2j1l

Crystal Structure of Human Rho-related GTP-binding protein RhoDCrystal Structure of Human Rho-related GTP-binding protein RhoD

Structural highlights

2j1l is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RHOD_HUMAN Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Gad AK, Nehru V, Ruusala A, Aspenstrom P. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Mol Biol Cell. 2012 Dec;23(24):4807-19. doi: 10.1091/mbc.E12-07-0555. Epub 2012, Oct 19. PMID:23087206 doi:http://dx.doi.org/10.1091/mbc.E12-07-0555
↑ Nehru V, Almeida FN, Aspenström P. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Biochem Biophys Res Commun. 2013 Apr 5;433(2):163-9. PMID:23454120 doi:10.1016/j.bbrc.2013.02.046
↑ Nehru V, Voytyuk O, Lennartsson J, Aspenström P. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. Traffic. 2013 Dec;14(12):1242-54. PMID:24102721 doi:10.1111/tra.12121

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OCA

[1] Gad AK, Nehru V, Ruusala A, Aspenstrom P. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Mol Biol Cell. 2012 Dec;23(24):4807-19. doi: 10.1091/mbc.E12-07-0555. Epub 2012, Oct 19. PMID:23087206 doi:http://dx.doi.org/10.1091/mbc.E12-07-0555

[2] Nehru V, Almeida FN, Aspenström P. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Biochem Biophys Res Commun. 2013 Apr 5;433(2):163-9. PMID:23454120 doi:10.1016/j.bbrc.2013.02.046

[3] Nehru V, Voytyuk O, Lennartsson J, Aspenström P. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. Traffic. 2013 Dec;14(12):1242-54. PMID:24102721 doi:10.1111/tra.12121

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2j1l

Crystal Structure of Human Rho-related GTP-binding protein RhoDCrystal Structure of Human Rho-related GTP-binding protein RhoD

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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2j1l

Crystal Structure of Human Rho-related GTP-binding protein RhoDCrystal Structure of Human Rho-related GTP-binding protein RhoD

Structural highlights

Function

Evolutionary Conservation

See Also

References

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