Troponin

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:

• TnC causes conformational change in TnI when it binds to calcium ions. For more details on TnC see Role of Troponin C in decreased muscle sensitivity to calcium.
  
• TnT binds to tropomyosin.
  
• TnI binds to actin which is found in thin muscle filaments.
  

See additional details in Human Cardiac Troponin C.

3D Structures of Troponin3D Structures of Troponin

Updated on 21-August-2014

Troponin C+Troponin I+Troponin TTroponin C+Troponin I+Troponin T

2w49, 2w4u – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
1ytz - cTnC+cTnI+cTnT+Ca++
1yv0 - cTnC+cTnI+cTnT
1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human

Troponin C+Troponin ITroponin C+Troponin I

2krd, 2mkp – hTnC+hTnI – NMR
1ozs - hTnC C-terminal+hTnI N-terminal – NMR
2l1r - hTnC C-terminal+hTnI switch region - NMR
1lxf, 1mxl - hTnC N-terminal+hTnI fragment
2kgb – hTnC (mutant) regulatory domain+TnI
1sbj – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR
1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
1npq - cTnC (mutant) N-terminal+cTnI fragment+rhodamine
1jc2 - cTnC C-terminal+cTnI N-terminal
1a2x - rTnC +rTnI fragment – rabbit
3tz1 - TnC C terminal +TnI fragment – akazara scallop

Troponin CTroponin C

2kdh – hTnC+green tea polyphenol – NMR
2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
2jxl - hTnC (mutant) N-terminal – NMR
3rv5, 3sd6, 3swb - hTnC N-terminal
4gjg - hTnC N-terminal (mutant)
4gjf - hTnC N-terminal (mutant) + Cd
4gje - hTnC N-terminal + Cd
1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
1spy - hTnC N-terminal – NMR
2mle - hTnC C-terminal – NMR
2mlf - hTnC C-terminal (mutant) – NMR
1ih0 - hTnC C-terminal+EMD 57033 – NMR
1ap4 - hTnC N-terminal+Ca++ – NMR
2l98 – hTnC EF-hand domains 3,4 + resveratrol
1la0, 4tnc – cTnC+Ca++
1dtl – cTnC (mutant)+Ca++ +bepridil
1skt, 1zac, 2ctn - cTnC N-terminal – NMR
1aj4 - cTnC (mutant) +Ca++ – NMR
3ctn - cTnC C-terminal – NMR
1avs - cTnC N-terminal+Ca++
1smg, 1tnq - cTnC N-terminal+Ca++ - NMR
1ncy – cTnC+Mn++
1ncx, 1ncz, 1top – cTnC
1pon, 1cta, 1ctd – cTnC fragment – NMR
1tnp - cTnC N-terminal – NMR
1tnw, 1tnx - cTnC +Ca++ - NMR
1trf - tTnC N-terminal+Ca++ - turkey – NMR
5tnc - tTnC
2k2a - TnC C-terminal – Lethocerus indicus – NMR
2jnf – TnC – fly – NMR
1r2u, 1r6p - TnC N-terminal – trout – NMR
1tcf – rTnC+Ca++
1tn4, 2tn4 – rTnC (mutant)+Ca++

Troponin ITroponin I

2jpw – TnI biphosphorylated – mouse – NMR
1vdi – cTnI – NMR
1vdj – cTnI+Ca++ - NMR

Troponin TTroponin T

2z5h – yTnT fragment+tropomyosin – yeast