Transcriptional activator

Function Transcriptional activators (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD). Structural highlights TA contains 3 domains: DBD, trans-activating domain (TAD) which binds coregulator proteins and an optional ligand-binding domain (LBD) which senses external signals. (PDB entry 1h89). . . Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of transcriptional activator C-Myb DNA-binding domain (deeppink) complex with DNA, CAAT/enhancer binding protein β (cyan and green) and K+ ion (purple) (PDB entry 1h89) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of transcriptional activator3D Structures of transcriptional activator

Updated on 25-September-2019

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• Gcn4 transcriptional activator see Gcn4
• Gcn5 transcriptional activator
  • 1e6i – yTA brododomain + histone H4 peptide - yeast
    
  • 1ygh – yTA histone acetyltransferase domain
    
• C-Myb transcriptional activator; domains - DBD repeat 1 38-89; DBD repeat 2 90-141; DBD repeat 3 142-193; TAD 291-315
  • 1mse, 1msf – mTA DBD repeat 1,2 + DNA - NMR
    
  • 1mbe, 1mbf – mTA DBD repeat 1 + DNA – mouse - NMR
    
  • 1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
    
  • 1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
    
  • 1h88 – mTA DBD repeat 1,2,3 + DNA + CCAAT/enhancer binding protein β
    
  • 1h89 – mTA DBD repeat 1,2,3 + DNA + CAAT/enhancer binding protein β
    
  • 1guu – mTA DBD repeat 1
    
  • 1gv2 – mTA DBD repeat 2,3
    
  • 1gv5 – mTA DBD repeat 2
    
  • 1gvd – mTA DBD repeat 2 (mutant)
    
  • 1idy, 1idz – mTA DBD repeat 3 (mutant) - NMR
    
  • 1sb0, 2agh – mTA TAD + CREB-binding protein - NMR
    
  • 2agh – mTA TAD + CREB-binding protein + HRX - NMR
    
  • 6dmx, 6dnq – mTA TAD + CREB-binding protein + BZIP factor
    
• Psp operon transcriptional activator
  • 2bjw – EcTA AAA domain – Escherichia coli
    
  • 2bjv, 2c9c, 4qnm – EcTA AAA domain (mutant)
    
  • 2c96 – EcTA AAA domain + ATP
    
  • 4qnr – EcTA AAA domain (mutant) + ATP
    
  • 4qos – EcTA AAA domain (mutant) + ADP
    
  • 2c98 – EcTA AAA domain + ADP
    
  • 2c99 – EcTA AAA domain + AMPPNP
    
  • 2vii – EcTA AAA domain + AMP + Mg
    
  • 5nss – EcTA AAA domain + RNAP subunits αββ'ω + DNA - Cryo EM
    
• TenA transcriptional activator
  • 1tyh, 1yaf – BsTA – Bacillus subtilis
    
  • 2qzc – TA – Sulfolobus solfataricus
    
  • 3no6 – TA – Staphylococcus epidermidis
    
  • 1yak – BsTA + pyrimidine derivative
    
  • 2qcx – BsTA (mutant) + pyrimidine derivative
    
• LasR transcriptional activator
  • 2uv0 – PaTA LBD – Pseudomonas aeruginosa
    
  • 3ix3 – PaTA LBD + oxo-dodecanoyl-homoserine lactone
    
  • 3ix4, 3ix8, 3jpu, 6d6a, 6d6b, 6d6c, 6d6d, 6d6l, 6d6m, 6d6n, 6d6o, 6d6p – PaTA LBD + benzoate derivative
    
  • 4ng2 – PaTA LBD + protein
    
• CadC transcriptional activator; domains - DBD 1-107; periplasmic 188-512
  • 3ly7, 3lya – EcTA periplasmic domain
    
  • 3ly8, 3ly9 – EcTA periplasmic domain (mutant)
    
  • 5ju7 – EcTA DBD domain
    
• CynR transcriptional activator
  • 2hxr – EcTA LBD
    
  • 3hfu – EcTA LBD + N3
    
• Mal-Rpel transcriptional activator
  • 2v51, 2v52 – mTA residues 16-41 + actin
    
  • 2yje, 2yjf – mTA Rpel domain + actin
    
• Brg1 transcriptional activator
  • 5ea1 – hTA bromodomain - human
    
  • 3uvd – hTA bromodomain + pyrrolidone derivative
    
  • 5dkd – hTA bromodomain + pyridine derivative
    
• VP30 transcriptional activator
  • 2i8b – TA C terminal – Zaire ebolavirus
    
  • 3v7o – TA C terminal – Reston ebolavirus
    
• TraR transcriptional activator
  • 1v4r – AtTA N-terminal - Streptomyces - NMR
    
  • 1l3l – AtTA + pheromone + DNA – Agrobacterium tumefaciens
    
  • 1h0m – AtTA + auto-inducer + DNA
    
  • 5w1s – EcTA + RNAP subunits αββ'ω + PROD + DNA
    
• Flagelar transcriptional activator
  • 1g8e – EcTA FLHD
    
  • 2avu – EcTA FLHC+FLHD
    
• TipA transcriptional activator
  • 1ny9 – SlTA antibiotic binding domain – Streptomyces lividans - NMR
    
  • 2mbz, 2mc0 - SlTA antibiotic binding domain + thiopeptide - NMR
    
  • 2vz4 – SlTA DBD + DNA
    
• MtaN transcriptional activator
  • 1r8d, 1jbg – BsTA N-terminal
    
  • 4p54 – TA (mutant) - Helicobacter pylori
    
• RfaH transcriptional activator
  • 2oug – EcTA
    
  • 2lcl – EcTA C terminal - NMR
    
  • 5ond – EcTA (mutant) + DNA
    
• SoxR transcriptional activator
  • 2zhh – EcTA
    
  • 2zhg – EcTA + DNA
    
• AmpR transcriptional activator
  • 3kos – CfTA effector binding domain – Citrobacter freundii
    
  • 3kot – CfTA effector binding domain (mutant)
    
  • 4wkm – CfTA effector binding domain + peptide
    
  • 5mmh – PaTA effector binding domain
    
• GlxR transcriptional activator
  • 4byy – CgTA – Corynebacterium glutamicum
    
  • 3r6s, 4cyd – CgTA + cAMP
    
• OxyR transcriptional activator
  • 3t22, 3ho7, 3uki – TA regulatory domain – Porphyromonas gingivalis
    
  • 3jvt – TA – Neiserria meningitidis
    
  • 4x6g – PaTA (mutant)
    
  • 4y0m – PaTA regulatory domain
    
  • 4xws – PaTA regulatory domain (mutant)
    
  • 5x0v – VvTA-2 regulatory domain - Vibrio vulnificus
    
  • 5x0q, 5b70, 5b7d, 5b7h – VvTA-2 regulatory domain (mutant)
    
• PlcR transcriptional activator
  • 4fsc – BtTA - Bacillus thuringiensis
    
  • 2qfc – BtTA + PAPR peptide
    
  • 3u3w – BtTA + DNA + PAPR peptide
    
• VirB transcriptional activator
  • 3vwb, 3w2a, 3w3c – TA core domain + DNA – Shigella flexneri
    
• MafA transcriptional activator
  • 4eot – hTA DBD
    
• CysB transcriptional activator
  • 4gwo, 4gxa, 4lon, 4lp2 – StTA C terminal – Salmonella typhimurium
    
  • 4lq2, 4lq5, 4m4g – StTA C terminal + acetylserine
    
  • 1al3 – TA cofactor binding domain – Klebsiella aerogenes
    
• HlyU transcriptional activator
  • 4k2e, 4ooi – TA - Vibrio cholerae
    
  • 3jth – VvTA
    
• Aft2 transcriptional activator
  • 4lmg – yTA + DNA