Deoxyuridine 5'-triphosphate nucleotidohydrolase

Function Deoxyuridine 5’-triphosphate nucleotidohydrolase (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. Prokaryotic DUTP contains metal ion. Relevance DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. Structural highlights The contains Mg+2 ions which are essensial for DUTP activity. The . Water molecules are labeled Wa.

spinqualitylabelsall models dUTPase complex with dUTP analog and Mg+2 ions (green) (PDB entry 1w2y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of dUTPase3D structures of dUTPase

Updated on 21-February-2019

{"openlevels":0}

• DUTP
  • 1dup, 1eu5, 1euw – EcDUTP – Escherichia coli
    
  • 1dun – EvDUTP – Equine infectious anemia virus
    
  • 1mq7 – MtDUTP – Mycobacterium tuberculosis
    
  • 4gk6 - DUTP – Mycobacterium abscessus
    
  • 1ogl – TcDUTP – Trypanosoma cruzi
    
  • 2d4l - MPmvDUTP residues 83-234 – Mason_Pfizer monkey virus
    
  • 2d4m - MPmvDUTP residues 83-234 (mutant)
    
  • 2okb, 2okd - VvDUTP – Vaccinia virus
    
  • 3hhq - yDUTP – yeast
    
  • 3lqw - DUTP – Entamoeba histolytica
    
  • 3mbq, 3mdx - DUTP – Brucella melitensis
    
  • 2xx6 - BsDUTP – Bacillus subtilis
    
  • 3tqz - DUTP – Coxiella burnetii
    
  • 1q5u - hDUTP – human
    
  • 4lhr - DUTP – Burkholderia thailandensis
    
  • 3h6x - DUTP – Streptococcus mutans
    
  • 5myf - SaDUTP – Staphylococcus aureus
    
  • 5myi - SaDUTP (mutant)
    
• DUTP binary complexes
  • 1dud – EcDUTP + dUDP
    
  • 2hrm - EcDUTP + dUTP derivative
    
  • 1seh - EcDUTP + dUMP
    
  • 3f4f - yDUTP + dUMP
    
  • 1dut – DUTP + Mg – Feline immunodeficiency virus
    
  • 1ogk – TcDUTP + dUTP
    
  • 1smc - MtDUTP + dUTP
    
  • 4gcy - MtDUTP (mutant) + dUTP
    
  • 4a6a - MtDUTP (mutant) + dTTP
    
  • 1vyq, 3t60, 3t64, 3t6y, 3t70 - PfDUTP + uridine derivative inhibitor – Plasmodium falciparum
    
  • 2y8c - PfDUTP + trityl ligand
    
  • 2bsy, 2we0 - EbvDUTP + dUMP – Epstein-Barr virus
    
  • 2we1, 2we2 - EbvDUTP (mutant) + dUMP
    
  • 2ol1 - VvDUTP + dUMP
    
  • 2y1t - BsDUTP + dUDP
    
  • 4ao5 - BsDUTP + dUMP
    
  • 2yb0 - LmDUTP + dU – Leishmania major
    
  • 3tq5, 3trl, 3trn, 3ts6, 3tsl, 3tta - MPmvDUTP catalytic domain (mutant) + dUMP
    
  • 4ooq, 2pc5 – AtDUTP + Mg – Arabidopsis thaliana
    
  • 4mz5, 4mz6 – hDUTP + importin subunit α-1
    
  • 5h4j - hDUTP + inhibitor
    
  • 3zf0, 3zf1, 3zf2, 3zf3, 3zf4, 3zf5, 3zf6, 5cct, 5nyz, 5nz2 - SpDUTP (mutant) + dUTP derivative – Staphylococcus phage 80α
    
  • 5cco - SpDUTP + dUMP
    
  • 4gv8 - DUTP + dUTP derivative – Staphylococcus phage 11
    
  • 4wrk - DUTP (mutant) + dUTP derivative – Staphylococcus phage φ11
    
  • 5myd - DUTP + dUTP derivative – Staphylococcus
    
• DUTP ternary complexes
  • 1duc – EvDUPT + Sr + dUTP
    
  • 1six, 1sjn, 2py4 – MtDUTP + Mg + dUTP derivative
    
  • 3h6d, 3hza, 3i93 - MtDUTP (mutant) + Mg + dUTP derivative
    
  • 3loj - MtDUTP (mutant) + Mg + Mn + dUTP derivative
    
  • 1rn8 - EcDUTP + Mg + dUTP derivative
    
  • 1rnj - EcDUTP (mutant) + Mg + dUTP derivative
    
  • 1syl - EcDUTP (mutant) + Mg + dUTP
    
  • 2hr6 - EcDUTP + Mn + dUDP
    
  • 1slh – MtDUTP + Mg + dUDP
    
  • 5ect, 5edd - MtDUTP (mutant) + Mg + dUTP derivative
    
  • 1sm8 – MtDUTP + Cr + dUTP
    
  • 1snf - MtDUTP + Mg + dUMP
    
  • 1w2y, 2cic - DUTP + Mg + dUTP derivative – Campylobacter jejuni
    
  • 5f9k - DUTP + Mg + dUTP derivative – slime mold
    
  • 2bt1 - EbvDUTP + Mg + dUTP derivative
    
  • 2we3 - EbvDUTP residues 1-256 + Mg + dUTP
    
  • 2d4n - MPmvDUTP residues 83-234 (mutant) + Mg + dUTP derivative
    
  • 3tp1 - MPmvDUTP catalytic domain + Mg + dUTP derivative
    
  • 3tpw, 3tpn, 3tps - MPmvDUTP catalytic domain (mutant) + Mg + dUTP derivative
    
  • 3tpy, 3tq3, 3tq4 - MPmvDUTP catalytic domain + Mg + dUMP + dUTP derivative
    
  • 2cje - LmDUTP + Mg + dUTP derivative
    
  • 2yay - LmDUTP + Ca + dUTP derivative
    
  • 2yaz - LmDUTP + Mg + dUMP
    
  • 2oke - VvDUTP + Mg + dUTP derivative
    
  • 2ol0 - VvDUTP + Mg + dUDP
    
  • 3c3i - PbcvDUTP (mutant) + Mg + dUDP – Paramecium bursaria chlorella virus
    
  • 3c2t, 3ca9 - PbcvDUTP + Mg + dUDP
    
  • 2hqu - hDUTP + Mg + dUTP derivative
    
  • 1q5h - hDUTP + Mg + dUDP
    
  • 3ehw - hDUTP + Mg + dUTP
    
  • 3ara, 3arn - hDUTP + Mg + uracil derivative
    
  • 3p48 - yDUTP + Mg + dUTP derivative
    
  • 2xy3 - BsDUTP + Mg + dUTP derivative
    
  • 4oop - AtDUTP + Mg + dUTP derivative
    
  • 4aoo, 4apz, 4aoz - BsDUTP + Mg + PPi + uridine