Thioesterase: Difference between revisions

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'''Thioesterase''' (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group.  TEs are substrate-specific.  Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation.  4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.  Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.  Fluoroacetyl-CoA TE from ''Streptomyces cattleya'' hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.  Ubiquitin TE removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.
'''Thioesterase''' (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group.  TEs are substrate-specific.  '''Palmitoyl protein TE''' removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation.  '''4-hydroxybenzoyl-CoA TE''' converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.  '''Acyl-CoA TE''' hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.  '''Fluoroacetyl-CoA TE''' from ''Streptomyces cattleya'' hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.  '''Ubiquitin TE''' (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.


==3D structures of thioesterase==
==3D structures of thioesterase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


'''Maristoyl-ACP-specific TE'''
'''Maristoyl-ACP-specific TE'''
Line 74: Line 75:
'''Ubiquitin TE'''
'''Ubiquitin TE'''


[[2kzr]] – mTE UBX-like domain – NMR<br />
''USP 2''
[[4dhi]] – CeTE + ubiquitin-conjugating enzyme E2 – ''Caenorhabditis elegans''<br />
 
[[4dhj]], [[4dhz]] – CeTE + ubiquitin-conjugating enzyme E2 + ubiquitin + ubiquitin aldehyde
[[2zfy]] – hUSP – human  <BR />
[[2hd5]], [[3nhe]] – hUSP + Ub  <BR />
[[1tff]] – hUSP (mutant)  <BR />
[[2ibi]] – hUSP (mutant) + Ub <BR />
 
''USP 3''
 
[[2qiy]] – USP + UBP-associated protein – yeast  <BR />
 
''USP 5''
 
[[3ihp]] – hUSP + Ub  <BR />
 
''USP 7''
 
[[2ylm]] – hUSP  <BR />
[[2kvr]] – hUSP UBL domain - NMR <BR />
[[3mqr]], [[3mqs]] – hUSP + peptide <BR />
[[2xxn]] – hUSP + VIRF-4 <BR />
[[4jjq]] – hUSP (mutant) + E2<BR />
 
''USP 8''
 
[[2gwf]] – hUSP rhodanese domain + ring finger protein  <BR />
[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – hUSP + SUS1 + SAGA-associated factors 11, 73  <BR />
[[3mhs]] – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub <BR />
[[3n3k]] – hUSP + Ub inhibitor <BR />
 
''USP 15''
 
[[3lmn]] – hUSP DUSP domain <BR />
 
''USP 16''
 
[[2i50]] – hUSP zinc finger domain - NMR <BR />
 
''USP 21''
 
[[3i3t]] – hUSP + Ub  <BR />
[[3mtn]] – hUSP + Ub inhibitor <BR />
 
''USP 28''
 
[[2lva]] – hUSP N terminal - NMR  <BR />
 
''USP 33''
 
[[2uzg]] – hUSP zinc finger domain - NMR  <BR />
 
''USP 37''
 
[[3ihr]] – hUSP (mutant)  <BR />
[[3a7s]] – hUSP catalytic domain (mutant)  <BR />
 
''USP Cyld''
 
[[2vhf]] – hUSP  <BR />
 
''USP L1''
 
[[3irt]] – hUSP  (mutant) <BR />
[[2len]] – hUSP  (mutant) - NMR<BR />
[[3ifw]], [[3kvf]], [[3kw5]] – hUSP  (mutant) + Ub<BR />
[[4dm9]] – hUSP + peptide inhibitor<BR />
 
''USP L5''
 
[[3ris]] – hUSP catalytic domain  <BR />
[[3rii]] – hUSP catalytic domain (mutant)  <BR />
[[3tb3]] – hUSP UCH domain (mutant)  <BR />
 
''USP ZranB1''
 
[[3zrh]] – hUSP  <BR />
 
''USP OTUB1''
 
[[3von]] – hUSP + E2 <BR />
[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
[[4ddi]] – hUSP (mutant) + Ub<BR />
[[4dhz]] – hUSP + E2 + Ub<BR />
[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
[[4dhi]] – nUSP + E2 <BR />
 
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR />


'''RedJ TE'''
'''RedJ TE'''

Revision as of 13:37, 25 June 2013

Template:STRUCTURE 1u8u

Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific. Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation. 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA. Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism. Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate. Ubiquitin TE (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.

3D structures of thioesterase3D structures of thioesterase

Updated on 25-June-2013

Maristoyl-ACP-specific TE

1tht – TE – Vibrio harveyi

4-hydroxybenzoyl-CoA TE

1bvq – PsTE – Pseudomonas
1lo7 – PsTE + 4-hydroxyphenyl CoA
1lo9 - PsTE (mutant) + 4-hydroxybenzoyl CoA
1lo8 - PsTE + 4-hydroxybenzyl CoA
1q4s - ArTE + 4-hydroxybenzoate – 'Arthrobacter'
1q4t - ArTE + 4-hydroxyphenyl CoA
1q4u - ArTE + 4-hydroxybenzyl CoA
3r32, 3r35, 3r37, 3r38, 3r3c, 3r3d, 3r3f - ArTE (mutant) + 4-hydroxyphenacyl CoA
3r3a - ArTE (mutant) + 4-hydroxybenzoate
3r34 - ArTE (mutant) + CoA

Palmitoyl protein TE

1eh5 – bTE1 + Palmitate – bovine
1ei9 – bTE1
1exw – bTE1 + hexadecylsulfonyl fluoride
1pja – hTEII – human
3gro - hTEI

Acyl-CoA TE

1c8u – EcTEII – Escherichia coli
1ivn – EcTEI
1jrl – EcTEI (mutant)
1j00 – EcTEI + diethyl phosphono derivative
1v2g, 1u8u - EcTEI + octanoic acid
2v1o – mTE7 hotdog domain – mouse
2q2b – mTE7 C terminal
3hlk – hTE2
3k2i – hTE4
2qq2 - hTE7 C terminal
3fo5 – hTE11 START domain
3b7k – hTE12
3rd7 – TE – Mycobacterium avium
3u0a – TEII – Mycobacterium marinum
1tbu – TE N terminal (peroximal) – yeast

Acyl protein TE

1fj2 – EcTEI

Acyl-ACP TE

2ess – TE – Bacterioides thetaiotaomicron

Fluoroacetyl-CoA TE

3kuv, 3kuw, 3kvi – ScTE (mutant) + acetate derivative – Streptomyces cattleya
3kv7, 3kv8, 3p2r, 3p2s – ScTE + acetate derivative
3kvu – ScTE + acetyl-CoA
3kvz – ScTE + FAcOPan
3kx7, 3fx8, 3p2q – ScTE
3p3f – ScTE (mutant)
3p3i - ScTE (mutant) + acetate derivative + CoA

Ubiquitin TE

USP 2

2zfy – hUSP – human
2hd5, 3nhe – hUSP + Ub
1tff – hUSP (mutant)
2ibi – hUSP (mutant) + Ub

USP 3

2qiy – USP + UBP-associated protein – yeast

USP 5

3ihp – hUSP + Ub

USP 7

2ylm – hUSP
2kvr – hUSP UBL domain - NMR
3mqr, 3mqs – hUSP + peptide
2xxn – hUSP + VIRF-4
4jjq – hUSP (mutant) + E2

USP 8

2gwf – hUSP rhodanese domain + ring finger protein
3mhh, 3m99, 4fip, 4fjc, 4fk5 – hUSP + SUS1 + SAGA-associated factors 11, 73
3mhs – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub
3n3k – hUSP + Ub inhibitor

USP 15

3lmn – hUSP DUSP domain

USP 16

2i50 – hUSP zinc finger domain - NMR

USP 21

3i3t – hUSP + Ub
3mtn – hUSP + Ub inhibitor

USP 28

2lva – hUSP N terminal - NMR

USP 33

2uzg – hUSP zinc finger domain - NMR

USP 37

3ihr – hUSP (mutant)
3a7s – hUSP catalytic domain (mutant)

USP Cyld

2vhf – hUSP

USP L1

3irt – hUSP (mutant)
2len – hUSP (mutant) - NMR
3ifw, 3kvf, 3kw5 – hUSP (mutant) + Ub
4dm9 – hUSP + peptide inhibitor

USP L5

3ris – hUSP catalytic domain
3rii – hUSP catalytic domain (mutant)
3tb3 – hUSP UCH domain (mutant)

USP ZranB1

3zrh – hUSP

USP OTUB1

3von – hUSP + E2
4ddg, 4ddi – hUSP + Ub
4ddi – hUSP (mutant) + Ub
4dhz – hUSP + E2 + Ub
4dhj – nUSP + E2 + Ub - nematode
4dhi – nUSP + E2

3znh – USP + Ub – Crimean-Congo hemorrhagic fever virus

RedJ TE

3qmv, 3qmw – TE – Streptomyces coelicolor


2av9 – TE – Pseudomonas aeruginosa

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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