Aldehyde dehydrogenase 3D structures

3D Structures of Aldehyde dehydrogenase3D Structures of Aldehyde dehydrogenase

Updated on 22-May-2024

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• ALDH class 1
  • 1hso – hALDH1 α subunit + Zn + NAD - human
    
  • 4wj9 - hALDH1 (mutant)
    
  • 4wpn - hALDH1 + inhibitor
    
  • 4wp7 - hALDH1 (mutant) + inhibitor
    
  • 4wb9 - hALDH1 + NAD derivative
    
  • 4x4l - hALDH1 + NAD derivative + inhibitor
    
  • 1ht0 – hALDH1 γ subunit (mutant) + Zn + NAD
    
  • 3fx4 – ALDH1 + NADP + inhibitor – pig
    
  • 1bxs – sALDH1 + NAD - sheep
    
  • 5abm - sALDH1 + NAD derivative
    
  • 5ac0 - sALDH1 + NAD + duocarmycin analog
    
  • 5ac1, 5ac2 - sALDH1 + duocarmycin analog
    
  • 1o9j – ALDH1 + NAD – Elephant shrew
    
  • 3rhj, 3rhl, 3rho, 3rhp, 3rhq, 3rhr – rALDH1 C- terminal (mutant) + NADP – rat
    
  • 3rhm - rALDH1 C- terminal
    
• ALDH family 1 A (retinal dehydrogenase)
  • 4x4l, 5l2m, 5l2n, 5l2o, 7jws, 7jwt, 7jwu, 7jwv, 7jww – hRALDH1A1 + inhibitor
    
  • 5tei, 6dum – hRALDH1A1 + NAD + inhibitor
    
  • 6alj, 6b5g, 6b5h, 6b5i – hRALDH1A22 + NAD + inhibitor
    
  • 7qk7 – hRALDH1A3
    
  • 7qk9 – hRALDH1A3 + ATP
    
  • 5fhz – hRALDH1A3 + NAD + retinol
    
  • 6s6w, 6te5, 6try, 7a6q, 7qk8 – hRALDH1A3 + NAD + inhibitor
    
  • 7mjc – hRALDH1B1 + NAD
    
  • 7mjd, 7rad – hRALDH1B1 + NAD + inhibitor
    
  • 5abm – sRALDHA1 + inhibitor
    
  • 7yob – mRALDHA1 - mouse
    
• ALDH class 2
  • 3n80, 1o05, 4kwf – hALDH2 residues 18-517
    
  • 3n81, 2onn, 2ono, 1zum – hALDH2 residues 18-517 (mutant)
    
  • 1ag8 – bALDH NAD binding domain - bovine
• ALDH2 binary complex
  • 3inj, 3inl, 4kwg - hALDH2 residues 18-517 + agonist
    
  • 2vle - hALDH2 residues 24-517 + daidzin
    
  • 1nzx, 1nzz, 1o00, 1o02, 1cw3, 4x2q - hALDH2 residues 18-517 + NAD
    
  • 3n82, 3n83, 2onm, 2onp, 1nzw, 1o04 – hALDH2 residues 18-517 (mutant) + NADH
    
  • 3sz9 - hALDH2 residues 18-517 + inhibitor
    
  • 1a4z – bALDH2 NAD-binding domain + NAD
    
  • 1bi9 – rALDH2 + NAD
    
  • 4pxl – mALDH2 + NAD - maize
    
  • 4pz2 – mALDH6 + NAD
    
  • 6d97 – mALDH12 + NAD
    
• ALDH2 ternary complex
  • 1o01 - hALDH2 residues 18-517 + NADH + aldehyde
    
  • 4fqf - hALDH2 residues 18-517 + NAD + NO2
    
  • 4fr8 - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin
    
  • 5l13 – hALDH2 + inhibitor
    
• ALDH class 3
  • 3sza - hALDH3A1
    
  • 3szb, 4l1o, 4l2o – hALDH3A1 + inhibitor
    
  • 4h80 - hALDH3A1 (mutant) + inhibitor
    
  • 4qgk – hALDH3A2 + ligand
    
  • 1ad3 – rALDH3
    
  • 5myp – TbALDH – Trypanosoma brucei
    
  • 5nno – TbALDH + NAD + inhibitor
    
• ALDH family 4 (delta-1-pyrroline-5-carboxylate dehydrogenase)
  • 3v9g, 4oe5 – hALDH4A1
    
  • 3v9h, 3v9i – hALDH4A1 (mutant)
    
  • 3v9j, 4e3x – mALDH4A1
    
  • 3v9k – mALDH4A1 + Glu
    
  • 4lh0 – mALDH4A1 + glyoxylate
    
  • 4lh1 – mALDH4A1 + malonate
    
  • 4lh2 – mALDH4A1 + succinate
    
  • 4lh3 – mALDH4A1 + glutarate
    
  • 4lgz – mALDH4A1 + acetate
    
  • 3v9l – mALDH4A1 + NAD
    
  • 7mer – mALDH4A1 + Pro derivative
    
• ALDH family 5 (succinate-semialdehyde dehydrogenase)
  • 2w8n, 2w8o, 2w8r – hALDH5A1
    
  • 2w8p – hALDH5A1 (mutant)
    
  • 2w8q – hALDH5A1 + succinate
    
  • 3jz4 - EcALDH5A1 + NADP
    
  • 4v6h - BpALDH5A1 – Burkholderia pseudomallei
    
  • 3rh9 - ALDH5A1 – Marinobacter aquaeolei
    
• ALDH family 7 (alpha-aminoadipic semialdehyde dehydrogenase)
  • 4zvw, 4zvx, 4zuk - hALDH7A1
    
  • 6o4d – hALDH7A1 + pipecolic acid
    
  • 2j6l, 4zvy – hALDH7A1 + NAD
  • 6o4b, 6o4c, 6o4e, 6o4h, 6o4k, 6o4l, 6u2x, 6v0z – hALDH7A1 (mutant) + NAD
    
  • 6o4d, 6o4i – hALDH7A1 (mutant) + pipecolic acid
    
  • 4x0u - hALDH7A1 + inhibitor
    
  • 4zul - hALDH7A1 + a-aminoadipate
    
  • 6o4f, 6o4g - hALDH7A1 (mutant) + a-aminoadipate
    
  • 4x0t - hALDH7A1 + NAD+ inhibitor
    
• ALDH family 9 (4-trimethylaminobutyraldehyde dehydrogenase)
  • 6qak, 6qao, 6qap – hALDH9A1
    
  • 6vr6, 6vwf – hALDH9A1 + NAD
    
• NAD-dependent ALDH
  • 3vos, 3tz6, 3vos – Aspartate-semi-MtALDH
    
  • 2cq8 - Formyltetrahydrofolate-hALDH PP-binding domain - NMR
    
  • 7rlt - Formyltetrahydrofolate-rALDH1L1
    
  • 2nac – Formate-PsALDH
    
  • 3i44 – ALDH – Bartonella henselae
    
  • 3ek1 – ALDH – Brucella melitensis
    
  • 3ros – ALDH – Lactobacillus acidophilus
    
  • 3r64 – ALDH – Corynebacterium glutamicum
    
  • 3rhe – Benzaldehyde-ALDH – Legionella pneumophila
    
  • 3u4j, 4i3t – SmALDH – Sinorhizobium meliloti
    
  • 5dru - CpALDH – Clostridium phytofermentans
    
  • 4qf6, 5gt6 – BcALDH – Bacillus cereus
    
  • 4qet – BcALDH (mutant)
    
  • 5uju - BmALDH – Burkholderia multivorans
    
  • 6fk3, 6fkv, 6fjx - TtALDH – Thermus thermophilus
    
• NAD-dependent ALDH binary complexes
  • 2cfi - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin
    
  • 7rlu - Formyltetrahydrofolate-rALDH1L1 + NADP
    
  • 2o2p – Formyltetrahydrofolate-rALDH C-terminal
    
  • 4a0m, 4v37 – spALDH + NAD – spinach
    
  • 5a2d, 4v3f – spALDH + choline
    
  • 3iwk – amino-ALDH + NAD – pea
    
  • 2nad - Formate-PaALDH + NAD
    
  • 3l4p, 1sij – ALDH + AsO3 – Desulfovibrio gigas
    
  • 3ju8 - Succinylglutamic–semi-PaALDH + NAD
    
  • 4c3s - CpALDH + NAD
    
  • 5dbv - CpALDH + CoA
    
  • 4i3u – SmALDH + phosphonoacetaldehyde
    
  • 5gtk – BcALDH + NAD
    
  • 5jfl – RpALDH + NAD – Rhodopseudomonas palustris
    
  • 6gvs – RpALDH + NADP
    
  • 5jfn – RpALDH + CoA
    
  • 6fku – TtALDH + NADP
    
• NAD-dependent ALDH ternary complexes
  • 2gsd – Formate-ALDH + NAD + azide – Moraxella
    
  • 1nvm – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD
    
  • 1llu - PaALDH + NAD + alcohol
    
  • 4i3v, 4i3w – SmALDH + aldehyde derivative + NAD
    
  • 4i3x – SmALDH + phosphonoacete + NAD
    
  • 5jfm – RpALDH + CoA + propionyl-CoA
    
• NADP-dependent ALDH
  • 4gac – mALDH
    
  • 2hg2, 2opx – Lactaldehyde-EcALDH
    
  • 2y51, 2y52, 2y53, 2y5d – BxALDH (mutant) – Burkholderia xenovorans
    
  • 3uw3 - aspartate–semi-BtALDH – Burkholderia thailandensis
    
  • 3v4c - SmALDH
    
  • 5eeb - PfALDH – Pyrobaculum ferrireducens
    
  • 6j75 – VvALDH – Vibrio variablis
    
  • 6pnu – PfALDH – Pseudoalteromonas fuliginea
    
• NADP-dependent ALDH binary complexes
  • 2wox, 2wme, 2xdr, 3zqa - PaBDH + NADP
    
  • 2ilu - Lactaldehyde-EcALDH + NADP
    
  • 3rhd - Lactaldehyde-MjALDH + NADP - Methanocaldococcus jannaschii
    
  • 2o2q, 2o2r - Formyltetrahydrofolate-rALDH C-terminal + NADP
    
  • 3b4w - MtALDH + NADP – Mycobacterium tuberculosis
    
  • 1eyy, 1ez0 – ALDH + NADP – Vibrio harveyi
    
  • 3hsk - aspartate–semi-ALDH + NADP – Candida albicans
    
  • 4h73, 4nmj, 4nmk, 5f2c, 5exf, 5euy, 5ekc, 5ek6 - PfALDH + NADP
    
  • 5kf0 - ALDH + NADP – Burkholderia vietnamiensis
    
  • 5jry - BmALDH + NADP
    
  • 5j6b - BtALDH + NADP
    
  • 5gtl – BcALDH + NADP
    
  • 6j76 – VvALDH + NADP
    
  • 6pop – PfALDH + NADP
    
• NADP-dependent ALDH ternary complexes
  • 2imp - Lactaldehyde-EcALDH + NADH + lactate
    
  • 2vro – BxALDH + NADP + alcohol
    
• Indole-3-acetaldehyde dehydrogenase
  • 5iuu – PsIALDH – Pseudomonas syringae
    
  • 5iuv – PsIALDH + NAD
    
  • 5iuw, 7jso – PsIALDH + NAD + indole acetate
    
• NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
  • 1vsu – CpGAPDH – Cryptosporidium parvum
    
  • 1ywg – PfGAPDH – Plasmodium falciparum
    
  • 2ep7 – GAPDH – Aquifex aeolicus
    
  • 2i5p – GAPDH – Kluyveromyces marxianus
    
  • 1obf – GAPDH – Achromobacter xylosoxidans
    
  • 1b7g – GAPDH – Sulfolobus solfataricus
    
  • 2gd1, 3cmc – GsGAPDH – Geobacillus stearothermophilus
    
  • 3e6a – OsGAPDH – Oryza sativa
    
  • 4gpd, 1gpd, 1crw – GAPDH – lobster
    
  • 3l6o, 3lc7 – SaGAPDH
    
  • 1dc3, 1dc5, 1s7c – EcGAPDH - Escherichia coli
    
• GAPDH binary complex
  • 1k3t - TcGAPDH + inhibitor
    
  • 3hja - GAPDH + NAD – Borellia burgdorferi
    
  • 1vsv, 3cps - CpGAPDH + NAD
    
  • 2vyn, 2vyv - rGAPDH residues 102-432 + EcGAPDH + NAD
    
  • 2b4r, 2b4t – PfGAPDH (mutant) + NAD
    
  • 1j0x – GAPDH + NAD – rabbit
    
  • 1ihx – PvGAPDH + NAD
    
  • 1dss, 1szj - PvGAPDH NAD-binding and catalytic domains+ NAD
    
  • 1ihy – PvGAPDH + ADP-ribose
    
  • 1gyq, 1gyp - LmGAPDH + NAD derivative – Leishmania mexicana
    
  • 1i32, 1i33 – LmGAPDH + inhibitor
    
  • 1a7k – LmGAPDH + NAD
    
  • 1cer, 2g82 - GAPDH + NAD – Thermus aquaticus
    
  • 1gd1 - GsGAPDH + NAD
    
  • 1npt, 1nq5, 1dbv, 2dbv, 3dbv, 4dbv - GsGAPDH (mutant) + NAD
    
  • 3e5r – OsGAPDH + NAD
    
  • 3k73, 3lvf – SaGAPDH + NAD
    
  • 3lc2 - SaGAPDH + G3P
    
  • 3k9q, 3ksd, 3lc1, 3hq4 - SaGAPDH (mutant) + NAD
    
  • 3gpd, 2u8f, 1znq – hGAPDH + NAD
    
  • 1gad, 1dc6 - EcGAPDH + NAD
    
  • 1gae - EcGAPDH (mutant) + NAD
    
  • 1dc4 – EcGAPDH + G3P
    
• GAPDH ternary complex
  • 3id5, 3dmt, 1ml3 – TcGAPDH + NAD + inhibitor
    
  • 1qxs - TcGAPDH + NAD + G3P analog
    
  • 3cif - CpGAPDH + NAD + G3P
    
  • 1nqa, 1nqo - GsGAPDH (mutant) + NAD + G3P
    
  • 3ksz, 3kv3, 3l4s - SaGAPDH (mutant) + NAD + G3P
    
• NADP-dependent GAPDH with cofactor NADP
  • 2dbv, 4dbv - GsGAPDH (mutant) + NADP
    
  • 2yyy - MjGAPDH + NADP
    
  • 2euh - SmGAPDH + NADP
    
  • 2id2 - SmGAPDH (mutant) + NADP
    
  • 1cf2 - GAPDH + NADP – Methanothermus fervidus
    
  • 1jn0, 1rm4, 2pkq, 2pkr - sGAPDH + NADP
    
  • 1rm3, 1rm5 - sGAPDH (mutant) + NADP
    
  • 1ky8 - TtGAPDH + NADP – Thermoproteus tenax
    
  • 3rhh - BhGAPDH + NADP
    
• NADP-dependent GAPDH ternary complexes containing glyceraldehyde-3-phosphate (G3P)"
  • 1qi1 - SmGAPDH + NADP + G3P
    
  • 2esd, 2qe0 - SmGAPDH (mutant) + NADP + G3P
    
  • 3lc2 – SaGAPDH-thioacyl + G3P
    
  • 1uxu - TtGAPDH (mutant) + NADP + AMP + G3P
    
• Other NADP-dependent GAPDH ternary complexes
  • 1k3t - TcGAPDH + coumarin derivative
    
  • 1uxv - TtGAPDH + NADP + AMP
    
  • 1uxp - TtGAPDH (mutant) + NADP + ADP
    
  • 1uxq - TtGAPDH (mutant) + NADP + G1P
    
  • 1uxr - TtGAPDH (mutant) + NADP + F6P
• NAD/NADP-dependent betaine ALDH
  • 1a4s - cBADH – cod
    
  • 1bpw - cBADH + NAD
    
  • 3r31 – BADH – Agrobacterium tumefaciens
    
  • 4mpb, 4nu9, 4q92, 4qto - SaBADH – Staphylococcus aureus
    
  • 4qje - SaBADH (mutant)
    
  • 4zxu, 4zwl - SaBADH (mutant) + NAD
    
  • 4cbb, 6bpg - PaBADH - Pseudomonas aeruginosa
    
  • 6bjp - PaBADH (mutant)
    
  • 4mpy, 4nea - SaBADH + NAD
    
  • 4qn2, 5ez4, 5eyu, 5dib - SaBADH (mutant) + NAD
    
  • 4caz - PaBADH + NAD derivative
    
  • 3k2w - BADH – Pseudoalteromonas atlantica
    
  • 6wsa - BpBADH
    
  • 6wsb - BpBADH + NAD
    
  • 2wox, 2wme, 2xdr, 3zqa - PaBADH + NADP
    
  • 3k2w - BADH – Pseudoalteromonas atlantica
    
• Uncharacterized ALDH
  • 3k9d – ALDH – Listeria monocytogenes
    
  • 4dng – ALDH – Bacillus subtilis
    
  • 3my7 – ALDH – Vibrio parahaemolyticus
    
  • 4qyj - PpALDH
    
  • 5mz5 – PhpALDH 21 – Physcomitrella patens
    
  • 5mz8 – PhpALDH 21 + succinate
    
  • 5n5s – PhpALDH 21 + NADP
    
  • 6mvr – LoALDH 16 - Loktanella
    
  • 6mvu – LoALDH 16 (mutant)
    
  • 6mvs, 6mvt – LoALDH 16 + NAD
    
  • 6ahc – EcALDH – Cryo EM
    
  • 6k0z - SaALDH
    
  • 6k10 – SaALDH (mutant)
    
• Antiquitin
  • 2jg7 – Antiquitin – Acanthopagrus schlegeli