ATPase

File:1mo8.png

NMR Structure of ATPase 1mo8

ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. Vacuolar-type H+ ATPase (V-ATPase) couples the energy to proton transport across membranes. The images at the left and at the right correspond to one representative ATPase, i.e. the NMR structure of rat ATPase (1mo8). Details on Cu transporting ATPase are in P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B. Details on Na/K transporting ATPase are in Sodium-Potassium ATPase.

3D Structures of ATPase3D Structures of ATPase

Update November 2011

Cu transporting ATPaseCu transporting ATPase

2kmv, 2kmx, 2arf – hATPase NBD – human – NMR
2kij - hATPase MBD – NMR
1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR
1y3j, 1y3k - hATPase 5th soluble domain – NMR
1s6o, 1s6u - hATPase 2nd soluble domain – NMR
1q8l - hATPase 2nd MBD – NMR
1aw0, 2aw0 - hATPase 4th MBD – NMR
1kvi, 1kvj - hATPase 1st MBD – NMR
3dxs - AtATPase MBD – Arabidopsis thaliana
2k1r - hATPase MBD+ ATOX1 – NMR
2rop, 2g9o, 2ga7 - hATPase MBD – NMR
2rml - BsATPase N-terminal – Bacillus subtilis – NMR
2gcf - sATPase N-terminal - Synechocystis – NMR
2iye - ATPase catalytic fragment – Sulfolobus solfataricus
1fvq, 1fvs - hATPase – NMR
3cjk – hATPase + Cu transporting protein ATX1
3rfu – ATPase – Legionella pneumophila

Na/K transporting ATPaseNa/K transporting ATPase

3a3y - SaATPase+K+ouabain – Squalus acanthias
3kdp, 3b8e – pATPase – pig
3n23 – pATPase + ouabain
3b8e - pATPase a+BeF3
2hc8 –AfATPase CopA A domain
2b8e - AfATPase CopA NBD
2xze - SaATPase
1mo8, 1mo7 - ATPase α-1 – rat
1q3i - pATPase NBD
3n2f - pATPase subunits α,β,γ
2zxe - ATPase subunits α,β + phospholemman-like protein – spiny dogfish

Ca transporting ATPaseCa transporting ATPase

3fgo - rATPase+CPA+AMPPCP – rabbit
3b9r, 1xp5 - rATPase+AlF4
1wpg - rATPase+MgF4
2zbe, 3b9b – rATPase+BeF3
2zbf - rATPase+BeF3+TG
2zbg - rATPase+AlF4+TG
2zbd, 3ar8 - rATPase+AlF4+nucleotide+Ca
3ar9 - rATPase+BeF3+nucleotide
2dqs, 3ar2, 1vfp - rATPase+AMPPCP
2c88, 2c8k, 3ar4, 3ar3, 3ar5, 3ar7 - rATPase+nucleotide+TG
2ear, 2c8l - rATPase+TG
1iwo - rATPase
2agv - rATPase+TG+BHQ
2eas - rATPase+CPA
2eat - rATPase+CPA+GT
3ar6 - rATPase+TNP-ADP+GT
2eau - rATPase+CPA+curcumin
3ba6 - rATPase phosphoenzyme intermediate
3fpb - rATPase+ATP+cyclopiazonic acid
3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid
2o9j - rATPase+MgF4+cyclopiazonic acid
1kju, 3n5k - rATPase E2 state
2c9m - rATPase Ca2E1 state
1t5s, 3n8g - rATPase Ca2E1 state+AMPPCP
1t5t - rATPase Ca2E1 state+ADP+AlF4
1su4 - rATPase +2Ca2
2by4, 2yfy, 3nal, 3nam, 3nan - rATPase HNE2 state+thapsigargin derivative

Zn transporting ATPaseZn transporting ATPase

2ofg, 2ofh - sATPase N-terminal – NMR

K+ transporting ATPaseK+ transporting ATPase

2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR
1svj, 1u7q - EcATPase NBD of KdpB – NMR

As+ transporting ATPaseAs+ transporting ATPase

1ii0, 1f48 - EcATPase
1ihu – EcATPase+Mg+ADP+AlF3
1ii9 - EcATPase
3h84, 3idq, 3a36, 3a37 - yATPase GET3 – yeast
3sja, 3sjb, 3sjc, 3sjd, 3zs8, 3zs9 - yATPase GET3 + GET1 cystolic domain
3ibg - ATPase GET3 – Aspergillus fumigatus

H+ transporting ATPaseH+ transporting ATPase

3b8c - AtATPase C terminal truncated
1mhs - ATPase – Neurospora crassa
2kz9 – yATPase V-type

Na+ transporting ATPaseNa+ transporting ATPase

2db4, 3aou - EhATPase subunit K – Enterococcus hirae
3aon - EhATPase subunits D,G
1yce - ATPase rotor ring – Ilyobacter tartaricus

H/K transporting ATPaseH/K transporting ATPase

1iwc, 1iwf - pATPase NBD
3ixz - pATPase a+AlF4
2xzb – pATPase subunits α, β

Mg++ transporting ATPaseMg++ transporting ATPase

3gwi – EcATPase P-1 NBD

Arg/ornithine transporting ATPaseArg/ornithine transporting ATPase

3md0 – MtATPase+GDP – Mycobacterium tuberculosis
1kmh - ATPase alpha subunit+tentoxin – spinach
1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
1h8h - cATPase+ AMPPNP
1efr - cATPase+efrapeptin
3fks – ATPase – yeast
3ea0 – ATPase ParA, fragment – Chlorobium tepidum
2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse
3cf2 - mATPase NBD+ADP+AMP-PNP
2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans
2zd2 – PdATPase (mutant) ATP12
1d8s – EcATPase F1
1vdz – PhATPase subunit A – Pyrococcus horikoshii

P-ATPase Cu transportingP-ATPase Cu transporting

3j08, 3j09 - AfATPase
3a1c – AfATPase + AMPPCP
3a1d - AfATPase + ADP-Mg
3a1e - AfATPase (mutant) + AMPPCP

RNA-dependent ATPaseRNA-dependent ATPase

3eaq, 3i31, 3i32 – TtATPase fragment
3mwj – TtATPase N-terminal (mutant)
3mwk, 3nbf – TtATPase N-terminal + 8-oxo-AMP
3mwl - TtATPase N-terminal (mutant) + 8-oxoadenine
3nej - TtATPase reca-like domain (mutant)

Proteasome-associated ATPaseProteasome-associated ATPase

3fp9, 3m9b, 3m9h – MtATPase intern domain
3m91, 3m9d - MtATPase coiled coil domain + protein PUP
3kw6 – hATPase 5

Transitional endoplasmic reticulum ATPaseTransitional endoplasmic reticulum ATPase

3hu1, 3hu2, 3hu3 – hTer-ATPase + ATPGS
3qc8, 3qq8 - hTer-ATPase N terminal + FAS-associated factor 1
3qq7 - hTer-ATPase N terminal
3tiw - hTer-ATPase N terminal + E3 ubiquitin-protein ligase peptide

LAO/AO transport system ATPaseLAO/AO transport system ATPase

3nxs – ATPase – Mycobacterium smegmatis

DNA double-strand repair ATPase (Rad50)DNA double-strand repair ATPase (Rad50)

3aux – MjRad50 – Methanocaldococcus jannaschii
3auy - MjRad50 + ADP
3av0 - MjRad50 + ATP
3qg5 – Rad50 NBD + MRE11 – Thermotoga maritima
3qkr, 3qks - PfRad50 NBD + MRE11 – Pyrococcus furiosus
3qkt - PfRad50 NBD + AMPPNP
3qku - PfRad50 NBD + AMPPNP + MRE11

3nbx – EcATPase Rava + ADP