Crystal Structure of the Non-phosphorylating glyceraldehyde-3-phosphate DehydrogenaseCrystal Structure of the Non-phosphorylating glyceraldehyde-3-phosphate Dehydrogenase
Structural highlights
1ky8 is a 1 chain structure with sequence from Thermoproteus tenax. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GAPN_THETE Catalyzes the irreversible NAD(P)-dependent non-phosphorylating oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3PG). It is highly specific for D-GAP.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Hensel R, Laumann S, Lang J, Heumann H, Lottspeich F. Characterization of two D-glyceraldehyde-3-phosphate dehydrogenases from the extremely thermophilic archaebacterium Thermoproteus tenax. Eur J Biochem. 1987 Dec 30;170(1-2):325-33. PMID:3121324
↑Brunner NA, Brinkmann H, Siebers B, Hensel R. NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. J Biol Chem. 1998 Mar 13;273(11):6149-56. PMID:9497334
