ATPase

ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. ATPase types include: F-ATPase - the prime producers of ATP; V-ATPase or Vacuolar-type H+ ATPase couples the energy to proton transport across membranes. For details see V-ATPase; A-ATPase are found in archaea. For details see A-ATP Synthase; P-ATPase transport ions; E-ATPase hydrolyze extracellular ATP. MipZ is an ATPase which forms a complex with the chromosome partitioning protein ParB and is responsible for the regulation of FtsZ ring formation. ATPase domains include metal-binding domain (MBD) and nucleotide-binding domain (NBD). For more details see: Cu transporting ATPase are in P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B. Na/K transporting ATPase are in Sodium-Potassium ATPase. H/K transporting ATPase are in Esomeprazole and H+/K+ - ATPase Interaction. Transitional endoplasmic reticulum ATPase are in Valosin Containing Protein D120. Central stalk in F(1)-ATPase is described in A-ATP Synthase RuvBL1/RuvBL2 complex (ATPase) For Ter-ATPase see Valosin Containing Protein D120

spinqualitylabelsall models An ATPase, Human RuvB-like 1 dodecamer complex with ADP (PDB code 2c9o) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ATPase3D Structures of ATPase

Updated on 25-March-2018

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• F-ATPase
• F1F0 ATPase α subunit
  • 2jmx - bF1-ATPS+subunit O
    
  • 2r9v - F1-ATPS – Thermotoga maritima
• F1F0 ATPase β subunit
  • 1b9u – EcF1-ATPS membrane domain – Escherichia coli -NMR
    
  • 4utq – EcF1-ATPS membrane domain + insertase YIDC – Cryo EM
    
  • 1l2p – EcF1-ATPS dimerization domain
    
  • 2khk - EcF1-ATPS fragment – NMR
    
  • 1pyv - F1-ATPS – NMR – tobacco
    
  • 4q4l - F1-ATPS – Burkholderia thailandensis
    
• F1F0 ATPase γ subunit
  • 1wu0 – BsATPS – NMR
    
  • 1a91, 1c0v, 1aty, 1c99 - EcF1-ATPS – NMR
    
  • 2wgm, 1yce – F0-ATPS – Ilyobacter tartaricus
    
  • 2x2v, 4cbk, 4cbj – F0-ATPS – Bacillus pseudofirmus
    
  • 4mjn - F1-ATPS - wheat
    
  • 4bem - F1F0-ATPS – Acetobacterium woodii
    
• F1F0 ATPase δ subunit
  • 1abv – EcF1-ATPS N terminal – NMR
    
• F1F0 ATPase ε subunit
  • 2rq6, 2rq7 - F1-ATPS – Thermosynechococcus elongatus
    
  • 1abv, 1aqt – EcF1-ATPS (mutant)
    
  • 1bsh, 1bsn – EcF1-ATPS – NMR
    
  • 2e5t, 2e5u – BsF1-ATPS C terminal – NMR
    
  • 2e5y – BsF1-ATPS
• F1F0 ATPase α, β subunits
  • [1sky]] – BsF1-ATPS – Bacillus sp. Ps3
    
  • 5cdf – PdATPase - Paracoccus denitrificans
    
• F1F0 ATPase α,γ subunits
  • 1c17 – EcF1-ATPS – NMR
    
• F1F0 ATPase α, δ subunits
  • 2a7u – EcF1-ATPS N termini – NMR
    
• F1F0 ATPase β, δ subunits
  • 2cly – bF1-ATPS + ATPS coupling factor
• F1F0 ATPase γ, ε subunits
  • 1fs0 – EcF1-ATPS
• F1F0 ATPase α, β, γ subunits
  • 1ohh, 2jiz, 4tt3, 4tsf, 4z1m – bF1-ATPS+ IF1 inhibitor – bovine
    
  • 1e1q, 2w6e, 2w6f, 2w6g, 2w6h, 2w6i, 2w6j - bF1-ATPS
    
  • 1e1r - bF1-ATPS+Mg+ADP+AlF4
    
  • 1w0j, 1w0k - bF1-ATPS+BeF3
    
  • 1nbm - bF1-ATPS+nitrobenzofurazan
    
  • 1mab, 2f43 - F1-ATPS – rat
• F1F0 ATPase α,β,γ,δ subunits
  • 1qo1 - yF1-ATPS + protein 9
    
• F1F0 ATPase α,β,γ,ε subunits
  • 1jnv - EcF1-ATPS
    
  • 3oaa – EcF1-ATPS (mutant)
    
  • 2qe7, 4xd7 – F1-ATPS – Bacillus
    
  • 5ik2, 5hkk – F1-ATPS – Cakdalkalibacillus thermarum
    

F1F0 ATPase α, β, γ, δ, ε subunits

4asu, 2jdi, 2jj1, 2jj2 - bF1-ATPS
2v7q, 1e79, 2ck3 - bF1-ATPS+inhibitor

• • 4yxw - bF1-ATPS+ ANP
    

2xnd, 2xok - bF1-ATPS+ATPS lipid-binding protein

2wpd, 2wss - yF1-ATPS+subunit 9+Mg+ADP+ATP - yeast
3oe7, 3oee, 3oeh, 3ofn - yF1-ATPS (mutant)
3fks, 3zry, 2hld - yF1-ATPS

• • 3zia - yF1-ATPS + inhibitor protein
    
  • 6f5d - F1-ATPS + ribonucleoprotein P18 – Trypanosoma brucei
    

3j0j – TtATPS α,β,γ,δ,ε,ζ - Cryo EM

F1F0 ATPase α, β, γ, ε subunits 3oaa – EcF1-ATPS (mutant)
1e79 - bF1-ATPS
F1F0 ATPase α,β,γ,δ,ε,9,B,D,6,O subunits 4b2q – yATPase – Cryo EM

• F1F0 ATPase α,β,γ,δ,ε,A,C subunits
  • 5dn6 – PdATPase + zeta inhibitor protein
    
• F1F0 ATPase α,β,γ,δ,ε,A,B,C subunits
  • 5t4q, 5t4p, 5t4o – EcATPase – Cryo EM
    
• F1F0 ATPase α,β,γ,δ,ε,A,B,C,D,F,H,AAP1 subunits
  • 5lqz, 5lqy, 5lqx – ATPase + ATPase inhibitor protein – Ogataea angusta - Cryo EM
    
• F1F0 ATPase α,β,γ,δ,ε,B1,C1,D,O subunits
  • 5fil, 5fik, 5fij, 5ari, 5arh, 5are, 5ara – bATPase – Cryo EM
    
• F1F0 ATPase A,B,C,D,E,F,G,J,K subunits
  • 6b2z – yATPase – Cryo EM
    
• F1F0 ATPase α,β,γ,δ,ε,A,D,E,F,G,J,K,H,4,5,8,9 subunits
  • 6b8h – yATPase
    

1bmf - bF1-ATPS

3dze – bF1-ATPS subunit S
1cow - bF1-ATPS+aurovertin B
4f4s – yATPase subunit 9 + oligomycin

V-ATPaseV-ATPase

V-ATPase subunit A

3i4l - PhATPS subunit A+AMPPNP
3mfy, 3m4y, 3nd8, 3nd9, 3p20, 3qg1, 3qia, 3qjy, 3sdz, 3se0, 5x09 - PhATPS subunit A (mutant)
3i72, 3i73, 3ikj - TtATPS subunit A (mutant)

• • 4o1s - ATPS subunit A – Thermoplasma volcanium
    
  • 5i1m – yATPase
    
  • 5bn5 – NeATPase + NEQ263 – Nanoarchaeum equitans
    
  • 5bn4 – NeATPase + NEQ263 + ANP
    
  • 5bn3 – NeATPase + NEQ263 + ADP
    

V-ATPase subunit B

2c61 - MmATPS subunit B – Methanosarcina mazei
2rkw, 3b2q, 3ssa, 3tgw, 3tiv - MmATPS subunit B (mutant)
3dsr - MmATPS subunit B+ADP
3eiu - MmATPS subunit B+ATP
V-ATPase subunit C 1u7l, 3u2f, 3u2y, 3u32, 3ud0 - yATPS subunit C
3v3c - ATPS subunit C - pea
1ijp, 1l6t – EcF1-ATPS subunit C (mutant) – Escherichia coli - NMR
1r5z, 1v9m - TtATPS subunit C – Thermus thermophilus
3lg8 - MtATPS subunit C C-terminal
2w5j - sATPS subunit C - spinach
2wie, 2xqs, 2xqt, 2xqu - ATPS subunit C – Arthrospira platensis
3zk1, 3zk2 - ATPS subunit C – Fusobacterium nucleatum
V-ATPase subunit D+F

• • 4rnd – yATPase subunit D+F
    

V-ATPase subunit E

2kz9 – yATPase subunit E
2dm9, 2dma, 4dt0 - PhATPS subunit E – Pyrococcus horikoshii
2kk7 - MjATPS subunit E – Methanocaldococcus jannaschii
3v6i – TtATPS subunit E + VAPC
V-ATPase subunit F 2qai - ATPS subunit F – Pyrococcus furiosus
2i4r - ATPS subunit F – Archaeoglobus fulgidus
2ov6 - MmATPS subunit F - NMR
2d00 - TtATPS subunit F
4ix9 – yATP subunit F (mutant)
V-ATPase subunit G 2k88 - yATPS subunit G residues 2-58 - NMR

• • 2kwy - yATPS subunit G residues 61-101 - NMR
    

V-ATPase subunit H

1ho8 – yATPS subunit H
V-ATPase subunit K 2bl2, 2cyd - EhATPS subunit K – Enterococcus hirae
V-ATPase subunit I 3rrk – ATPS subunit I N terminal – Meiothermus ruber

• V-ATPase multi subunits

4dl0, 4efa - yATPase subunits C,G,E

3w3a - yATPS subunit A,B,D,F

• • 5tj5 - yATPS subunit A,C,C’,C’’,D,E,F
    
  • 5voz, 5voy, 5vox - yATPS subunit A,C,C’,C’’,D,E,F,H – Cryo EM
    
  • 6c6l - yATPS subunit A,C,C’,C’’,D,E,F + V0 assembly protein 1
    
  • 5bw9 - yATPS subunit A,B,D,E,G,H – Cryo EM
    
  • 5d80 - yATPS subunit A,B,D,E,F,G,H
    

3a5c, 3a5d - TtATPS subunit A,B,D,F

• • 5tsj - TtATPS subunit A,B,C,D,E,F,G + antibody - Cryo-EM
    
  • 5gas, 5gar - TtATPS subunit A,B,C,D,E,F,G,I - Cryo-EM
    
  • 5y60. 5y5z, 5y5y, 5y5x - TtATPS subunit A,B,C,D,E,F,I,K - Cryo-EM
    

3gqb - TtATPS subunit A (mutant),B (mutant)

3k5b - TtATPS subunit E (mutant)+C

• • 5knd, 5knc, 5knb - EhATPS subunit A,B,D,F
    

P-ATPaseP-ATPase

Cu+2 transporting ATPase

2kmv, 2kmx, 2arf, 2koy – hATPase NBD – human – NMR
2kij - hATPase actuator domain – NMR
1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR
1y3j, 1y3k - hATPase 5th soluble domain – NMR

• • 2ew9 - hATPase 5th+6th soluble domains – NMR
    

1s6o, 1s6u, 2lqb - hATPase 2nd soluble domain – NMR

1q8l - hATPase 2nd MBD – NMR
1aw0, 2aw0 - hATPase 4th MBD – NMR
1kvi, 1kvj - hATPase 1st MBD – NMR

• • 5t7l - hATPase 1st MBD + Cu transport protein
    

3dxs - AtATPase RAN1 MBD (mutant) – Arabidopsis thaliana

• • 5lbd – AtATPase PAA1 N-domain
    
  • 5lbk – AtATPase PAA2 N-domain
    

3voy - AfATPase – Archaeoglobus fulgidus – CryoEM

3skx, 3sky - AfATPase NBD
2k1r - hATPase MBD+ ATOX1 – NMR
2rop, 2g9o, 2ga7 - hATPase MBD – NMR
2rml - BsATPase N-terminal – Bacillus subtilis – NMR
2gcf - sATPase N-terminal - Synechocystis – NMR

• • 4a4j - sATPase N-terminal
    

4a48 - sATPase

2iye - SsATPase catalytic domain – Sulfolobus solfataricus
2yj3 - SsATPase catalytic domain (mutant)
2yj4, 2yj5, 2yj6 - SsATPase catalytic domain (mutant) + nucleotide
1fvq, 1fvs - hATPase – NMR
3cjk – hATPase + Cu transporting protein ATX1
3rfu, 4bbj, 4bev, 4byg – LpATPase – Legionella pneumophila
4f2f - ATPase metal-binding domain – Streptococcus pneumonia
3j08, 3j09 - AfATPase
3a1c – AfATPase + AMPPCP
3a1d - AfATPase + ADP-Mg
3a1e - AfATPase (mutant) + AMPPCP
Na/K transporting ATPase 3a3y - SaATPase+K+ouabain – Squalus acanthias
3kdp, 3b8e – pATPase – pig
3n23 – pATPase + ouabain

• • 3wgv, 3wgu – pATPase + oligomycin
    

3b8e - pATPase a+BeF3

2hc8 –AfATPase CopA A domain
2b8e - AfATPase CopA NBD
2xze - SaATPase

• • 5aw9, 5aw8, 5aw7, 5aw6, 5aw5, 5aw4, 5aw3, 5aw2, 5aw1, 5aw0, 5avz, 5avy, 5avx, 5avw, 5avv, 5avu, 5avt, 5avs, 5avr, 5avq – SaATPase + phospholemman-like protein
    
  • 4xe5 - bATPase
    

1mo8, 1mo7 - rATPase α-1 – rat

1q3i - pATPase NBD
4ret, 4res, 4hyt, 4hqj - pATPase subunits α,β,γ
2zxe - ATPase subunits α,β + phospholemman-like protein – spiny dogfish Ca+2 transporting ATPase 3fgo - rATPase+CPA+AMPPCP – rabbit
3b9r, 1xp5 - rATPase+AlF4
1wpg - rATPase+MgF4
3w5b - rATPase+Mg

• • 4h1w, 3w5a - rATPase+ sarcolipin
    

3w5c, 3w5d, 1iwo - rATPase

• • 4bew - rATPase+ phosphate analog
    

2zbe, 3b9b – rATPase+BeF3

2zbf - rATPase+BeF3+TG
2zbg - rATPase+AlF4+TG
2zbd, 3ar8 - rATPase+AlF4+nucleotide+Ca
3ar9 - rATPase+BeF3+nucleotide
2dqs, 3ar2, 1vfp, 4xou - rATPase+AMPPCP

• • 5a3r - rATPase + BeF3 + AMPPCP
    

2c88, 2c8k, 3ar4, 3ar3, 3ar5, 3ar7 - rATPase+nucleotide+TG

2ear, 2c8l - rATPase+TG
2agv - rATPase+TG+BHQ
4ycl - rATPase+CPA
2eat - rATPase+CPA+GT
3ar6 - rATPase+TNP-ADP+GT
2eau - rATPase+CPA+curcumin
3ba6 - rATPase phosphoenzyme intermediate
3fpb - rATPase+ATP+cyclopiazonic acid
3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid
2o9j - rATPase+MgF4+cyclopiazonic acid
1kju, 3n5k - rATPase E2 state
2c9m - rATPase Ca2E1 state
1t5s, 3n8g - rATPase Ca2E1 state+AMPPCP

• • 4nab - rATPase Ca2E1 state (mutant) +AMPPCP
    

1t5t - rATPase Ca2E1 state+ADP+AlF4

1su4 - rATPase +2Ca2
2by4, 2yfy, 3nal, 3nam, 3nan, 4uu1, 4uu0, 4j2t, 5a3s - rATPase HNE2 state+thapsigargin derivative

• • 5a3q - rATPase + thapsigargin derivative + AMPPCP
    
  • 4ycn, 4ycm - rATPase + macrolide
    
  • 4y3u - rATPase + phospholamban
    

Zn+2 transporting ATPase

2ofg, 2ofh - sATPase N-terminal – NMR

• • 4umw, 4umv - ATPase +Mg – Shigella sonni
    

K+ transporting ATPase

2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR
1svj, 1u7q - EcATPase NBD of KdpB – NMR
2ynr, 4ux2, 4ux1, 5y0b – pATPase – Cryo EM As+ transporting ATPase 1ii0, 1f48 - EcATPase
1ihu – EcATPase+Mg+ADP+AlF3
1ii9 - EcATPase
3h84, 3idq, 3a36, 3a37 - yATPase GET3

• • 4pwx, 5bwk - yATPase GET3 + golgi to ER traffic protein + ubiquitin-like protein
    
  • 5bw8 - yATPase GET3 + golgi to ER traffic protein + ubiquitin-like protein + protein
    
  • 4xwo - yATPase GET3 + antibody + Sec22
    
  • 4xvu - yATPase GET3 + antibody + NYV1
    
  • 4xtr - yATPase GET3 + antibody + pep12p
    

3sja, 3sjb, 3sjc, 3sjd, 3zs8, 3zs9, 3b2e, 3vlc - yATPase GET3 + GET1 cystolic domain

3ibg - ATPase GET3 – Aspergillus fumigatus H+ transporting ATPase 5ksd - AtATPase C terminal truncated
1mhs - ATPase – Neurospora crassa
Na+ transporting ATPase 2db4, 3aou - EhATPase subunit K – Enterococcus hirae
3aon - EhATPase subunits D,G
3vr2 - EhATPase subunits A,B
3vr4, 3vr5 - EhATPase subunits A,B,D,G
3vr3 - EhATPase subunits A,B + AMPPNP
3vr6 - EhATPase subunits A,B,D,G + AMPPNP
1yce - ATPase rotor ring – Ilyobacter tartaricus H/K transporting ATPase 1iwc, 1iwf - pATPase NBD
3ixz - pATPase a+AlF4
2xzb – pATPase subunits α, β
Mg+2 transporting ATPase 3gwi – EcATPase P-1 NBD Arg/ornithine transporting ATPase 3md0 – MtATPase+GDP – Mycobacterium tuberculosis
1kmh - ATPase alpha subunit+tentoxin – spinach
1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
1h8h - cATPase+ AMPPNP
1efr - cATPase+efrapeptin
3fks – yATPase
3ea0 – ATPase ParA, fragment – Chlorobium tepidum
2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse
3cf2 - mATPase NBD+ADP+AMP-PNP
2r31, 2p4x – PdATPase ATP12
2zd2 – PdATPase (mutant) ATP12
1d8s – EcATPase F1
1vdz – PhATPase subunit A – Pyrococcus horikoshii

• Monosaccharide transporting ATPase
  • 5dte – AsATPase – Actinobacillus succinogenes
    
  • 4zjp – AsATPase + ribopyranose
    

RNA-dependent ATPaseRNA-dependent ATPase

3eaq, 3i31, 3i32 – TtATPase fragment

• • 4kbg, 4kbf - TtATPase helicase core domain
    
  • 5mao - TtATPase RRM domain
    
  • 4i69, 4i68 - TtATPase RRM domain (mutant)
    
  • 4i67 - TtATPase RRM domain + RNA
    

3mwj – TtATPase N-terminal (mutant)

3mwk, 3nbf – TtATPase N-terminal + 8-oxo-AMP
3mwl - TtATPase N-terminal (mutant) + 8-oxoadenine
3nej - TtATPase reca-like domain (mutant)

• DNA-dependent ATPase
  • 5tnu - ATPase – Sulfolobus tokodaii
    
• ATP-dependent ATPase
  • 5txv – EcATPase subunit HSLU
    
  • 5ji3, 5ji2 – EcATPase subunits HSLU+HSLV
    

Proteasome-associated ATPaseProteasome-associated ATPase

3fp9, 3m9b, 3m9h – MtATPase intern domain

3m91, 3m9d - MtATPase coiled coil domain + protein PUP

• • 5kzf – MtATPase residues 98-609
    
  • 5kwa – MtATPase residues 22-529
    

3kw6 – hATPase 5

• • 6epf, 6epe, 6epd, 6epc – rATPase 6 + proteasome – Cryo EM
    

Transitional endoplasmic reticulum ATPaseTransitional endoplasmic reticulum ATPase

• • 5c19 – hTer-ATPase (mutant)
    

3hu1, 3hu2, 3hu3, 5ftn, 5ftm, 5ftl, 5ftk, 5ftj – hTer-ATPase + ATPGS

• • 4ko8, 4kln, 5dyg, 5c18 – hTer-ATPase (mutant) + ATPGS
    
  • 5dyi – hTer-ATPase + ADP
    
  • 4kod – hTer-ATPase (mutant) + ADP
    

3qc8, 3qq8, 3qwz - hTer-ATPase N terminal + FAS-associated factor 1

3qq7 - hTer-ATPase N terminal
3tiw - hTer-ATPase N terminal + E3 ubiquitin-protein ligase peptide

• • 5c1b - hTer-ATPase N terminal + UFD1--SHP peptide
    
  • 5glf - hTer-ATPase N terminal + derlin-1 peptide
    
  • 5epp - hTer-ATPase N terminal + rhomboid-related protein 4 peptide
    
  • 4kdl, 4kdi - hTer-ATPase N terminal + ubiquitin thioesterase OTU1
    
  • 5b6c - hTer-ATPase N terminal + ubiquitin fusion degradation protein
    
  • 5ifw, 5ifs - hTer-ATPase + tether containing UBX domain
    
  • 5x4l - hTer-ATPase + UBX domain-containing protein
    
  • 5kiy, 5kiw - hTer-ATPase (mutant) + Selenoprotein S
    
  • 1s3s - mTer-ATPase ND1 domain + P47 C terminal
    
  • 4rv0 - Ter-ATPase N terminal + nuclear protein localization protein – Drosophila melanogaster
    
• Sarcoplasmic/endoplasmic reticulum ATPase
  • 5xa7, 5xa8, 5xa9, 5xaa, 5xab – rATPase
    
  • 5ncq – rATPase + ATP derivative + carbazole derivative
    
  • 5mpm – pATPase
    

LAO/AO transport system ATPaseLAO/AO transport system ATPase

3nxs – ATPase – Mycobacterium smegmatis

DNA double-strand repair ATPase (Rad50)DNA double-strand repair ATPase (Rad50)

3aux – MjRad50 – Methanocaldococcus jannaschii

3auy - MjRad50 + ADP
3av0 - MjRad50 + ATP

• • 5f3w - MjRad50 + MRE11 + ATPGS
    
  • 5dny - MjRad50 + MRE11 + DNA
    

3qg5 – Rad50 NBD + MRE11 – Thermotoga maritima

3qkr, 3qks, 3qf7 - PfRad50 NBD + MRE11 – Pyrococcus furiosus

• • 4nck, 4nci, 4nch - PfRad50 NBD (mutant)
    
  • 4ncj - PfRad50 NBD (mutant) + BeF3 + ADP
    

3qkt - PfRad50 NBD + AMPPNP

3qku - PfRad50 NBD + AMPPNP + MRE11

MipZ ATPaseMipZ ATPase

2xit, 2xj4 – CcMipZ – Caulobacter crescentus

2xj9 – CcMipZ (mutant)

• ATPase Rava
  • 5fl2, 4upf – EcATPase LARA domain + lysine decarboxylase
    
  • 4upb – EcATPase + lysine decarboxylase – Cryo EM
    

3nbx – EcATPase Rava + ADP

FlaI ATPase 4ihq, 4ii7 – ATPase (mutant) – Sulfolobus acidocaldarius

• The RuvBL1/RuvBL2 complex (ATPase)
  • RuvBL1/RuvBL2 complex (ATPase) - Structural and functional insights into a dodecameric molecular machine