Transcriptional activator

<StructureSection load='1h89' size='350' side='right' caption='Structure of transcriptional activator C-Myb DNA-binding domain (pink) complex with DNA, CAAT/enhancer binding protein β (grey and green) and K+ ion (PDB entry 1h89)' scene=>

Transcriptional activators (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD).

3D Structures of transcriptional activator3D Structures of transcriptional activator

Updated on 07-July-2013

Gcn4 TA

See Gcn4

C-Myb TA

1mse, 1msf – TA DBD + DNA - NMR
1mbe, 1mbf – mTA DBD repeat 1 + DNA – mouse - NMR
1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
1h88 – mTA DBD + DNA + CCAAT/enhancer binding protein β
1h89 – mTA DBD + DNA + CAAT/enhancer binding protein β
1guu – mTA DBD repeat 1
1gv2 – mTA DBD repeat 2,3
1gv5 – mTA DBD repeat 2
1gvd – mTA DBD repeat 2 (mutant)
1sb0, 2agh – mTA transcription activation domain + CREB-binding protein - NMR

Psp operon TA

2bjw – EcTA AAA domain – Escherichia coli
2bjv, 2c9c – EcTA AAA domain (mutant)
2c96 – EcTA AAA domain + ATP
2c98 – EcTA AAA domain + ADP
2c99 – EcTA AAA domain + AMPPNP
2vii – EcTA AAA domain + AMP + Mg

TenA TA

1tyh, 1yaf – BsTA – Bacillus subtilis
1yak – BsTA + pyrimidine derivative
1qcx – BsTA (mutant) + pyrimidine derivative

LasR TA

2uv0 – PaTA ligand-binding domain – Pseudomonas aeruginosa
3ix3 – PaTA ligand-binding domain + oxo-dodecanoyl-homoserine lactone
3ix3, 3ix8, 3jpu – PaTA ligand-binding domain + benzoate derivative

CadC TA

3ly7, 3lya – EcTA periplasmic domain
3ly8, 3ly9 – EcTA periplasmic domain (mutant)

CynR TA

2hxr – EcTA ligand-binding domain
3hfu – EcTA ligand-binding domain + N3

Mal-Rpel TA

2v51, 2v52 – mTA residues 16-41 + actin
2yje, 2yjf – mTA Rpel domain + actin

Brg1 TA

3uvd – TA bromodomain + pyrrolidone derivative - human

VP30 TA

2i8b – TA C terminal – Zaire ebolavirus
3v7o – TA C terminal – Reston ebolavirus