3arn

Human dUTPase in complex with novel uracil derivativeHuman dUTPase in complex with novel uracil derivative

Structural highlights

3arn is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUT_HUMAN This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.^[1]

References

↑ Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593

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OCA

[1] Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593

[1]

3arn

Human dUTPase in complex with novel uracil derivativeHuman dUTPase in complex with novel uracil derivative

Structural highlights

Function

See Also

References

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3arn

Human dUTPase in complex with novel uracil derivativeHuman dUTPase in complex with novel uracil derivative

Structural highlights

Function

See Also

References

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