Troponin

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:

• TnC causes conformational change in TnI when it binds to calcium ions. For more details on TnC see Role of Troponin C in decreased muscle sensitivity to calcium.
  
• TnT binds to tropomyosin.
  
• TnI binds to actin which is found in thin muscle filaments.
  

See additional details in Human Cardiac Troponin C.

3D Structures of Troponin3D Structures of Troponin

Updated on 22-June-2015

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• Troponin C+Troponin I+Troponin T
  • 2w49, 2w4u – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
    
  • 1ytz - cTnC+cTnI+cTnT+Ca
    
  • 1yv0 - cTnC+cTnI+cTnT
    
  • 1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
• Troponin C+Troponin I
  • 2krd, 2mkp – hTnC+hTnI – NMR
    
  • 1ozs - hTnC C-terminal+hTnI N-terminal – NMR
    
  • 2l1r - hTnC C-terminal+hTnI switch region - NMR
    
  • 1lxf, 1mxl - hTnC N-terminal+hTnI fragment
    
  • 2kgb – hTnC (mutant) regulatory domain+TnI
    
  • 2mzp - hTnC regulatory domain+TnI switch region (mutant)
    
  • 1sbj – cTnC C-terminal+cTnI N-terminal+Mg - NMR
    
  • 1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
    
  • 1npq - cTnC (mutant) N-terminal+cTnI fragment+rhodamine
    
  • 1jc2 - cTnC C-terminal+cTnI N-terminal
    
  • 1a2x - rTnC +rTnI fragment – rabbit
    
  • 3tz1 - TnC C terminal +TnI fragment – akazara scallop
    
• Troponin C
  • 2kdh – hTnC+green tea polyphenol – NMR
    
  • 2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
    
  • 2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
    
  • 2jxl - hTnC (mutant) N-terminal – NMR
    
  • 3rv5, 3sd6, 3swb - hTnC N-terminal
    
  • 4gjg - hTnC N-terminal (mutant)
    
  • 4gjf - hTnC N-terminal (mutant) + Cd
    
  • 4gje - hTnC N-terminal + Cd
    
  • 1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
    
  • 1spy - hTnC N-terminal – NMR
    
  • 2mle - hTnC C-terminal – NMR
    
  • 2mlf - hTnC C-terminal (mutant) – NMR
    
  • 1ih0 - hTnC C-terminal+EMD 57033 – NMR
    
  • 1ap4 - hTnC N-terminal+Ca – NMR
    
  • 2l98 – hTnC EF-hand domains 3,4 + resveratrol
    
  • 1la0, 4tnc – cTnC+Ca
    
  • 1dtl – cTnC (mutant)+Ca +bepridil
    
  • 1skt, 1zac, 2ctn - cTnC N-terminal – NMR
    
  • 1aj4 - cTnC (mutant) +Ca – NMR
    
  • 3ctn - cTnC C-terminal – NMR
    
  • 1avs - cTnC N-terminal+Ca
    
  • 1smg, 1tnq - cTnC N-terminal+Ca - NMR
    
  • 1ncy – cTnC+Mn
    
  • 1ncx, 1ncz, 1top – cTnC
    
  • 1pon, 1cta, 1ctd – cTnC fragment – NMR
    
  • 1tnp - cTnC N-terminal – NMR
    
  • 1tnw, 1tnx - cTnC +Ca - NMR
    
  • 1trf - tTnC N-terminal+Ca - turkey – NMR
    
  • 5tnc - tTnC
    
  • 2k2a - TnC C-terminal – Lethocerus indicus – NMR
    
  • 2jnf – TnC – fly – NMR
    
  • 1r2u, 1r6p - TnC N-terminal – trout – NMR
    
  • 1tcf – rTnC+Ca
    
  • 1tn4, 2tn4 – rTnC (mutant)+Ca
• Troponin I
  • 2jpw – TnI biphosphorylated – mouse – NMR
    
  • 1vdi – cTnI – NMR
    
  • 1vdj – cTnI+Ca - NMR
• Troponin T
  • 2z5h – yTnT fragment+tropomyosin – yeast