Aminoacyl tRNA Synthetase

Aminoacyl tRNA synthetase (aaRS) or tRNA ligase catalyzes the esterification of a specific amino acid to its cognate tRNA to form an aminoacyl-tRNA. The amino acid is transferred by the ribosome from the aminoacylated-tRNA onto a growing polypeptide chain. Class I of aaRS is a monomer or dimer, it has 2 highly conserved sequence motifs and it aminoacylates at the 2’-OH of an adenosine nucleotide. Class II of aaRS is a dimer or tetramer, it has 3 highly conserved sequence motifs and it aminoacylates at the 3’-OH of an adenosine nucleotide. CP1 domain of RS edits a mischarged aa-tRNA. Some of the crystal structures are complexes of the RS with their reactant analog: amino acid-sulfamoyl adenine (aa-SA).. For leucine-RS details see Leucyl-tRNA Synthetase. For pyrrolysyl-RS of pyrrolysine-tRNA ligase details see Pyrrolysyl-tRNA synthetase, Pyrrolysine. 3D Structures of Aminoacyl tRNA synthetase Aminoacyl tRNA synthetase 3D structures

spinqualitylabelsall models Arginine tRNA synthetase complex with Arg-tRNA 1f7v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Aminoacyl tRNA synthetase3D Structures of Aminoacyl tRNA synthetase

Updated on 12-March-2019

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• Class I aaRS
• Arg-RS
  • 1bs2 – yArgRS
    
  • 3gdz – ArgRS residues 1-106 – Klebsiella pneumoniae
    
  • 1iq0 – TtArgRS - Thermus thermophilus
• Arg-RS + tRNA
  • 2zuf - PhArgRS + Arg-tRNA - Pyrococcus horikoshii
    
  • 1f7v - yArgRS + Arg-tRNA
• Arg-RS ternary complex
  • 1f7u – yArgRS + Arg-tRNA + Arg
    
  • 2zue – PhArgRS + Arg-tRNA + ATP analog
• Cys-RS
  • 1li5 - EcCysRS - Escherichia coli
    
  • 1li7 - EcCysRS + Cys
    
  • 1u0b – EcCysRS + Cys-tRNA
• Gln-RS
  • 1nyl– EcGlnRS
    
  • 2gls, 1lgr – StGlnRS – Salmonella typhimurium
    
  • 4p2b – GlnRS catalytic domain – Toxoplasma gondii
    
  • 2lgs – StGlnRS + Glu
    
  • 1qrt, 1qru, 1qrs - EcGlnRS (mutant) + Gln-tRNA
    
  • 1gtr, 1gts, 1gsg - EcGlnRS + Gln-tRNA
    
  • 1qtq - EcGlnRS + Gln-tRNA + Gln analog
• Gln-RS ternary complex
  • 1euq, 1euy – EcGlnRS + Gln-tRNA + Gln-SA
    
  • 1exd - EcGlnRS + Gln-tRNA (mutant) + AMP
• Glu-RS
  • 1gln – TtGluRS
    
  • 2o5r - TmGluRS
    
  • 3aii – GluRS – Methanothermobacter thermautotrophicus
    
  • 2ja2 – MtGluRS – Mycobacterium tuberculosis
    
  • 4a91 – EcGluRS
    
  • 2hz7 – DrGluRS – Deinococcus radiodurans
    
  • 2hra – yGluRS N-terminal

• Glu-RS + small substrates or analogs
  • 3afh - TmGluRS + Glu-AMP analog
    
  • 2rd2, 2re8 – EcGluRS (mutant) + Glu-SA
    
  • 2cuz – TtGluRS + Glu
    
  • 1j09 - TtGluRS + Glu + ATP
    
  • 1n75 - TtGluRS + ATP
    
  • 2fco - GluRS residues 2-485 + Glu – Synechococcus elongatus
• Glu-RS + tRNA
  • 1zjw – EcGluRS + Glu-tRNA
• Glu-RS ternary complex
  • 3akz, 3al0 – TmGluRS + tRNA + Glu-AMP analog – Thermotoga maritima
    
  • 1o0b, 1o0c - EcGluRS + Glu-tRNA + Glu + AMP
    2cv0, 1n77 - TtGluRS + Glu + Glu-tRNA
    
  • 1n78 - TtGluRS + Glu-ol + Glu-tRNA
    
  • 2cv1 - TtGluRS + Glu-ol + ATP + Glu-tRNA
    
  • 2cv2 - TtGluRS + Glu-SA + Glu-tRNA
    
  • 2hrk, 2hsm - yGluRS N-terminal + GU4 nucleic-binding protein 1
    
  • 5bmu – hGluRS GST-like domain + EPRS-AIMP3
    
• Ile-RS
  • 1ile - TtIleRS
    
  • 1wny, 1udz – TtIleRS editing domain
• Ile-RS + small substrates or analogs
  
  • 1ue0 - TtIleRS editing domain + Val
    
  • 1wnz - TtIleS editing domain + Val-adenylate
    
  • 1wk8 - TtIleRS editing domain + Val-SA
    
  • 1jzq – TtIleS + Ile-adenylate analog
    
  • 1jzs – TtIleS + antibiotic
• Ile-RS ternary complex
  
  • 1ffy, 1qu2, 1qu3 - SaIleRS + Ile-tRNA + antibiotic - Staphylococcus aureus
• Leu-RS
  • 3o0a – AaLeuRS hydrolytic domain – Aquifex aeolicus
    2wfd – hLeuRS editing domain – human
    
  • 2wfe - CaLeuRS editing domain – Candida albicans
    
  • 2ajg - EcLeuRS editing domain
    
  • 1wkb – PhLeuRS residues 1-810
• Leu-RS + small substrates or analogs
  
  • 2wfg - CaLeuRS editing domain + benzoxaborole-AMP
    
  • 2v0c – TtLeuRS + Leu-SA + benzoxaborole-AMP
    
  • 1h3n - TtLeuRS + Leu-SA
    
  • 1obc, 1obh – TtLeuRS + substrate analog
    
  • 2ajh, 2aji - EcLeuRS editing domain + aa
• Leu-RS + tRNA
  
  • 1wz2 – PhLeuRS Leu-tRNA
• Leu-RS ternary complex
  
  • 2v0g - TtLeuRS + Leu-tRNA + benzoxaborole-AMP
    
  • 2bte, 2byt - TtLeuRS + Leu-tRNA + Leu
• Lys-RS
  • 1irx – PhLysRS
    
  • 1bbw – EcLysRS
    
  • 1krs, 1krt – EcLysRS anticodon-binding domain – NMR
    
  • 3dsq – DhLysRS – Desulfitobacterium hafniense
    
  • 3bju – hLysRS residues 70-579
• Lys-RS + small substrates or analogs
  
  • 3a74 – GsLysRS + diadenosine tetraphosphate – Geobacillus stearothermophilus
    
  • 3e9h, 3e9i – BsLysRS + Lys-SA - Bacillus stearothermophilus
    
  • 1bbu, 1e10, 1lyl – EcLysRS + Lys
    
  • 1e1t - EcLysRS + Lys-adenylate
    
  • 1e22 - EcLysRS + Lys + AMPPCP
    
  • 1e24 - EcLysRS + Lys + ATP
• Lys-RS + tRNA
  
  • 2zni, 2znj – DhLysRS + tRNA
• Met-RS
  • 1a8h – TtMetRS
    
  • 1med, 1mea – EcMetRS Zinc-binding domain - NMR
    
  • 1qqt - EcMetRS residues 2-552
    
  • 2x1l - MsMetRS residues 2-515 – Mycobacterium smegmatis
    
  • 3h97 – EcMetRS residues 2-548 (mutant)
    
  • 3h9c - EcMetRS residues 2-548
    
  • 2d54, 2d5b – TtMetRS (mutant)
    
  • 1woy – TtMetRS residues 1-500 (mutant)
    
  • 2djv – hMetRS WHEP-TRS domain – NMR
    
  • 1pyb – AaMetRS β subunit
    
  • 1rqg – PaMetRS – Pyrococcus abyssi
    
  • 1mkh – PaMetRS C-terminal
• Met-RS + small substrates or analogs
  
  • 3kfl – LmMetRS residues 206-747+ Met-adenylate - Leishmania major
    
  • 2x1m - MsMetRS residues 2-515 + Met
    
  • 1p7p, 1pfu, 1pfv, 1pfw - EcMetRS residues 2-548 + Met
    
  • 1pfy - EcMetRS residues 1-551 + Met-SA
    
  • 1f4l - EcMetRS residues 1-551 + Met
    
  • 1pg0 - EcMetRS residues 1-551 + Met-adenylate
    
  • 1pg2 - EcMetRS residues 1-551 + Met + adenine
    
  • 3h99 - EcMetRS residues 2-548 (mutant) + Met
    
  • 3h9b - EcMetRS residues 2-548 (mutant) + azidonorleucine
    
  • 4dlp - BmMetRS + SMet – Brucella melitensis
    
  • 4py2 – BmMetRS + inhibitor
    
• Met-RS + tRNA
  
  • 2csx – AaMetRS + Met-tRNA
• Met-RS + tRNA
  
  • 2ct8 - AaMetRS + Met-tRNA + Met-SA
    
  • 2dxi – TtMetRS + tRNA + ATP + Glu-ol
• Met-RS coplex
  
  • 4bl7, 4bvx, 4bvy - hMetRS N-terminal + elongation factor P18
    
  • 2hsn - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
• Trp-RS
  • 1d2r - GsTrpRS
    
  • 3prh – TrpRS (mutant) – Bacillus subtilis
    
  • 3n9i – TrpRS – Yarsinia pestis
    
  • 3m5w – CjTrpRS – Campylobacter jejuni
    
  • 3a04 – ApTrpRS – Aeropyrum pernix
    
  • 3hzr – EhTrpRS – Entamoeba histolytica
    
  • 3i05 – TbTrpRS residues 3-389 – Trypanosoma brucei
    
  • 3hv0 – CpTrpRS residues 206-593 – Cryptosporidium parvum
    
  • 3foc – GlTrpRS – Giardia lamblia
    
  • 1o5t – hTrpRS catalytic fragment
    
  • 1ulh – hTrpRS residues 35-424
    
  • 2el7 – TtTrpRS
    
  • 2ip1, 3kt0 – yTrpRS – yeast
    
  • 2yy5 – TrpRS – Mycoplasma pneumoniae
    
  • 2g36 – TmTrpRS
    
  • 1bks – StTrpRS + pyridoxal phosphate
• Trp-RS + small substrates or analogs
  
  • 3a05 – ApTrpRS + Trp
    
  • 3kt3 – yTrpRS + Trp-adenylate
    
  • 3kt6, 3kt8 – yTrpRS + Trp
    
  • 3jxe – PhTrpRS + Trp-adenylate
    
  • 3fhj, 3ghd – BsTrpRS + Trp + AMP + Pi
    
  • 2quh – hTrpRS + Trp
    
  • 2qui - hTrpRS + Trp-amide + ATP
    
  • 2quj - hTrpRS + Trp-adenylate
    
  • 2quk – hTrpRS + ATP
    
  • 2ov4 – GsTrpRS + adenosine tetraphosphate
    
  • 1i6k, 1i6l, 1i6m – GsTrpRS + Trp-adenylate
    
  • 1yid, 2a4m – DrTrpRS + ATP
    
  • 1yi8, 1yia – DrTrpRS + Trp
    
  • 1mau – GsTrpRS + Trp + ATP
    
  • 1maw, 1m83 - GsTrpRS + ATP
    
  • 1mb2 - GsTrpRS + Trp
    
  • 3tze - TrpRS + Trp - Encephalitozoon cuniculi
    
  • 3tzl - CjTrpRS + Trp + ADP
    
  • 3sz3 - TrpRS + Trp - Vibrio cholerae
    
  • 6dfu - TrpRS + Trp - Haemophillus influenzae
    
• Trp-RS + tRNA
  
  • 2ake, 2dr2 - hTrpRS + Trp-tRNA
• Tyr-RS
  • 1tya, 1tyb, 1tyc, 1tyd, 2ts1 – GsTyrRS
    
  • 3qe4, 3d6u, 3d6v, 2pxh, 2hgz, 1u7d – MjTyrRS – Methanocaldococcus jannaschii
    
  • 1u7x, 4hjr, 4hk4- MjTyrRS (mutant)
    
  • 2jan – MtTyrRS
    
  • 1y42 - NcTyrRS – Neurospora crassa
    
  • 2cya – ApTyrRS
    
  • 1n3l - hTyrRS residues 1-364
    
  • 1r6t, 1r6u – yTyrRS (mutant)
    
  • 1jh3 – GsTyrRS C-terminal – NMR
    
• Tyr-RS + small substrates or analogs
  
  • 3ts1 – GsTyrRS + Tyr-adenylate intermediate
    
  • 4ts1 – GsTyrRS + Tyr
    
  • 3p0h, 3p0i, 3p0j – LmTyrRS + inhibitor
    
  • 3n2y – MjTyrRS + tetrazolyl phenylalanine
    
  • 2zp1 – MjTyrRS (mutant) + Tyr
    
  • 1zh0 - MjTyrRS (mutant) + naphthyl-Ala
    
  • 1zh6 - MjTyrRS (mutant) + acetyl-Phe
    
  • 2ag6 - MjTyrRS (mutant) + bromo-Phe
    
  • 4hjx - MjTyrRS (mutant) + di-fluoro-Tyr
    
  • 2yxn – EcTyrRS residues 1-322 + azido-Tyr
    
  • 1vbm – EcTyrRS + Tyr-SA
    
  • 1vbn – EcTyrRS (mutant) + Tyr-SA
    
  • 1wq3, 1wq4 - EcTyrRS (mutant) + Tyr
    
  • 1x8x – EcTyrRS + Tyr
    
  • 2pid – hTyrRS residues 28-375 + Tyr-SA
    
  • 2j5b – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus
    
  • 2dlc – yTyrRS + tRNA + Tyr-SA
    
  • 2cyb – AfTyrRS + Tyr - Archaeoglobus fulgidus
    
  • 2cyc – PhTyrRS + Tyr
    
  • 1q11 – hTyrRS residues 1-364 + Tyr-ol
    
  • 1h3e - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP
    
  • 1h3f - TtTyrRS + Tyr-ol
    
  • 1jh3 – GsTyrRS C-terminal – NMR
    
  • 1jii, 1jij, 1jil, 1jik – SaTyrRS + inhibitor
• Tyr-RS + tRNA
  
  • 1j1u – MjTyrRS + Tyr-tRNA
  • 2rkj – NcTyrRS + RNA
• Val-RS
  • 1iyw - TtValRS
    
  • 1wk9, 1wka – TtValRS CP1 domain
• Val-RS ternary complex
  
  • 1ivs – TtValRS + Val-SA + Val-tRNA
    
  • 1gax - TtValRS + Val-adenylate analog + Val-tRNA
• Class II aaRS
• Ala-RS
  • 3g98 – AaAlaRS residues 758-867
    
  • 1riq - AaAlaRS catalytic fragment
    
  • 2zze, 2zzf, 1wnu, 1wxo, 1v4p – PhAlaRS
    
  • 2zvf – AfAlaRS C-terminal
• Ala-RS + small substrates or analogs
  
  • 3hxu, 3hxv, 3hxw – EcAlaRS catalytic fragment + aa-adenylate
    
  • 3hxz, 3hy0, 3hy1 - EcAlaRS catalytic fragment (mutant) + aa-adenylate
    
  • 3hxx - EcAlaRS catalytic fragment + AMPPCP
    
  • 3hxy - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP
    
  • 3htz - AaAlaRS residues 2-454 + Ser
    
  • 1yfr – AaAlaRS + ATP
    
  • 1yfs – AaAlaRS + Ala
    
  • 1yft, 1ygb - AaAlaRS catalytic fragment + aa
    
  • 2zzg - PhAlaRS + Ala-SA<br /
  • 2ztg – AfAlaRS + Ala-SA
    
• Asp-RS
  • 3nen, 1b8a – TkAspRS - Thermococcus kodakarensis
    
  • 3i7f – EhAspRS
    
  • 1wyd – AspRS – Sulfolobus tokodaii
    
  • 1eov - yAspRS
    
  • 1n9w, 1l0w, 1g51 – TtAspRS
    
  • 1eqr – EcAspRS
• Asp-RS + small substrates or analogs
  
  • 3nel – TkAspRS + Asp
    
  • 3nem - TkAspRS + Asp-adenylate
• Asp-RS + tRNA
  
  • 3kfu, 1efw – TtAspRS + tRNA
    
  • 1asy, 1asz – yAspRS + Asp-tRNA
• Asp-RS ternary complex
  
  • 1il2, 1c0a – EcAspRS + Asp-tRNA + Asp-adenylate
• Asn-RS
  • 1x56 - PhAsnRS
    
  • 2kqr – BmAsnRS N-terminal – NMR – Brugia malayi
• Asn-RS + small substrates or analogs
  
  • 2xti – BmAsnRS catalytic fragment + Asn-adenine analog
    
  • 2xgt - BmAsnRS catalytic fragment + Asn-SA
    
  • 1x54 – PhAsnRS + Asn-adenylate
    
  • 1x55 - PhAsnRS + Asn-SA
    
  • 11as – EcAsnRS + Asn
    
  • 12as - EcAsnRS + Asn + AMP
• Gly-RS
  • 1ati – TtGlyRS
    
  • 2q5h – hGlyRS residues 55-739
    
  • 2q5i - hGlyRS residues 55-739 (mutant)
    
  • 2pme – hGlyRS
    
  • 2pmf – hGlyRS (mutant)
    
  • 1j5w – TmGlyRS α chain
• Gly-RS + small substrates or analogs
  
  • 2zt5, 2zxf – hGlyRS residues 55-739 + bis-adenosine tetraphosphate
    
  • 2zt6 - hGlyRS residues 55-739 + AMPCPP
    
  • 2zt7 - hGlyRS residues 55-739 + Gly + ATP
    
  • 2zt8 - hGlyRS residues 55-739 + Gly-AMP analog
    
  • 1b76 – TtGlyRS + ATP
    
  • 1ggm – TtGlyRS + Gly-adenylate
• His-RS
  • 3net – HisRS – Nostoc
    
  • 1h4v – TtHisRS
    
  • 1qe0 – SaHisRS
    
  • 3hri – TbHisRS
    
  • 1x59 – hHisRS WHEP-TRS domain - NMR
• His-RS + small substrates or analogs
  
  • 3lc0 – HisRS residues 45-478 + His – Trypanosoma cruzi
    
  • 1adj – TtHisRS + His
    
  • 3hrk - TbHisRS + His-adenylate
    
  • 2el9 - EcHisRS + His-SA
    
  • 1kmm, 1ady - EcHisRS + His-adenylate
    
  • 1kmn - EcHisRS + His-ol + ATP
• Phe-RS
  • 1pys – TtPheRS
    
  • 3l4g, 3cmq – hPheRS
    
  • 2cxi – PhPheRS β chain N-terminal
    3ica – PheRS β chain – Porphyromonas gingivalis

• Phe-RS + small substrates or analogs
  
  • 3pco – EcPheRS + phenylalanine+ AMP
    
  • 3hfz, 2amc – TtPheRS α+β chains + Tyr
    
  • 2akw, 1b70 - TtPheRS α+β chains + Phe
    
  • 1jjc, 1b7y - TtPheRS α+β chains + Phe-adenylate
    
  • 2aly - TtPheRS α+β chains + Phe-SA
    
  • 2rhq, 2rhs – PheRS α+β chains (mutant) + inhibitor – Staphylococcus haemolyticus
• Phe-RS + tRNA
  
  • 1eiy - TtPheRS α+β chains + Phe-tRNA
• Phe-RS ternary complex
  • 2iy5 - TtPheRS α+β chains + Phe-ol + Phe-tRNA
• Pro-RS
  • 1hc7 – TtProRS
    
  • 2i4l – RpProRS – Rhodopseudomonas palustris
    
  • 1nj2 - MtProRS – Methanothermobacter thermautotrophicus
    
  • 1nj8 – MjProRS
    
  • 4k86 – hProRS residues 1000-1512
    
• Pro-RS + small substrates or analogs
  
  • 3ial – GlProRS residues 34-542 + Pro-adenylate
    
  • 2i4m, 2i4n – RpProRS + aa-SA
    
  • 2i4o – RpProRS + ATP
    
  • 2j3l – EfProRS + Pro-SA – Enterococcus faecalis
    
  • 2j3m – EfProRS + Pro-ol + ATP
    
  • 1nj1, 1nj5, 1nj6 – MtProRS + aa-SA
    
  • 1h4t - TtProRS + Pro
• Pro-RS ternary complex
  
  • 1h4q - TtProRS + Pro-tRNA + Pro-ol
    
  • 1h4s - TtProRS + Pro-tRNA + Pro-SA
    
  • 5f9z – CpProRS residues 186-688 + halofuginone + AMPPNP
    
  • 5f9y – CpProRS residues 186-688 + proline + AMP
    
  • 4k87 – hProRS residues 1000-1512 + proline + adenosine
    
  • 4k88 – hProRS residues 1000-1512 + halofunginone
    
• Bifunctional RS (bifunctional glutamate/proline tRNA ligase)
  • 4hvc – hEPRS residues 1003-1513 + halofunginone + ATP analog
    
  • 5v58 – hEPRS residues 1003-1513 + AZ-SA
    
  • 5vad – hEPRS residues 1003-1513 + inhibitor
    
  • 5a1n, 5a34, 5a5h – hEPRS GST-like domain + EPRS-AIMP2
    
• Pyrrolysyl-RS; domains – RNA-binding 1-101; catalytic 188-454
  • 2e3c - MmPylRS catalytic domain - Methanosarcina mazei
    
  • 3vqw, 3vqx, 4cs2 - MmPylRS catalytic domain (mutant)
    
  • 3dsq – DhPylRS
    
• Pyrrolysyl-RS binary complex
  • 3qtc – MmPylRS catalytic domain (mutant) + AMP-ATP analog
    
  • 2q7e - MmPylRS catalytic domain + ATP analog
    
  • 2q7g - MmPylRS C-terminal+ pyrro-Lys analog+ ATP
    
  • 3vqv - MmPylRS catalytic domain + AMPPNP
    
  • 4bw9, 4cs4, 5k1p, 5k1x - MmPylRS catalytic domain (mutant) + AMPPNP
    
  • 4bwa - MmPylRS catalytic domain (mutant) + adenylated norbornene
    
  • 4ch3, 4ch4, 4ch5, 4ch6 - MmPylRS catalytic domain + adenylated lysine derivative
    
  • 4cs3 - MmPylRS catalytic domain (mutant) + adenylated lysine derivative
    
  • 5ud5 - MmPylRS RNA-binding domain + Pyl-RNA
    
  • 5v6x - MmPylRS RNA-binding domain (mutant) + Pyl-RNA
    
  • 2zni, 2znj – DhPylRS + tRNA
    
• Pyrrolysyl-RS ternary complex
  • 2zce - MmPylRS catalytic domain + pyrrolysine + ATP analog
    
  • 2q7g - MmPylRS catalytic domain + pyrrolysine analog + ATP
    
  • 2zim, 2q7h - MmPylRS catalytic domain + adenylated pyrrolysine + pyrophosphate
    
  • 2zio - MmPylRS catalytic domain + AlocLys-AMP + ATP analog
    
  • 3vqy - MmPylRS catalytic domain + butoxycarbonyl lysine + AMPPNP
    
  • 4q6g - MmPylRS catalytic domain + acetyl lysine + ADPNP
    
  • 4tqd - MmPylRS catalytic domain + iodo-Phe + ATP
    
  • 4tqf, 4zib - MmPylRS catalytic domain + bromothienylo-Ala + ATP
    
  • 2zin - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog
    
• Ser-RS
  • 3lsq – TbSerRS
    
  • 1sry - TtSerRS
    
  • 3err – TtSerRS/dynein heavy chain
    
  • 2zr3 – PhSerRS
    
  • 2dq3 – AaSerRS
    
  • 2du7 – MjSerRS
    
  • 2odr – SerRS – Methanococcus maripaludis
    
  • 2cim – MbSerRS – Methanosarcina barkeri
    
  • 1wle – SerRS – bovine
• Ser-RS + small substrates or analogs
  
  • 2zr2 – PhSerRS + ATP
    
  • 2cj9 – MbSerRS + Ser-SA
    
  • 2cjb – MbSerRS + Ser
    
  • 2cja – MbSerRS + ATP
    
  • 1ses, 1set – TtSerRS + Ser-adenylate analog
    
  • 3lss – TbSerRS + ATP
• Ser-RS + tRNA
  
  • 1ser – TtSerRS + Ser-tRNA
    
  • 2du4 - AfSerRS + Cys-tRNA
• Ser-RS ternary complex
  
  • 2du3 – AfSerRS + Cys-tRNA + phosphoserine
    
  • 2du5, 2du6 - AfSerRS (mutant) + Cys-tRNA + phosphoserine
• Thr-RS
  • 1y2q - PaThrRS editing domain
    
  • 1wwt – hThrRS TGS domain – NMR
    
  • 1tje - EcThrRS editing domain
• Thr-RS + small substrates or analogs
  
  • 3pd2, 3pd3, 3pd4, 3pd5 – PaThrRS editing domain + aa-aminoadenosine
    
  • 2hkz – PaThrRS editing domain + Ser
    
  • 2hl0, 2hl1 - PaThrRS editing domain + Ser-adenylate
    
  • 2hl2 - PaThrRS editing domain + Ser-SA
    
  • 1tke - EcThrRS editing domain + Ser
    
  • 1tkg - EcThrRS editing domain + Ser-SA
    
  • 1tky - EcThrRS editing domain + Ser-adenylate
    
  • 1fyf, 1evl - EcThrRS catalytic and anticodon-binding domains + aa-SA
    
  • 1evk - EcThrRS catalytic and anticodon-binding domains + Thr
    
  • 1nyq – SaThrRS + Thr-SA
    
  • 1nyr – SaThrRS + ATP
• Thr-RS + tRNA
  
  • 1qf6 – EcThrRS + Thr-tRNA
    
  • 1kog – EcThrRS catalytic and anticodon-binding domains + mRNA
• Multifunctional RS
  • 1fyj – hRS - NMR