Progestogens

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Progesterone

Progesterone is a negative allosteric modulator of nicotinic acetylcholine receptors, and a potent antagonist of the mineralocorticoid receptor.

  • Hydroxysteroid dehydrogenase, 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone.


Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y)

Drag the structure with the mouse to rotate

ReferencesReferences

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Alexander Berchansky