Profilin: Difference between revisions
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PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>. | PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>. | ||
== 3D Structures of profilin == | |||
[[Profilin 3D Structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[1pne]] – bPFN – bovine <br /> | **[[1pne]] – bPFN – bovine <br /> | ||
**[[1cqa]] – biPFN - birch <br /> | **[[1cqa]] – biPFN - birch <br /> | ||
**[[3nul]], [[1a0k]] – | **[[3nul]], [[1a0k]] – AtPFN – ''Arabidopsis thaliana'' <br /> | ||
**[[4esp]] – PFN – peanut <br /> | |||
**[[5fef]] - PFN - maize<br /> | |||
**[[5em0]] - PFN - mugwort<br /> | |||
**[[5em1]] - rPFN - ragweed<br /> | |||
**[[6b6j]] – PFN – mugwort<br /> | |||
**[[6mbx]] – PFN – muskmelon<br /> | |||
**[[1ypr]], [[1k0k]] – PFN - yeast <br /> | **[[1ypr]], [[1k0k]] – PFN - yeast <br /> | ||
**[[3d9y]], [[3dav]] – PFN – fission yeast <br /> | **[[3d9y]], [[3dav]] – PFN – fission yeast <br /> | ||
**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br /> | **[[1g5u]] – PFN – ''Hevea brasiliensis'' <br /> | ||
**[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br /> | **[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br /> | ||
**[[4qwo]] – PFN – monkeypox virus <br /> | **[[4qwo]] – PFN – monkeypox virus <br /> | ||
**[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br /> | **[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br /> | ||
**[[1prq]] – AcPFN <br /> | **[[1prq]] – AcPFN <br /> | ||
**[[3nec]] – PFN – ''Toxoplasma gondii''<br /> | **[[3nec]] – PFN – ''Toxoplasma gondii''<br /> | ||
*Profilin I complex | *Profilin I complex | ||
**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br /> | |||
**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br /> | |||
**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br /> | **[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br /> | ||
**[[1hlu]] – bPFN + β-actin + ATP <br /> | **[[1hlu]] – bPFN + β-actin + ATP <br /> | ||
**[[2jkg]] – PfPFN + poly-Pro peptide <br /> | **[[2jkg]] – PfPFN + poly-Pro peptide <br /> | ||
**[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br /> | **[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br /> | ||
*Profilin II | *Profilin II | ||
**[[1d1j]] – hPFN <br /> | |||
**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br /> | **[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br /> | ||
**[[2vk3]] – PFN - rat <br /> | **[[2vk3]] – PFN - rat <br /> | ||
**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br /> | **[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br /> | ||
**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br /> | **[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br /> | ||
**[[5fds]], [[5feg]] - PFN - rubber tree<br /> | |||
**[[5nzb]], [[5nzc]] – biPFN <br /> | **[[5nzb]], [[5nzc]] – biPFN <br /> | ||
**[[6iqi]] – AtPFN <br /> | |||
**[[6iqj]] – AtPFN + formin1 <br /> | |||
**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br /> | |||
*Profilin III | |||
**[[6iqf]] – AtPFN <br /> | |||
*Profilin V | |||
**[[6iqk]] – AtPFN + ATPRF3 <br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:42, 27 November 2019
FunctionProfilin (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin[1]. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. DiseasePFN from birch, peanut and other plants is a major allergen[2]. 3D Structures of profilin
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3D Structures of profilin3D Structures of profilin
Updated on 27-November-2019
ReferencesReferences
- ↑ Nejedla M, Sara S, Sulimenko V, de Almeida FN, Blom H, Draber P, Aspenstrom P, Karlsson R. Profilin connects Actin Assembly with Microtubule dynamics. Mol Biol Cell. 2016 Jun 15. pii: mbc.E15-11-0799. PMID:27307590 doi:http://dx.doi.org/10.1091/mbc.E15-11-0799
- ↑ Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro MJ, Barber D. Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy. 2014 Dec;69(12):1610-6. doi: 10.1111/all.12509. Epub 2014 Oct 3. PMID:25123397 doi:http://dx.doi.org/10.1111/all.12509