B-cell lymphoma proteins 3D structures

3D structures of B-cell lymphoma proteins3D structures of B-cell lymphoma proteins

Updated on 27-October-2022

{"openlevels":0}

• Bcl-xL (Bcl-2-like protein 1)
  • 1maz, 1r2d, 2b48, 4ppi, 7ca4 – hBcl-xL – human
    
  • 1r2e, 1r2g, 1r2h, 1r2i, 3cva - hBcl-xL (mutant)
    
  • 2lpc, 2m03, 2me8, 2me9, 1lxl - hBcl-xL – NMR
    
  • 6bf2 - hBcl-xL (mutant) – NMR
    
  • 6x7i - hBcl-xL C terminal - NMR
    
  • 3fdm - hBcl-xL + α/β peptide foldamer
    
  • 2mej - hBcl-xL + p53 - NMR
    
  • 6lhd - hBcl-xL/p53
    
  • 1ysg, 3sp7, 3spf, 3wiz, 4tuh, 3zln, 3zk6, 3zlo, 3zlr, 4c52, 4c5d, 2yxj, 4qnq, 4qvx, 6rnu, 6vwc, 7jgv, 7jgw, 7lh7 - hBcl-xL + inhibitor
    
  • 7xgf - hBcl-xL + inhibitor protein
    
  • 3inq - hBcl-xL (mutant) + inhibitor
    
  • 2w3l – hBcl-xL + quinoline derivative
    
  • 2o1y, 2o2m, 2o2n, 1ysi, 1ysn, 2o21, 2o22, 2o2f - hBcl-xL + sulfonamide derivative – NMR
    
  • 3qkd, 4ehr - hBcl-xL + sulfonamide derivative
    
  • 2pon - hBcl-xL + Beclin-1 residues 1-23 - NMR
    
  • 6zhc - hBcl-xL + elongin B + elongin C + VHL
    
  • 6ijq - hBcl-xL + p73 peptide - NMR
    
  • 6yli - hBcl-xL + TRBak peptide
    
  • 6hjl, 6st2, 6stj – hBcl-2-L-1 + affirmer
    
  • 3ihc, 3iih, 1pq0 – mBcl-xL residues 1-196 – mouse
    
  • 3ihd, 3ihe, 3ihf, 3iig, 3ilb, 3ilc - mBcl-xL residues 1-196 (mutant)
    
  • 2bzw - mBcl-xL residues 1-211 + BAD
    
  • 1pq1, 5c3g - mBcl-xL residues 1-196 + BIM peptide
    
  • 1af3 - rBcl-xL soluble domain
    
  • 6wh0 - Bcl-xL + BAX peptide - hydra
    
  • 1bxl - Bcl-xL + Bak peptide – Escherichia coli – NMR
    
  • 5twa - Bcl-xL + Bak peptide – sponge
    
• Bcl-xL complex with BH3 domain peptide
  • 3pl7 - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain
    
  • 5fmk, 5fmj - hBcl-xL + Bak BH3 domain
    
  • 4qve - hBcl-xL + BID BH3 domain
    
  • 1g5j - hBcl-xL + BAD BH3 peptide
    
  • 5b1z - hBcl-xL + BHX BH3 domain
    
  • 4z9v - hBcl-xL + TCTP BH3 domain
    
  • 7wjh - hBcl-xL + Pxt1 BH3 domain
    
  • 6dcn, 6dco - hBcl-xL + Beclin-1 BH3 domain
    
  • 2p1l - hBcl-xL (mutant) + Beclin-1 BH3 domain
    
  • 2yq6, 4qvf, 4yk9, 3fdl, 5agx, 4yj4, 3io8, 2yq7, 5vx3, 5agw - hBcl-xL + BIM BH3 domain
    
  • 2yj1, 4bpk, 4hnj - hBcl-xL + alpha-beta-puma BH3 domain
    
  • 4a1u, 4a1w - hBcl-xL + alpha-beta-foldamer BH3 domain
    
  • 3r85 - hBcl-xL + heme-binding protein BH3 peptide
    
  • 2lp8 – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide- NMR
    
  • 2m04 – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR
    
  • 5wos - Bcl-xL + hBIM BH3 domain – canarypox virus
    
  • 5tzp - fpvBcl-xL + BIK BH3 domain – fowlpox virus
    
  • 5tzq - fpvBcl-xL + Bmf BH3 domain
    
  • 6yld - Bcl-xL + Bak BH3 domain - Trichoplax
    
• Bcl-2 or apoptosis regulator Bcl-2
  • 1gjh, 1g5m – hBcl-2
    
  • 4aq3, 4man, 5jsn, 4ieh, 6gl8, 6qgg, 6qgj, 6qgk, 7jmt – hBcl-2 + inhibitor
    
  • 4lvt, 4lxd, 6o0k, 6o0m, 6o0o, 6o0p – hBcl-2 (mutant) + inhibitor
    
  • 7lhb – hBcl-2 (mutant) + drug
    
  • 5fcg – hBcl-2 (mutant) + HBX BH3 domain
    
  • 2xa0 – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain
    
  • 2o21, 2o22, 2o2f, 1ysw - hBcl-2 + sulfonamide derivative – NMR
    
  • 6v4m – Bcl-2 – Trichuris suis
    
• Bcl-2-related protein A1 (Bfl-1)
  • 6vo4 - hBcl-2A1
    
  • 5whi - hBcl-2A1 (mutant)
    
  • 2vm6, 3mqp, 4zeq, 5uuk, 5uul, 5uup, 6e3i, 6e3j, 6rjp - hBcl-2A1 + peptide
    
  • 2vof - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide
    
  • 2vog - mBcl-2A1 + Bmf BH3 peptide
    
  • 2voh - mBcl-2A1 + Bak BH3 peptide
    
  • 2voi - mBcl-2A1 + BID BH3 peptide
    
• Bcl-3
  • 1k1a, 1k1b – hBcl-3 ankyrin repeat domain
    
• Bcl-6
  • 3e4u, 1r28, 1r29, 4u2m, 6xwf – hBcl-6 BTB domain 6-129
    
  • 3lbz, 5mw6, 5mw2, 5mwd, 5n1x, 5n1z, 5n20, 5n21, 5x4m, 5x4n, 5x4o, 5x4p, 5x9o, 5x9p, 5x4o, 5x4q, 6ew8, 6ew7, 6ew6, 6c3n – hBcl-6 BTB domain + inhibitor
    
  • 6cq1, 6c3l – hBcl-6 BTB domain (mutant) + inhibitor
    
  • 4cp3 – hBcl-6 BTB domain + antibiotic
    
  • 6xxs, 6xyx, 6xzz, 6zbu – hBcl-6 BTB domain + corepressor peptide
    
  • 3bim – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor
    
  • 5h7g, 5h7h – hBcl-6 BTB domain + F1324 peptide
    
  • 1r2b – hBcl-6 BTB domain + SMRT peptide
    
  • 6tof, 6tog, 6toh, 6toi, 6toj, 6too – hBcl-6 BTB domain + peptide + pyridine derivative
    
  • 6tok, 6tol, 6tom, 6ton – hBcl-6 BTB domain + peptide + pyrimidine derivative
    
  • 2lce – hBcl-6 zinc fingers 2-3 residues 540-602 - NMR
    
  • 2yrm, 2eos – hBcl-6 zinc finger-C2H2 residues 515-544 - NMR
    
  • 2en2 – hBcl-6 zinc finger-C2H2 residues 598-626 - NMR
    
• Bcl-9
  • 3sl9 – hBcl-9 residues 344-396 + catenin beta-1
    
  • 2gl7 – hBcl-9 residues 344-396 + catenin beta-1 + transcription factor 7-like
    
• Bcl-10
  • 2mb9 – hBcl-10 CARD domain (mutant) – NMR
    
  • 6bze – hBcl-10 CARD domain – Cryo EM
    
  • 6gk2 – hBcl-10 CARD domain + MALTI death domain – Cryo EM
    
• Bcl-11A
  • 6ki6 – hBcl-11A + DNA
    
• Bcl-W (Bcl-2-like protein 2)
  • 1o0l, 1mk3, 2y6w – hBcl-W (mutant)
    
  • 1zy3, 4cim - hBcl-W (mutant) + BID BH3 peptide
    
  • 4k5a, 4k5b - Bcl-W (mutant) + ankyrin repeat - bovine
    
  • 4cin - hBcl-W + BH3 peptide
    
• Bcl-2-like protein 4 (Bax or apoptosis regulator Bax)
  • 4bd7, 4s0o, 4s0p - hBax
    
  • 4bd8, 5w60, 5w61, 6eb6 – hBax (mutant)
    
  • 6l8v - hBax helix2-helix5 - NMR
    
  • 2lr1 - hBax + VMIA peptide
    
  • 4bd6 – hBax (mutant) + BH3 peptide
    
  • 2k7w – hBax + BIM BH3 peptide - NMR
    
  • 4zie, 4zif, 4zig, 4zih, 4zii, 5vww – hBax (mutant) + BIM BH3 peptide
    
  • 6wgz – hBax + MBP + Bak BH3 peptide
    
  • 4bd2 – hBax (mutant) + BID BH3 peptide
    
  • 5w5z, 5w5x – hBax (mutant) + antibody
    
• Bcl-2-like protein 5
  • 3i1h - hBcl-2-L-5 + hBak
    
• Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
  • 2yv6, 2imt, 2jcn, 2ims, 6odh, 7k02 – hBak
    
  • 5fmi, 4u2u, 5vx1 – hBak (mutant)
    
  • 4u2v – hBak/GFP
    
  • 7ofm, 7ofo – hBak transmembrane helix - NMR
    
  • 3qbr - hBak + sjA
    
  • 6uxm, 6uxn, 6uxo, 6uxp, 6uxq, 6uxr - hBak + inhibitor
    
  • 2xpx - hBak fragment + BHRF1
    
  • 5vwx, 5vwy, 5vwz, 5vx0 - hBak + BIM BH3 domain
    
  • 5vwv - hBak (mutant)+ BIM BH3 domain
    
  • 2m5b - hBak + BID BH3 domain - NMR
    
  • 7m5c – hBak + Bak BH3 peptide
    
  • 7m5a, 7m5b – hBak + M3W5 BID
    
  • 7lk4 – hBak (mutant) + antibody
    
  • 6mcy – mBak
    
• Bcl-2-like protein 10
  • 4b4s - hBcl-2-L-10 + hBIM BH3 peptide
    
  • 2kua – mBcl-2-L-10
    
  • 6fbx, 6h1n – Bcl-2-L-10 - zebrafish
    
• Bcl-2-like protein 11 (Bim)
  • 2nl9 – hBim + Mcl-1
    
  • 6x8o – hBim BH3 peptide
    
• Bcl-2-like protein 15
  • 7ccl, 7ccm - hBcl-2-L-15
    

Mcl-1 (Bcl-2-like protein 3 or Myeloid cell leukemia-1)

• • 3mk8 - hMcl-1 residues 174-324
    
  • 2mhs - hMcl-1 residues 174-324 (mutant)
    
  • 4wms - hMcl-1/MBP (mutant)
    
  • 5lof - hMcl-1/MBP + inhibitor
    
  • 4wmx, 4wmw, 4wmv - hMcl-1/MBP + ligand
    
  • 4wmu, 4wmt - hMcl-1/MBP (mutant) + ligand
    
  • 4wgi - hMcl-1/MBP (mutant) + macrolactam
    
  • 3wix, 3wiy, 4oq5, 4oq6, 4hw2, 4hw3, 4hw4, 4wmr, 4zbf, 4zbi, 5fc4, 5fdo, 5fdr, 5iez, 5if4, 5jsb, 5ku9, 5vkc, 6b4l, 6b4u, 6bw2, 6bw8, 6fs1, 6fs2, 6ne5, 6o4u, 6o6f, 6oqb, 6oqc, 6oqd, 6oqn, 6p3p, 6qgd, 6qfq, 6qyp, 6qz5, 6qz6, 6qz8, 6qzb, 6u63, 6u64, 6u65, 6u67, 6u6f, 6ud2, 6udi, 6udt, 6udu, 6udv, 6udx, 6udy, 6ybg, 7nb4, 7nb7 - hMcl-1 residues 174-324 + inhibitor
    
  • 7xge, 7xgg - hMcl-1 residues 174-324 + protein inhibitor
    
  • 6ovc - hMcl-1 residues 174-324 + inhibitor - NMR
    
  • 6qxj, 6qyk, 6qyl, 6qyn, 6qyo, 6qz7, 6ybj, 6ybk, 6ybl - hMcl-1 residues 174-324/MBP + inhibitor
    
  • 5c3f, 5uum, 6mbb, 6mbc, 6mbd, 6mbe, 6qfm, 6ua3, 6uab - hMcl-1 residues 174-324 + peptide
    
  • 6qb3, 6qfc - hMcl-1 residues 174-324 + scFv
    
  • 6qb4 - hMcl-1 residues 174-324 + scFv + inhibitor
    
  • 6qb6 - hMcl-1 residues 174-324 + antibody
    
  • 6zie - hMcl-1 residues 174-324 + alphabody
    
  • 5mes, 5mev - hMcl-1 residues 153-221 + inhibitor + antibody
    
  • 6fs0 - hMcl-1 residues 174-324 + inhibitor + antibody
    
  • 1wsx – mMcl-1 residues 152-308 - NMR
    
  • 6dm8 - mMcl-1/MBP + inhibitor
    
• Mcl-1 complex with BH3 domain peptide
  • 2nla, 4g35 – rMcl-1 fragment + NoxaB BH3 domain
    
  • 2jm6, 2rod – mMcl-1 fragment + NoxaB fragment – NMR
    
  • 2roc - mMcl-1 fragment + Puma BH3 domain
    
  • 3kz0 - hMcl-1 + MB7 BH3 domain
    
  • 3pk1 – hMcl-1 fragment + hBax BH3 domain
    
  • 2kbw - hMcl-1 fragment + BID BH3 peptide – NMR
    
  • 4bpj, 4bpi - hMcl-1 fragment + Puma BH3 peptide
    
  • 5c6h - hMcl-1 fragment + Mule BH3 peptide
    
  • 5w89, 5w8f, 3kj0, 3kj1, 3kj2, 3io9, 3d7v, 2pqk, 5vx2, 6qfi - hMcl-1 fragment + BIM BH3 peptide
    
  • 2kbw - hMcl-1 fragment + BID BH3 peptide - NMR
    
• M11
  • 2o42, 2jbx – MvM11L – Myxoma virus
    
  • 2jby – MvM11L + Bak
    
  • 3dvu, 3bl2, 4mi8 – M11 + Beclin-1 – Murid herpesvirus
    
• N1L
  • 2i39 – VvN1L – Vaccinia virus
    
  • 4bbb, 4bbc, 4bbd – VvN1L (mutant)