Proteasome

Function Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. For more details see 3unb. Structural highlights The core particle two outer rings contain 7 α subunits (Y7, Y13, PRE6, PRE5, PUP2, C1, C7-α) which form the PRTS gate. The two inner rings contain 7 β subunits (PRE2, PRE4, PRE3, PUP1, PUP3, C5, C11) with protease activity. . of chain H. . 3D Structures of Proteasome Proteasome 3D structures

spinqualitylabelsall models Yeast proteasome 20S core complex with salinosporamide derivative, 3gpt Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Proteasome3D Structures of Proteasome

Updated on 28-November-2019

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• Proteasome 20S core
  • 4r3o, 5le5, 5lex – h20S core – human
    
  • 6rgq, 6r70 – h20S core – Cryo EM
    
  • 1iru – 20S core - bovine
    
  • 3une – m20S core – mouse
    
  • 3unh – m20S core (immuno)
    
  • 3gpt, 3gpw, 1g0u, 5cz4 – y20S core - yeast
    
  • 1ryp, 3wxr, 4qux, 4quy, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9, 4y8r, 4y9y, 4ya1, 4ya4, 5bxl, 5cgf, 5cza, 5d0w, 6hwc - y20S core (mutant)
    
  • 3c91, 3c92, 1pma, 3j9i, 5vy3, 6bdf, 5vy4 – Ta20S core - Themoplasma acidophilum - Cryo EM
    
  • 3h4p – 20S core – Methanocaldococcus janaschii
    
  • 2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
    
  • 1q5q - Re20S core
    
  • 1j2q – Af20S core - Archaeoglobus fulgidus
    
  • 6he7 – Af20S - Cryo EM
    
  • 6qm8 – Lt20S core – Leishmania tarentolae - Cryo EM
    
  • 6muw – Pf20S – Plasmodium falciparum - Cryo EM
    
  • 3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
    
  • 3mka, 3hfa – Mt20S core (mutant)
    
• Proteasome 20S+activator protein
  • 6rey – h20S + activator PA200 – Cryo EM
    
  • 4v7o, 5nif – y20S core+ Blm10
    
  • 1z7q, 1fnt – y20S core+PA26
    
  • 3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
    
  • 5lzp - Mt20S subunits a+b + BPA - Cryo EM
    
  • 6bgo, 6bgl – Mt20S + activator
    
  • 6mux, 6muv – Pf20S + activator PA28 - Cryo EM
    
  • 6hed, 6hec, 6hea, 6he9, 6he8, 6he5 – Af20S + PAN – Cryo EM
    
• Proteasome 20S+inhibitor
  • 4r67 – h20S + cancer drug
    
  • 5ley, 5lf0, 5lf1, 5lf3, 5lf4, 5lf7, 5lez, 5lf6, 6avo, 6e5b - h20S + inhibitor
    
  • 5a0q - h20S + substrate analog
    
  • 3unb, 3unf – m20S + inhibitor
    
  • 3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3shj, 3un4, 3un8, 3sdi, 3sdk, 4fzc, 4fzg, 4gk7, 4eu2, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r17, 4r18, 4rur, 5ahj, 4y69, 4y6v, 4y6z, 4y70, 4y74, 4y75, 4y77, 4y78, 4y7w, 4y7x, 4y7y, 4y80, 4y81, 4y82, 4y8g, 4y8h, 4y8i, 4y8j, 4y8k, 4y8l, 4y8m, 5dki, 5dkj, 5l52, 5l54, 5l55, 4y6a, 4y84, 4y8n, 4y8o, 4y8p, 4y8q, 4y8s, 4y8t, 4y8u, 4y9z, 4ya0, 4ya2, 4ya3, 4ya5, 4ya7, 4ya9, 5jhr, 5jhs, 5lai, 4r02, 2zcy, 5bou, 5laj, 6gop, 6hwb, 6hwa, 6hw9, 6hw8, 6hw7, 6hw6, 6hw5, 6hw4, 6hw3, 6hw0, 6hvy, 6hvx, 6hvw, 6hvv, 6hvu, 6hvt, 6hvs, 6hvr, 6hva, 6hv7, 6hv5, 6hv4, 6hv3, 6huv, 6huu, 6huq, 6huc, 6hub, 6htr, 6htp, 6htd, 6htc, 6htb, 6h39 – y20S core+inhibitor
    
  • 4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02, 5cgg, 5cgh, 5cgi, 5d0t, 5fgh, 6hwf, 6g8n, 6g8m, 6g7f – y20S (mutant) + inhibitor
    
  • 4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s - y20S core + antibiotics
    
  • 4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9, 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - y20S core+ peptide inhibitor
    
  • 5cz6, 5cz7 - y20S (mutant) + peptide inhibitor
    
  • 3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
    
  • 3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
    
  • 4qvl, 4qw4, 4z1l, 3tdd, 4j70 – y20S + cancer drug
    
  • 4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu, 5cz8, 5cz9, 5fgd, 5fge, 5fgf, 5fgg, 5fgi, 5fhs, 5d0z, 5d0x, 5d0v, 5d0s, 5cz5, 5bxn, 6hwe, 6hwd - y20S (mutant) + cancer drug
    
  • 4x6z - y20S + modulator
    
  • 5gjq - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin
    
  • 5l5a - y20S + h20S beta5i
    
  • 5ltt - y20S + h20S beta5i + inhibitor
    
  • 5l5b, 5l5r - y20S + h20S beta5i + h20S beta6
    
  • 5l5w - y20S + h20S beta5c + h20S beta6
    
  • 5l5x, 5l60, 5l61 - y20S + h20S beta5c + h20S beta6 + inhibitor
    
  • 5l5y, 5l5z - y20S + h20S beta5c + h20S beta6 + cancer drug
    
  • 5l5d, 5l5h, 5l5q, 5l5i, 5l5j, 5l5o, 5l5p, 5l5s, 5l5t, 5l5u, 5l5v, 5l62, 5l63, 5l64, 5l68, 5l69, 5l6a, 5l6c, 5m2b - y20S + h20S beta5i + h20S beta6 + inhibitor
    
  • 5l5e, 5l5f - y20S + h20S beta5i + h20S beta6 + cancer drug
    
  • 5l65, 5l66 - y20S + m20S beta5i + m20S beta6 + cancer drug
    
  • 5l67, 5l6b - y20S + m20S beta5i + m20S beta6 + inhibitor
    
  • 5fmg - Pf20S + inhibitor - Plasmodium falciparum - Cryo EM
    
  • 5trr, 5trs, 5try, 5ts0, 5tho, 5trg - Mt20S + peptide
    
  • 3h6f, 3h6i, 3hf9, 2fhh, 3krd, 6ode, 6ocz, 6ocw – Mt20S core+inhibitor
    
  • 6qm7 – Lt20S + leishmania drug – Cryo EM
    
• Proteasome partial 20S particle
  • 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
    
  • 2ku1, 2ku2 – Taa-PRTS chains A-G
    
  • 3fp9 – MtATPase chains A-L
    
  • 1j2p – AfPRTS α subunit
    
  • 2jay – MtPRTS β subunit
    
  • 5nyw – PRTS β subunit – Yersinia bercovieri
    
• Proteasome partial 26S particle
  • 5l4k - hPRTS lid - CryoEM
    
  • 5dsv - hPRTS subunit a type-3
    
  • 1p9c – hPRTS subunit 4 C-terminal
    
  • 1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
    
  • 1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
    
  • 1yx4 - hPRTS subunit 4 – NMR
    
  • 1yx5, 1yx6, 2kde, 2kdf, 6mun - hPRTS subunit 4+ubiquitin – NMR
    
  • 2o95, 2o96 - hPRTS subunit 7
    
  • 3kw6 - hPRTS subunit 8
    
  • 2krk - hPRTS subunit 8 – NMR
    
  • 1qym, 1uoh - hPRTS subunit 10
    
  • 1tr4 - hPRTS subunit 10 – NMR
    
  • 4nik - hPRTS subunit 10 + single-chain Fv
    
  • 3t5x - hPRTS subunit Dss1 + PCI domain-containing protein 2
    
  • 2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
    
  • 3aji - mPRTS subunit 10 + subunit 4
    
  • 2z59 - mPRTS subunit RPN13+ubiquitin
    
  • 2x5n - PRTS subunit RPN10 VWA domain – fission yeast
    
  • 4ady - yPRTS subunit RPN2
    
  • 5zmr - yPRTS subunit RPN5 N terminal – NMR
    
  • 3vlf - yPRTS subunit 7 + DNA mismatch repair protein
    
  • 4o8x, 4o8y, 5w83, 4owp - yPRTS subunit RPN8 + RPN11
    
  • 4ocl, 4ocm, 4ocn - yPRTS subunit RPN8 + RPN11 + nanobody
    
  • 5u4p - yPRTS subunit RPN8 + RPN11 + S31
    
  • 2mr3 - yPRTS subunit RPN9 – NMR
    
  • 2mqw - yPRTS subunit RPN9 N terminal – NMR
    
  • 2mri - yPRTS subunit RPN9 C terminal – NMR
    
  • 5ln1 - yPRTS subunit RPN10 + polyubiquitin
    
  • 4b0z - yPRTS subunit RPN12
    
  • 2z4d - yPRTS subunit RPN13
    
  • 3vl1 - yPRTS subunit RPN14 (mutant)
    
  • 3t5v, 5l3t, 5g5p, 4trq - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /
  • 3txm, 3txn – PRTS subunit P42B – Drosophila melanogaster
    
  • 5ubp - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator
    
• Proteasome 26S particle
  • 5l4g, 5gjr, 5ln3, 5t0c, 5t0g, 5t0h, 5t0i, 5t0j, 5vhs, 5vhr, 5vhq, 5vhp, 5vho, 5vhn, 5vhm, 5vhj, 5vhi, 5vhh, 5vhf, 5vgz, 5vft, 5vfr, 5vfo - hPRTS - Cryo EM
    
  • 5m32 - hPRTS + inhibitor - Cryo EM
    
  • 6epf, 6epe, 6epd, 6epc – PRTS – rat - Cryo EM
    
  • 3j47, 4cr2, 4cr3, 4cr4, 5wvi, 5mpc – yPRTS – Cryo EM
    
  • 5wvk - yPRTS + ADP - Cryo EM
    
  • 5mp9, 5mpa, 5mpd, 5mpe - yPRTS + ATP - Cryo EM
    
  • 5mpb - yPRTS + AMPPNP - Cryo EM
    
  • 4g4s – yPRTS + proteasome assembly chaperon 1 & 2
    
  • 5a5b - yPRTS + UBP6 - Cryo EM
    
  • 6ef3, 6ef2, 6ef1, 6ef0 – yPRTS + ubiquitin-L40 – Cryo EM