2ec1

Solution structure of the RanBD1 domain from human Nucleoporin 50 kDaSolution structure of the RanBD1 domain from human Nucleoporin 50 kDa

Structural highlights

2ec1 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NUP50_HUMAN Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Ogawa Y, Miyamoto Y, Asally M, Oka M, Yasuda Y, Yoneda Y. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol Biol Cell. 2010 Feb 15;21(4):630-8. doi: 10.1091/mbc.E09-05-0374. Epub 2009, Dec 16. PMID:20016008 doi:http://dx.doi.org/10.1091/mbc.E09-05-0374

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OCA

[1] Ogawa Y, Miyamoto Y, Asally M, Oka M, Yasuda Y, Yoneda Y. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol Biol Cell. 2010 Feb 15;21(4):630-8. doi: 10.1091/mbc.E09-05-0374. Epub 2009, Dec 16. PMID:20016008 doi:http://dx.doi.org/10.1091/mbc.E09-05-0374

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