Polyhedrin

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Polyhedrin is a viral protein in cytoplasmic polyhedrosis viruses which parasitize insects. Polyhedrin forms a protective layer around a virus and resists its solubilization and thus ensures its long-term viability[1].

Relevance

Polyhedrins protect viruses which cause disease in silkworm[2].

Structural highlights

The biological assembly of Uranotaenia sapphirina cypovirus Polyhedrin is (PDB code 4s1k). [3]. Water molecules are shown as red spheres. .


Polyhedrin complex with ATP (PDB code 4s1k)

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3D structures of polyhedrin3D structures of polyhedrin

Updated on 04-September-2023

ReferencesReferences

  1. Rohrmann GF. Polyhedrin structure. J Gen Virol. 1986 Aug;67 ( Pt 8):1499-513. doi: 10.1099/0022-1317-67-8-1499. PMID:3525744 doi:http://dx.doi.org/10.1099/0022-1317-67-8-1499
  2. Kunimi Y. Current status and prospects on microbial control in Japan. J Invertebr Pathol. 2007 Jul;95(3):181-6. doi: 10.1016/j.jip.2007.03.007. Epub, 2007 Mar 25. PMID:17462666 doi:http://dx.doi.org/10.1016/j.jip.2007.03.007
  3. Ginn HM, Messerschmidt M, Ji X, Zhang H, Axford D, Gildea RJ, Winter G, Brewster AS, Hattne J, Wagner A, Grimes JM, Evans G, Sauter NK, Sutton G, Stuart DI. Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data. Nat Commun. 2015 Mar 9;6:6435. doi: 10.1038/ncomms7435. PMID:25751308 doi:http://dx.doi.org/10.1038/ncomms7435

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Michal Harel, Alexander Berchansky