4hkp

Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxideCrystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide

Structural highlights

4hkp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.75Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

UMPS_HUMAN Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.^[1]

Function

UMPS_HUMAN

References

↑ Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, Wada Y. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. Am J Hum Genet. 1997 Mar;60(3):525-39. PMID:9042911

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OCA

[1] Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, Wada Y. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. Am J Hum Genet. 1997 Mar;60(3):525-39. PMID:9042911

[1]

4hkp

Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxideCrystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide

Structural highlights

Disease

Function

See Also

References

Contents

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4hkp

Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxideCrystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide

Structural highlights

Disease

Function

See Also

References

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