Profilin

Function Profilin (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. Disease PFN from birch, peanut and other plants is a major allergen. 3D Structures of profilin Profilin 3D Structures

spinqualitylabelsall models Human profilin I (green) complex with α-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code 2pbd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image