Profilin: Difference between revisions
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<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin ( | <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''> | ||
== Function == | == Function == | ||
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes. | '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes. | ||
Revision as of 16:15, 23 October 2017
FunctionProfilin (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin[1]. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. DiseasePFN from birch, peanut and other plants is a major allergen[2].
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3D Structures of profilin3D Structures of profilin
Updated on 23-October-2017
ReferencesReferences
- ↑ Nejedla M, Sara S, Sulimenko V, de Almeida FN, Blom H, Draber P, Aspenstrom P, Karlsson R. Profilin connects Actin Assembly with Microtubule dynamics. Mol Biol Cell. 2016 Jun 15. pii: mbc.E15-11-0799. PMID:27307590 doi:http://dx.doi.org/10.1091/mbc.E15-11-0799
- ↑ Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro MJ, Barber D. Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy. 2014 Dec;69(12):1610-6. doi: 10.1111/all.12509. Epub 2014 Oct 3. PMID:25123397 doi:http://dx.doi.org/10.1111/all.12509