Heat Shock Protein structures: Difference between revisions

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*Hsp40 or DnaJ homolog subfamily C member 12
*Hsp40 or DnaJ homolog subfamily C member 12


**[[2qld]] – hHsp40<br />
**[[2qld]] – hHsp40 residues 158-340<br />
**[[1hdj]], [[2ctq]] – hHsp40 J domain - NMR<br />
**[[1hdj]], [[2ctq]] – hHsp40 J domain 1-76 - NMR<br />
**[[6u3r]], [[6u3s]] – hHsp40 1-127, 184-241 – NMR<br />
**[[1c3g]] – yHsp40 CT<br />  
**[[1c3g]] – yHsp40 CT<br />  
**[[5vso]] – yHsp40 J domain – NMR<br />
**[[5vso]] – yHsp40 J domain – NMR<br />
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**[[4pj1]] – hHsp60 + hHsp10<br />
**[[4pj1]] – hHsp60 + hHsp10<br />
**[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />


* Hsp60 - the large subunit of the chaperonin molecule GroEL  
* Hsp60 - the large subunit of the chaperonin molecule GroEL  
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**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[6rzy]] – PfHsp70 residues 81-148  – ''Plasmodium falciparum''<br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />


*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
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**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5hph]] – hHsp75 residues 60-554<br />
**[[5hph]] – hHsp75 residues 60-554<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]] – hHsp75 + inhibitor<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]] – hHsp75 + inhibitor<br />


*Hsp83
*Hsp83
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**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]] - hHsp90 NTD + inhibitor<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]] - hHsp90 NTD + inhibitor<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
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**[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
**[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
**[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
**[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
**[[3ied]] - PfHsp90 NTD+AMPPN – ''Plasmodium falciparum''<br />
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[3k60]] - PfHsp90 NTD+ADP<br />



Revision as of 13:37, 12 August 2020

3D Structures of Heat Shock Proteins3D Structures of Heat Shock Proteins

Updated on 12-August-2020

    • 4pj1 – hHsp60 + hHsp10
    • 6mrc, 6mrd – hHsp60 + hHsp10 + ADP – Cryo EM
  • Hsp60 - the large subunit of the chaperonin molecule GroEL
    • 3los – MmHsp60 - GroEL – Methanococcus maripaludis – closed state
    • 3iyf - MmHsp60 - GroEL – open state
    • 3e76 – EcHsp60 – GroEL+Tl ion – Escherichia coli
    • 2nwc, 1oel, 1grl, 1la1 - EcHsp60 – GroEL
    • 2eu1 - EcHsp60 (mutant) – GroEL
    • 2cgt - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31
    • 2c7c, 2c7d - EcHsp60 – GroEL+GroES – cryo EM
    • 1gr5 - EcHsp60 – GroEL – cryo EM
    • 1gru - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM
    • 1dkd - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide
    • 1dk7, 1jon - EcHsp60 – GroEL apical domain
    • 1kid - EcHsp60 (mutant) – GroEL apical domain
    • 1srv - TtHsp60 – GroEL apical domain
    • 4v4o - TtHsp60 – GroEL+GroES
    • 1ass, 1asx - Hsp60 – GroEL apical domain – Thermoplasma acidophilum
  • Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
    • 5bn8, 2e88, 1s3x, 1hjo, 6g3s, 6g3r, 6fhk – hHsp70 NBD
    • 5bn9, 5bpl, 5bpm, 5bpn – hHsp70 NBD (mutant)
    • 3a8y – hHsp70 NBD+BAG domain regulator protein
    • 4io8, 5aqw, 5aqx, 5aqy, 5aqz, 5ar0, 5mkr, 5mks - hHsp70 NBD + inhibitor
    • 6b1i - hHsp70 NBD + ADP
    • 6b1n - hHsp70 NBD (mutant) + ADP
    • 6b1m - hHsp70 NBD (mutant) + ANP
    • 2e8a - hHsp70 NBD+AMPPNP
    • 3jxu, 3i33, 3gdq, 3fe1 - hHsp70 NBD+ADP+P
    • 3iuc, 3atu, 3atv, 3ay9 - hHsp70 NBD+ADP
    • 3lof – hHsp70 CT
    • 4po2 - hHsp70 CT + peptide
    • 2lmg – hHsp70 CT - NMR
    • 3dob, 3dqg, 2op6 - CeHsp70 SBD – Caenoharbditis elegans
    • 4i2w – CeHsp70 + myosin chaperone
    • 2p32 - CeHsp70 CT
    • 1xqs – hHsp70 SBD + Hsp-binding protein core domain
    • 4j8f, 4wv5, 5xi9, 5gjj - hHsp70 SBD
    • 5xir - hHsp70 SBD (mutant)
    • 4wv7 - hHsp70 SBD + novolactone
    • 1hx1 - bHsp70 NBD + molecular chaperone regulator 1 BAG domain
    • 1q5l - EcHsp70 SBD +peptide - NMR
    • 3gl1 - ScHsp70 NBD – Saccharomyces cerevisiae
    • 2d2e, 3d2f – ScHsp70 NBD+SSE1(Hsp110)
    • 2v7y – Hsp70 NBD+SBD – Geobacillus kaustophilus
    • 3l6q - CpHsp70 NBD – Cryptosporidium parvum
    • 3kvg - CpHsp70 NBD+AMPPNP
    • 3l4i - CpHsp70 NBD+ADP+P
    • 6rzy – PfHsp70 residues 81-148 – Plasmodium falciparum
    • 6rzq – PfHsp70 NTD+ANP
    • 6s02 – PfHsp70 NTD+ADP
  • Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
    • 6cz1, 6dfm, 6dfo, 6do2, 6dws - hBIP ATPase domain + adenosine derivative 26-407
    • 6hab - haBIP (mutant) - hamster
    • 6h9u, 6ha7 - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster
  • DnaK (Hsp70 from E. coli) Domains: NBD 1-383; SBD 389-607
  • Hsp75

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman