Phosphoribosyltransferase 3D structures: Difference between revisions

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**[[2pry]] - yOPRT – yeast<br />
**[[2pry]] - yOPRT – yeast<br />
**[[1oro]] - EcOPRT – ''Escherichia coli''<br />
**[[1oro]], [[6tai]] - EcOPRT – ''Escherichia coli''<br />
**[[1j7j]] - StOPRT – ''Salmonella typhimurium''<br />
**[[1j7j]] - StOPRT – ''Salmonella typhimurium''<br />
**[[2aee]] - OPRT – ''Streptococcus pyogenes''<br />
**[[2aee]] - OPRT – ''Streptococcus pyogenes''<br />
Line 35: Line 35:
**[[5hkf]] - MtOPRT + PRPP<BR />
**[[5hkf]] - MtOPRT + PRPP<BR />
**[[5hkl]] - MtOPRT (mutant) + Pi<BR />
**[[5hkl]] - MtOPRT (mutant) + Pi<BR />
**[[6taj]], [[6tak]] - EcOPRT + orotate <BR />
*'''Hypoxanthine PRT'''
*[[7cmj]] - LdHPRT – ''Leishmania donovani''<br />


*'''Hypoxanthine-guanine phosphoribosyltransferase'''
*'''Hypoxanthine-guanine phosphoribosyltransferase'''
Line 124: Line 129:
**[[5bqo]] - SsHGXPRT <br />
**[[5bqo]] - SsHGXPRT <br />
**[[5bqp]] - SsHGXPRT + pyrophosphate <br />
**[[5bqp]] - SsHGXPRT + pyrophosphate <br />
**[[7kl6]], [[7kl7]] - HpHGXPRT <br />


*'''Quinolinic acid phosphoribosyltransferase'''
*'''Quinolinic acid phosphoribosyltransferase'''
Line 170: Line 176:
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
**[[1o5o]] - TmUPRT + UMP<br />
**[[1o5o]] - TmUPRT + UMP<br />
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP  
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP <br />
**[[7rh8]] - UPRT + UTP – ''Candida albicans''<br />


*'''Adenine phosphoribosyltransferase'''
*'''Adenine phosphoribosyltransferase'''
Line 176: Line 183:
**[[6hgp]] – hAPRT <br />
**[[6hgp]] – hAPRT <br />
**[[1g2p]], [[1g2q]] – yAPRT <br />
**[[1g2p]], [[1g2q]] – yAPRT <br />
**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
**[[1qcc]], [[1qcd]] - LdAPRT <br />
**[[2dy0]] - EcAPRT <br />
**[[2dy0]] - EcAPRT <br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
Line 183: Line 190:
**[[4trb]] – SsAPRT <br />
**[[4trb]] – SsAPRT <br />
**[[5yw2]] - FtAPRT <br />
**[[5yw2]] - FtAPRT <br />
**[[5zgo]] - TtAPRT <br />
**[[5zgo]], [[6fsp]] - TtAPRT <br />


*Adenine phosphoribosyltransferase complex
*Adenine phosphoribosyltransferase complex
Line 238: Line 245:
*'''Anthranilate phosphoribosyltransferase'''
*'''Anthranilate phosphoribosyltransferase'''


**[[7dsm]] – yANPRT<BR />
**[[7dsp]] – yANPRT (mutant) <BR />
**[[1o17]] - SsANPRT <br />
**[[1o17]] - SsANPRT <br />
**[[1khd]] – PcANPRT – ''Pectobacterium carotovorum''<br />
**[[1khd]] – PcANPRT – ''Pectobacterium carotovorum''<br />
Line 250: Line 259:
*Anthranilate phosphoribosyltransferase complex containing anthranilate
*Anthranilate phosphoribosyltransferase complex containing anthranilate


**[[7dso]], [[7dsr]] - yANPRT + anthranilate derivative<BR />
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], [[4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], [[4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
Line 260: Line 270:
*Anthranilate phosphoribosyltransferase other complexes
*Anthranilate phosphoribosyltransferase other complexes
   
   
**[[7dsj]] - yANPRT + PRPP<BR />
**[[1kgz]] - PcANPRT + PRPP<BR />  
**[[1kgz]] - PcANPRT + PRPP<BR />  
**[[1zvw]], [[5byt]], [[5c1r]], [[5c7s]] - MtANPRT + PRPP<BR />
**[[1zvw]], [[5byt]], [[5c1r]], [[5c7s]] - MtANPRT + PRPP<BR />
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**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]], [[6e68]], [[5wi1]], [[5wi0]], [[6b76]], [[6b75]], [[6atb]], [[6peb]] - hNMPRT + inhibitor<br />
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]], [[6e68]], [[5wi1]], [[5wi0]], [[6azj]], [[6b76]], [[6b75]], [[6atb]], [[6peb]], [[6tac]] - hNMPRT + inhibitor<br />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[6ta0]] - hNMPRT + nicotinic acid + PRPP<BR />
**[[6ta2]] - hNMPRT + nicotinic acid + phosphate<BR />
**[[5nsd]], [[5lx5]], [[5lx3]] - hNMPRT + piperidine derivative<br />
**[[5nsd]], [[5lx5]], [[5lx3]] - hNMPRT + piperidine derivative<br />
**[[2h3d]] - mNMPRT + NMN<BR />
**[[2h3d]] - mNMPRT + NMN<BR />
**[[7q8t]] - mNMPRT + inhibitor<br />
**[[2g96]] - rNMPRT + NMN<BR />
**[[2g96]] - rNMPRT + NMN<BR />
**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />

Revision as of 11:41, 15 December 2021

3D structures of phosphoribosyltransferase3D structures of phosphoribosyltransferase

Updated on 15-December-2021

Hypoxanthine-guanine PRT binary complexHypoxanthine-guanine PRT binary complex

  • Hypoxanthine-guanine phosphoribosyltransferase ternary complex
    • 1bzy - hHPRT + inhibitor + guanine derivative
    • 1a95 - EcHPRT + guanine + PRPP derivative
    • 1a96 - EcHPRT + xanthine + PRPP derivative
    • 1tc2, 1i0i, 1i0l, 1i13, 1i14 – TcHPRT + pyrimidine derivative + PRPP derivative
    • 1p18 - TcHPRT (mutant) + pyrimidine derivative + PRPP
    • 1qk5 - TgHPRT (mutant) + XMP + pyrophosphate
    • 1fsg - TgHPRT + guanine derivative + PRPP
    • 1cjb - PfHPRT + pyrophosphate + inhibitor
    • 5knq, 5knp - MtHGPRT + pyrophosphate + nucleoside phosphonate
    • 4rhy - MtHGPRT + pyrophosphate + GMP
    • 6d9r - BaHGPRT + PRPP + deazaquanine
  • Hypoxanthine-guanine-xanthine PRT or purine PRT
  • Quinolinic acid phosphoribosyltransferase
    • 2jbm, 5ayx, 4kwv – hQAPRT
    • 3c2e - yQAPRT
    • 1o4u - TmQAPRT – Thermotoga maritima
    • 1qpo – MtQAPRT – Mycobacterium tuberculosis
    • 5hul - SpQAPRT (mutant)
  • Quinolinic acid phosphoribosyltransferase complex
    • 5ayy - hQAPRT + quinolinic acid
    • 4kww – hQAPRT + phthalate
    • 5ayz – hQAPRT + nicotinate mononucleotide
    • 4i9a – QAPRT + nicotinate mononucleotide – pig
    • 3c2o - yQAPRT + quinolinic acid
    • 3c2f - yQAPRT + PRPP
    • 3c2r - yQAPRT + inhibitor
    • 3c2v - yQAPRT + inhibitor + PRPP
    • 1qap - StQAPRT + quinolinic acid
    • 1qpr - MtQAPRT + PRPP derivative
    • 1qpn – MtQAPRT + nicotinate mononucleotide
    • 1qpq - MtQAPRT + quinolinic acid
    • 2b7n – HpQAPRT + quinolinic acid
    • 2b7p – HpQAPRT + phthalate
    • 2b7q – HpQAPRT + nicotinate mononucleotide
  • Uracil phosphoribosyltransferase
    • 1w30, 5e38 - MtUPRT
    • 1bd3 - TgUPRT (mutant)
    • 1v9s - TtUPRT
    • 2e55 - UPRT – Aquifex aeolicus
    • 6wn8 - UPRT – Klebsiella pneumoniae
    • 2ehj - EcUPRT
    • 3dmp - UPRT – Burkholderia pseudomallei
  • Uracil phosphoribosyltransferase complex
    • 1upu - TgUPRT (mutant) + UMP
    • 1jlr - TgUPRT (mutant) + GTP
    • 1bd4 - TgUPRT (mutant) + uracil
    • 1upf - TgUPRT (mutant) + fluorouracil
    • 1jls - TgUPRT (mutant) + uracil + PRPP
    • 1i5e, 2igb - UPRT + UMP – Bacillus caldolyticus
    • 1o5o - TmUPRT + UMP
    • 1vst, 3g6w - SsUPRT + GTP + PRPP
    • 7rh8 - UPRT + UTP – Candida albicans
  • Adenine phosphoribosyltransferase
  • Adenine phosphoribosyltransferase complex
  • Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase
    • 1l4b – StNN:DBI PRT
    • 4kqh - StNN:DBI PRT (mutant)
    • 1wx1 – TtNN:DBI PRT
    • 3u4g – PhNN:DBI PRT
    • 6b5f – NN:DBI – Yersinia enterocolitica
  • Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
    • 1jh8, 4kqf – StNN:DBI PRT + adenine
    • 1l4e, 1l4f, 1l4g, 1l4h, 1l4k, 1l4l, 1l4m, 1l4n, 1l5f, 1l5k, 1l5l, 1l5m, 1l5n, 1l5o - StNN:DBI PRT + product-aldimine complex
    • 1jha – StNN:DBI PRT + AMP + nicotinate
    • 4kqi, 1dov - StNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate
    • 1jhm – StNN:DBI PRT + benzimidazole
    • 1jho – StNN:DBI PRT + NaMN + benzimidazole
    • 1jhp, 1d0s – StNN:DBI PRT + benzimidazole derivative
    • 1jhq - StNN:DBI PRT + NaMN + benzimidazole derivative
    • 1jhr - StNN:DBI PRT + NaMN + hydroxypurine
    • 1jhu - StNN:DBI PRT + cresol
    • 4kqk - StNN:DBI PRT (mutant) + cresol
    • 1jhv - StNN:DBI PRT + nicotinate + cresol
    • 1jhx - StNN:DBI PRT + phenol
    • 1jhy - StNN:DBI PRT + phenol + nicotinate
    • 4kqj - StNN:DBI PRT (mutant) + NaMN + cresol
    • 4kqg - StNN:DBI PRT (mutant) + cobamide
  • Anthranilate phosphoribosyltransferase
    • 7dsm – yANPRT
    • 7dsp – yANPRT (mutant)
    • 1o17 - SsANPRT
    • 1khd – PcANPRT – Pectobacterium carotovorum
    • 1v8g, 2elc - TtANPRT
    • 1vqu - ANPRT – Nostoc
    • 3qr9, 5c2l – MtANPRT
    • 4x5a - MtANPRT (mutant)
    • 4hkm - ANPRT – Xanthomonas campestris
    • 4gtn – AcANPRT – Acinetobacter
    • 5nof, 5noe – ANPRT – Thermococcus kodkarensis
  • Anthranilate phosphoribosyltransferase complex containing anthranilate
    • 7dso, 7dsr - yANPRT + anthranilate derivative
    • 4owm, 4own, 4owo, 4owq, 4ows, 4owu, 4n5v, 4n93 - MtANPRT + PRPP + anthranilate derivative
    • 4ij1, 4m0r, 4owv, 4n8q - MtANPRT + anthranilate derivative
    • 4x5d - MtANPRT (mutant) + anthranilate
    • 4x5e - MtANPRT (mutant) + anthranilate + POP
    • 1zyk - SsANPRT + anthranilate + PRPP
    • 4giu, 4gkm- PfANPRT + anthranilate derivative + PRPP
    • 4yi7 - AcMtANPRT + anthranilate
  • Anthranilate phosphoribosyltransferase other complexes
  • ATP phosphoribosyltransferase See ATP Phosphoribosyl Transferase
  • Nicotinate phosphoribosyltransferase
    • 4yub - hNIPRT
    • 1vlp - yNIPRT
    • 1ybe - NIPRT – Agrobacterium tumefaciens
    • 1yir - NIPRT – Pseudomonas aeruginosa
    • 1ytd, 2i1o - TaNIPRT – Thermoplasma acidophilum
    • 2bpq - MtNIPRT
    • 2im5 - NIPRT – Porphyromonas gingivalis
    • 3os4 - NIPRT – Yersinia pestis
    • 4hl7 - VcNIPRT
  • Nicotinate phosphoribosyltransferase complex
    • 1yte - TaNIPRT + PRPP
    • 1ytk - TaNIPRT + NAMN
    • 4mzy – NIPRT + malonate + Pi – Enterococcus faecalis
  • Nicotinamide phosphoribosyltransferase
    • 2e5b – hNMPRT
    • 2gvl - mNMPRT – mouse
    • 2h3b – mNMPRT (mutant)
    • 2g95 - NMPRT - rat
  • Nicotinamide phosphoribosyltransferase complex

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Michal Harel
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