MAPK/ERK pathway

Under development!!! MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. Cell surface receptors that can activate this pathway via GRB2 Epidermal Growth Factor Receptor (EGFR; see also Epidermal growth factor). EGFR belongs to Receptor tyrosine kinases, class I. Trk A/B: High affinity nerve growth factor receptor (TrkA). TrkB tyrosine kinase receptor. See also Neurotrophin. Fibroblast growth factor receptor Platelet-derived growth factors and receptors Growth factor receptor-bound proteins Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see Grb10 SH2 Domain. Ras activation GTPase KRas Allosteric modulation of H-Ras GTPase. Kinase cascade RAF kinase B-Raf is related to retroviral oncogenes and participates in cellular signal transduction. B-Raf domains include the kinase domain - residues 444-721 and Ras-binding domain - residues 153-237. Mutated B-Raf was found in some human cancers. See more in B-RAF with PLX4032. c-Raf is part of the MAPK pathway. c-Raf domains include the kinase domain - residues 323-618, cysteine-rich domain – residues 136-187 and Ras-binding domain - residues 51-132. Mutations of c-Raf are possible causes of Noonan syndrome. For details on c-Raf see Molecular Playground/C-Raf. MAPKs Mitogen-activated protein kinase Mitogen-activated protein kinase kinase Mitogen-activated protein kinase kinase kinase Michael Roberts/BIOL115/ERK2 p38 MAPK (UMass Chem 423 Student Projects 2011-2)

spinqualitylabelsall models Glycosylated EGFR (PDB code 3i2t) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image