4a6a

A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTPA115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP

Structural highlights

4a6a is a 12 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.9Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCDB_MYCTU Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar.^[1]

References

↑ Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M. Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis. J Mol Biol. 2008 Feb 15;376(2):554-69. Epub 2007 Dec 5. PMID:18164314 doi:http://dx.doi.org/10.1016/j.jmb.2007.11.099

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OCA

[1] Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M. Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis. J Mol Biol. 2008 Feb 15;376(2):554-69. Epub 2007 Dec 5. PMID:18164314 doi:http://dx.doi.org/10.1016/j.jmb.2007.11.099

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