Nucleoporin: Difference between revisions

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**[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br />
**[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br />
**[[4lir]] – hNUP53 residues 151-266<br />
**[[4lir]] – hNUP53 residues 151-266<br />
**[[5uaz]] – yNUP53 <br />
**[[5hb8]], [[5hb7]] – CtNUP53 - ''Chaetomium thermophilum''<br />
**[[5hb8]], [[5hb7]] – CtNUP53 - ''Chaetomium thermophilum''<br />
**[[5hb3]] – CtNUP53 + NUP NIC96 <br />
**[[5hb3]] – CtNUP53 + NUP NIC96 <br />
Line 38: Line 39:
**[[3t98]] – rNUP54 + rNUP58/45 <br />
**[[3t98]] – rNUP54 + rNUP58/45 <br />
**[[4jo7]], [[4jo9]] – hNUP54 + hNUP58/45 <br />
**[[4jo7]], [[4jo9]] – hNUP54 + hNUP58/45 <br />
**[[5c3l]] – NUP54 coiled coil + NUP58 coiled coil + NUP62 coiled coil + nanobody - frog<br />
*NUP57
**[[5cwt]] – CtNUP57 residues 265-317<br />
**[[5cws]] – CtNUP57 residues 74-319 + NUP49 + NIC96 + antibody<br />
*NUP58
*NUP58
**[[2osz]] – rNUP58/45 <br />
**[[2osz]] – rNUP58/45 <br />
**[[4jq5]] – hNUP58/45 <br />
**[[4jq5]] – hNUP58/45 <br />
*NUP62
**[[5h1x]] – rNUP62 coiled-coil domain<br />
*NUP82
*NUP82
**[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 CTD<br />
**[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 CTD<br />
Line 90: Line 97:
**[[5hb0]] – CtNUP170 (mutant) + CtNUP145 peptide<br />
**[[5hb0]] – CtNUP170 (mutant) + CtNUP145 peptide<br />
**[[5hax]] – CtNUP170 NTD + CtNUP53 peptide<br />
**[[5hax]] – CtNUP170 NTD + CtNUP53 peptide<br />
*NUP188
**[[5cwu]] – CtNUP192 tail domain<br />
*NUP192
*NUP192
**[[4ifq]] – yNUP192<br />
**[[4ifq]] – yNUP192<br />
**[[5hb4]] – CtNUP192 <br />
**[[5hb4]] – CtNUP192 <br />
**[[5cwv]] – CtNUP192 tail domain<br />
*NUP214
*NUP214
**[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
**[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
Line 110: Line 120:


*NUP Gle1
*NUP Gle1
**[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
**[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6<br />
**[[6b4e]] – yNUP-Gle1 + NUP42 <br />
**[[6b4g]], [[6b4h]] – CtNUP-Gle1 + NUP Amo1 <br />
 
*Nuclear pore complex
 
**[[5ijo]], [[5ijn]] – hNUP93 + NUP155 + NUP205 + NUP54 + NUP58 + NUP62 + NUP188 – Cryo EM<br />
**[[5a9q]] – hNUP96 + NUP133 + NUP160 + NUP43 + NUP37 + NUP85 + NUP155 + NUP107 + Sec13 + Seh1 – Cryo EM<br />


**[[2rfo]], [[2qx5]] – yNic96<br />
**[[2rfo]], [[2qx5]] – yNic96<br />

Revision as of 09:47, 15 August 2018

Function

Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)[1].

  • NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture[2].
  • NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α[3].
  • NUP Gle1 is a yeast and human nucleoprotein required mRNA export.

Disease

NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids[4].

Yeast nucleoporin NUP159 N-terminal domain (PDB entry 1xip)

Drag the structure with the mouse to rotate

3D Structures of Nucleoporin3D Structures of Nucleoporin

Updated on 15-August-2018

ReferencesReferences

  1. ↑ Doye V, Hurt E. From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol. 1997 Jun;9(3):401-11. PMID:9159086
  2. ↑ Belanger KD, Kenna MA, Wei S, Davis LI. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994 Aug;126(3):619-30. PMID:8045927
  3. ↑ Solsbacher J, Maurer P, Vogel F, Schlenstedt G. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol. 2000 Nov;20(22):8468-79. PMID:11046143
  4. ↑ Cronshaw JM, Matunis MJ. The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 2004 Jan-Feb;15(1):34-9. PMID:14693424

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