Caspase: Difference between revisions
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==3D structures of caspase== | ==3D structures of caspase== | ||
''Update November 2011'' | |||
===CASP-1=== | ===CASP-1=== | ||
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[[1sc3]] - hCASP (mutant) + malonate<br /> | [[1sc3]] - hCASP (mutant) + malonate<br /> | ||
[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br /> | [[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
[[2hbq]], [[1bmq]] - hCASP + inhibitor<br /> | [[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br /> | ||
[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | [[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | ||
[[1m72]] – SfCASP + polypeptide inhibitor<br /> | [[1m72]] – SfCASP + polypeptide inhibitor<br /> | ||
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[[2p2c]] – hCASP<br /> | [[2p2c]] – hCASP<br /> | ||
[[1pyo]] - hCASP + polypeptide inhibitor<br /> | [[3r7s]] - hCASP subunits P12, P18<br /> | ||
[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br /> | |||
===CASP-3=== | ===CASP-3=== | ||
[[1qx3]] - hCASP<br /> | [[1qx3]] - hCASP<br /> | ||
[[2xyg]], [[2xyh]], [[2xyp]] – hCASP subunits P12, P17 + inhibitor<brt /> | |||
[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[[[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br /> | [[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[[[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br /> | ||
[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br /> | [[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
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[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | [[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | ||
[[3nkf]], [[3nr2]] – hCASP (mutant) <br /> | [[3nkf]], [[3nr2]] – hCASP (mutant) <br /> | ||
[[3od5]] – hCASP + polypeptide inhibitor<br /> | [[3od5]], [[3p4u]], [[3qnw]] – hCASP + polypeptide inhibitor<br /> | ||
===CASP-7=== | ===CASP-7=== | ||
[[3rk5]], [[3ibf]] – hCASP<br /> | [[3rk5]], [[3ibf]] – hCASP<br /> | ||
[[1k86]] - hCASP (mutant) <br /> | [[1k86]], [[3r5k]] - hCASP (mutant) <br /> | ||
[[1k88]] – hpro-CASP (mutant) <br /> | [[1k88]] – hpro-CASP (mutant) <br /> | ||
[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[1f1j]] - hCASP + polypeptide inhibitor<br /> | [[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[1f1j]] - hCASP + polypeptide inhibitor<br /> | ||
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[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | [[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | ||
[[3ygs]] – hpro-CASP + APAF-1 CARD | [[3ygs]] – hpro-CASP + APAF-1 CARD | ||
[[2fp3]] – DmCASP NC – ''Drosophila melanogaster''<br /> | |||
[[3sip]] – DmCASP + apoptosis inhibitor<br /> | |||
Revision as of 15:05, 22 November 2011
Template:STRUCTURE 3d6f
Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-6 details in Molecular Playground/Caspase-6 (new). CASP-7 details in Molecular Playground/Caspase-7 Dynamics. CASP-9 details in Molecular Playground/Caspase-9 Regulation.
3D structures of caspase3D structures of caspase
Update November 2011
CASP-1CASP-1
3e4c – hpro-CASP (mutant) - human
2nn3 – pro-SfCASP (mutant) – Spodoptera frugiperda
1sc1, 1sc4 - hCASP (mutant)
1sc3 - hCASP (mutant) + malonate
3d6f, 3d6h, 3d6m, 1ibc - hCASP (mutant) + polypeptide inhibitor
2hbq, 1bmq, 3ns7 - hCASP + inhibitor
2h4w, 2h4y, 2h51, 2h54, 2hbr, 2hby, 2hbz, 2h48, 2fqq, 1rwk, 1rwm, 1rwn, 1rwo, 1rwp, 1rwv, 1rww, 1rwx - hCASP (mutant) + inhibitor
1m72 – SfCASP + polypeptide inhibitor
CASP-2CASP-2
2p2c – hCASP
3r7s - hCASP subunits P12, P18
1pyo, 3r5j, 3r6g, 3r6l, 3r7b, 3r7n, 3rjm - hCASP + polypeptide inhibitor
CASP-3CASP-3
1qx3 - hCASP
2xyg, 2xyh, 2xyp – hCASP subunits P12, P17 + inhibitor<brt />
3pcx, 3pd1, 3pd0, 3gjq, 3gjr, 3gjs, 3gjt, 3edq, 3edr, 2cnk, 2cnl, 2cnn, 2cno, 2cdr, [[2h65, 1cp3, 1pau – hCASP + polypeptide inhibitor
2dko, 2cjx, 2cjy - hCASP (mutant) + polypeptide inhibitor
3kjf, 3h0e, 3deh, 3dei, 3dej, 3dek, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 1nme, 1nmq, 1nms, 1gfw – hCASP + inhibitor
3itn, 2j30, 2j31, 2j32, 2j33, 2c1e, 2c2k, 2c2m, 2c2o, 2c2z, 2h5i, 2h5j – hpro-CASP + polypeptide inhibitor
1i3o - hCASP (mutant) + XIAP-BIR2
CASP-6CASP-6
3p45, 3k7e, 2wdp – hCASP
3nkf, 3nr2 – hCASP (mutant)
3od5, 3p4u, 3qnw – hCASP + polypeptide inhibitor
CASP-7CASP-7
3rk5, 3ibf – hCASP
1k86, 3r5k - hCASP (mutant)
1k88 – hpro-CASP (mutant)
3ibc, 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 1f1j - hCASP + polypeptide inhibitor
3h1p - hCASP (mutant) + polypeptide inhibitor
1shj, 1shl - hCASP (mutant) + inhibitor
1i51, 1kmc - hCASP (mutant) + XIAP-BIR2
1i4o - hCASP + XIAP
CASP-8CASP-8
3kjn, 3kjq – hCASP + inhibitor
1f9e, 1qtn, 1qdu - hCASP + polypeptide inhibitor
3h11 - hCASP (mutant) + polypeptide inhibitor
2k7z – hpro-CASP (mutant) – NMR
2fun, 1i4e – CASP + P35 – Autographa californica
CASP-9CASP-9
2ar9 – hCASP (mutant)
1jxq - hCASP + polypeptide inhibitor
1nw9 – hCASP catalytic domain + XIAP-BIR3
3ygs – hpro-CASP + APAF-1 CARD
2fp3 – DmCASP NC – Drosophila melanogaster
3sip – DmCASP + apoptosis inhibitor