ACANTHAMOEBA CASTELLANII PROFILIN IBACANTHAMOEBA CASTELLANII PROFILIN IB

Structural highlights

1acf is a 1 chain structure with sequence from Acanthamoeba castellanii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRO1B_ACACA Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Evolutionary Conservation

 

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1acf, resolution 2.00Å

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OCA