Potassium channel 3D structures

3D structures of Potassium Channels3D structures of Potassium Channels

Updated on 27-November-2019

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• Potassium Channel
  • 2pnv – rKCh leucine zipper domain SKCa – rat
    
  • 3lut - rKCh Kv1.2 (mutant)
    
  • 1dsx - rKCh N-terminal (mutant)
    
  • 1qdv, 1qdw - rKCh Kv1.2 N-terminal
    
  • 1kn7 - rKCh Kv1.4 N-terminal (mutant) - NMR
    
  • 1nn7 - rKCh Kv4.2 N-terminal T1 domain
    
  • 5wie - rKCh β-2 (mutant)
    
  • 3eau - rKCh β-2 +cortisone
    
  • 3eb3, 3eb4 - rKCh β-2 (mutant) + cortisone
    
  • 6ci1 - rKCh β-2.1 – Cryo EM
    
  • 4hoi – mKCh Kv10.1 PAS domain – mouse
    
  • 4llo – mKCh EAG1
    
  • 5u76, 5u70, 5a6g, 5a6f, 5a6e – cKCh SLO2.2 – chicken – CryoEM
    
  • 1wlj, 2wlh, 2wli, 2wlj, 2wlm, 2wln, 2wlo - MmKCh - Magnetospirillum magnetoacticum
    
  • 2k44 – KCh voltage-sensor paddle domain – NMR
    
  • 3e86, 3e83 – BcKCh transmembrane domain – Bacillus cereus
    
  • 3e8g, 3e89, 3e8b, 3e8f, 3e8h, 6dz1, 6cpv – BcKCh transmembrane domain +ions
    
  • 4r8c, 4r50, 2ahz, 2ahy, 4rai, 2q67, 2q68, 2q69, 2q6a, 3ouf, 4pdv, 4pdr, 4pdl, 4pdm, 4ro2, 4r7c, 4r6z – BcKCh transmembrane domain (mutant) + ion
    
  • 4pdv, 4pdr, 4pdl, 4pdm – BcKCh (mutant)
    
  • 1bl8, 1f6g - SlKCh Kcsa (mutant) - Streptomyces lividans
    
  • 2qto - SlKCh Kcsa
    
  • 1j95 - SlKCh Kcsa +K+tetrabutylammonium
    
  • 1jvm - SlKCh Kcsa (mutant)+Rb+tetrabutylammonium
    
  • 1jq1, 1jq2 - SlKCh Kcsa inner transmembrane segment - NMR
    
  • 3ifx - SlKCh Kcsa pore domain
    
  • 1a68, 1eod, 1eoe, 1eof, 3kvt - AcKCh Kv1.1 T1 domain (mutant) - Aplysia californica
    
  • 1t1d - AcKCh Kv1.1 T1 domain
    
  • 6eo1 - MlotiK1 + K – Mesorhizobium loti
    
  • 3co2, 1vp6 - MlotiK1 cyclic nucleotide binding domain - Mesorhizobium loti
    
  • 1ho2, 1ho7 - DmKCh L45 segment - Drosophila melanogaster - NMR
    
  • 2kyh - AeKCh voltage ensing domain - Aeropyrum pernix - NMR
    
  • 2wll - KCh KIRBAC1.1 - Burkholderia pseudomalie
    
  • 1bei - KCh Kv1.3 – Stichodactyla helianthus
    
• Potassium channel complex with protein
  • 2i2r - rKCh Kv4.3 N-terminal+KV channel interacting protein 1
    
  • 1s6c - rKCh Kv4.2 N-terminal+KV channel interacting protein 1
    
  • 2a79, 1qrq - rKCh Kv1.2 + beta2
    
  • 4jta, 4jtc, 4jtd - rKCh Kv1.2-2.1 + KCh toxin
    
  • 2r9r - rKCh Kv2.1/KCh Kv1.2 + Kv β-2
    
  • 1exb - rKCh Kv1.1 T1 domain + KV beta2 protein
    
  • 2p7t - rKCh + FAV
    
  • 3lnm, 6ebl, 6ebk - rKCh Kv2.1/KCh Kv1.2 (mutant)
    
  • 5k7l - rKCh EAG1 + calmodulin
    
  • 6pbx, 6pby - rKCh EAG1 + calmodulin – Cryo EM
    
  • 3eff - mKCh + FAB
    
  • 2w0f - mKCh + FAB + tetraoctylammonium
    
  • 2hg5, 2h8p, 2hfe - KCh + mFAB
    
  • 3f7v, 3f7y, 3fb5, 3fb7, 3fb8, 3gb7, 3hpl, 3iga, 3or6, 3or7, 1r3i, 1r3j, 1r3k,1r3l, 1s5h, 2atk, 2bob, 2boc, 2dwd, 2dwe, 2hvj, 2hvk, 2ih1, 2ih3, 2itc, 2itd, 2jk5, 2nlj - mKCh (mutant) + FAB
    
  • 3f5w, 1zwi, 2hjf - mKCh (mutant) + antibody heavy+light chains
    
  • 5vms - KCh Kv7.1 + calmodulin - frog
    
  • 3pjs, 5j9p, 4uuj, 4msw, 5vkh, 5vke, 5vk6 – SlKCh Kcsa + antibody
    
  • 1k4c, 1k4d, 4lcu, 5ec2, 5ec1, 5ebw, 5ebm, 5ebl, 5e1a, 4lbe, 6pa0, 6nfu, 6nfv - SlKCh Kcsa (mutant) + antibody
    
  • 2a9h - SlKCh Kcsa (mutant) + charybdotoxin
    
  • 6by2, 6by3 - KCh Kcsa (mutant) + antibody – Streptomyces coelicolor
    
  • 2a0l - AeKCh + FV
    
  • 1orq - AeKCh (mutant) + FAB
    
  • 5hu3, 5h9b, 5fg8 - DmKCh EAG + CAMKII
    
• Human potassium Channel
  • 1b4g, 1b4i - hKCh inactivation domain - human - NMR
    
  • 1byw - hKCh ERG N-terminal (mutant)
    
  • 4hqa, 4hp9 - hKCh ERG PAS domain
    
  • 1ujl - hKCh ERG1 extracellular linker - NMR
    
  • 2l1m, 2l4r, 2l0w - hKCh HERG - NMR
    
  • 1s1g - hKCh Kv4.3 T1 domain
    
  • 2nz0 – hKCh Kv4.3 N-terminal+KV channel interacting protein 1
    
  • 2ovc - hKCh Kv7.4 T1 domain
    
  • 3bj4 - hKCh Kv7.1 C-termianl
    
  • 3hfc, 3hfe - hKCh Kv7.1 (mutant)
    
  • 5va2, 5va1 – hKCh Kv11.1 - CryoEM
    
  • 5va3 – hKCh Kv11.1 (mutant) - CryoEM
    
  • 1zsx - hKCh β-2
    
  • 5j7e – hKCh EAG1 PAS domain
    
  • 1ztn – hKCH RAW3 inactivation gate – NMR
    
  • 1zto - hKCH RCK4 inactivation gate – NMR
    
  • 4v0c - hKCh Kv7.1 + calmodulin
    
  • 4umo - hKCh Kv7.1 (mutant) + calmodulin
    
  • 5j03, 6feh, 6feg - hKCh Kv7.2 + calmodulin
    
  • 6b8p, 6b8n, 6b8m, 6b8l, 6n5w - hKCh Kv7.4 + calmodulin
    
  • 6b8q - hKCh Kv7.5 + calmodulin
    
  • 6rv2 - hKCh TASK-1
    
  • 6rv3, 6rv4 - hKCh TASK-1 + inhibitor
    
• Inward rectifier KCh
  • 6c3p, 6c3o - hIRK 11 + SUR1 + ATP + ADP – Cryo EM
    
  • 6baa - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 3ukm – hIRK TWIK-1
    
  • 3um7 – hIRK TRAAK
    
  • 4ruf, 4rue - hIRK TRAAK (mutant)
    
  • 4wfh, 4wfg, 4wfe, 4wff - hIRK TRAAK + antibody
    
  • 4i9w - hIRK TRAAK (mutant) + antibody
    
  • 6pz9, 6pza, 5twv - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 1u4f,3agw - mIRK 2 cytoplasmic domain
    
  • 2xky - mIRK 2 cytoplasmic domain - EM
    
  • 2gix, 3vsq - mIRK 2 cytoplasmic domain (mutant)
    
  • 2e4f - mIRK 2 fragment
    
  • 1n9p, 1u4e - mIRK 1 cytoplasmic domain
    
  • 3k6n - mIRK 1 cytoplasmic domain (mutant)
    
  • 5um4 - mIRK 3.1 (mutant)
    
  • 3at8, 3at9, 3ata, 3atb, 3atd, 3ate, 3atf, 3auw, 3syo - mIRK 3.2
    
  • 3syc, 3syp - mIRK 3.2 (mutant)
    
  • 3sya - mIRK 3.2 + PIP2
    
  • 3syq - mIRK 3.2 (mutant) + PIP2
    
  • 4kfm - mIRK 3.2 + guanine nucleotide-biding protein
    
  • 5wua, 5twv - mIRK 11 + SUR1 - Cryo EM
    
  • 5ywc, 5ywb - mIRK 11 + SUR1 + ADP – Cryo EM
    
  • 5ywa, 5yw9, 5yw8 - mIRK 11 + SUR1 + ATP – Cryo EM
    
  • 5ykg, 5ykf, 5yke, 6jb1 - mIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 6m85 – cIRK 2.2
    
  • 3spj, 6m86 – cIRK 2.2 (mutant)
    
  • 3spc – cIRK 2.2 + DGPP
    
  • 3spg, 3sph, 5kum, 5kuk, 6m84 – cIRK 2.2 (mutant) + PIP2
    
  • 3spi – cIRK 2.2 + PIP2
    
  • 1xl4, 1xl6, 2wlk, 2x6a, 2x6b, 2x6c - MmIRK KIRBAC3.1
    
  • 4lp8 - MmIRK KIRBAC3.1 (mutant)
    
  • 3zrs – MmIRK 10
    
  • 1p7b - BpIRK C-terminal
    
• Outward rectifier KCh
  • 4twk – hKCh TREK-1
    
  • 4bw5, 4xdj – hKCh TREK-2
    
  • 4xdl, 4xdk – hKCh TREK-2 + Prozac derivative
    
  • 6cq9, 6cq8, 6cq6 – mKCh TREK-1 (mutant)
    
• MthK
  • 2ogu, 2fy8, 2aej, 2aem, 1lnq, 4ro0 - MthK RCK domain - Methanobacterium thermoautrophicum
    
  • 3ldc, 3ldd, 3lde, 3ous – MthK residues 28-99 (mutant)
    
  • 4qe9, 4qe7 - MthK residues 18-100 (mutant)
    
  • 2aef, 3kxd, 4ei2, 4l73, 4l74, 4l75, 4l76 - MthK RCK domain + Ca
    
  • 3rbx, 3rbz - MthK RCK domain (mutant) + Ca
    
  • 3r65, 4hyo, 4hz3 – MthK pore domain (mutant)
• Large conductance calcium-activated KCh
  • 3mt5 - hBK cytoplasmic domain
    
  • 1jo6 - BK beta 2 N-terminal KCNMB2 encoded LKCa - NMR
    
  • 3u6n – BK – Danio rerio
    
  • 5tji, 5tj6 – AcBK - CryoEM
    
• Potassium/Sodium channel
  • 3k03, 3k04, 3k06, 3k08, 3k0d, 3k0g – BcNaK
    
  • 3t1c, 3t2m, 3t4d, 3t4z, 3tcu, 3tet – BcNaK (mutant)
• Calcium-activated KCh
  • 3naf – hKCh α1 subunit
    
  • 4hpf - hKCh α 3 subunit
    
  • 5y7l - hKCh β 4 subunit extracellular loop
    
• Small conductance calcium-activated KCh; Domains - calmodulin-binding 395-487; leucine zipper 488-526
  • 6ale, 5v03, 5v02 - hKCh SKCa2 calmodulin-binding domain + calmodulin
    
  • 5wc5, 5wbx - hKCh SKCa2 calmodulin-binding domain (mutant) + calmodulin
    
  • 1kkd – rKCh calmodulin-binding domain - NMR
    
  • 3sjq, 4g27, 4g28, 4j9y, 4j9z, 1g4y, 4qnh, 1qx7, 6czq - rKCh calmodulin-binding domain + calmodulin
    
  • 2pnv – rKCh leucine zipper domain SKCa
    
• Intermediate conductance calcium-activated KCh
  • 6cno, 6cnn, 6cnm - hKCa 3.1 + calmodulin – Cryo EM
    
  • 6d42- rKCa 3.1 C terminal
    
• Potassium/Sodium hyperpolarization-activated cyclic nucleotide-gated channel or cyclic nucleotide-gated channel or HCN channel see Ion channels