Lactoferrin: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 43: Line 43:
**[[1blf]] – bLTF + 2Fe <BR />
**[[1blf]] – bLTF + 2Fe <BR />
**[[1sdx]] - bLTF C lobe + 3Zn<BR />
**[[1sdx]] - bLTF C lobe + 3Zn<BR />
**[[5cry]], [[5hbc]] - bLTF C lobe + Fe+3<br />
**[[5cry]], [[5hbc]], [[7enu]], [[7equ]], [[7ev0]], [[7evq]], [[7fdw]] - bLTF C lobe + Fe+3<br />
**[[1nkx]], [[3u8q]] - bLTF C lobe + 2Zn + Fe<br />
**[[1nkx]], [[3u8q]] - bLTF C lobe + 2Zn + Fe<br />
**[[1b1x]], [[1f9b]] – hoLTF + 2Fe<br />
**[[1b1x]], [[1f9b]] – hoLTF + 2Fe<br />
Line 51: Line 51:
**[[1jw1]] – LTF + 2Fe – goat
**[[1jw1]] – LTF + 2Fe – goat


*Lactoferrin binary complex
*Lactoferrin complex


**[[1bka]] - hLTF + 2Fe + oxalate<BR />
**[[1bka]] - hLTF + 2Fe + oxalate<BR />
**[[7jrd]] - hLTF + 2Fe + LTF-binding protein<br />
**[[7n88]] - hLTF + 2Fe + LTF-binding protein – Cryo EM<br />
**[[1lcf]] - hLTF + 2Cu + oxalate<BR />
**[[1lcf]] - hLTF + 2Cu + oxalate<BR />
**[[2pms]] – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe<br />
**[[2pms]] – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe<br />

Latest revision as of 10:40, 15 June 2023


Function

Lactoferrin or lactotransferrin (LTF) is found in secretory fluids. LTF interacts with DNA, RNA, polysaccharides and heparin[1]. For detailed discussion of human lactoferrin see Human lactoferrin.

Relevance

LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity[2]. LTF can be used as a marker for inflammatory bowel disease[3].

Structural highlights

LTF is a bilobal protein with the . LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe[4]. The binding site is between the 2 domains of each lobe.

.

The .

.

The .


Human lactoferrin complex with oxalate and Fe+3 ion (PDB entry 1bka)

Drag the structure with the mouse to rotate

3D Structures of lactoferrin3D Structures of lactoferrin

Updated on 15-June-2023

ReferencesReferences

  1. ↑ Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15(17):1956-73. PMID:19519436
  2. ↑ Farnaud S, Evans RW. Lactoferrin--a multifunctional protein with antimicrobial properties. Mol Immunol. 2003 Nov;40(7):395-405. PMID:14568385
  3. ↑ Kayazawa M, Saitoh O, Kojima K, Nakagawa K, Tanaka S, Tabata K, Matsuse R, Uchida K, Hoshimoto M, Hirata I, Katsu K. Lactoferrin in whole gut lavage fluid as a marker for disease activity in inflammatory bowel disease: comparison with other neutrophil-derived proteins. Am J Gastroenterol. 2002 Feb;97(2):360-9. PMID:11866274 doi:http://dx.doi.org/10.1111/j.1572-0241.2002.05470.x
  4. ↑ Baker HM, Anderson BF, Brodie AM, Shongwe MS, Smith CA, Baker EN. Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin. Biochemistry. 1996 Jul 16;35(28):9007-13. PMID:8703903 doi:10.1021/bi960288y

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Lactoferrin&oldid=3790979"