ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. ATPase types include:

  • F-ATPase - the prime producers of ATP;
  • V-ATPase or Vacuolar-type H+ ATPase couples the energy to proton transport across membranes. For details see V-ATPase;
  • A-ATPase are found in archaea. For details see A-ATP Synthase;
  • P-ATPase transport ions;
  • E-ATPase hydrolyze extracellular ATP.
  • MipZ is an ATPase which forms a complex with the chromosome partitioning protein ParB and is responsible for the regulation of FtsZ ring formation.

ATPase domains include metal-binding domain (MBD) and nucleotide-binding domain (NBD). For more details see:



An ATPase, Human RuvB-like 1 dodecamer complex with ADP (PDB code 2c9o)

Drag the structure with the mouse to rotate


3D Printed Physical Model of ATP Synthase3D Printed Physical Model of ATP Synthase

Shown below is a 3D printed physical model of the Respiration Electron Transport Chain. Complex I is colored red, complex II is purple, complex III is green, complex IV is blue and the atp synthase protein is colored orange, yellow and red.  


The MSOE Center for BioMolecular ModelingThe MSOE Center for BioMolecular Modeling

 

The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery.

3D Structures of ATPase3D Structures of ATPase

Updated on 10-May-2018

V-ATPaseV-ATPase

(mutant)

    • 3i72, 3i73, 3ikj - TtATPS subunit A (mutant)
    • 4o1s - ATPS subunit A – Thermoplasma volcanium
    • 5i1m – yATPase
    • 5bn5 – NeATPase + NEQ263 – Nanoarchaeum equitans
    • 5bn4 – NeATPase + NEQ263 + ANP
    • 5bn3 – NeATPase + NEQ263 + ADP
  • V-ATPase subunit B
    • 2c61 - MmATPS subunit B – Methanosarcina mazei
    • 2rkw, 3b2q, 3ssa, 3tgw, 3tiv - MmATPS subunit B (mutant)
    • 3dsr - MmATPS subunit B+ADP
    • 3eiu - MmATPS subunit B+ATP
  • V-ATPase subunit C
    • 1u7l, 3u2f, 3u2y, 3u32, 3ud0 - yATPS subunit C
    • 3v3c - ATPS subunit C - pea
    • 1ijp, 1l6t – EcF1-ATPS subunit C (mutant) – Escherichia coli - NMR
    • 1r5z, 1v9m - TtATPS subunit C – Thermus thermophilus
    • 3lg8 - MtATPS subunit C C-terminal
    • 2w5j - sATPS subunit C - spinach
    • 2wie, 2xqs, 2xqt, 2xqu - ATPS subunit C – Arthrospira platensis
    • 3zk1, 3zk2 - ATPS subunit C – Fusobacterium nucleatum<br />
  • V-ATPase subunit D+F
    • 4rnd – yATPase subunit D+F
  • V-ATPase subunit E
    • 2kz9 – yATPase subunit E
    • 2dm9, 2dma, 4dt0 - PhATPS subunit E – Pyrococcus horikoshii
    • 2kk7 - MjATPS subunit E – Methanocaldococcus jannaschii
    • 3v6i – TtATPS subunit E + VAPC
  • V-ATPase subunit F
    • 2qai - ATPS subunit F – Pyrococcus furiosus
    • 2i4r - ATPS subunit F – Archaeoglobus fulgidus
    • 2ov6 - MmATPS subunit F - NMR
    • 2d00 - TtATPS subunit F
    • 4ix9 – yATP subunit F (mutant)
  • V-ATPase subunit G
    • 2k88 - yATPS subunit G residues 2-58 - NMR
    • 2kwy - yATPS subunit G residues 61-101 - NMR
  • V-ATPase subunit H
    • 1ho8 – yATPS subunit H
  • V-ATPase subunit K
    • 2bl2, 2cyd - EhATPS subunit K – Enterococcus hirae
  • V-ATPase subunit I
    • 3rrk – ATPS subunit I N terminal – Meiothermus ruber
  • V-ATPase multi subunits
    • 4dl0, 4efa - yATPase subunits C,G,E
    • 3w3a - yATPS subunit A,B,D,F
    • 5tj5 - yATPS subunit A,C,C’,C’’,D,E,F
    • 5voz, 5voy, 5vox - yATPS subunit A,C,C’,C’’,D,E,F,H – Cryo EM
    • 6c6l - yATPS subunit A,C,C’,C’’,D,E,F + V0 assembly protein 1
    • 5bw9 - yATPS subunit A,B,D,E,G,H – Cryo EM
    • 5d80 - yATPS subunit A,B,D,E,F,G,H
    • 3a5c, 3a5d - TtATPS subunit A,B,D,F
    • 5tsj - TtATPS subunit A,B,C,D,E,F,G + antibody - Cryo-EM
    • 5gas, 5gar - TtATPS subunit A,B,C,D,E,F,G,I - Cryo-EM
    • 5y60. 5y5z, 5y5y, 5y5x - TtATPS subunit A,B,C,D,E,F,I,K - Cryo-EM
    • 3gqb - TtATPS subunit A (mutant),B (mutant)
    • 3k5b - TtATPS subunit E (mutant)+C
    • 5knd, 5knc, 5knb - EhATPS subunit A,B,D,F

P-ATPaseP-ATPase

  • Cu+2 transporting ATPase
    • 2kmv, 2kmx, 2arf, 2koy – hATPase NBD – human – NMR
    • 2kij - hATPase actuator domain – NMR
    • 1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR
    • 1y3j, 1y3k - hATPase 5th soluble domain – NMR
    • 2ew9 - hATPase 5th+6th soluble domains – NMR
    • 1s6o, 1s6u, 2lqb - hATPase 2nd soluble domain – NMR
    • 1q8l - hATPase 2nd MBD – NMR
    • 1aw0, 2aw0 - hATPase 4th MBD – NMR
    • 1kvi, 1kvj - hATPase 1st MBD – NMR
    • 5t7l - hATPase 1st MBD + Cu transport protein
    • 3dxs - AtATPase RAN1 MBD (mutant) – Arabidopsis thaliana
    • 5lbd – AtATPase PAA1 N-domain
    • 5lbk – AtATPase PAA2 N-domain
    • 3voy - AfATPase – Archaeoglobus fulgidus – CryoEM
    • 3skx, 3sky - AfATPase NBD
    • 2k1r - hATPase MBD+ ATOX1 – NMR
    • 2rop, 2g9o, 2ga7 - hATPase MBD – NMR
    • 2rml - BsATPase N-terminal – Bacillus subtilis – NMR
    • 2gcf - sATPase N-terminal - Synechocystis – NMR
    • 4a4j - sATPase N-terminal
    • 4a48 - sATPase
    • 2iye - SsATPase catalytic domain – Sulfolobus solfataricus
    • 2yj3 - SsATPase catalytic domain (mutant)
    • 2yj4, 2yj5, 2yj6 - SsATPase catalytic domain (mutant) + nucleotide
    • 1fvq, 1fvs - hATPase – NMR
    • 3cjk – hATPase + Cu transporting protein ATX1
    • 3rfu, 4bbj, 4bev, 4byg – LpATPase – Legionella pneumophila
    • 4f2f - ATPase metal-binding domain – Streptococcus pneumonia
    • 3j08, 3j09 - AfATPase
    • 3a1c – AfATPase + AMPPCP
    • 3a1d - AfATPase + ADP-Mg
    • 3a1e - AfATPase (mutant) + AMPPCP
  • Na/K transporting ATPase
  • Ca+2 transporting ATPase
  • Zn+2 transporting ATPase
    • 2ofg, 2ofh - sATPase N-terminal – NMR
    • 4umw, 4umv - ATPase +Mg – Shigella sonni
  • K+ transporting ATPase
  • As+ transporting ATPase
    • 1ii0, 1f48 - EcATPase
    • 1ihu – EcATPase+Mg+ADP+AlF3
    • 1ii9 - EcATPase
    • 3h84, 3idq, 3a36, 3a37 - yATPase GET3
    • 4pwx, 5bwk - yATPase GET3 + golgi to ER traffic protein + ubiquitin-like protein
    • 5bw8 - yATPase GET3 + golgi to ER traffic protein + ubiquitin-like protein + protein
    • 4xwo - yATPase GET3 + antibody + Sec22
    • 4xvu - yATPase GET3 + antibody + NYV1
    • 4xtr - yATPase GET3 + antibody + pep12p
    • 3sja, 3sjb, 3sjc, 3sjd, 3zs8, 3zs9, 3b2e, 3vlc - yATPase GET3 + GET1 cystolic domain

3ibg - ATPase GET3 – Aspergillus fumigatus

  • H+ transporting ATPase
    • 5ksd - AtATPase C terminal truncated
    • 1mhs - ATPase – Neurospora crassa
  • Na+ transporting ATPase
    • 2db4, 3aou - EhATPase subunit K – Enterococcus hirae
    • 3aon - EhATPase subunits D,G
    • 3vr2 - EhATPase subunits A,B
    • 3vr4, 3vr5 - EhATPase subunits A,B,D,G
    • 3vr3 - EhATPase subunits A,B + AMPPNP
    • 3vr6 - EhATPase subunits A,B,D,G + AMPPNP
    • 1yce - ATPase rotor ring – Ilyobacter tartaricus
  • H/K transporting ATPase
  • Mg+2 transporting ATPase
    • 3gwi – EcATPase P-1 NBD
  • Arg/ornithine transporting ATPase
    • 3md0 – MtATPase+GDP – Mycobacterium tuberculosis
    • 1kmh - ATPase alpha subunit+tentoxin – spinach
    • 1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
    • 1h8h - cATPase+ AMPPNP
    • 1efr - cATPase+efrapeptin
    • 3fks – yATPase
    • 3ea0 – ATPase ParA, fragment – Chlorobium tepidum
    • 2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
    • 3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse
    • 3cf2 - mATPase NBD+ADP+AMP-PNP
    • 2r31, 2p4x – PdATPase ATP12
    • 2zd2 – PdATPase (mutant) ATP12
    • 1d8s – EcATPase F1
    • 1vdz – PhATPase subunit A – Pyrococcus horikoshii
  • Monosaccharide transporting ATPase
    • 5dte – AsATPase – Actinobacillus succinogenes
    • 4zjp – AsATPase + ribopyranose
  • RNA-dependent ATPase
    • 3eaq, 3i31, 3i32 – TtATPase fragment
    • 4kbg, 4kbf - TtATPase helicase core domain
    • 5mao - TtATPase RRM domain
    • 4i69, 4i68 - TtATPase RRM domain (mutant)
    • 4i67 - TtATPase RRM domain + RNA
    • 3mwj – TtATPase N-terminal (mutant)
    • 3mwk, 3nbf – TtATPase N-terminal + 8-oxo-AMP
    • 3mwl - TtATPase N-terminal (mutant) + 8-oxoadenine
    • 3nej - TtATPase reca-like domain (mutant)
  • DNA-dependent ATPase
    • 5tnu - ATPase – Sulfolobus tokodaii
  • ATP-dependent ATPase
    • 5txv – EcATPase subunit HSLU
    • 5ji3, 5ji2 – EcATPase subunits HSLU+HSLV
  • Proteasome-associated ATPase
    • 3fp9, 3m9b, 3m9h – MtATPase intern domain
    • 3m91, 3m9d - MtATPase coiled coil domain + protein PUP
    • 5kzf – MtATPase residues 98-609
    • 5kwa – MtATPase residues 22-529
    • 3kw6 – hATPase 5
    • 6epf, 6epe, 6epd, 6epc – rATPase 6 + proteasome – Cryo EM
  • Transitional endoplasmic reticulum ATPase
    • 5c19 – hTer-ATPase (mutant)
    • 3hu1, 3hu2, 3hu3, 5ftn, 5ftm, 5ftl, 5ftk, 5ftj – hTer-ATPase + ATPGS
    • 4ko8, 4kln, 5dyg, 5c18 – hTer-ATPase (mutant) + ATPGS
    • 5dyi – hTer-ATPase + ADP
    • 4kod – hTer-ATPase (mutant) + ADP
    • 3qc8, 3qq8, 3qwz - hTer-ATPase N terminal + FAS-associated factor 1
    • 3qq7 - hTer-ATPase N terminal
    • 3tiw - hTer-ATPase N terminal + E3 ubiquitin-protein ligase peptide
    • 5c1b - hTer-ATPase N terminal + UFD1--SHP peptide
    • 5glf - hTer-ATPase N terminal + derlin-1 peptide
    • 5epp - hTer-ATPase N terminal + rhomboid-related protein 4 peptide
    • 4kdl, 4kdi - hTer-ATPase N terminal + ubiquitin thioesterase OTU1
    • 5b6c - hTer-ATPase N terminal + ubiquitin fusion degradation protein
    • 5ifw, 5ifs - hTer-ATPase + tether containing UBX domain
    • 5x4l - hTer-ATPase + UBX domain-containing protein
    • 5kiy, 5kiw - hTer-ATPase (mutant) + Selenoprotein S
    • 1s3s - mTer-ATPase ND1 domain + P47 C terminal
    • 4rv0 - Ter-ATPase N terminal + nuclear protein localization protein – Drosophila melanogaster
  • Sarcoplasmic/endoplasmic reticulum ATPase
  • LAO/AO transport system ATPase
    • 3nxs – ATPase – Mycobacterium smegmatis
  • DNA double-strand repair ATPase (Rad50)
    • 3aux – MjRad50 – Methanocaldococcus jannaschii
    • 3auy - MjRad50 + ADP
    • 3av0 - MjRad50 + ATP
    • 5f3w - MjRad50 + MRE11 + ATPGS
    • 5dny - MjRad50 + MRE11 + DNA
    • 3qg5 – Rad50 NBD + MRE11 – Thermotoga maritima
    • 3qkr, 3qks, 3qf7 - PfRad50 NBD + MRE11 – Pyrococcus furiosus
    • 4nck, 4nci, 4nch - PfRad50 NBD (mutant)
    • 4ncj - PfRad50 NBD (mutant) + BeF3 + ADP
    • 3qkt - PfRad50 NBD + AMPPNP
    • 3qku - PfRad50 NBD + AMPPNP + MRE11
  • MipZ ATPase

2xit, 2xj4 – CcMipZ – Caulobacter crescentus

2xj9 – CcMipZ (mutant)

  • ATPase Rava
    • 5fl2, 4upf – EcATPase LARA domain + lysine decarboxylase
    • 4upb – EcATPase + lysine decarboxylase – Cryo EM
    • 3nbx – EcATPase Rava + ADP
  • FlaI ATPase
    • 4ihq, 4ii7 – ATPase (mutant) – Sulfolobus acidocaldarius
  • The RuvBL1/RuvBL2 complex (ATPase)



ReferencesReferences

  1. Gorynia S, Bandeiras TM, Pinho FG, McVey CE, Vonrhein C, Round A, Svergun DI, Donner P, Matias PM, Carrondo MA. Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex. J Struct Biol. 2011 Sep 10. PMID:21933716 doi:10.1016/j.jsb.2011.09.001

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Alexander Berchansky, Jaime Prilusky, Michal Harel, Wayne Decatur, Mark Hoelzer, Karsten Theis