Progesterone receptor

Function Progesterone receptor (PR) binds to DNA and inhibits transcription. It is nuclear receptor. The inhibition terminates when progesterone binds to PR. The ovarian steroid progesterone which is essential for breast development and reproductive behavior, is mediated by PR. See also Intracellular receptors Relevance The response to hormone therapy in breast cancer correlates with PR. PR absence in breast tumor cells predicts resistance to hormone therapy . Mometasone is a potent agonist of PR. Structural highlights The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the . Water molecules are shown as red spheres. (1a28).

spinqualitylabelsall models Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of progesterone receptor3D Structures of progesterone receptor

Updated on 18-January-2024

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• Progesterone receptor residues 1-125
  • 1ejf – hPR - human
    
• Progesterone receptor residues 72-195
  • 4x8y – hPR
    
• Progesterone receptor DNA-binding domain residues 399-476
  • 2c7a – hPR DBD + DNA
    
• Progesterone receptor ligand-binding domain residues 673-933
  • 3g8o, 3hq5, 3kba, 4a2j, 4apu – hPR LBD + partial agonist
    
  • 1zuc – hPR LBD + agonist
    
  • 1sqn, 3d90 – hPR LBD + contraceptive
    
  • 2w8y – hPR LBD + RU486
    
  • 1a28 – hPR LBD + progesterone
    
  • 1e3k – hPR LBD + metribolone
    
  • 1sr7 – hPR LBD + skin inflammation drug
    
  • 3zr7, 3zra, 3zrb – hPR LBD + modulator
    
  • 2ovh, 2ovm – hPR LBD + modulator + co-repressor peptide
    
  • 4oar – hPR LBD + contraceptive + co-repressor peptide