 (Atlastin-1)
  • 4idn – hGDP3 cytoplasmic domain + GNP
    
  • 4ido, 4idq, 3q5d, 3q5e, 3qnu, 3qof – hGDP3 cytoplasmic domain + GDP
    
  • 6b9f, 6b9e, 6b9d – hGDP3 cytoplasmic domain (mutant) + GDP
    
• GTP-binding protein LepA
  • 2ywe – AaLepA – Aquifex aeolicus
    
  • 2ywf – AaLepA + GMP-PNP
    
  • 2ywg - AaLepA + GTP
    
  • 2ywh - AaLepA + GDP
    
  • 3cb4 – EcLepA
    
  • 3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
    
  • 4k8w – LepA – Streptococcus pyogenes
    
• G protein bound to a G protein-coupled receptor
  • 3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated G protein-coupled receptor in a complex with its G protein.
• Ras-related small GTP-binding protein
  • 3llu – hRag-C nucleotide-binding domain
    
  • 2rhd – Rab-1a – Cryptosporidium parvum
    
• Ras-related small GTP-binding protein complex with nucleotide
  • 2l0x – rRheb + GDP
    
  • 2gjs – hRad1 + GDP
    
  • 3q72, 3q7p, 3q7q – hRad G-domain + GTP analog
    
  • 2dpx – hRad GTPase domain
    
  • 2gf0 – hDiRas1 + GDP
    
  • 2erx – hDiRas2 + Pi + GDP
    
  • 3x1z, 3x1y, 3x1x, 3x1w – hRab-1B (mutant) + GPPNHP
    
  • 1yu9 - hRab-4A + GPPNHP
    
  • 1yzq - hRab-6 + GNP
    
  • 1x3s – hRab-18 + GPPNHP
  • 6huf - hRab-27A + GNP
    
  • 6s6a, 6s6d - hRagA (mutant) + RagC (mutant) + GDP + GTP
    
  • 2atx – hTc10 + GPPNHP
    
  • 1g16 – ySec4 + GDP
    
  • 1g17 - ySec4 + GIP
    
• Ras-related small GTP-binding protein complex with protein
  • 3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
    
  • 3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
    
  • 3brw - hRap-1B + Rap GTPase-activating protein
    
  • 4kvg – hRab-1A + RIAM
    
  • 6ba6 – hRab-1B + talin-1
    
  • 4m8n – hRab-1B + plexin
    
  • 4dxa – hRab-1B (mutant) + KRIT1
    
  • 4hdq, 4hdo – hRab-1B + HEG1 + KRIT1
    
  • 6axf – hRab-1B + Ras guanyl-releasing protein 2
    
  • 5kho – hRab-1B + Ras-interacting protein 1
    
  • 4mh0, 4mgz, 4mgy, 4mgk, 4mgi - hRap-1B + Rap guanine nucleotide exchange factor 4
    
  • 1z0k – hRab-4 + rabenosyn-5
    
  • 3tw8 – hRab-1C + DENND
    
  • 4ojk – hRab-11B + cGMP-dependent protein kinase 2
    
  • 6ekk – hRab-35 + connecdenn + GDP
    
  • 6if2 – hRab-35 (mutant) + iporin + GTP
    
  • 6if3 – hRab-35 (mutant) + ACAP2 + GTP
    
  • 6ces – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM
    
  • 6ehr, 5x6v – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5
    
  • 6u62 – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM
    
  • 6nzd, 6ulg – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM
    
  • 6sb2 – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM
    
  • 6sb0 – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM
    
  • 6oq3, 6oq4 – hRap-1B + krev interacting trapped protein + GNP
    
• Interferon-induced GTP-binding protein
  • 3ljb – hMx1 stalk region
    
  • 4p4u – hMx1 stalk region (mutant)
    
  • 4p4t – hMx1 stalk region (mutant) + GDP
    
  • 4p4s – hMx1 stalk region (mutant) + GMPPCP
    
  • 3szr – hMx1 residues 33-662
    
  • 5gtm – hMx1 residues 33-662 (mutant)
    
  • 3zys – hMx1 + dynamin-1
    
  • 4x0r – hMx2 stalk region (mutant)
    
  • 4whj – hMx2 residues 84-715 (mutant)
    
• Rho-related small GTP-binding protein
  • 2j1l – hRhoD
• Rho-related small GTP-binding protein complex with nucleotide
  • 2cls – hRho6 + GTP
    
  • 2fv8 - hRhoB + GDP
    
  • 6hxu - hRhoB (mutant) + GTP
    
  • 2gcn – hRhoC + GDP
    
  • 2gco – hRhoC + GPPNHP
    
  • 1z2c - hRhoC (mutant) + GMPPNP
    
  • 2gcp – hRhoC + GSP
    
  • 1m7b - hRhoE + GTP
    
  • 1gwn - mRhoE + GTP
    
• Rho-related small GTP-binding protein complex with protein
  • 2v55 – hRhoE + Rho-associated protein kinase
    
  • 3q3j – hRho6 + plexin-A2 nucleotide-binding domain
    
  • 2rex – hRho6 + plexin-B1
    
  • 1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
    
  • 6bca - hRhoA + kinase anchor protein + GTP
    
  • 6sge - hRhoB + nanobody + GTP
    
  • 3a58 – yRho1 (mutant) + exocyst complex component Sec3 + cancidas
    
• G25K GTP-binding protein or cell division control protein 42 homolog
  • 1a4r - hCdc42 (mutant) + GDP
    
  • 1an0 - hCdc42 + GDP
    
  • 2qrz - hCdc42 + GCP
    
  • 1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
    
  • 2kb0 - hCdc42 (mutant)
    
  • 1kz7 - hCdc42 + guanine nucleotide exchange factor
    
  • 1kzg - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)
    
  • 2dfk – hCdc42 + collybistin II
    
  • 2wm9, 2wmn, 2wmo - hCdc42 + DOCK9
    
  • 3eg5 - hCdc42 + protein diaphanous homolog 1 + GMPPNP
    
  • 3gcg - hCdc42 + MAP
    
  • 1nf3 - hCdc42 + Par6
    
  • 2ase - hCdc42 (mutant) - NMR
    
  • 1ki1 – hCdc42 + intersectin long form
    
  • 5hzk - hCdc42 (mutant) + intersectin
    
  • 1ees – hCdc42 + MapK3 peptide - NMR
    
  • 1doa - hCdc42 + GDP-dissociation inhibitor
    
  • 6tky, 6tkz - hCdc42 + dedicator of cytokinesis protein
    
  • 2ngr – hCdc42 + GTPase-activating protein C terminal + GDP
    
  • 1am4 – hCdc42 + GTPase-activating protein rhoGAP + GNP
    
  • 1grn – hCdc42 + GTPase-activating protein rhoGAP + GDP
    
  • 1cf4 – hCdc42 (mutant) + ACK GTPase-binding domain + GNP - NMR
    
  • 1cee – hCdc42 + WASP GTPase-binding domain + GCP - NMR
    
  • 2odb – hCdc42 + PAK6 CRIB domain + GCP
    
  • 3qbv – hCdc42 (mutant) + intersectin + GDP
    
  • 4did – hCdc42 + inositol phosphate phosphatase + GDP
    
  • 1cf4 – hCdc42 (mutant) + dedicator of cytokinesis protein 8
    
  • 4itr – hCdc42 + AMP-protein transferase + GDP + AMP
    
  • 6aj4, 6ajl - hCdc42 (mutant) + dedicator of cytokinesis protein
    
  • 5upl, 5upk - hCdc42 + PAK 4
    
  • 5fi1 - hCdc42 + PTDINS dependent RAC exchanger
    
  • 6siu - hCdc42 + IBPA + GDP
    
• Rac-like GTP-binding protein
  • 4u5x – Arac1 (mutant) + GNPPNP – rice
    
  • 2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
    
  • 3bwd – AtArac6
    
  • 2nty – AtArac5 + prone8
    
  • 2j0v – AtArac7 (mutant)
    
• Rab-related small GTP-binding protein
  • 2ys8 – hRabJ DNAJ domain – NMR
    
• Flagella-associated GTP-binding protein
  • 2px0 – BsFlhF + GMP-PNP
    
  • 2px3 – BsFlhF + GTP
    
• Small GTP-binding protein
  • 5kh0 – GBP – Thermotoga neapolitana
    
• Small GTP-binding protein ERA
  • 1ega – EcERA
    
  • 3ieu – EcERA + GDP
    
  • 3iev – AaERA + RNA + Mg-GNP
    
  • 1x1l – TtERA + RNA – Cryo EM
    
  • 1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
    
• Small GTP-binding protein Rheb
  • 1xtq, 5yxh – hRheb + GDP
    
  • 1xts - hRheb + GTP
    
  • 1xtr - hRheb + GPPNHP
    
  • 3sea - hRheb + GDP + GNP
    
  • 6bt0, 6bsx - hRheb + GDP + inhibitor
    
  • 3t5g – hRheb + GMP-PDE delta
    
  • 4o25 – mRheb + GTP - mouse
    
  • 4o2l - mRheb (mutant) + GTP
    
  • 4o2r - mRheb (mutant) + GDP
    
  • 3t5g – hRheB + GMP-PDE δ
    
  • 2l0x – rRheb + GDP
    
• Small GTP-binding protein Gem
  • 2cjw, 2ht6, 2g3y – hGem G domain + GDP
    
• Small GTP-binding protein Ran
  • 2mmc, 2mmg – hRan
    
• Ran binary complex
  • 3gj0, 5ciw, 5cit, 5ciq – hRan + GDP
    
  • 5cj2 – hRan (mutant) + GDP
    
  • 1i2m – hRan + regulator of chromosome condensation 1
    
  • 1byu – Ran + GDP - dog
    
  • 1qg2, 1qg4, 3ran – dRan (mutant) + GDP
    
  • 2bku – dRan + importin
    
• Ran ternary complex
  • 1rrp – hRan + Nup358 + GTP analog
    
  • 1qbk – hRan + karyopherin β2 + GTP analog
    
  • 1ibr – hRan + importin β1 subunit + GTP analog
    
  • 4ol0 – hRan + importin 12 + GTP
    
  • 3ea5 – hRan (mutant) + importin β1 subunit + GDP
    
  • 6q82 – hRan (mutant) + importin β-like protein + GTP
    
  • 4c0q - hRan (mutant) + importin 12 + GTP
    
  • 3nc1 – hRan (mutant) + exportin 1 + GTP
    
  • 5clq – hRan (mutant) + RanBD1 + GNP
    
  • 5cll – hRan + RanBD1 + GDP
    
  • 3ch5, 3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8 – hRan + Nup153 + GDP
    
  • 3w3z – dRan + importin β1 subunit + GTP
    
  • 5bxq – dRan + NTF-2 + GDP
    
• Ran larger complex
  • 3gjx – hRan + snurportin 1 + exportin 1 + GTP
    
  • 3nby, 3nbz, 3nc0 – hRan (mutant) + snurportin 1 + exportin 1 + GTP
    
  • 6tvo – hRan (mutant) + exportin 1 + leptomycin + GTP
    
  • 6x2p, 6x2s – hRan (mutant) + exportin 1 + Mkk1 + GNP
    
  • 1k5d, 5zpu – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog
    
  • 1k5g – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP
    
  • 4gpt, 4gmx, 4hat, 4hb2, 4hb3 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP
    
  • 4hat, 4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb4 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic
    
  • 5jlj – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor
    
  • 4wvf – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor
    
  • 6cit, 6kft – hRan + Ran-specific GTPase-activating protein + exportin + NS2 + GNP
    
  • 6x2r – hRan + Ran-specific GTPase-activating protein + exportin + Eif4E + GNP
    
  • 6x2u, 6x2v, 6x2w – hRan + Ran-specific GTPase-activating protein + exportin + Pki-alpha peptide + GNP
    
  • 6x2x – hRan + Ran-specific GTPase-activating protein + exportin + Mkk1 peptide + GNP
    
  • 6x2y – hRan + Ran-specific GTPase-activating protein + exportin + diaphanous homolog peptide + GNP
    
  • 6a3e, 6a3c, 6a3b, 6a3a, 6a38 – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP
    
  • 5ytb, 5yst, 5yro – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP
    
  • 5ysu – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP + plumbagin
    
  • 5uww, 5uwu, 5uwt, 5uws, 5uwr, 5uwq, 5uwp, 5uwo, 5uwj, 5uwi, 5uwh, 5dif, 5di9, 5dhf, 5dha, 5dh9 – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide
    
  • 3zjy – hRan (mutant) + importin 13 + EIF-1A + GTP
    
  • 6q84 – hRan (mutant) + importin β-like protein + EIF-4D + GTP
    
  • 5dlq – hRan (mutant) + exportin 4 + EIF-5A + GTP
    
  • 5dis – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP
    
  • 3a6p – dRan + pre-microRNA + exportin 5 + peptide
    
  • 5yu6 – dRan + exportin 5 + peptide + GTP
    
  • 3icq – yRan + RNA + exportin T
    
  • 3m1i – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP
    
• Small GTP-binding protein
  • 5kh0 - GBP – Thermosipho melanesiensis
    
• Small GTP-binding protein ERA
  • 1ega – EcERA
    
  • 3ieu – EcERA + GDP
    
  • 3iev – AaERA + RNA + Mg-GNP
    
  • 1x1l – TtERA + RNA – Cryo EM
    
  • 1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
    
• Small GTP-binding protein Gem
  • 2cjw, 2ht6, 2g3y – hGem G domain + GDP
    
• Small GTP-binding protein Rheb
  • 1xtq, 5yxh – hRheb + GDP
    
  • 7bta, 7btc - hRheb (mutant) + GDP
    
  • 1xts - hRheb + GTP
    
  • 1xtr - hRheb + GPPNHP
    
  • 7btd - hRheb (mutant) + GPPNHP
    
  • 3sea - hRheb + GDP + GNP
    
  • 6bt0, 6bsx - hRheb + GDP + inhibitor
    
  • 3t5g – hRheb + GMP-PDE delta
    
  • 4o25 – mRheb + GTP - mouse
    
  • 4o2l - mRheb (mutant) + GTP
    
  • 4o2r - mRheb (mutant) + GDP
    
  • 2l0x – rRheb + GDP
    
• Small GTPase h-Ras see GTPase HRas
• Heterotrimeric G protein see Transducin