High affinity nerve growth factor receptor

Function High affinity nerve growth factor receptor (TrkA) is a tyrosine kinase receptor. Trk stands for Topomyosin-Related Kinase. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation. See also Neurotrophin. Relevance TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease. TrkA inhibition may be a novel therapeutic approach to Alzheimer disease and a new method to treat intractable pain. Structural highlights . An , conserved in all neutrophins, forms the most important binding determinant between TrkA and its ligand - nerve growth factor - which forms the active homodimer of the receptor, . .

spinqualitylabelsall models Glycosylated human TrkA (cyan and green) complex with nerve growth factor (yellow and magenta) (PDB code 2ifg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of high affinity nerve growth factor receptor3D structures of high affinity nerve growth factor receptor

Updated on 16-May-2023

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• High affinity nerve growth factor receptor; Domains – nerve growth factor-binding 36-383; transmembrane 410-447; catalytic+juxtamembrane 376-698; kinase 498-796
  • 1he7 – hTrkA residues 282-413 – human
    
  • 2n90 – hTrkA transmembrane domain – NMR
    
  • 4crp – hTrkA nerve growth factor-binding domain (mutant) – NMR
    
  • 4f0i, 4gt5 – hTrkA kinase domain
    
• High affinity nerve growth factor receptor complex
  • 5kvt, 5wr7 – hTrkA kinase domain + anticancer drug
    
  • 4aoj, 4pmm, 4pmp, 4pms, 4pmt, 4yne, 4yps, 5h3q, 6dkb, 6dkg, 6dki, 6dkw, 6j5l, 6npt, 6nsp, 6nss, 6iqn, 6pl1, 6pl2, 6pl3, 6pl4, 7xaf, 7xbi - hTrkA kinase domain + inhibitor
    
  • 5kmj, 5kmk, 5kml, 5kmm, 5kmn, 5kmo, 6d1y, 6d1z, 6d20, 5i8a, 5jfs, 5jfv, 5jfw, 5jfx, 5kmi, 6pma, 6pmb, 6pmc, 6pme – hTrkA catalytic+juxtamembrane domains 376-698 + inhibitor
    
  • 2ifg – hTrkA nerve growth factor-binding domain + nerve growth factor
    
  • 7n3t – hTrkA nerve growth factor-binding domain + TrkA-binding miniprotein