Alpha-glucosidase

Function Alpha glucosidase (AGS) or maltase breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. Maltase breaks down maltose. Isomaltase breaks the 1,6 bond. See also Kennedy research. Disease AGS deficiency is the cause of Pompe Disease. AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells. Structural highlights (PDB code 3a4a). Water molecules shown as red spheres. . 3D structures of α-glucosidase Alpha-glucosidase 3D structures

spinqualitylabelsall models Structure of yeast isomaltase complex with α-D-glucose and Ca+2 ion (green) (PDB code 3a4a). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of α-glucosidase3D structures of α-glucosidase

Updated on 06-March-2019

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• α glucosidase
  • 2g3m – SsAGS – Sulfolobus solfataricus
    
  • 2ze0, 5zcb – GeAGS – Geobacillus
    
  • 3w38 – bAGS - beet
    
  • 2d73, 2jka, 3wfa, 5djw, 5f7c, 3wfa, 3a24, 5xfm – BtAGS – Bacterioides thetaiotaomicron
    
  • 5hq4 – PaAGS - Pseudoalteromonas
    
  • 1lf6 – TtAGS – Thermoanaerobobacterium thermosaccharolyticum
    
  • 1kum, 1kul – AnAGS starch-binding domain – Aspergillus niger - NMR
    
  • 3eqa – AnAGS catalytic domain
    
  • 1glm, 3gly – AaAGS – Aspergillus awamori
    
  • 1ayx, 2fba – SfAGS – Saccharomycopsis fibuligera
    
  • 5f0e – mAGS - mouse
    
  • 5aed, 5aee, 5aeg – AGS - Esherichia coli
    
  • 3wy1 – HaAGS - Halomonas
    
  • 4xpo – PsAGS - Pedobacter saltans
    
  • 4xpr – PsAGS (mutant)
    
  • 2lvx – fyAGS 2 MRH domain – fission yeast - NMR
    
  • 2n1h – fyAGS 2 MRH domain (mutant) - NMR
    
• α-glucosidase complex
  • 2jke – BtAGS + deoxynojirimycin
    
  • 2jkp – BtAGS + castasnospermine
    
  • 2zq0 – BtAGS + acarbose
    
  • 5hqa – PaAGS + acarbose
    
  • 5hqb – PaAGS (mutant) + panose
    
  • 1lf9 – TtAGS + acarbose
    
  • 1gai, 1gah, 1agm – AaAGS + acarbose
    
  • 2f6d – SfAGS + acarbose
    
  • 1dog – AaAGS + deoxynojirimycin
    
  • 1acz, 1ac0 – AGS starch-binding domain + cyclodextrin - NMR
    
  • 5hjr – AGS + glucosidase subunit beta - mouse
    
  • 5h9o – mAGS + glucose
    
  • 5hjo – mAGS + substrate analog
    
  • 5h9r – mAGS + intermediate
    
  • 5ied, 5iee, 5ief, 5ieg – mAGS + iminosugar antiviral
    
  • 3wy2 – HaAGS + glucose
    
  • 3wy3 – HaAGS (mutant) + glucose
    
  • 3wy4 – HaAGS (mutant) + maltose
    
  • 4xpp – PsAGS + galactose
    
  • 4xpq – PsAGS + fucose
    
  • 4xps – PsAGS (mutant) + galactpiranoside
    
  • 3wel, 3wem, 3wen, 3weo, 3w37 – bAGS + substrate
    
  • 4xqm – fyAGS 2 MRH domain + mannose
    
  • 5zcc – GeAGS (mutant) + maltose
    
  • 5zcd – GeAGS (mutant) + maltotriose
    
  • 5zce – GeAGS (mutant) + maltotetraose
    
• Alpha-glucosidase YIHQ
  • 5ohs – RrYIHQ + sulfoquinovoside derivative – Rhizobium radiobacter
    
  • 5ohy – RrYIHQ + inhibitor
    
• Maltase
  • 1vjt – TmAGS + NAD – Thermotoga maritima
    
  • 1obb – TmAGS + NAD + maltose
    
  • 2g3n – SsAGS + octylglucoside
    
  • 3ton, 5kzw, 5kzx, 5nn3, 5nn4 – hAGS C-terminal - human
    
  • 5nn8 – hAGS + acarbose
    
  • 3top – hAGS C-terminal + acarbose
    
  • 3l4y, 3l4z, 3l4x, 3l4w, 3l4v, 3l4u, 3l4t – hAGS N-terminal + inhibitor
    
  • 5nn5, 5nn6 – hAGS + jiromycin derivative
    
• Maltase-glucoamylase
  • 2qly – hAGS N-terminal catalytic subunit
    
  • 2qmj – hAGS N-terminal catalytic subunit + acarbose
    
  • 3ctt – hAGS N-terminal catalytic subunit + casuarine
    
• Isomaltase or oligo-1,6-glucosidase
  • 3a47, 3aj7 – yAGS – yeast
    
  • 3a4a, 3axh – yAGS + glucose
    
  • 3axi – yAGS (mutant) + glucose
    
  • 3n04 – RoAGS – Ruminococcus obeum
    
  • 3nsx, 3nuk – RoAGS (mutant)
    
  • 3pha, 3poc – RoAGS (mutant) + acarbose
    
  • 3mkk – RoAGS + isomaltose
    
  • 4m8u, 4maz, 4mb1 – BsAGS 1 (mutant) – Bacillus subtilis
    
  • 4m56 – BsAGS 1 + glucose
    
  • 5wcz – BsAGS 1 + deoxynojirimycin analog
    
  • 1uok – AGS – Bacillus cereus
    
• Sucrase–isomaltase
  • 3lpo – hAGS N-terminal
    
  • 3lpp – hAGS N-terminal + kotalanol
    
• Maltodextrin glucosidase
  • 5bn7 – EcAGS
    
• 6-phospho-α-glucosidase
  • 1u8x – BsPAGS + α-glucose phosphate + NAD
    
  • 6dux – KpPAGS + malate + NAD – Klebsiella pneumoniae
    
  • 6dvv – KpPAGS + Mn + NAD
    
• Glucan 1,4-alpha glucosidase or glucoamylase
  • 6frv – AnGAGS catalytic domain residues 25-640
    
  • 5ghl – AnGAGS starch-binding domain residues 533-640
    
  • 6fhv – GAGS – Penicillium oxalicum
    
  • 6fhw – GAGS – Amorphotheca resinae
    
• Glucan 1,6-α-glucosidase or dextran glucosidase
  • 4aie – GAGS – Lactobacillus acidophilus
    
  • 2zic, 4xb3 – SmGAGS (mutant) – Streptococcus mutans
    
  • 4wlc – SmGAGS + glucose
    
  • 2zid – SmGAGS (mutant) + isomaltotriose