Epidermal growth factor

Function Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. Some details on EGF exon in EGF1 on Gla domain in Gla domain Pre-prozymogen. Relevance EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination. Structural highlights All EGF family proteins contain a conserved amino acid sequence which includes (PDB code 1jl9).

spinqualitylabelsall models Dimer of the monomeric human epidermal growth factor (PDB code 1jl9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of epidermal growth factor3D structures of epidermal growth factor

Updated on 23-February-2023

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• EGF
  • 1jl9 – hEGF
    
  • 2kv4 – hEGF - NMR
    
  • 1gk5, 1p9j – hEGF/transforming growth factor alpha - NMR
    
  • 1ivo, 3njp – hEGF 1-53 + EGFR
    
  • 1nql – hEGF 971-1023 + EGFR
    
  • 7syd, 7sye, 7sz0, 7sz1, 8hgs - hEGF 971-1023 + EGFR – Cryo EM
    
  • 7om4 - hEGF 971-1023 + EGFR + nanobody
    
  • 1egf, 1epg, 1eph, 1epi, 1epj, 3egf – mEGF – mouse – NMR
    
  • 1a3p – mEGF (mutant) – NMR
    
• Heparin-binding EGF-like growth factor
  • 1xdt – hHB-EGF extracellular domain + diphtheria toxin
• EGF-like Cripto protein
  • 2j5h – mCR-EGF residues 96-134 - NMR